{ "uniprot_canonical_ac": "Q91V24-1", "uniprot_ac": "Q91V24", "uniprot_id": "ABCA7_MOUSE", "mass": { "chemical_mass": 236884.0, "monoisotopic_mass": 236884.0 }, "refseq": {}, "gene_names": [ { "name": "Abca7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q91V24", "id": "Q91V24" } ], "protein_names": [ { "name": "ATP-binding cassette sub-family A member 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q91V24" } ], "function": [ { "annotation": "Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:15550377, PubMed:16908670, PubMed:27472885, PubMed:27030769, PubMed:20495215). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (PubMed:28091533). Plays a role in phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (PubMed:20495215). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (PubMed:27472885). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791, PubMed:27030769).", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24#function" }, { "database": "PubMed", "id": "16908670", "url": "https://glygen.org/publication/PubMed/16908670" }, { "database": "PubMed", "id": "20495215", "url": "https://glygen.org/publication/PubMed/20495215" }, { "database": "PubMed", "id": "27030769", "url": "https://glygen.org/publication/PubMed/27030769" }, { "database": "PubMed", "id": "27472885", "url": "https://glygen.org/publication/PubMed/27472885" }, { "database": "PubMed", "id": "26260791", "url": "https://glygen.org/publication/PubMed/26260791" }, { "database": "PubMed", "id": "15550377", "url": "https://glygen.org/publication/PubMed/15550377" }, { "database": "UniProtKB", "id": "Q8IZY2", "url": "https://www.uniprot.org/uniprot/Q8IZY2#function" }, { "database": "PubMed", "id": "12917409", "url": "https://glygen.org/publication/PubMed/12917409" }, { "database": "PubMed", "id": "28091533", "url": "https://glygen.org/publication/PubMed/28091533" } ] } ], "disease": [ { "disease_id": "DOID:0111364", "recommended_name": { "id": "DOID:0111364", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111364", "name": "Alzheimer's disease 9", "description": "An Alzheimer's disease that has_material_basis_in heterozygous mutation in the ABCA7 gene on chromosome 19p13.3." }, "synonyms": [ { "id": "DOID:0111364", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111364", "name": "AD9", "description": "" }, { "id": "DOID:0111364", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111364", "name": "Alzheimer's disease 9, late onset", "description": "" }, { "id": "MONDO:0012153", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012153", "name": "Alzheimer disease 9", "description": "" }, { "id": "MONDO:0012153", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012153", "name": "AD9", "description": "" }, { "id": "MONDO:0012153", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012153", "name": "Alzheimer disease 9", "description": "" }, { "id": "MONDO:0012153", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012153", "name": "Alzheimer disease 9, late-onset", "description": "" }, { "id": "MONDO:0012153", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012153", "name": "Alzheimer disease 9, susceptibility to", "description": "" }, { "id": "MIM:608907", "resource": "MIM", "url": "https://www.omim.org/entry/608907", "name": "Alzheimer disease 9", "description": "Alzheimer disease 9" } ], "evidence": [ { "id": "0111364", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111364" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Abca7", "url": "https://www.uniprot.org/uniprot/Q91V24", "locus": { "chromosome": "10", "start_pos": 79851406, "end_pos": 79832328, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000035722", "url": "https://www.ensembl.org/id/ENSMUSG00000035722" } ] } } ], "crossref": [ { "id": "ENSMUSG00000035722", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035722", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "2142", "url": "https://glyconnect.expasy.org/browser/proteins/2142", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0002534", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002534", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0007026", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007026", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "Q91V24", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q91V24*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:27403", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:27403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1351646", "url": "http://www.informatics.jax.org/marker/MGI:1351646", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "AQEPLHS", "url": "https://omabrowser.org/oma/group/AQEPLHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "6951at2759", "url": "http://www.orthodb.org/?query=6951at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "http://pfam.xfam.org/family/PF00005", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12698", "url": "http://pfam.xfam.org/family/PF12698", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q91V24", "url": "http://purl.obolibrary.org/obo/PR_Q91V24", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1369062", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1369062", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_017169446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017169446", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9Q6G4", "url": "https://www.uniprot.org/uniprot/E9Q6G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q6G4-1", "url": "https://www.uniprot.org/uniprot/E9Q6G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q91V24-1", "url": "https://www.uniprot.org/uniprot/Q91V24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGTQLMLLLWKNYTYRRRQPIQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADTRTVLGGHSIQDMLDALGKLIPVLRAVGGGARPQESDQPTSQGSVTKLLEKILQRASLDPVLGQAQDSMRKFSDAIRDLAQELLTLPSLMELRALLRRPRGSAGSLELVSEALCSTKGPSSPGGLSLNWYEANQLNEFMGPEVAPALPDNSLSPACSEFVGTLDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGRLAGILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDPSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGPEASVLENGELAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQSKPRLLPPLGEEDEDVAQERERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELREVHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQEAEEEEVSKPGRQHPKRVSRFLEDPSSVETMI", "length": 