{ "uniprot_canonical_ac": "Q91V64-1", "uniprot_ac": "Q91V64", "uniprot_id": "ISOC1_MOUSE", "mass": { "chemical_mass": 32033.0, "monoisotopic_mass": 32033.0 }, "refseq": { "ac": "NP_079754", "name": "isochorismatase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754" }, "gene_names": [ { "name": "Isoc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91V64", "id": "Q91V64" }, { "name": "2610034N03Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754", "id": "NP_079754" }, { "name": "Isoc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754", "id": "NP_079754" } ], "protein_names": [ { "name": "Isochorismatase domain-containing protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91V64" }, { "name": "isochorismatase domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754", "id": "NP_079754" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Isoc1", "url": "https://www.uniprot.org/uniprot/Q91V64", "locus": { "chromosome": "18", "start_pos": 58813440, "end_pos": 58792538, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000024601", "url": "https://www.ensembl.org/id/ENSMUSG00000024601" } ] } } ], "crossref": [ { "id": "ENSMUSG00000024601", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024601", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "66307", "url": "https://www.ncbi.nlm.nih.gov/gene/66307", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:66307", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66307", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1913557", "url": "http://www.informatics.jax.org/marker/MGI:1913557", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q91V64", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q91V64", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "NERCKLR", "url": "https://omabrowser.org/oma/group/NERCKLR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "166875at2759", "url": "http://www.orthodb.org/?query=166875at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00857", "url": "http://pfam.xfam.org/family/PF00857", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91V64", "url": "http://purl.obolibrary.org/obo/PR_Q91V64", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_079754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079754", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A494B952", "url": "https://www.uniprot.org/uniprot/A0A494B952", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B952-1", "url": "https://www.uniprot.org/uniprot/A0A494B952-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91V64-1", "url": "https://www.uniprot.org/uniprot/Q91V64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQLDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297, "header": "sp|Q91V64-1|ISOC1_MOUSE Isoform 1 of Isochorismatase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Isoc1 PE=1 SV=1 CANONICAL=Q91V64-1" }, "isoforms": [ { "isoform_ac": "A0A494B952-1", "url": "", "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQLDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 257, "header": "tr|A0A494B952-1|ISOC1_MOUSE Computationally mapped isoform of Isochorismatase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Isoc1 PE=1 SV=1 CANONICAL=Q91V64-1" }, "locus": { "chromosome": "18", "start_pos": 58810980, "end_pos": 58792564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238139.2", "url": "https://www.ensembl.org/id/ENSMUST00000238139.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157494.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157494.2" } ] } }, { "isoform_ac": "Q91V64-1", "url": "", "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQLDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297, "header": "sp|Q91V64-1|ISOC1_MOUSE Isoform 1 of Isochorismatase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Isoc1 PE=1 SV=1 CANONICAL=Q91V64-1" }, "locus": { "chromosome": "18", "start_pos": 58810980, "end_pos": 58792564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000025503", "url": "https://www.ensembl.org/id/ENSMUST00000025503" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000025503", "url": "https://www.ensembl.org/id/ENSMUSP00000025503" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q91V64", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q91V64" }, { "id": "28135057", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28135057" } ] } ], "phosphorylation": [ { "start_pos": 159, "end_pos": 159, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "site_lbl": "Tyr159" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Screening and identification of tumor related genes in early stages of transformed NIH3T3 cells associated with overexpressed PTPalpha.", "journal": "Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao", "date": "2002", "authors": "Yang JS, Zheng XM, Chen SS", "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "reference": [ { "type": "PubMed", "id": "12198563", "url": "https://glygen.org/publication/PubMed/12198563" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.", "journal": "ACS chemical biology", "date": "2017", "authors": "Zaro BW, Batt AR, Chuh KN, Navarro MX, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q91V64", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q91V64" } ], "reference": [ { "type": "PubMed", "id": "28135057", "url": "https://glygen.org/publication/PubMed/28135057" } ] } ], "pathway": [ { "id": "mmu:66307", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66307", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6I7R3-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "Isoc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQVDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVPLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297 }, "evidence": [ { "id": "45228232", "url": "http://www.informatics.jax.org/homology/45228232", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96CN7-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "ISOC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAEPAVLALPNSGAGGAGAPSGTVPVLFCFSVFARPSSVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGVEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 298 }, "evidence": [ { "id": "45228232", "url": "http://www.informatics.jax.org/homology/45228232", "database": "MGI" }, { "id": "Q91V64", "url": "https://omabrowser.org/oma/group/Q91V64/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q91V64", "url": "https://www.uniprot.org/uniprot/Q91V64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }