{
    "uniprot_canonical_ac": "Q923X4-1",
    "uniprot_ac": "Q923X4",
    "uniprot_id": "GLRX2_MOUSE",
    "mass": {
        "chemical_mass": 17307.0,
        "monoisotopic_mass": 17307.0
    },
    "refseq": {
        "ac": "NP_001033681",
        "name": "glutaredoxin-2, mitochondrial isoform a",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
    },
    "gene_names": [
        {
            "name": "Glrx2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q923X4",
            "id": "Q923X4"
        },
        {
            "name": "1700010P22Rik; Grx2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681",
            "id": "NP_001033681"
        },
        {
            "name": "Glrx2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681",
            "id": "NP_001033681"
        },
        {
            "name": "Grx2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q923X4",
            "id": "Q923X4"
        }
    ],
    "protein_names": [
        {
            "name": "Glutaredoxin-2, mitochondrial",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q923X4"
        },
        {
            "name": "glutaredoxin-2, mitochondrial isoform a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681",
            "id": "NP_001033681"
        },
        {
            "name": "glutaredoxin-2, mitochondrial; thioltransferase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681",
            "id": "NP_001033681"
        }
    ],
    "function": [
        {
            "annotation": "Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                },
                {
                    "database": "PubMed",
                    "id": "33581580",
                    "url": "https://glygen.org/publication/PubMed/33581580"
                }
            ]
        },
        {
            "annotation": "Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                },
                {
                    "database": "PubMed",
                    "id": "37541331",
                    "url": "https://glygen.org/publication/PubMed/37541331"
                }
            ]
        },
        {
            "annotation": "Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q923X4",
                    "url": "https://www.uniprot.org/uniprot/Q923X4#function"
                },
                {
                    "database": "PubMed",
                    "id": "11397793",
                    "url": "https://glygen.org/publication/PubMed/11397793"
                },
                {
                    "database": "PubMed",
                    "id": "15347644",
                    "url": "https://glygen.org/publication/PubMed/15347644"
                }
            ]
        },
        {
            "annotation": "Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                },
                {
                    "database": "PubMed",
                    "id": "35290904",
                    "url": "https://glygen.org/publication/PubMed/35290904"
                }
            ]
        },
        {
            "annotation": "The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                },
                {
                    "database": "PubMed",
                    "id": "37277068",
                    "url": "https://glygen.org/publication/PubMed/37277068"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q923X4",
                    "url": "https://www.uniprot.org/uniprot/Q923X4"
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            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Glrx2",
            "url": "https://www.uniprot.org/uniprot/Q923X4",
            "locus": {
                "chromosome": "1",
                "start_pos": 143625414,
                "end_pos": 143592076,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000018196",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000018196"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000018196",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000018196",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03419",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03419",
            "database": "CDD",
            "categories": [
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            ]
        },
        {
            "id": "69367",
            "url": "https://www.ncbi.nlm.nih.gov/gene/69367",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR002109",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002109",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011899",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011899",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR014025",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014025",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036249",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:69367",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69367",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1916617",
            "url": "http://www.informatics.jax.org/marker/MGI:1916617",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "INGNCVG",
            "url": "https://omabrowser.org/oma/group/INGNCVG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "203654at2759",
            "url": "http://www.orthodb.org/?query=203654at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46679:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46679:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00462",
            "url": "http://pfam.xfam.org/family/PF00462",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q923X4",
            "url": "http://purl.obolibrary.org/obo/PR_Q923X4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001033681",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A0MQ94",
            "url": "https://www.uniprot.org/uniprot/A0A0A0MQ94",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A0MQ94-1",
            "url": "https://www.uniprot.org/uniprot/A0A0A0MQ94-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B7ZC40",
            "url": "https://www.uniprot.org/uniprot/B7ZC40",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B7ZC40-1",
            "url": "https://www.uniprot.org/uniprot/B7ZC40-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q923X4",
            "url": "https://www.uniprot.org/uniprot/Q923X4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q923X4-1",
            "url": "https://www.uniprot.org/uniprot/Q923X4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q923X4-2",
            "url": "https://www.uniprot.org/uniprot/Q923X4-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSTTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQDALHKMTGERTVPRIFVNGRFIGGAADTHRLHKEGKLLPLVHQCYLKKKQEERH",
        "length": 156,
        "header": "sp|Q923X4-1|GLRX2_MOUSE Isoform 1 of Glutaredoxin-2, mitochondrial  OS=Mus musculus OX=10090 GN=Glrx2 PE=1 SV=1 CANONICAL=Q923X4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0A0MQ94-1",
            "url": "",
            "sequence": {
                "sequence": "MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSTTTPVNQIQVSDGEDRGRRNSSHGNNF",
                "length": 72,
                "header": "tr|A0A0A0MQ94-1|GLRX2_MOUSE Computationally mapped isoform of Glutaredoxin-2, mitochondrial  OS=Mus musculus OX=10090 GN=Glrx2 PE=1 SV=1 CANONICAL=Q923X4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 143620795,
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                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000050491.11",
                        "url": "https://www.ensembl.org/id/ENSMUST00000050491.11"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000053443.11",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000053443.11"
                    }
                ]
            }
        },
        {
            "isoform_ac": "B7ZC40-1",
            "url": "",
            "sequence": {
                "sequence": "MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSTTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQDALHKMTGERTVSTVSALLLLEMGWCHTTPRTLDFPASKSKPDISADYTLISKWQIYKETSLIEYETA",
                "length": 170,
                "header": "tr|B7ZC40-1|GLRX2_MOUSE Computationally mapped isoform of Glutaredoxin-2, mitochondrial  OS=Mus musculus OX=10090 GN=Glrx2 PE=1 SV=1 CANONICAL=Q923X4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 143621132,
                "end_pos": 143615399,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000145571.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000145571.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000115893.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115893.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q923X4-1",
            "url": "",
            "sequence": {
                "sequence": "MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSTTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQDALHKMTGERTVPRIFVNGRFIGGAADTHRLHKEGKLLPLVHQCYLKKKQEERH",
                "length": 156,
                "header": "sp|Q923X4-1|GLRX2_MOUSE Isoform 1 of Glutaredoxin-2, mitochondrial  OS=Mus musculus OX=10090 GN=Glrx2 PE=1 SV=1 CANONICAL=Q923X4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 143622374,
                "end_pos": 143615399,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000185362",
                        "url": "https://www.ensembl.org/id/ENSMUST00000185362"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000141022",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141022"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q923X4-2",
            "url": "",
            "sequence": {
                "sequence": "MGNSTSSFWGKSTTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQDALHKMTGERTVPRIFVNGRFIGGAADTHRLHKEGKLLPLVHQCYLKKKQEERH",
                "length": 123,
                "header": "sp|Q923X4-2|GLRX2_MOUSE Isoform 2 of Glutaredoxin-2, mitochondrial  OS=Mus musculus OX=10090 GN=Glrx2 PE=1 SV=1 CANONICAL=Q923X4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 143622374,
                "end_pos": 143617387,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000111957",
                        "url": "https://www.ensembl.org/id/ENSMUST00000111957"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000107588",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000107588"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2.",
            "journal": "J. Biol. Chem.",
            "date": "2001",
            "authors": "Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, Kryukov VM, Kryukov GV, Lou MF",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q923X4",
                    "url": "https://www.uniprot.org/uniprot/Q923X4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11397793",
                    "url": "https://glygen.org/publication/PubMed/11397793"
                }
            ]
        },
        {
            "title": "Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse.",
            "journal": "J. Biol. Chem.",
            "date": "2003",
            "authors": "Jurado J., Madrid-Risquez J., Prieto-Alamo M.-J., Pueyo C.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q923X4",
                    "url": "https://www.uniprot.org/uniprot/Q923X4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12954614",
                    "url": "https://glygen.org/publication/PubMed/12954614"
                }
            ]
        },
        {
            "title": "Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant defense.",
            "journal": "J. Biol. Chem.",
            "date": "2004",
            "authors": "Runswick M.J., Murphy M.P., Brown S.E., Taylor E.R., Beer S.M., Costa N.J., Dahm C.C.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q923X4",
                    "url": "https://www.uniprot.org/uniprot/Q923X4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15347644",
                    "url": "https://glygen.org/publication/PubMed/15347644"
                }
            ]
        },
        {
            "title": "Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.",
            "journal": "International immunopharmacology",
            "date": "2021",
            "authors": "Li C, Xin H, Shi Y, Mu J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33581580",
                    "url": "https://glygen.org/publication/PubMed/33581580"
                }
            ]
        },
        {
            "title": "Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.",
            "journal": "Redox biology",
            "date": "2022",
            "authors": "Scalcon V, Folda A, Lupo MG, Tonolo F, Pei N, Battisti I, Ferri N, Arrigoni G, Bindoli A, Holmgren A, Coppo L, Rigobello MP",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35290904",
                    "url": "https://glygen.org/publication/PubMed/35290904"
                }
            ]
        },
        {
            "title": "The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.",
            "journal": "Experimental eye research",
            "date": "2023-08",
            "authors": "Zhang Jinmin, Yu Yu, Dang Terry, Lal Kevin, Wu Hongli",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37277068",
                    "url": "https://glygen.org/publication/PubMed/37277068"
                }
            ]
        },
        {
            "title": "Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.",
            "journal": "Experimental eye research",
            "date": "2023-09",
            "authors": "Chen Xi, Chen Ying, Li Chenshuang, Li Jiankui, Zhang Siqi, Liang Chen, Deng Qi, Guo Zaoxia, Guo Chenjun, Yan Hong",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001033681",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033681"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37541331",
                    "url": "https://glygen.org/publication/PubMed/37541331"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:69367",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69367",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6AXW1-1",
            "protein_name": "Glutaredoxin-2, mitochondrial",
            "gene_name": "Glrx2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSWYRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSATTPVNQIQETISNNCVVIFSKSSCSYCSMAKKIFHDMNVNYKVVELDMVEYGSQFQEALYKMTGERTVPRIFVNGIFIGGAADTHRLHKEGKLLPLVHQCYLNKSKRKDVE",
                "length": 157
            },
            "evidence": [
                {
                    "id": "45237926",
                    "url": "http://www.informatics.jax.org/homology/45237926",
                    "database": "MGI"
                },
                {
                    "id": "Q923X4",
                    "url": "https://omabrowser.org/oma/group/Q923X4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9NS18-1",
            "protein_name": "Glutaredoxin-2, mitochondrial",
            "gene_name": "GLRX2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQIQETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ",
                "length": 164
            },
            "evidence": [
                {
                    "id": "45237926",
                    "url": "http://www.informatics.jax.org/homology/45237926",
                    "database": "MGI"
                },
                {
                    "id": "Q923X4",
                    "url": "https://omabrowser.org/oma/group/Q923X4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 7,
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                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
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                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
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                    {
                        "name": "mitochondrion",
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                        "evidence": [
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                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial matrix",
                        "id": "GO:0005759",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuronal cell body",
                        "id": "GO:0043025",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
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                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular membrane-bounded organelle",
                        "id": "GO:0043231",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
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                                "database": "UniProtKB",
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                    {
                        "name": "2 iron, 2 sulfur cluster binding",
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                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-disulfide reductase activity",
                        "id": "GO:0015035",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
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                        "pmid": ""
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                "name": "Biological Process",
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                    {
                        "name": "response to hydrogen peroxide",
                        "id": "GO:0042542",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042542",
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                                "database": "UniProtKB",
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                                "url": "https://www.uniprot.org/uniprot/Q923X4"
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                    {
                        "name": "response to organic substance",
                        "id": "GO:0010033",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010033",
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                            {
                                "database": "UniProtKB",
                                "id": "Q923X4",
                                "url": "https://www.uniprot.org/uniprot/Q923X4"
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            "start_pos": 36,
            "end_pos": 38,
            "annotation": "n_glycosylation_sequon"
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
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