2159, "header": "sp|Q91V24-1|ABCA7_MOUSE Isoform 1 of ATP-binding cassette sub-family A member 7 OS=Mus musculus OX=10090 GN=Abca7 PE=1 SV=1 CANONICAL=Q91V24-1" }, "isoforms": [ { "isoform_ac": "E9Q6G4-1", "url": "", "sequence": { "sequence": "MALGTQLMLLLWKNYTYRRRQPIQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADTRTVLGGHSIQDMLDALGKLIPVLRAVGGGARPQESDQPTSQGSVTKLLEKILQRASLDPVLGQAQDSMRKFSDAIRDLAQELLTLPSLMELRALLRRPRGSAGSLELVSEALCSTKGPSSPGGLSLNWYEANQLNEFMGPEVAPALPDNSLSPACSEFVGTLDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGRLAGILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDPSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGPEASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQSKPRLLPPLGEEDEDVAQERERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELREVHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQEAEEEEVSKPGRQHPKRVSRFLEDPSSVETMI", "length": 2167, "header": "tr|E9Q6G4-1|E9Q6G4_MOUSE Computationally mapped isoform of ATP-binding cassette, sub-family A (ABC1), member 7 OS=Mus musculus OX=10090 GN=Abca7 PE=1 SV=1 CANONICAL=Q91V24-1" }, "locus": { "chromosome": "10", "start_pos": 79851289, "end_pos": 79833449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000171637.8", "url": "https://www.ensembl.org/id/ENSMUST00000171637.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000128121.2", "url": "https://www.ensembl.org/id/ENSMUSP00000128121.2" } ] } }, { "isoform_ac": "Q91V24-1", "url": "", "sequence": { "sequence": "MALGTQLMLLLWKNYTYRRRQPIQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADTRTVLGGHSIQDMLDALGKLIPVLRAVGGGARPQESDQPTSQGSVTKLLEKILQRASLDPVLGQAQDSMRKFSDAIRDLAQELLTLPSLMELRALLRRPRGSAGSLELVSEALCSTKGPSSPGGLSLNWYEANQLNEFMGPEVAPALPDNSLSPACSEFVGTLDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGRLAGILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDPSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGPEASVLENGELAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQSKPRLLPPLGEEDEDVAQERERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELREVHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQEAEEEEVSKPGRQHPKRVSRFLEDPSSVETMI", "length": 2159, "header": "sp|Q91V24-1|ABCA7_MOUSE Isoform 1 of ATP-binding cassette sub-family A member 7 OS=Mus musculus OX=10090 GN=Abca7 PE=1 SV=1 CANONICAL=Q91V24-1" }, "locus": { "chromosome": "10", "start_pos": 79851289, "end_pos": 79833449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000132517", "url": "https://www.ensembl.org/id/ENSMUST00000132517" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115111", "url": "https://www.ensembl.org/id/ENSMUSP00000115111" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1471, "start_aa": "Asn", "end_pos": 1471, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1471", "evidence": [ { "id": "2142", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2142" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1471, "start_aa": "Asn", "end_pos": 1471, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1471", "evidence": [ { "id": "2142", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2142" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1532, "start_aa": "Asn", "end_pos": 1532, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1532", "evidence": [ { "id": "2142", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2142" }, { "id": "30899004", "database": "PubMed", "url": 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"https://glygen.org/publication/PubMed/10708515" } ] }, { "title": "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.", "journal": "Cytogenet. Cell Genet.", "date": "2001", "authors": "Broccardo C, Osorio J, Luciani MF, Schriml LM, Prades C, Shulenin S, Arnould I, Naudin L, Lafargue C, Rosier M, Jordan B, Mattei MG, Dean M, Denefle P, Chimini G", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "11435699", "url": "https://glygen.org/publication/PubMed/11435699" } ] }, { "title": "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, Chen W, Martinez LO, Tall AR", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "12917409", "url": "https://glygen.org/publication/PubMed/12917409" } ] }, { "title": "Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Freeman M.W., Okuhira K., Moore K.J., Lu N., Kim W.S., Kang K., Fitzgerald M.L., Bell S.A., Koehn S.L., Manning J.J.", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "15550377", "url": "https://glygen.org/publication/PubMed/15550377" } ] }, { "title": "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.", "journal": "Clin. Exp. Pharmacol. Physiol.", "date": "2005", "authors": "Ando H., Ishibashi K., Kasanuki H., Tsuruoka S., Wakaumi M.", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "16445568", "url": "https://glygen.org/publication/PubMed/16445568" } ] }, { "title": "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.", "journal": "J. Cell Biol.", "date": "2006", "authors": "Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW, Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "16908670", "url": "https://glygen.org/publication/PubMed/16908670" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" }, { "database": "UniProtKB", "id": "E9Q6G4", "url": "https://www.uniprot.org/uniprot/E9Q6G4" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.", "journal": "J. Lipid