{ "uniprot_canonical_ac": "Q8VHE6-1", "uniprot_ac": "Q8VHE6", "uniprot_id": "DYH5_MOUSE", "mass": { "chemical_mass": 527558.0, "monoisotopic_mass": 527558.0 }, "refseq": {}, "gene_names": [ { "name": "Dnah5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8VHE6", "id": "Q8VHE6" }, { "name": "Dnahc5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8VHE6", "id": "Q8VHE6" } ], "protein_names": [ { "name": "Dynein axonemal heavy chain 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8VHE6" }, { "name": "Axonemal beta dynein heavy chain 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VHE6" }, { "name": "Ciliary dynein heavy chain 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VHE6" }, { "name": "mDNAH5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VHE6" } ], "function": [ { "annotation": "Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6#function" }, { "database": "PubMed", "id": "15269178", "url": "https://glygen.org/publication/PubMed/15269178" } ] } ], "disease": [ { "disease_id": "DOID:0050144", "recommended_name": { "id": "DOID:0050144", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050144", "name": "Kartagener syndrome", "description": "A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development." }, "synonyms": [ { "id": "DOID:0050144", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050144", "name": "Kartagener's syndrome", "description": "" } ], "evidence": [ { "id": "0050144", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050144" } ] }, { "disease_id": "DOID:0050545", "recommended_name": { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "visceral heterotaxy", "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen." }, "synonyms": [ { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "heterotaxia", "description": "" }, { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "situs ambiguus", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "heterotaxy, visceral, 2, autosomal", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "DTGA2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "heterotaxy, visceral, 2, autosomal", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "transposition of the great arteries, dextro-looped 2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "HTX2", "description": "" }, { "id": "MONDO:0011546", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011546", "name": "Htx", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "heterotaxy, visceral, 3, autosomal", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "HTX3", "description": "" }, { "id": "MONDO:0011659", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011659", "name": "heterotaxy, visceral, 3, autosomal", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia." }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "ZIC3 visceral heterotaxy", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "visceral heterotaxy caused by mutation in ZIC3", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "HTX1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "X-linked visceral heterotaxy 1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, multiple types, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "dextrocardia with Other Cardiac malformations", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "laterality, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "heterotaxy, visceral, 6, autosomal recessive", "description": "" }, { "id": "MONDO:0013887", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013887", "name": "HTX6", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "heterotaxy, visceral, 4, autosomal", "description": "Any visceral heterotaxy in which the cause of the disease is a mutation in the ACVR2B gene." }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "ACVR2B visceral heterotaxy", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "heterotaxy, visceral, 4, autosomal", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "visceral heterotaxy caused by mutation in