{
    "uniprot_canonical_ac": "Q91WQ5-1",
    "uniprot_ac": "Q91WQ5",
    "uniprot_id": "TAF5L_MOUSE",
    "mass": {
        "chemical_mass": 65911.0,
        "monoisotopic_mass": 65911.0
    },
    "refseq": {
        "ac": "NP_598727",
        "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727"
    },
    "gene_names": [
        {
            "name": "Taf5l",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q91WQ5",
            "id": "Q91WQ5"
        },
        {
            "name": "1110005N04Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727",
            "id": "NP_598727"
        },
        {
            "name": "Paf65b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q91WQ5",
            "id": "Q91WQ5"
        },
        {
            "name": "Taf5l",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727",
            "id": "NP_598727"
        }
    ],
    "protein_names": [
        {
            "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q91WQ5"
        },
        {
            "name": "PAF65-beta; PCAF-associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727",
            "id": "NP_598727"
        },
        {
            "name": "PAF65-beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q91WQ5"
        },
        {
            "name": "PCAF-associated factor 65 beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q91WQ5"
        },
        {
            "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727",
            "id": "NP_598727"
        },
        {
            "name": "TAF5L",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q91WQ5"
        }
    ],
    "function": [
        {
            "annotation": "Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91WQ5",
                    "url": "https://www.uniprot.org/uniprot/Q91WQ5#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "O75529",
                    "url": "https://www.uniprot.org/uniprot/O75529#function"
                },
                {
                    "database": "PubMed",
                    "id": "31005419",
                    "url": "https://glygen.org/publication/PubMed/31005419"
                }
            ]
        },
        {
            "annotation": "TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598727",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727"
                },
                {
                    "database": "PubMed",
                    "id": "31005419",
                    "url": "https://glygen.org/publication/PubMed/31005419"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91WQ5",
                    "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Taf5l",
            "url": "https://www.uniprot.org/uniprot/Q91WQ5",
            "locus": {
                "chromosome": "8",
                "start_pos": 124723057,
                "end_pos": 124748136,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000038697",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000038697"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000038697",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038697",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00200",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd08044",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08044",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "102162",
            "url": "https://www.ncbi.nlm.nih.gov/gene/102162",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q91WQ5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q91WQ5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001680",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR007582",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007582",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019775",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020472",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037264",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037264",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:102162",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:102162",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1919039",
            "url": "http://www.informatics.jax.org/marker/MGI:1919039",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "RTEHVQM",
            "url": "https://omabrowser.org/oma/group/RTEHVQM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3138699at2759",
            "url": "http://www.orthodb.org/?query=3138699at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR19879",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19879",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR19879:SF6",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19879:SF6",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00400",
            "url": "http://pfam.xfam.org/family/PF00400",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04494",
            "url": "http://pfam.xfam.org/family/PF04494",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q91WQ5",
            "url": "http://purl.obolibrary.org/obo/PR_Q91WQ5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_598727",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5RMJ9",
            "url": "https://www.uniprot.org/uniprot/A0A1D5RMJ9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5RMJ9-1",
            "url": "https://www.uniprot.org/uniprot/A0A1D5RMJ9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91WQ5",
            "url": "https://www.uniprot.org/uniprot/Q91WQ5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q91WQ5-1",
            "url": "https://www.uniprot.org/uniprot/Q91WQ5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MKRVRTEQVQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAEPQQYEVQFGRLRSFLTDSDSQYSREVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHIHLDVQPAKRTDYQLYASGGSSRTENSSLEPPEVPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSEPHHVDTSRIRLACDTLEEEENEEDNTGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCNTPADGSSGELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH",
        "length": 589,
        "header": "sp|Q91WQ5-1|TAF5L_MOUSE Isoform 1 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L  OS=Mus musculus OX=10090 GN=Taf5l PE=2 SV=1 CANONICAL=Q91WQ5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1D5RMJ9-1",
            "url": "",
            "sequence": {
                "sequence": "MKRVRTEQVQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTDSDSQYSREVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHIHLDVQPAKRTDYQLYASGGSSRTENSSLEPPE",
                "length": 192,
                "header": "tr|A0A1D5RMJ9-1|TAF5L_MOUSE Computationally mapped isoform of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L  OS=Mus musculus OX=10090 GN=Taf5l PE=2 SV=1 CANONICAL=Q91WQ5-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 124736569,
                "end_pos": 124730007,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000212010.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000212010.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000148808.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000148808.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q91WQ5-1",
            "url": "",
            "sequence": {
                "sequence": "MKRVRTEQVQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAEPQQYEVQFGRLRSFLTDSDSQYSREVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHIHLDVQPAKRTDYQLYASGGSSRTENSSLEPPEVPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSEPHHVDTSRIRLACDTLEEEENEEDNTGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCNTPADGSSGELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH",
                "length": 589,
                "header": "sp|Q91WQ5-1|TAF5L_MOUSE Isoform 1 of TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L  OS=Mus musculus OX=10090 GN=Taf5l PE=2 SV=1 CANONICAL=Q91WQ5-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 124736569,
                "end_pos": 124724051,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000165628",
                        "url": "https://www.ensembl.org/id/ENSMUST00000165628"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000128710",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000128710"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.",
            "journal": "Mol. Cell",
            "date": "2019",
            "authors": "Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, Das PP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q91WQ5",
                    "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_598727",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31005419",
                    "url": "https://glygen.org/publication/PubMed/31005419"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:102162",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:102162",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75529-1",
            "protein_name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",
            "gene_name": "TAF5L",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH",
                "length": 589
            },
            "evidence": [
                {
                    "id": "45235884",
                    "url": "http://www.informatics.jax.org/homology/45235884",
                    "database": "MGI"
                },
                {
                    "id": "Q91WQ5",
                    "url": "https://omabrowser.org/oma/group/Q91WQ5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription factor TFTC complex",
                        "id": "GO:0033276",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033276",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear speck",
                        "id": "GO:0016607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic ribonucleoprotein granule",
                        "id": "GO:0036464",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone acetyltransferase complex",
                        "id": "GO:0000123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SAGA complex",
                        "id": "GO:0000124",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "transcription coactivator activity",
                        "id": "GO:0003713",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA-templated transcription",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
                                "url": "https://www.uniprot.org/uniprot/Q91WQ5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q91WQ5",
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