{ "uniprot_canonical_ac": "Q91ZV8-1", "uniprot_ac": "Q91ZV8", "uniprot_id": "AGRA2_MOUSE", "mass": { "chemical_mass": 143170.0, "monoisotopic_mass": 143170.0 }, "refseq": { "ac": "NP_473385", "name": "adhesion G protein-coupled receptor A2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385" }, "gene_names": [ { "name": "Adgra2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "id": "Q91ZV8" }, { "name": "8430414O08Rik; 9530074E10Rik; Gpr124; mKIAA1531; Tem5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "id": "NP_473385" }, { "name": "Adgra2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "id": "NP_473385" }, { "name": "Gpr124", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "id": "Q91ZV8" }, { "name": "Tem5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "id": "Q91ZV8" } ], "protein_names": [ { "name": "Adhesion G protein-coupled receptor A2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91ZV8" }, { "name": "G-protein coupled receptor 124; tumor endothelial marker 5; G protein coupled receptor Gpr124", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "id": "NP_473385" }, { "name": "G-protein coupled receptor 124", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZV8" }, { "name": "Tumor endothelial marker 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91ZV8" }, { "name": "adhesion G protein-coupled receptor A2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "id": "NP_473385" } ], "function": [ { "annotation": "An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.", "evidence": [ { "database": "RefSeq", "id": "NP_473385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385" }, { "database": "PubMed", "id": "35649360", "url": "https://glygen.org/publication/PubMed/35649360" } ] }, { "annotation": "Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:25373781, PubMed:25558062, PubMed:28803732). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781, PubMed:28288111). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8#function" }, { "database": "PubMed", "id": "21421844", "url": "https://glygen.org/publication/PubMed/21421844" }, { "database": "PubMed", "id": "25558062", "url": "https://glygen.org/publication/PubMed/25558062" }, { "database": "PubMed", "id": "21282641", "url": "https://glygen.org/publication/PubMed/21282641" }, { "database": "UniProtKB", "id": "Q96PE1", "url": "https://www.uniprot.org/uniprot/Q96PE1#function" }, { "database": "PubMed", "id": "21071672", "url": "https://glygen.org/publication/PubMed/21071672" }, { "database": "PubMed", "id": "25373781", "url": "https://glygen.org/publication/PubMed/25373781" }, { "database": "PubMed", "id": "28803732", "url": "https://glygen.org/publication/PubMed/28803732" }, { "database": "PubMed", "id": "28288111", "url": "https://glygen.org/publication/PubMed/28288111" } ] }, { "annotation": "The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.", "evidence": [ { "database": "RefSeq", "id": "NP_473385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385" }, { "database": "PubMed", "id": "35552394", "url": "https://glygen.org/publication/PubMed/35552394" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 1333, "end_pos": 1336, "sequence_org": "ETTV", "sequence_mut": "", "comment": "Fails to interact with DLG1. No effect on cell surface localization.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" }, { "database": "PubMed", "id": "25558062", "url": "https://glygen.org/publication/PubMed/25558062" } ] }, { "start_pos": 364, "end_pos": 364, "sequence_org": "D", "sequence_mut": "E", "comment": "No effect on potentiation of WNT7A signaling.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" }, { "database": "PubMed", "id": "25558062", "url": "https://glygen.org/publication/PubMed/25558062" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Adgra2", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "locus": { "chromosome": "8", "start_pos": 27613464, "end_pos": 27575611, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031486", "url": "https://www.ensembl.org/id/ENSMUSG00000031486" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031486", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031486", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15998", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15998", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "78560", "url": "https://www.ncbi.nlm.nih.gov/gene/78560", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:78560", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78560", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1925810", "url": "http://www.informatics.jax.org/marker/MGI:1925810", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CAEDRPK", "url": "https://omabrowser.org/oma/group/CAEDRPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2900279at2759", "url": "http://www.orthodb.org/?query=2900279at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45930", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45930", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45930:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45930:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "http://pfam.xfam.org/family/PF00002", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01825", "url": "http://pfam.xfam.org/family/PF01825", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91ZV8", "url": "http://purl.obolibrary.org/obo/PR_Q91ZV8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_473385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473385", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "J3QMG7", "url": "https://www.uniprot.org/uniprot/J3QMG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QMG7-1", "url": "https://www.uniprot.org/uniprot/J3QMG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QPB6", "url": "https://www.uniprot.org/uniprot/J3QPB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QPB6-1", "url": "https://www.uniprot.org/uniprot/J3QPB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QPS6", "url": "https://www.uniprot.org/uniprot/J3QPS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QPS6-1", "url": "https://www.uniprot.org/uniprot/J3QPS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91ZV8-1", "url": "https://www.uniprot.org/uniprot/Q91ZV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAGGRRMPVPPARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPALKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTRIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGAQPSSVGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGADPMAAWWNQDGPGGWSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPLEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRSHVAQNPKQGNRISLEPGEELRGSTRLRSSGVLLNDSGSLLATVSAGVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHVPARALPTATEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASVAARGDGEPEPTGSRGSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAPIAETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGSMKTGLWKSETTV", "length": 1336, "header": "sp|Q91ZV8-1|AGRA2_MOUSE Isoform 1 of Adhesion G protein-coupled receptor A2 OS=Mus musculus OX=10090 GN=Adgra2 PE=1 SV=2 CANONICAL=Q91ZV8-1" }, "isoforms": [ { "isoform_ac": "J3QMG7-1", "url": "", "sequence": { "sequence": "MGAGGRRMPVPPARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPALKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTRIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPLEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRSHVAQNPKQGNRISLEPGEELRGSTRLRSSGVLLNDSGSLLATVSAGVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHVPARALPTATEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASVAARGDGEPEPTGSRGSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAPIAETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGSMKTGLWKSETTV", "length": 1121, "header": "tr|J3QMG7-1|J3QMG7_MOUSE Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Mus musculus OX=10090 GN=Adgra2 PE=1 SV=1 CANONICAL=Q91ZV8-1" }, "locus": { "chromosome": "8", "start_pos": 27612060, "end_pos": 27575974, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000178514.8", "url": "https://www.ensembl.org/id/ENSMUST00000178514.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000136277.2", "url": "https://www.ensembl.org/id/ENSMUSP00000136277.2" } ] } }, { "isoform_ac": "J3QPB6-1", "url": "", "sequence": { "sequence": "XTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGAQPSSVGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKPRQQHFPSWSSWAWQEAWCGHPSHICRNQWLWCGKLDGARGCVTEALG", "length": 210, "header": "tr|J3QPB6-1|J3QPB6_MOUSE Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Mus musculus OX=10090 GN=Adgra2 PE=1 SV=1 CANONICAL=Q91ZV8-1" }, "locus": { "chromosome": "8", "start_pos": 27607403, "end_pos": 27604161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000179207.3", "url": "https://www.ensembl.org/id/ENSMUST00000179207.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000137181.2", "url": "https://www.ensembl.org/id/ENSMUSP00000137181.2" } ] } }, { "isoform_ac": "J3QPS6-1", "url": "", "sequence": { "sequence": "WAEGADPMAAWWNQDGPGGWSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSAWSSPHAPVLLDCWRDPPHNLRHHRCGQHPQLPGPQSLLLAGVASKPWCLLHTGGVDSAYHLDLLLVCRPSLTEPCGPESKAG", "length": 176, "header": "tr|J3QPS6-1|J3QPS6_MOUSE Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Mus musculus OX=10090 GN=Adgra2 PE=4 SV=1 CANONICAL=Q91ZV8-1" }, "locus": { "chromosome": "8", "start_pos": 27611030, "end_pos": 27607397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000179351.2", "url": "https://www.ensembl.org/id/ENSMUST00000179351.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000137457.2", "url": "https://www.ensembl.org/id/ENSMUSP00000137457.2" } ] } }, { "isoform_ac": "Q91ZV8-1", "url": "", "sequence": { "sequence": "MGAGGRRMPVPPARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPALKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTRIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGAQPSSVGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGADPMAAWWNQDGPGGWSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPLEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRSHVAQNPKQGNRISLEPGEELRGSTRLRSSGVLLNDSGSLLATVSAGVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHVPARALPTATEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASVAARGDGEPEPTGSRGSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAPIAETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGSMKTGLWKSETTV", "length": 1336, "header": "sp|Q91ZV8-1|AGRA2_MOUSE Isoform 1 of Adhesion G protein-coupled receptor A2 OS=Mus musculus OX=10090 GN=Adgra2 PE=1 SV=2 CANONICAL=Q91ZV8-1" }, "locus": { "chromosome": "8", "start_pos": 27612060, "end_pos": 27575974, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000033876", "url": "https://www.ensembl.org/id/ENSMUST00000033876" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000033876", "url": "https://www.ensembl.org/id/ENSMUSP00000033876" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 101, "start_aa": "Asn", "end_pos": 101, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn101", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 162, "start_aa": "Asn", "end_pos": 162, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn162", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 275, "start_aa": "Asn", "end_pos": 275, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn275", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 602, "start_aa": "Asn", "end_pos": 602, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn602", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 691, "start_aa": "Asn", "end_pos": 691, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn691", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 735, "start_aa": "Asn", "end_pos": 735, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn735", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 84, "start_aa": "Asn", "end_pos": 84, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn84", "evidence": [ { "id": "Q91ZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZV8#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 1104, "end_pos": 1104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "site_lbl": "Ser1104" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cell surface tumor endothelial markers are conserved in mice and humans.", "journal": "Cancer Res.", "date": "2001", "authors": "Kinzler K.W., Vogelstein B., St Croix B., Carson-Walter E.B., Nanda A., Watkins D.N.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "11559528", "url": "https://glygen.org/publication/PubMed/11559528" } ] }, { "title": "Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.", "journal": "Gene Expr. Patterns", "date": "2009", "authors": "Homma S., Shimada T., Hikake T., Yaginuma H.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "18848646", "url": "https://glygen.org/publication/PubMed/18848646" } ] }, { "title": "Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.", "journal": "Science", "date": "2010", "authors": "Kuo C.J., Su H., Wang H.T., Florek M., Choksi V., Fruttiger M., Heilshorn S.C., Kuhnert F., Mancuso M.R., Shamloo A., Young W.L.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "21071672", "url": "https://glygen.org/publication/PubMed/21071672" } ] }, { "title": "Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2011", "authors": "Xue Y., Burfeind P., Murphy A.J., Thurston G., Valenzuela D.M., Wei Y., Yancopoulos G.D., Pan L., Yang X.M., Gale N.W., Economides A.N., Lin H.C., Macdonald L.E., Anderson K.D., Daly C., Dominguez M.G., Hughes V.C., Simmons M.V., Walls J.R.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "21282641", "url": "https://glygen.org/publication/PubMed/21282641" } ] }, { "title": "GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2011", "authors": "Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "21421844", "url": "https://glygen.org/publication/PubMed/21421844" } ] }, { "title": "Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling.", "journal": "Dev. Cell", "date": "2014", "authors": "Zhou Y., Nathans J.", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "25373781", "url": "https://glygen.org/publication/PubMed/25373781" } ] }, { "title": "GPR124 functions as a WNT7-specific coactivator of canonical beta-catenin signaling.", "journal": "Cell Rep.", "date": "2015", "authors": "Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "25558062", "url": "https://glygen.org/publication/PubMed/25558062" } ] }, { "title": "Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.", "journal": "Nat. Med.", "date": "2017", "authors": "Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "28288111", "url": "https://glygen.org/publication/PubMed/28288111" } ] }, { "title": "Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation.", "journal": "Neuron", "date": "2017", "authors": "Cho C, Smallwood PM, Nathans J", "evidence": [ { "database": "UniProtKB", "id": "Q91ZV8", "url": "https://www.uniprot.org/uniprot/Q91ZV8" } ], "reference": [ { "type": "PubMed", "id": "28803732", 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