ACVR2B", "description": "" }, { "id": "MONDO:0013403", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013403", "name": "HTX4", "description": "" }, { "id": "MIM:605376", "resource": "MIM", "url": "https://www.omim.org/entry/605376", "name": "Heterotaxy, visceral, 2, autosomal", "description": "Heterotaxy, visceral, 2, autosomal" }, { "id": "MIM:306955", "resource": "MIM", "url": "https://www.omim.org/entry/306955", "name": "Heterotaxy, visceral, 1, X-linked", "description": "Heterotaxy, visceral, 1, X-linked" }, { "id": "MIM:614779", "resource": "MIM", "url": "https://www.omim.org/entry/614779", "name": "Heterotaxy, visceral, 6, autosomal", "description": "Heterotaxy, visceral, 6, autosomal" }, { "id": "MIM:613751", "resource": "MIM", "url": "https://www.omim.org/entry/613751", "name": "Heterotaxy, visceral, 4, autosomal", "description": "Heterotaxy, visceral, 4, autosomal" } ], "evidence": [ { "id": "0050545", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050545" } ] }, { "disease_id": "DOID:0110599", "recommended_name": { "id": "DOID:0110599", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110599", "name": "primary ciliary dyskinesia 3", "description": "A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, ciliary akinesia and variable occurence of situs inversus and has_material_basis_in homozygous or compound heterozygous mutation in the DNAH5 gene on chromosome 5p15." }, "synonyms": [ { "id": "DOID:0110599", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110599", "name": "CILD3", "description": "" }, { "id": "DOID:0110599", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110599", "name": "primary ciliary dyskinesia 3 with or without situs inversus", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "primary ciliary dyskinesia 3", "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAH5 gene." }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "CILD3", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "DNAH5 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "ciliary dyskinesia, primary, type 3", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "primary ciliary dyskinesia 3", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "primary ciliary dyskinesia 3 with or without situs inversus", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "primary ciliary dyskinesia caused by mutation in DNAH5", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "primary ciliary dyskinesia type 3", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "ciliary dyskinesia, primary, 3", "description": "" }, { "id": "MONDO:0012085", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012085", "name": "ciliary dyskinesia, primary, 3, with or without situs inversus", "description": "" }, { "id": "MIM:608644", "resource": "MIM", "url": "https://www.omim.org/entry/608644", "name": "Ciliary dyskinesia, primary, 3", "description": "Ciliary dyskinesia, primary, 3" } ], "evidence": [ { "id": "0110599", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110599" } ] }, { "disease_id": "DOID:10754", "recommended_name": { "id": "DOID:10754", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10754", "name": "otitis media", "description": "A otitis which involves inflammation of the middle ear." }, "synonyms": [], "evidence": [ { "id": "10754", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10754" } ] }, { "disease_id": "DOID:6419", "recommended_name": { "id": "DOID:6419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6419", "name": "tetralogy of Fallot", "description": "" }, "synonyms": [ { "id": "DOID:6419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6419", "name": "Ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle", "description": "" }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "tetralogy of fallot", "description": "Tetralogy of Fallot is a congenital cardiac malformation that consists of an interventricular communication, also known as a ventricular septal defect, obstruction of the right ventricular outflow tract, override of the ventricular septum by the aortic root, and right ventricular hypertrophy." }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "tetralogy