{
    "uniprot_canonical_ac": "Q8VIB5-1",
    "uniprot_ac": "Q8VIB5",
    "uniprot_id": "BARH2_MOUSE",
    "mass": {
        "chemical_mass": 41459.0,
        "monoisotopic_mass": 41459.0
    },
    "refseq": {
        "ac": "NP_001005477",
        "name": "barH-like 2 homeobox protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477"
    },
    "gene_names": [
        {
            "name": "Barhl2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8VIB5",
            "id": "Q8VIB5"
        },
        {
            "name": "Barh1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8VIB5",
            "id": "Q8VIB5"
        },
        {
            "name": "Barhl2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477",
            "id": "NP_001005477"
        },
        {
            "name": "E130309B19Rik; MBH1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477",
            "id": "NP_001005477"
        },
        {
            "name": "Mbh1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8VIB5",
            "id": "Q8VIB5"
        }
    ],
    "protein_names": [
        {
            "name": "BarH-like 2 homeobox protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8VIB5"
        },
        {
            "name": "Bar-class homeodomain protein MBH1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8VIB5"
        },
        {
            "name": "BarH-class homeodomain transcription factor; homeobox protein B-H1; bar-class homeodomain protein MBH1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477",
            "id": "NP_001005477"
        },
        {
            "name": "Homeobox protein B-H1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8VIB5"
        },
        {
            "name": "barH-like 2 homeobox protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477",
            "id": "NP_001005477"
        }
    ],
    "function": [
        {
            "annotation": "Data suggest that Barhl2 may function to specify the identity of glycinergic amacrine cells from competent progenitors during retinogenesis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005477",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477"
                },
                {
                    "database": "PubMed",
                    "id": "14998930",
                    "url": "https://glygen.org/publication/PubMed/14998930"
                }
            ]
        },
        {
            "annotation": "Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).",
            "evidence": [
                {
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                    "id": "Q8VIB5",
                    "url": "https://www.uniprot.org/uniprot/Q8VIB5#function"
                }
            ]
        }
    ],
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                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050866",
                "name": "oral squamous cell carcinoma",
                "description": "An oral cavity cancer that has_material_basis_in squamous cells."
            },
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050866",
                    "name": "mouth squamous cell carcinoma",
                    "description": ""
                }
            ],
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                    "database": "Alliance of Genome Resources",
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                }
            ]
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                "resource": "Disease Ontology",
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                "name": "stomach cancer",
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            },
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10534",
                    "name": "gastric cancer",
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                },
                {
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                    "resource": "Disease Ontology",
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                    "description": ""
                },
                {
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                    "resource": "MONDO",
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                {
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                    "resource": "MONDO",
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                    "name": "gastric neoplasm",
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                },
                {
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                    "description": ""
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                    "description": ""
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                    "name": "malignant neoplasm of stomach",
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                {
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                {
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                    "resource": "MONDO",
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                    "name": "malignant tumor of body of stomach",
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                {
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                    "resource": "MONDO",
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            ],
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                    "description": ""
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                {
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                    "resource": "MONDO",
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                },
                {
                    "id": "MIM:114500",
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                    "name": "Colorectal cancer",
                    "description": "Colorectal cancer"
                }
            ],
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                {
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                    "url": "https://www.alliancegenome.org/disease/DOID:9256"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
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                {
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            ],
            "common_name": "Mouse"
        }
    ],
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                    {
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                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000034384",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034384",
            "database": "Bgee",
            "categories": [
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            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "104382",
            "url": "https://www.ncbi.nlm.nih.gov/gene/104382",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020479",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:104382",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:104382",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1859314",
            "url": "http://www.informatics.jax.org/marker/MGI:1859314",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "SVSMEHP",
            "url": "https://omabrowser.org/oma/group/SVSMEHP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4204245at2759",
            "url": "http://www.orthodb.org/?query=4204245at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24330",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24330",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24330:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24330:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8VIB5",
            "url": "http://purl.obolibrary.org/obo/PR_Q8VIB5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001005477",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VIB5",
            "url": "https://www.uniprot.org/uniprot/Q8VIB5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VIB5-1",
            "url": "https://www.uniprot.org/uniprot/Q8VIB5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTAMEGASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVTLEPPEPHLVTDGPQHHHHLHHSQQPPPPSAVPAQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAAHESFRPKLEQEDGKTKLDKREDPQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR",
        "length": 384,
        "header": "sp|Q8VIB5-1|BARH2_MOUSE Isoform 1 of BarH-like 2 homeobox protein  OS=Mus musculus OX=10090 GN=Barhl2 PE=2 SV=2 CANONICAL=Q8VIB5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q8VIB5-1",
            "url": "",
            "sequence": {
                "sequence": "MTAMEGASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVTLEPPEPHLVTDGPQHHHHLHHSQQPPPPSAVPAQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAAHESFRPKLEQEDGKTKLDKREDPQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR",
                "length": 384,
                "header": "sp|Q8VIB5-1|BARH2_MOUSE Isoform 1 of BarH-like 2 homeobox protein  OS=Mus musculus OX=10090 GN=Barhl2 PE=2 SV=2 CANONICAL=Q8VIB5-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 106605707,
                "end_pos": 106601226,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000086795",
                        "url": "https://www.ensembl.org/id/ENSMUST00000086795"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000084005",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000084005"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells.",
            "journal": "Development (Cambridge, England)",
            "date": "2004",
            "authors": "Mo Z, Li S, Yang X, Xiang M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005477",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005477"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14998930",
                    "url": "https://glygen.org/publication/PubMed/14998930"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:104382",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:104382",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O88181-1",
            "protein_name": "BarH-like 2 homeobox protein",
            "gene_name": "Barhl2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MTAMEGASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDFRSQATPSPCSEIDTVGTAPSSPISVTLEPPEPHLVTDGPQHHHHLHHGQQPPPPSAPPAQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQECNAAHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR",
                "length": 384
            },
            "evidence": [
                {
                    "id": "45237680",
                    "url": "http://www.informatics.jax.org/homology/45237680",
                    "database": "MGI"
                },
                {
                    "id": "Q8VIB5",
                    "url": "https://omabrowser.org/oma/group/Q8VIB5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9NY43-1",
            "protein_name": "BarH-like 2 homeobox protein",
            "gene_name": "BARHL2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTMEGASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFRSQATPSPCSEIDTVGTAPSSPISVTMEPPEPHLVADATQHHHHLHHSQQPPPPAAAPTQSLQPLPQQQQPLPPQQPPPPPPQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAVHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSSPIPGTPHPR",
                "length": 387
            },
            "evidence": [
                {
                    "id": "45237680",
                    "url": "http://www.informatics.jax.org/homology/45237680",
                    "database": "MGI"
                },
                {
                    "id": "Q8VIB5",
                    "url": "https://omabrowser.org/oma/group/Q8VIB5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA-binding transcription factor activity",
                        "id": "GO:0003700",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nervous system development",
                        "id": "GO:0007399",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron migration",
                        "id": "GO:0001764",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron differentiation",
                        "id": "GO:0030182",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of axon extension",
                        "id": "GO:0030516",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030516",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of translation",
                        "id": "GO:0045727",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell fate determination",
                        "id": "GO:0001709",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001709",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell fate commitment",
                        "id": "GO:0045165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "amacrine cell differentiation",
                        "id": "GO:0035881",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035881",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VIB5",
                                "url": "https://www.uniprot.org/uniprot/Q8VIB5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
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            "start_pos": 267,
            "end_pos": 269,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 300,
            "end_pos": 302,
            "annotation": "n_glycosylation_sequon"
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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        {
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        {
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}