{ "uniprot_canonical_ac": "Q91W97-1", "uniprot_ac": "Q91W97", "uniprot_id": "HKDC1_MOUSE", "mass": { "chemical_mass": 102259.0, "monoisotopic_mass": 102259.0 }, "refseq": { "ac": "NP_663394", "name": "hexokinase HKDC1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" }, "gene_names": [ { "name": "Hkdc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91W97", "id": "Q91W97" }, { "name": "Hkdc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394", "id": "NP_663394" } ], "protein_names": [ { "name": "Hexokinase HKDC1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91W97" }, { "name": "2.7.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91W97" }, { "name": "Hexokinase domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q91W97" }, { "name": "hexokinase HKDC1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394", "id": "NP_663394" }, { "name": "putative hexokinase HKDC1; hexokinase domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394", "id": "NP_663394" } ], "function": [ { "annotation": "Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation (PubMed:30543855). Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (PubMed:25648650, PubMed:27459389).", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97#function" }, { "database": "UniProtKB", "id": "Q2TB90", "url": "https://www.uniprot.org/uniprot/Q2TB90#function" }, { "database": "PubMed", "id": "25648650", "url": "https://glygen.org/publication/PubMed/25648650" }, { "database": "PubMed", "id": "30543855", "url": "https://glygen.org/publication/PubMed/30543855" }, { "database": "PubMed", "id": "27459389", "url": "https://glygen.org/publication/PubMed/27459389" } ] }, { "annotation": "Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" }, { "database": "PubMed", "id": "37198225", "url": "https://glygen.org/publication/PubMed/37198225" } ] }, { "annotation": "Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" }, { "database": "PubMed", "id": "37545422", "url": "https://glygen.org/publication/PubMed/37545422" } ] }, { "annotation": "The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" }, { "database": "PubMed", "id": "34232412", "url": "https://glygen.org/publication/PubMed/34232412" } ] } ], "disease": [ { "disease_id": "DOID:10584", "recommended_name": { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss." }, "synonyms": [ { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "Retinitis pigmentosa (RP) is an inherited retinal dystrophy leading to progressive loss of the photoreceptors and retinal pigment epithelium and resulting in blindness usually after several decades." }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "Rod-cone dystrophy", "description": "" }, { "id": "MIM:268000", "resource": "MIM", "url": "https://www.omim.org/entry/268000", "name": "Retinitis pigmentosa", "description": "Retinitis pigmentosa" } ], "evidence": [ { "id": "10584", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10584" } ] }, { "disease_id": "DOID:4194", "recommended_name": { "id": "DOID:4194", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4194", "name": "glucose metabolism disease", "description": "" }, "synonyms": [ { "id": "DOID:4194", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4194", "name": "disorder of glucose metabolism", "description": "" } ], "evidence": [ { "id": "4194", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4194" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Hkdc1", "url": "https://www.uniprot.org/uniprot/Q91W97", "locus": { "chromosome": "10", "start_pos": 62218916, "end_pos": 62258270, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000020080", "url": "https://www.ensembl.org/id/ENSMUSG00000020080" } ] } } ], "crossref": [ { "id": "ENSMUSG00000020080", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000020080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "216019", "url": "https://www.ncbi.nlm.nih.gov/gene/216019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q91W97", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q91W97*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:216019", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:216019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2384910", "url": "http://www.informatics.jax.org/marker/MGI:2384910", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "PNEITRG", "url": "https://omabrowser.org/oma/group/PNEITRG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5481886at2759", "url": "http://www.orthodb.org/?query=5481886at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19443", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19443", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19443:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19443:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00349", "url": "http://pfam.xfam.org/family/PF00349", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03727", "url": "http://pfam.xfam.org/family/PF03727", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91W97", "url": "http://purl.obolibrary.org/obo/PR_Q91W97", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-70171", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-70171", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17825", "url": "https://www.rhea-db.org/rhea/17825", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22740", "url": "https://www.rhea-db.org/rhea/22740", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91W97-1", "url": "https://www.uniprot.org/uniprot/Q91W97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIAVQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLYKTHPQYPKRLHKVVRRLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKELAPQCDVTFMLSEDGSGKGAALITAVAKRLQQPRKDI", "length": 915, "header": "sp|Q91W97-1|HKDC1_MOUSE Isoform 1 of Hexokinase HKDC1 OS=Mus musculus OX=10090 GN=Hkdc1 PE=2 SV=1 CANONICAL=Q91W97-1" }, "isoforms": [ { "isoform_ac": "Q91W97-1", "url": "", "sequence": { "sequence": "MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIAVQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLYKTHPQYPKRLHKVVRRLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKELAPQCDVTFMLSEDGSGKGAALITAVAKRLQQPRKDI", "length": 915, "header": "sp|Q91W97-1|HKDC1_MOUSE Isoform 1 of Hexokinase HKDC1 OS=Mus musculus OX=10090 GN=Hkdc1 PE=2 SV=1 CANONICAL=Q91W97-1" }, "locus": { "chromosome": "10", "start_pos": 62258139, "end_pos": 62219557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000020277", "url": "https://www.ensembl.org/id/ENSMUST00000020277" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000020277", "url": "https://www.ensembl.org/id/ENSMUSP00000020277" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.", "journal": "Nat. Commun.", "date": "2015", "authors": "Guo Cong, Ludvik Anton E, Arlotto Michelle E, Hayes M Geoffrey, Armstrong Loren L, Scholtens Denise M, Brown Christopher D, Newgard Christopher B, Becker Thomas C, Layden Brian T, Lowe William L, Reddy Timothy E", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "reference": [ { "type": "PubMed", "id": "25648650", "url": "https://glygen.org/publication/PubMed/25648650" } ] }, { "title": "HKDC1 is a novel hexokinase involved in whole-body glucose use.", "journal": "Endocrinology", "date": "2016", "authors": "Ding X., Guo C., Lo A., Yang G.Y., Lowe W.L. Jr., Layden B.T., Ludvik A.E., Pusec C.M., Angueira A.R., Hershenhouse K.S., Priyadarshini M., Reddy T.E.", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "reference": [ { "type": "PubMed", "id": "27459389", "url": "https://glygen.org/publication/PubMed/27459389" } ] }, { "title": "Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.", "journal": "Hum. Mol. Genet.", "date": "2018", "authors": "Zhang L, Sun Z, Zhao P, Huang L, Xu M, Yang Y, Chen X, Lu F, Zhang X, Wang H, Zhang S, Liu W, Jiang Z, Ma S, Chen R, Zhao C, Yang Z, Sui R, Zhu X", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "reference": [ { "type": "PubMed", "id": "30085091", "url": "https://glygen.org/publication/PubMed/30085091" } ] }, { "title": "Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.", "journal": "Biochim. Biophys. Acta", "date": "2019", "authors": "Khan MW, Priyadarshini M, Cordoba-Chacon J, Becker TC, Layden BT", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "reference": [ { "type": "PubMed", "id": "30543855", "url": "https://glygen.org/publication/PubMed/30543855" } ] }, { "title": "The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.", "journal": "Current diabetes reports", "date": "2021", "authors": "Zapater JL, Lednovich KR, Layden BT", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" } ], "reference": [ { "type": "PubMed", "id": "34232412", "url": "https://glygen.org/publication/PubMed/34232412" } ] }, { "title": "Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.", "journal": "Scientific reports", "date": "2023-05-17", "authors": "Pusec Carolina M, Ilievski Vladimir, De Jesus Adam, Farooq Zeenat, Zapater Joseph L, Sweis Nadia, Ismail Hagar, Khan Md Wasim, Ardehali Hossein, Cordoba-Chacon Jose, Layden Brian T", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" } ], "reference": [ { "type": "PubMed", "id": "37198225", "url": "https://glygen.org/publication/PubMed/37198225" } ] }, { "title": "Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.", "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "date": "2023-10-01", "authors": "Martinez-Garza Ursula, Choi Joseph, Scafidi Susana, Wolfgang Michael J", "evidence": [ { "database": "RefSeq", "id": "NP_663394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663394" } ], "reference": [ { "type": "PubMed", "id": "37545422", "url": "https://glygen.org/publication/PubMed/37545422" } ] } ], "pathway": [ { "id": "mmu:216019", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:216019", "resource": "KEGG Pathway" }, { "id": "R-MMU-70171", "name": "Glycolysis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-70171", "resource": "Reactome", "description": "Glycolysis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2TB90-1", "protein_name": "Hexokinase HKDC1", "gene_name": "HKDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIWTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQAQKEN", "length": 917 }, "evidence": [ { "id": "45237909", "url": "http://www.informatics.jax.org/homology/45237909", "database": "MGI" }, { "id": "Q91W97", "url": "https://omabrowser.org/oma/group/Q91W97/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "glucokinase activity", "id": "GO:0004340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004340", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "fructokinase activity", "id": "GO:0008865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008865", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "glucose binding", "id": "GO:0005536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "glucose metabolic process", "id": "GO:0006006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006006", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "intracellular glucose homeostasis", "id": "GO:0001678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001678", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "carbohydrate phosphorylation", "id": "GO:0046835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046835", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" }, { "name": "glucose 6-phosphate metabolic process", "id": "GO:0051156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051156", "evidence": [ { "database": "UniProtKB", "id": "Q91W97", "url": "https://www.uniprot.org/uniprot/Q91W97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17825", "name": "", "equation": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P05708-1", "P17712-1", "P27881-1", "P27926-1", "M0R3X7-1", "P35557-1", "Q2TB90-1", "P52790-1", "P19367-1", "P52789-1", "P52792-1", "Q91W97-1", "P17710-1", "O08528-1", "Q3TRM8-1", "P17709-1", "P04806-1", "P04807-1", "Q04409-1", "Q9NFT9-1", "Q9NFT7-1", "Q9W330-1", "Q7JYW9-1" ], "evidence": [ { "id": "17825", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17825" } ] }, { "id": "22740", "name": "", "equation": "ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P05708-1", "P17712-1", "P27881-1", "P27926-1", "M0R3X7-1", "P35557-1", "Q2TB90-1", "P52790-1", "P19367-1", "P52789-1", "P52792-1", "Q91W97-1", "P17710-1", "O08528-1", "Q3TRM8-1", "P04806-1", "P04807-1", "Q9NFT9-1", "Q9NFT7-1", "Q9W330-1", "Q7JYW9-1" ], "evidence": [ { "id": "22740", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22740" } ] }, { "id": "R-MMU-70420", "name": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08528-1", "Q3TRM8-1", "Q91W97-1" ], "evidence": [ { "id": "R-MMU-70420", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-70420" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "M0R3X7", "gene_name": "Hkdc1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "M0R3X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R3X7" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "M0R3X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R3X7" } ] } ] }, { "uniprot_ac": "O08528", "gene_name": "Hk2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "O08528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08528" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "O08528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08528" } ] } ] }, { "uniprot_ac": "P04806", "gene_name": "HXK1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P04806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04806" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P04806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04806" } ] } ] }, { "uniprot_ac": "P04807", "gene_name": "HXK2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P04807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04807" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P04807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04807" } ] } ] }, { "uniprot_ac": "P05708", "gene_name": "Hk1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P05708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05708" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P05708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05708" } ] } ] }, { "uniprot_ac": "P17709", "gene_name": "GLK1", "activity": [ { "ec_number": "2.7.1.2", "activity": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+).", "evidence": [ { "id": "P17709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17709" } ] }, { "ec_number": "2.7.1.2", "activity": "", "evidence": [ { "id": "P17709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17709" } ] } ] }, { "uniprot_ac": "P17710", "gene_name": "Hk1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P17710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17710" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P17710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17710" } ] }, { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "P17710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17710" } ] } ] }, { "uniprot_ac": "P17712", "gene_name": "Gck", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P17712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17712" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P17712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17712" } ] }, { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "P17712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17712" } ] } ] }, { "uniprot_ac": "P19367", "gene_name": "HK1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P19367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19367" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P19367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19367" } ] }, { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "P19367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19367" } ] } ] }, { "uniprot_ac": "P27881", "gene_name": "Hk2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P27881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27881" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P27881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27881" } ] } ] }, { "uniprot_ac": "P27926", "gene_name": "Hk3", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P27926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27926" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P27926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27926" } ] } ] }, { "uniprot_ac": "P35557", "gene_name": "GCK", "activity": [ { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "P35557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35557" } ] }, { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P35557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35557" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P35557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35557" } ] } ] }, { "uniprot_ac": "P52789", "gene_name": "HK2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P52789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52789" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P52789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52789" } ] } ] }, { "uniprot_ac": "P52790", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P52790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52790" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P52790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52790" } ] }, { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "P52790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52790" } ] } ] }, { "uniprot_ac": "P52792", "gene_name": "Gck", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P52792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52792" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P52792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52792" } ] } ] }, { "uniprot_ac": "Q04409", "gene_name": "EMI2", "activity": [ { "ec_number": "2.7.1.2", "activity": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+).", "evidence": [ { "id": "Q04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04409" } ] }, { "ec_number": "2.7.1.2", "activity": "", "evidence": [ { "id": "Q04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04409" } ] } ] }, { "uniprot_ac": "Q2TB90", "gene_name": "HKDC1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q2TB90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TB90" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q2TB90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TB90" } ] } ] }, { "uniprot_ac": "Q3TRM8", "gene_name": "Hk3", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q3TRM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM8" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q3TRM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM8" } ] }, { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "Q3TRM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM8" } ] } ] }, { "uniprot_ac": "Q7JYW9", "gene_name": "Hex-C", "activity": [ { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "Q7JYW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7JYW9" } ] } ] }, { "uniprot_ac": "Q91W97", "gene_name": "Hkdc1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q91W97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W97" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q91W97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W97" } ] } ] }, { "uniprot_ac": "Q9NFT7", "gene_name": "Hex-t2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q9NFT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT7" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q9NFT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT7" } ] } ] }, { "uniprot_ac": "Q9NFT9", "gene_name": "Hex-t1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q9NFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT9" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q9NFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT9" } ] } ] }, { "uniprot_ac": "Q9W330", "gene_name": "Hex-A", "activity": [ { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "Q9W330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W330" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }