{ "uniprot_canonical_ac": "Q91XA5-1", "uniprot_ac": "Q91XA5", "uniprot_id": "SNPC2_MOUSE", "mass": { "chemical_mass": 38370.0, "monoisotopic_mass": 38370.0 }, "refseq": { "ac": "NP_598729", "name": "snRNA-activating protein complex subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729" }, "gene_names": [ { "name": "Snapc2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91XA5", "id": "Q91XA5" }, { "name": "0610007H10Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729", "id": "NP_598729" }, { "name": "Snapc2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729", "id": "NP_598729" } ], "protein_names": [ { "name": "snRNA-activating protein complex subunit 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91XA5" }, { "name": "SNAPc 45 kDa subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91XA5" }, { "name": "SNAPc subunit 2; SNAPc 45 kDa subunit; snRNA-activating protein complex 45 kDa subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729", "id": "NP_598729" }, { "name": "SNAPc subunit 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91XA5" }, { "name": "Small nuclear RNA-activating complex polypeptide 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91XA5" }, { "name": "snRNA-activating protein complex 45 kDa subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91XA5" }, { "name": "snRNA-activating protein complex subunit 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729", "id": "NP_598729" } ], "function": [ { "annotation": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Snapc2", "url": "https://www.uniprot.org/uniprot/Q91XA5", "locus": { "chromosome": "8", "start_pos": 4306220, "end_pos": 4303080, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000011837", "url": "https://www.ensembl.org/id/ENSMUSG00000011837" } ] } } ], "crossref": [ { "id": "ENSMUSG00000011837", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000011837", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "102209", "url": "https://www.ncbi.nlm.nih.gov/gene/102209", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:102209", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:102209", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1914861", "url": "http://www.informatics.jax.org/marker/MGI:1914861", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "EPKSAWQ", "url": "https://omabrowser.org/oma/group/EPKSAWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5363345at2759", "url": "http://www.orthodb.org/?query=5363345at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15132:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15132:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11035", "url": "http://pfam.xfam.org/family/PF11035", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91XA5", "url": "http://purl.obolibrary.org/obo/PR_Q91XA5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6807505", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76071", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_598729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598729", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140LHE1", "url": "https://www.uniprot.org/uniprot/A0A140LHE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LHE1-1", "url": "https://www.uniprot.org/uniprot/A0A140LHE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LHV3", "url": "https://www.uniprot.org/uniprot/A0A140LHV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LHV3-1", "url": "https://www.uniprot.org/uniprot/A0A140LHV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LID1", "url": "https://www.uniprot.org/uniprot/A0A140LID1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LID1-1", "url": "https://www.uniprot.org/uniprot/A0A140LID1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91XA5-1", "url": "https://www.uniprot.org/uniprot/Q91XA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPPQRRRRVPARYVGEATGPTAWSPREMRHLLRLLQARRGQPEPDAAELAQELRGRSEAEICRFIQQLKGRVVREAIQKMQPGGREGPRHQGTPLPAPVEVWMDLAEKLTGPMEEALTAAFSQVLTIAAAEPLSLLHSRPGKPTKARGKALVFLSNQDGQKDPASEGSGPVPMTAADPTREASVSDPKASGANPETSGLASEVTVPDPDAPTKSLAGSSTERDLAVDFEKIYKYLSFSSRGGHGPELSAAESAVVLNLLMALPEELSHLPCTALLEHMTKTYAQLMAPQTALPGEKRPRPGTEDGGTGSTGPEEPDQASPQASEPIEPRLAWKAVGICPLNPFLVPLGLVSQAPSPSR", "length": 359, "header": "sp|Q91XA5-1|SNPC2_MOUSE Isoform 1 of snRNA-activating protein complex subunit 2 OS=Mus musculus OX=10090 GN=Snapc2 PE=2 SV=1 CANONICAL=Q91XA5-1" }, "isoforms": [ { "isoform_ac": "A0A140LHE1-1", "url": "", "sequence": { "sequence": "XLVFLSNQDGQKDPASEEVAMALSSQQLSQLWSLTCSWHFQRNCPTCLARPCWNI", "length": 55, "header": "tr|A0A140LHE1-1|SNPC2_MOUSE Computationally mapped isoform of snRNA-activating protein complex subunit 2 OS=Mus musculus OX=10090 GN=Snapc2 PE=2 SV=1 CANONICAL=Q91XA5-1" }, "locus": { "chromosome": "8", "start_pos": 4305562, "end_pos": 4305071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208110.2", "url": "https://www.ensembl.org/id/ENSMUST00000208110.