{ "uniprot_canonical_ac": "Q91ZZ5-1", "uniprot_ac": "Q91ZZ5", "uniprot_id": "RXFP2_MOUSE", "mass": { "chemical_mass": 82934.0, "monoisotopic_mass": 82934.0 }, "refseq": { "ac": "NP_001276495", "name": "relaxin receptor 2 isoform 3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" }, "gene_names": [ { "name": "Rxfp2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "id": "Q91ZZ5" }, { "name": "Gpr106; Great; Lgr8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493", "id": "NP_001276493" }, { "name": "Gpr106", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "id": "Q91ZZ5" }, { "name": "Great", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "id": "Q91ZZ5" }, { "name": "Lgr8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "id": "Q91ZZ5" }, { "name": "Rxfp2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493", "id": "NP_001276493" } ], "protein_names": [ { "name": "Relaxin receptor 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91ZZ5" }, { "name": "G protein-coupled receptor 106; leucine-rich repeat-containing G protein-coupled receptor 8; relaxin receptor 2; G protein coupled receptor affecting testicular descent", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495", "id": "NP_001276495" }, { "name": "G-protein coupled receptor 106", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZZ5" }, { "name": "G-protein coupled receptor affecting testicular descent", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZZ5" }, { "name": "Leucine-rich repeat-containing G-protein coupled receptor 8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZZ5" }, { "name": "Relaxin family peptide receptor 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZZ5" }, { "name": "relaxin receptor 2 isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493", "id": "NP_001276493" }, { "name": "relaxin receptor 2 isoform 3 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495", "id": "NP_001276495" } ], "function": [ { "annotation": "Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor.", "evidence": [ { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" }, { "database": "PubMed", "id": "14666470", "url": "https://glygen.org/publication/PubMed/14666470" }, { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" } ] }, { "annotation": "Insulin-like 3 peptide or great cause cryptorchidism (undescended testes) in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" }, { "database": "PubMed", "id": "12933905", "url": "https://glygen.org/publication/PubMed/12933905" }, { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" } ] }, { "annotation": "Loss of function of Lgr6 did not impact epidermal cell proliferation, cell migration and wound healing.", "evidence": [ { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" }, { "database": "PubMed", "id": "27579888", "url": "https://glygen.org/publication/PubMed/27579888" }, { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" } ] }, { "annotation": "Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q91ZZ5", "url": "https://www.uniprot.org/uniprot/Q91ZZ5#function" } ] } ], "disease": [ { "disease_id": "DOID:11383", "recommended_name": { "id": "DOID:11383", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11383", "name": "cryptorchidism", "description": "" }, "synonyms": [ { "id": "DOID:11383", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11383", "name": "Cryptorchism", "description": "" }, { "id": "DOID:11383", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11383", "name": "Undescended testicle", "description": "" }, { "id": "DOID:11383", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11383", "name": "Undescended testis", "description": "" }, { "id": "DOID:11383", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11383", "name": "undescended testicles", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "cryptorchidism", "description": "The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life." }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "cryptorchidism", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "cryptorchidism (disease)", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "cryptorchism", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "undescended testes", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "undescended testicle", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "undescended testicles", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "undescended testis", "description": "" }, { "id": "MONDO:0009047", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009047", "name": "cryptorchidism, unilateral or bilateral", "description": "" }, { "id": "MIM:219050", "resource": "MIM", "url": "https://www.omim.org/entry/219050", "name": "Cryptorchidism", "description": "Cryptorchidism" } ], "evidence": [ { "id": "11383", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11383" } ] } ], "snv": [ { "evidence": [ { "id": "rs3388793383", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388793383" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 706, "end_pos": 706, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SAS->NAS).", "chr_id": "5", "chr_pos": "150004644", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S706", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91ZZ5", "url": "https://www.uniprot.org/uniprot/Q91ZZ5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rxfp2", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "locus": { "chromosome": "5", "start_pos": 150005649, "end_pos": 149942140, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000053368", "url": "https://www.ensembl.org/id/ENSMUSG00000053368" } ] } } ], "crossref": [ { "id": "ENSMUSG00000053368", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000053368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3714702", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3714702", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "140498", "url": "https://www.ncbi.nlm.nih.gov/gene/140498", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:140498", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:140498", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2153463", "url": "http://www.informatics.jax.org/marker/MGI:2153463", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MYLSMVN", "url": "https://omabrowser.org/oma/group/MYLSMVN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2913881at2759", "url": "http://www.orthodb.org/?query=2913881at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24372", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24372", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24372:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24372:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "http://pfam.xfam.org/family/PF00057", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91ZZ5", "url": "http://purl.obolibrary.org/obo/PR_Q91ZZ5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-444821", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-444821", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0J9YV81", "url": "https://www.uniprot.org/uniprot/A0A0J9YV81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YV81-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YV81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q0U9", "url": "https://www.uniprot.org/uniprot/E9Q0U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q0U9-1", "url": "https://www.uniprot.org/uniprot/E9Q0U9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91ZZ5", "url": "https://www.uniprot.org/uniprot/Q91ZZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91ZZ5-1", "url": "https://www.uniprot.org/uniprot/Q91ZZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRENELECVKADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVALASIWVVGFLIAAVPFTREDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESSLKLGVLSKIALGDSIMKPVSP", "length": 737, "header": "sp|Q91ZZ5-1|RXFP2_MOUSE Isoform 1 of Relaxin receptor 2 OS=Mus musculus OX=10090 GN=Rxfp2 PE=2 SV=2 CANONICAL=Q91ZZ5-1" }, "isoforms": [ { "isoform_ac": "A0A0J9YV81-1", "url": "", "sequence": { "sequence": "MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRENELECVKADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLNIPNIGNILMCFVRILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVALASIWVVGFLIAAVPFTREDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESSLKLGVLSKIALGDSIMKPVSP", "length": 727, "header": "tr|A0A0J9YV81-1|A0A0J9YV81_MOUSE Computationally mapped isoform of Relaxin/insulin-like family peptide receptor 2 OS=Mus musculus OX=10090 GN=Rxfp2 PE=1 SV=1 CANONICAL=Q91ZZ5-1" }, "locus": { "chromosome": "5", "start_pos": 150004666, "end_pos": 149942333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000201612.2", "url": "https://www.ensembl.org/id/ENSMUST00000201612.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000144536.2", "url": "https://www.ensembl.org/id/ENSMUSP00000144536.2" } ] } }, { "isoform_ac": "E9Q0U9-1", "url": "", "sequence": { "sequence": "MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRENELECVKADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVALASIWVVGFLIAAVPFTREDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESSLKLGVLSKIALGDSIMKPVSP", "length": 713, "header": "tr|E9Q0U9-1|RXFP2_MOUSE Computationally mapped isoform of Relaxin receptor 2 OS=Mus musculus OX=10090 GN=Rxfp2 PE=2 SV=1 CANONICAL=Q91ZZ5-1" }, "locus": { "chromosome": "5", "start_pos": 150004666, "end_pos": 149942333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110496.5", "url": "https://www.ensembl.org/id/ENSMUST00000110496.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106122.2", "url": "https://www.ensembl.org/id/ENSMUSP00000106122.2" } ] } }, { "isoform_ac": "Q91ZZ5-1", "url": "", "sequence": { "sequence": "MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRENELECVKADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVALASIWVVGFLIAAVPFTREDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESSLKLGVLSKIALGDSIMKPVSP", "length": 737, "header": "sp|Q91ZZ5-1|RXFP2_MOUSE Isoform 1 of Relaxin receptor 2 OS=Mus musculus OX=10090 GN=Rxfp2 PE=2 SV=2 CANONICAL=Q91ZZ5-1" }, "locus": { "chromosome": "5", "start_pos": 150004666, "end_pos": 149942333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000065745", "url": "https://www.ensembl.org/id/ENSMUST00000065745" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000067897", "url": "https://www.ensembl.org/id/ENSMUSP00000067897" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 121, "start_aa": "Asn", "end_pos": 121, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn121", "evidence": [ { "id": "Q91ZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZZ5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 257, "start_aa": "Asn", "end_pos": 257, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "Q91ZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZZ5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 318, "start_aa": "Asn", "end_pos": 318, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn318", "evidence": [ { "id": "Q91ZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZZ5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 350, "start_aa": "Asn", "end_pos": 350, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn350", "evidence": [ { "id": "Q91ZZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZZ5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": 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Harrison W.R., Sutherland R.W., Overbeek P.A., Bishop C.E., Agoulnik A.I., Boettger-Tong H.L., Houston J.B.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZZ5", "url": "https://www.uniprot.org/uniprot/Q91ZZ5" } ], "reference": [ { "type": "PubMed", "id": "11353515", "url": "https://glygen.org/publication/PubMed/11353515" } ] }, { "title": "GREAT/LGR8 is the only receptor for insulin-like 3 peptide.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2003", "authors": "Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI", "evidence": [ { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" }, { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" } ], "reference": [ { "type": "PubMed", "id": "12933905", "url": "https://glygen.org/publication/PubMed/12933905" } ] }, { "title": "Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.", "journal": "Journal of pediatric surgery", "date": "2003", "authors": "Tomiyama H, Hutson JM, Truong A, Agoulnik AI", "evidence": [ { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" }, { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" } ], "reference": [ { "type": "PubMed", "id": "14666470", "url": "https://glygen.org/publication/PubMed/14666470" } ] }, { "title": "Lgr6 is dispensable for epidermal cell proliferation and wound repair.", "journal": "Experimental dermatology", "date": "2017", "authors": "Jiang L, Wang L, Chen CP, Li MQ, Liao XH", "evidence": [ { "database": "RefSeq", "id": "NP_001276493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276493" }, { "database": "RefSeq", "id": "NP_001276495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276495" } ], "reference": [ { "type": "PubMed", "id": "27579888", "url": "https://glygen.org/publication/PubMed/27579888" } ] } ], "pathway": [ { "id": "mmu:140498", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:140498", "resource": "KEGG Pathway" }, { "id": "R-MMU-418555", "name": "G alpha (s) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-MMU-444821", "name": "Relaxin receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-444821", "resource": "Reactome", "description": "Relaxin receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZRR3-1", "protein_name": "Relaxin family peptide receptor 2", "gene_name": "Rxfp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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