Res.", "date": "2010", "authors": "Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "20495215", "url": "https://glygen.org/publication/PubMed/20495215" } ] }, { "title": "ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.", "journal": "J. Biol. Chem.", "date": "2015", "authors": "Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "26260791", "url": "https://glygen.org/publication/PubMed/26260791" } ] }, { "title": "ABCA7 Deficiency Accelerates Amyloid-beta Generation and Alzheimer's Neuronal Pathology.", "journal": "J. Neurosci.", "date": "2016", "authors": "Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "27030769", "url": "https://glygen.org/publication/PubMed/27030769" } ] }, { "title": "ABCA7 Mediates Phagocytic Clearance of Amyloid-beta in the Brain.", "journal": "J. Alzheimers Dis.", "date": "2016", "authors": "Fu Y, Hsiao JH, Paxinos G, Halliday GM, Kim WS", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "27472885", "url": "https://glygen.org/publication/PubMed/27472885" } ] }, { "title": "ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.", "journal": "Sci. Rep.", "date": "2017", "authors": "Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, Fitzgerald ML, Kronenberg M, Hedrick CC", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "reference": [ { "type": "PubMed", "id": "28091533", "url": "https://glygen.org/publication/PubMed/28091533" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2142", "url": "https://glyconnect.expasy.org/browser/proteins/2142" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] } ], "pathway": [ { "id": "mmu:27403", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:27403", "resource": "KEGG Pathway" }, { "id": "R-MMU-1369062", "name": "ABC transporters in lipid homeostasis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1369062", "resource": "Reactome", "description": "ABC transporters in lipid homeostasis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 27, "go_terms": [ { "name": "negative regulation of endocytosis", "id": "GO:0045806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045806", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { 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"url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "high-density lipoprotein particle assembly", "id": "GO:0034380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034380", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "peptide cross-linking", "id": "GO:0018149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018149", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "protein localization to nucleus", "id": "GO:0034504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034504", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "apolipoprotein A-I-mediated signaling pathway", "id": "GO:0038027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038027", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "positive regulation of amyloid-beta clearance", "id": "GO:1900223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900223", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "positive regulation of engulfment of apoptotic cell", "id": "GO:1901076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901076", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "positive regulation of phospholipid efflux", "id": "GO:1902995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902995", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "amyloid-beta formation", "id": "GO:0034205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034205", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "negative regulation of MAPK cascade", "id": "GO:0043409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043409", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "negative regulation of PERK-mediated unfolded protein response", "id": "GO:1903898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903898", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "amyloid-beta clearance by cellular catabolic process", "id": "GO:0150094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150094", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "plasma membrane raft organization", "id": "GO:0044857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044857", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "phagocytic cup", "id": "GO:0001891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001891", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "glial cell projection", "id": "GO:0097386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097386", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "phospholipid transporter activity", "id": "GO:0005548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005548", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "apolipoprotein A-I receptor activity", "id": "GO:0034188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034188", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "phosphatidylcholine floppase activity", "id": "GO:0090554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090554", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "phosphatidylserine floppase activity", "id": "GO:0090556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090556", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" }, { "name": "floppase activity", "id": "GO:0140328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140328", "evidence": [ { "database": "UniProtKB", "id": "Q91V24", "url": "https://www.uniprot.org/uniprot/Q91V24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1349, "end_pos": 1351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1395, "end_pos": 1397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1471, "end_pos": 1473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1532, "end_pos": 1534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1675, "end_pos": 1677, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, 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