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146378.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146378.2" } ] } }, { "isoform_ac": "A0A140LHV3-1", "url": "", "sequence": { "sequence": "MQPGGREGPRHQGTPLPAPVEVWMDLAEKLTGPMEEALTAAFSQVLTIAAAEPLSLLHSRPGKPTKARGKALVFLSNQDGQKDPASEGSGPVPMTAADPTREASVSDPKASGANPETSGLASEVTVPDPDAPTKSLAGSSTERDLAVDFEKIYKYLSFSSRGGHGPELSAAESAVVLNLLMALPEELSHLPCTALLEHMTKTYAQLMAPQTALPGEKRPRPG", "length": 222, "header": "tr|A0A140LHV3-1|A0A140LHV3_MOUSE Computationally mapped isoform of Small nuclear RNA activating complex, polypeptide 2 OS=Mus musculus OX=10090 GN=Snapc2 PE=1 SV=1 CANONICAL=Q91XA5-1" }, "locus": { "chromosome": "8", "start_pos": 4305632, "end_pos": 4304339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208459.2", "url": "https://www.ensembl.org/id/ENSMUST00000208459.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146560.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146560.2" } ] } }, { "isoform_ac": "A0A140LID1-1", "url": "", "sequence": { "sequence": "MKPPQRRRRVPARYVGEATGPTAWSPREMRHLLRLLQARRGQPEPDAAELAQELRGRSEAEICRFIQQLKGRVVREAIQKMQPGGREGPRHQGTPLPAPVEVWMDLAEKLTERDLAVDFEKIYKYLSFSSRGGHGPELSAAESAVVLNLLMALPEELSHLPCTALLEHMTKTYAQLMAPQTALPGEKRPRPGTEDGGTGSTGPEEPDQASPQASEPIEPRLAWKAVGICPLNPFLVPLGLVSQAPSPSR", "length": 249, "header": "tr|A0A140LID1-1|SNPC2_MOUSE Computationally mapped isoform of snRNA-activating protein complex subunit 2 OS=Mus musculus OX=10090 GN=Snapc2 PE=2 SV=1 CANONICAL=Q91XA5-1" }, "locus": { "chromosome": "8", "start_pos": 4305803, "end_pos": 4303122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208316.2", "url": "https://www.ensembl.org/id/ENSMUST00000208316.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146771.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146771.2" } ] } }, { "isoform_ac": "Q91XA5-1", "url": "", "sequence": { "sequence": "MKPPQRRRRVPARYVGEATGPTAWSPREMRHLLRLLQARRGQPEPDAAELAQELRGRSEAEICRFIQQLKGRVVREAIQKMQPGGREGPRHQGTPLPAPVEVWMDLAEKLTGPMEEALTAAFSQVLTIAAAEPLSLLHSRPGKPTKARGKALVFLSNQDGQKDPASEGSGPVPMTAADPTREASVSDPKASGANPETSGLASEVTVPDPDAPTKSLAGSSTERDLAVDFEKIYKYLSFSSRGGHGPELSAAESAVVLNLLMALPEELSHLPCTALLEHMTKTYAQLMAPQTALPGEKRPRPGTEDGGTGSTGPEEPDQASPQASEPIEPRLAWKAVGICPLNPFLVPLGLVSQAPSPSR", "length": 359, "header": "sp|Q91XA5-1|SNPC2_MOUSE Isoform 1 of snRNA-activating protein complex subunit 2 OS=Mus musculus OX=10090 GN=Snapc2 PE=2 SV=1 CANONICAL=Q91XA5-1" }, "locus": { "chromosome": "8", "start_pos": 4305803, "end_pos": 4303122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000011981", "url": "https://www.ensembl.org/id/ENSMUST00000011981" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000011981", "url": "https://www.ensembl.org/id/ENSMUSP00000011981" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:102209", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:102209", "resource": "KEGG Pathway" }, { "id": "R-MMU-6807505", "name": "RNA polymerase II transcribes snRNA genes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-MMU-76071", "name": "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76071", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13487-1", "protein_name": "snRNA-activating protein complex subunit 2", "gene_name": "SNAPC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR", "length": 334 }, "evidence": [ { "id": "45231482", "url": "http://www.informatics.jax.org/homology/45231482", "database": "MGI" }, { "id": "Q91XA5", "url": "https://omabrowser.org/oma/group/Q91XA5/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q68FX5-1", "protein_name": "snRNA-activating protein complex subunit 2", "gene_name": "Snapc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPPQRRRKVPARYTGEATGPTAWSPREMRHLLRLLQARRGQPEPDAKELAKELRGRSEAEICRFIQQLKGRVVREAIRKVQPGGRDGPRHRETQLPAPIEVWMDLAEKLTGPLEEALTAAFSQVLTIAAAEPLSLLHSKPGKPTKACGRALVFLSTQDAQKDPAPEGSGPEPMTAADPTPEASVPEPKASGTNPETSGLVPEVSVPDPDAPTESLAGSSTERDFAVDFEKIYKYLSSSSRGGHGPELSAVESAVVLNLLMSLAEELPHLPCTALVDHLTKTYAQLTAPQASLDREKRPRPGTEDGGTDSTGPEETGQGSPQASEPTEPRLTWKAAGVCPLNPFLVPLDLLSQALAPAR", "length": 359 }, "evidence": [ { "id": "45231482", "url": "http://www.informatics.jax.org/homology/45231482", "database": "MGI" }, { "id": "Q91XA5", "url": "https://omabrowser.org/oma/group/Q91XA5/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "snRNA transcription", "id": "GO:0009301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009301", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "Q91XA5", "url": "https://www.uniprot.org/uniprot/Q91XA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }