{
    "uniprot_canonical_ac": "Q91ZR5-1",
    "uniprot_ac": "Q91ZR5",
    "uniprot_id": "CTSR1_MOUSE",
    "mass": {
        "chemical_mass": 78706.0,
        "monoisotopic_mass": 78706.0
    },
    "refseq": {
        "ac": "NP_647462",
        "name": "cation channel sperm-associated protein 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
    },
    "gene_names": [
        {
            "name": "Catsper1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q91ZR5",
            "id": "Q91ZR5"
        },
        {
            "name": "Catsper1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462",
            "id": "NP_647462"
        },
        {
            "name": "Catsper; KSper",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462",
            "id": "NP_647462"
        }
    ],
    "protein_names": [
        {
            "name": "Cation channel sperm-associated protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q91ZR5"
        },
        {
            "name": "CatSper1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q91ZR5"
        },
        {
            "name": "cation channel sperm-associated protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462",
            "id": "NP_647462"
        },
        {
            "name": "sperm protein CATSPER1; sperm ion channel; sperm calcium channel 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462",
            "id": "NP_647462"
        }
    ],
    "function": [
        {
            "annotation": "Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "35248021",
                    "url": "https://glygen.org/publication/PubMed/35248021"
                }
            ]
        },
        {
            "annotation": "C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "34919125",
                    "url": "https://glygen.org/publication/PubMed/34919125"
                }
            ]
        },
        {
            "annotation": "CatSper1 and CatSper2 null sperm show identical phenotypes in mice",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "16036917",
                    "url": "https://glygen.org/publication/PubMed/16036917"
                }
            ]
        },
        {
            "annotation": "CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "14657352",
                    "url": "https://glygen.org/publication/PubMed/14657352"
                }
            ]
        },
        {
            "annotation": "Catsper1's function in sperm physiology and role in sperm competition using rodent models",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "15930155",
                    "url": "https://glygen.org/publication/PubMed/15930155"
                }
            ]
        },
        {
            "annotation": "Potential role for CatSper in sperm motility and fertility in mouse and human. CatSper is therefore implicated as a potential target to explore the molecular mechanisms of male infertility.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                },
                {
                    "database": "PubMed",
                    "id": "14688170",
                    "url": "https://glygen.org/publication/PubMed/14688170"
                }
            ]
        },
        {
            "annotation": "Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5#function"
                },
                {
                    "database": "PubMed",
                    "id": "14657352",
                    "url": "https://glygen.org/publication/PubMed/14657352"
                },
                {
                    "database": "PubMed",
                    "id": "11595941",
                    "url": "https://glygen.org/publication/PubMed/11595941"
                },
                {
                    "database": "PubMed",
                    "id": "16467839",
                    "url": "https://glygen.org/publication/PubMed/16467839"
                },
                {
                    "database": "PubMed",
                    "id": "17174296",
                    "url": "https://glygen.org/publication/PubMed/17174296"
                },
                {
                    "database": "PubMed",
                    "id": "16036917",
                    "url": "https://glygen.org/publication/PubMed/16036917"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070173",
            "recommended_name": {
                "id": "DOID:0070173",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070173",
                "name": "spermatogenic failure 7",
                "description": "A spermatogenic failure that is characterized by autosomal recessive inheritance of impaired or absent sperm motility and increased incidence of morphologically abnormal sperm that has_material_basis_in mutation in the CATSPER1 gene on chromosome 11q13."
            },
            "synonyms": [
                {
                    "id": "DOID:0070173",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070173",
                    "name": "SPGF7",
                    "description": ""
                },
                {
                    "id": "MONDO:0013070",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013070",
                    "name": "spermatogenic failure 7",
                    "description": ""
                },
                {
                    "id": "MONDO:0013070",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013070",
                    "name": "spermatogenic failure 7",
                    "description": ""
                },
                {
                    "id": "MONDO:0013070",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013070",
                    "name": "spermatogenic failure type 7",
                    "description": ""
                },
                {
                    "id": "MONDO:0013070",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013070",
                    "name": "Male infertility, nonsyndromic, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013070",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013070",
                    "name": "SPGF7",
                    "description": ""
                },
                {
                    "id": "MIM:612997",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/612997",
                    "name": "Spermatogenic failure 7",
                    "description": "Spermatogenic failure 7"
                }
            ],
            "evidence": [
                {
                    "id": "0070173",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070173"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Catsper1",
            "url": "https://www.uniprot.org/uniprot/Q91ZR5",
            "locus": {
                "chromosome": "19",
                "start_pos": 5394308,
                "end_pos": 5385769,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000038498",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000038498"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000038498",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038498",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "CHEMBL3886121",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3886121",
            "database": "ChEMBL",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "225865",
            "url": "https://www.ncbi.nlm.nih.gov/gene/225865",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q91ZR5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q91ZR5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR005821",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027359",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028746",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028746",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:225865",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:225865",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2179947",
            "url": "http://www.informatics.jax.org/marker/MGI:2179947",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "EDWGKEE",
            "url": "https://omabrowser.org/oma/group/EDWGKEE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2914780at2759",
            "url": "http://www.orthodb.org/?query=2914780at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47193",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47193",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47193:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47193:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "7EEB",
            "url": "https://www.rcsb.org/structure/7EEB",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00520",
            "url": "http://pfam.xfam.org/family/PF00520",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q91ZR5",
            "url": "http://purl.obolibrary.org/obo/PR_Q91ZR5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-1300642",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1300642",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_647462",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494B9U9",
            "url": "https://www.uniprot.org/uniprot/A0A494B9U9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494B9U9-1",
            "url": "https://www.uniprot.org/uniprot/A0A494B9U9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91ZR5",
            "url": "https://www.uniprot.org/uniprot/Q91ZR5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91ZR5-1",
            "url": "https://www.uniprot.org/uniprot/Q91ZR5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK",
        "length": 686,
        "header": "sp|Q91ZR5-1|CTSR1_MOUSE Isoform 1 of Cation channel sperm-associated protein 1  OS=Mus musculus OX=10090 GN=Catsper1 PE=1 SV=1 CANONICAL=Q91ZR5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A494B9U9-1",
            "url": "",
            "sequence": {
                "sequence": "XHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK",
                "length": 496,
                "header": "tr|A0A494B9U9-1|CTSR1_MOUSE Computationally mapped isoform of Cation channel sperm-associated protein 1  OS=Mus musculus OX=10090 GN=Catsper1 PE=1 SV=1 CANONICAL=Q91ZR5-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 5394179,
                "end_pos": 5386226,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000235380.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000235380.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000157759.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000157759.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q91ZR5-1",
            "url": "",
            "sequence": {
                "sequence": "MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK",
                "length": 686,
                "header": "sp|Q91ZR5-1|CTSR1_MOUSE Isoform 1 of Cation channel sperm-associated protein 1  OS=Mus musculus OX=10090 GN=Catsper1 PE=1 SV=1 CANONICAL=Q91ZR5-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 5394178,
                "end_pos": 5385769,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000043380",
                        "url": "https://www.ensembl.org/id/ENSMUST00000043380"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000045430",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000045430"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "A sperm ion channel required for sperm motility and male fertility.",
            "journal": "Nature",
            "date": "2001",
            "authors": "Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11595941",
                    "url": "https://glygen.org/publication/PubMed/11595941"
                }
            ]
        },
        {
            "title": "CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2003",
            "authors": "Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14657352",
                    "url": "https://glygen.org/publication/PubMed/14657352"
                }
            ]
        },
        {
            "title": "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility.",
            "journal": "Hum. Reprod.",
            "date": "2004",
            "authors": "Nikpoor P, Mowla SJ, Movahedin M, Ziaee SA, Tiraihi T",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14688170",
                    "url": "https://glygen.org/publication/PubMed/14688170"
                }
            ]
        },
        {
            "title": "Positive selection for indel substitutions in the rodent sperm protein catsper1.",
            "journal": "Mol. Biol. Evol.",
            "date": "2005",
            "authors": "Podlaha O, Webb DM, Tucker PK, Zhang J",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15930155",
                    "url": "https://glygen.org/publication/PubMed/15930155"
                }
            ]
        },
        {
            "title": "Identical phenotypes of CatSper1 and CatSper2 null sperm.",
            "journal": "J. Biol. Chem.",
            "date": "2005",
            "authors": "Carlson AE, Quill TA, Westenbroek RE, Schuh SM, Hille B, Babcock DF",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91ZR5",
                    "url": "https://www.uniprot.org/uniprot/Q91ZR5"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_647462",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647462"
                }
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