of fallot", "description": "" }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle", "description": "" }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "Fallot tetralogy", "description": "" }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "TOF", "description": "" }, { "id": "MONDO:0008542", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008542", "name": "tetralogy of FALLOT", "description": "" }, { "id": "MIM:187500", "resource": "MIM", "url": "https://www.omim.org/entry/187500", "name": "Tetralogy of Fallot", "description": "Tetralogy of Fallot" } ], "evidence": [ { "id": "6419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6419" } ] }, { "disease_id": "DOID:9562", "recommended_name": { "id": "DOID:9562", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9562", "name": "primary ciliary dyskinesia", "description": "A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube." }, "synonyms": [ { "id": "DOID:9562", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9562", "name": "ciliary motility disorder", "description": "" }, { "id": "DOID:9562", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9562", "name": "immotile ciliary syndrome", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "primary ciliary dyskinesia 1", "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAI1 gene." }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "CILD1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "DNAI1 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "ciliary dyskinesia, primary, type 1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "primary ciliary dyskinesia 1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "primary ciliary dyskinesia 1 with or without situs inversus", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "primary ciliary dyskinesia caused by mutation in DNAI1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "primary ciliary dyskinesia type 1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "Kartagener syndrome", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "PCD", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "Polynesian bronchiectasis", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "Siewert syndrome", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "ciliary dyskinesia, primary, 1", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "ciliary dyskinesia, primary, 1, with or without situs inversus", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "dextrocardia, bronchiectasis, and sinusitis", "description": "" }, { "id": "MONDO:0009484", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "name": "immotile cilia syndrome", "description": "" }, { "id": "MIM:244400", "resource": "MIM", "url": "https://www.omim.org/entry/244400", "name": "Kartagener syndrome", "description": "Kartagener syndrome" } ], "evidence": [ { "id": "9562", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9562" } ] } ], "snv": [ { "evidence": [ { "id": "rs3389337558", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389337558" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 2061, "end_pos": 2061, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IFT->NFT).", "chr_id": "15", "chr_pos": "28327466", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I2061", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389337590", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389337590" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 807, "end_pos": 807, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAF->NAS).", "chr_id": "15", "chr_pos": "28252728", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F807", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dnah5", "url": "https://www.uniprot.org/uniprot/Q8VHE6", "locus": { "chromosome": "15", "start_pos": 28472198, "end_pos": 28203898, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022262", "url": "https://www.ensembl.org/id/ENSMUSG00000022262" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022262", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022262", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q8VHE6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8VHE6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:110082", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "107718", "url": "http://www.informatics.jax.org/marker/MGI:107718", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8VHE6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8VHE6", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "FQKRDRY", "url": "https://omabrowser.org/oma/group/FQKRDRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "166463at2759", "url": "http://www.orthodb.org/?query=166463at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46532", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46532", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46532:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46532:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03028", "url": "http://pfam.xfam.org/family/PF03028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08385", "url": "http://pfam.xfam.org/family/PF08385", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08393", "url": "http://pfam.xfam.org/family/PF08393", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12774", "url": "http://pfam.xfam.org/family/PF12774", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12775", "url": "http://pfam.xfam.org/family/PF12775", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12777", "url": "http://pfam.xfam.org/family/PF12777", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12780", "url": "http://pfam.xfam.org/family/PF12780", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12781", "url": "http://pfam.xfam.org/family/PF12781", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17852", "url": "http://pfam.xfam.org/family/PF17852", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17857", "url": "http://pfam.xfam.org/family/PF17857", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18198", "url": "http://pfam.xfam.org/family/PF18198", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18199", "url": "http://pfam.xfam.org/family/PF18199", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8VHE6", "url": "http://purl.obolibrary.org/obo/PR_Q8VHE6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VHE6-1", "url": "https://www.uniprot.org/uniprot/Q8VHE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRIGRRQLWKQSVTRVLTQRLKEEKEAKRARLDGRHDYLFAIVASCLDLNKPEVEDALLEGNQIERMDQLFAVGGLRHLMFYYQDVEGAEAGHCGSSGGVNPASGKMKKPKVFVTEGKDVALMGACVFFIRSDPSKAITPENIHREVSFNTLDTADGGLLNSVRRLLSDIFIPALRASSHGWGELEGLQDASSIRQEFLSSLEGFVGILSGAQNSLKEKVNLQKCDIIELKSLKEPTDYLALASNPETVEKVECCMRVWIKQMEQILAENSQLRKEADDVGPRAELEHWKQRLSRFNYLLDQLKSPDVKAALALLAAAKSKLLKVWRDTDIRITDAANEAKDNVKYLYTLEKCCDPLYSSDPVTMIDAIPTLINAIKMVYSISHYYNTSEKITSLFVKVTNQMISACKAHITNNGTATIWSQPQEIVMQKIAAVIKLKQGYQSCFQETKQKLKQNPSEKQFDFSEMYIFGKFETFHRRLAKIMDIFTTFKTYSVLQDSKIEGLEDMATKYQDIVAAIKKKEYNFLDQREMDFDQDYEEFCKRINELHNDLQRFMDITFEKIPSTRQALSTLKKFERLNIPNLGIEEKYQIIFQNFATDIDTISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRLEQPMQLFQQHPFVLRTAEAKPVIRSYNRIAKVLLEFEVLYHRAWLQQIEEIHAGLEASLLVKAPGTGELFVNFDPQILVLFRETQCMSQLGLPVSPFAAALFQKRDMFKKNFSDMKMMLSEYERVKLKMPPAIEQLMFPHLARVDEALQPGLAVLTWTSLNIGGYLENAFAKIKDLELLLDRVNDLIEFRIHAILEEMSSMALCQLPQDDPLTCEEFLQMTKDLCVSGAQLLHFKSSLVEEAVNELINMLLDVDVPPEEAAENVCHENASPSGNTSGRREGHSEALASSFNAGASSLPLTATARKKKETEVLEEARELLSHFNHQNTDALLKVTRNTLEAIRRRIHFSHMINFRDSNDASKAKQNHLPIFRASVTLAIPNIAMTPALEDIQQTLNKAVECIISVPKGVRQWSSELLSKRKMHERKMAAVKNNEDSDSDAEVEENELQETLEIASINLPIPVQTQNYYKNISDNKEIVKLVSVLSTVISSTKKEVITSMDRFKRYNHIWQKEKEDTIMTFIAQNPLLPEFESRILYFQSLEQEINAEPEYIRVGSIALYTADLKLSLTAETKAWMAVIGRHCNRKYRAEMENILTVVEESQKKLSRPIKDLDDIRIAMAALKEIREQQISTDFQVGPIEESYALLNKYGLLVAKEEMDKVDTLRYAWEKLLARASDVQNELGALQPSFRKELISTVEVFLQDCQQFYLDYDLNGPMASGLKPQEASGRLIIFQNQFDNIYRKYITYTGGEELFGLPVTPYPQLLEIKRQLNLLQKIYSLYNNVIETVNSYQDTLWSDVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKTIDDFSECCPLLEYMASNAMVERHWQRITALTGHSLDVGNETFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQKLRQVINEWDNKTLTFSGFKTRGELLLRGDSTSEVIASMEDSLMLLGSLLSNRYNMPFKAQIQKWVQCLSNSTDIIENWMTVQNLWIYLEAVFVGGDIAKQLPKEAKRFSNIDKSWVKIMTRAHEIPNVVQCCVGDETMGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLEILGQASDSHTIQAHLLNVFDNIKTVKFHDKIYDRILSISSREGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQEPGFQLIEFLSSFPAQVGLLGIQMLWTRDSEEALRNAKFDKKIMQKTNQAFLELLNMLIEITTKDLSSMERVKYETLITIHVHQRDIFDDLCHMHVKSPTDFEWLKQCRFYFKEDSDKTMIHITDVAFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCGFIDNVVLARKFFTLYQLCEEQLSKQVHYDFGLRNILSVLRTLGAAKRASPTDTESTIVMRVLRDMNLSKLIDEDEPLFLSLIEDLFPNILLDKAGYPELETAISKQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGSGKTTCIHTLMKAMTDCGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRKTLKAKKGEHIWIVLDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPNCKIVFEPHNIDNASPATVSRNGMVFMSSSVLDWSPILEGFLKRRSPQEAEILRQLYAETFPDLYRFSIQNLEFKMEVLEAFVITQSTHMLQGLIPPKEQAGEVDPEHLGRLFVFAMMWSVGAVLELEGRRRMELWLRSREGPTLHLPQLTDAGDTMFDYYVAPNGTWRHWSLCTPEYVYPPDTTPEYGSILVPNVDNVRTDFLIKTIAKQGKAVLLIGEQGTAKTVIIKGFMSKFDPESHMVKNLNFSSATTPVMFQRTIESYVDKRMGTTYGPPAGKKMAVFIDDLNMPVINEWGDQVTNEIVRQLMEQSGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLKRQFSIFNCTLPSDASMDKIFGVIGAGYYCAQRGFSEEVQDALIKLVPLTRRLWQMTKLKMLPTPAKFHYVFNLRDLSRIWQGMLNITSEVIKDTDELLRLWKHECKRVIADRFSMSSDVTWFDKAVVSLVEEEFGEEKAPVVDCGVDAYFVDFLRDAPEATGETPEEADAEMPKLYEPIASLNHLRERLSVFLQLYNESIRGTGMDMVFFIDAMVHLVKISRVIRTPRGNALLVGVGGSGKQSLTRLASFIAGYTSFQITLTRSYNTSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKEESFLEYMNNVLSSGEVSNLFARDEIDEINSDLTPIMKKEHPRRPPTNDNLYEYFMSRVRGNLHIVLCFSPVGEKFRNRALKFPALISGCTIDWFSRWPKDALVAVSEHFLSSYTIDCTAEIKKELVQCMGSFQDGVAEKCADYFQRFRRSTHVTPKSYLSFIQGYKFIYEEKHMEVQSLANRMNTGLEKLKEASESVAALSKELAGKEKELQVANEKADTVLKEVTMKAQAAEKVKAEVQKVKDKAQAIVDSISKDKAIAEEKLEAAKPALEEAEAALQTIKPSDIATVRTLGRPPHLIMRIMDCVLLLFQRRVNAVKIDVDKGCTMPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLNPYFEMSDYNIETAKRVCGNVAGLCSWTKAMASFFSINKEVLPLKANLIVQENRHILAMQDLQKAQAELDAKQAELDVVQAEYEQAMAEKQTLLEDADRCRHKMQTASTLISGLAGEKERWTEQSKEFAAQTKRLVGDVLLATAFLSYSGPFNQEFRDLLLHDWKKEMKARKIPFGNGLNLNEMLIDAPTISEWNLQGLPNDDLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESQNELQITSLNHKYFRNHLEDSLSLGRPLLIEDVGEELDPALDNVLEKNFIKTGSTFKVKVGDKEVDVMDGFKLYITTKLPNPAYTPEISARTSIIDFTVTVKGLEDQLLGRVILTEKQELEKERTHLLEDVTANKRRMKELEDNLLYRLTSTQGSLVEDESLIIVLSNTKKTAEEVTQKLEISGETEIQINSAREEYRPVATRGSILYFLITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVFKYAARGLYEEHKFLFTLLLTLKIDIQRNLVKHEEFLTLIKGGASLDLKACPPKPSKWILDMTWLNLVELSKLKQFSDILDQISRNEKMWRVWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWCPDRTIAQARKYIMDSMGENYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKIETRYVSMGQGQEVHARKLLHQTMANGGWVLLQNCHLGLDFLDELMDVVTETETVHDTFRLWITTEVHKQFPITLLQMSIKFANEPPQGLRAGLRRTYGGVSQDLLDVSVGAQWKPMLYAVAFLHSTVQERRKFGPLGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTVRYMIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFTFYQGYNIPKCSTVDGYLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDSSGGGDETREAVVARLADDMLEKLPEDYSPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAVDGTIIMSENLRDALDCMFDARIPARWKKASWVSSTLGFWFTELLERNCQFTSWVSNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKFMKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIFAENNTARDPRLYCCPIYKKPVRTDLNYIAAVDLKTAQAPEHWVLRGVALLCDVK", "length": 4621, "header": "sp|Q8VHE6-1|DYH5_MOUSE Isoform 1 of Dynein axonemal heavy chain 5 OS=Mus musculus OX=10090 GN=Dnah5 PE=1 SV=2 CANONICAL=Q8VHE6-1" }, "isoforms": [ { "isoform_ac": "Q8VHE6-1", "url": "", "sequence": { "sequence": "MFRIGRRQLWKQSVTRVLTQRLKEEKEAKRARLDGRHDYLFAIVASCLDLNKPEVEDALLEGNQIERMDQLFAVGGLRHLMFYYQDVEGAEAGHCGSSGGVNPASGKMKKPKVFVTEGKDVALMGACVFFIRSDPSKAITPENIHREVSFNTLDTADGGLLNSVRRLLSDIFIPALRASSHGWGELEGLQDASSIRQEFLSSLEGFVGILSGAQNSLKEKVNLQKCDIIELKSLKEPTDYLALASNPETVEKVECCMRVWIKQMEQILAENSQLRKEADDVGPRAELEHWKQRLSRFNYLLDQLKSPDVKAALALLAAAKSKLLKVWRDTDIRITDAANEAKDNVKYLYTLEKCCDPLYSSDPVTMIDAIPTLINAIKMVYSISHYYNTSEKITSLFVKVTNQMISACKAHITNNGTATIWSQPQEIVMQKIAAVIKLKQGYQSCFQETKQKLKQNPSEKQFDFSEMYIFGKFETFHRRLAKIMDIFTTFKTYSVLQDSKIEGLEDMATKYQDIVAAIKKKEYNFLDQREMDFDQDYEEFCKRINELHNDLQRFMDITFEKIPSTRQALSTLKKFERLNIPNLGIEEKYQIIFQNFATDIDTISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRLEQPMQLFQQHPFVLRTAEAKPVIRSYNRIAKVLLEFEVLYHRAWLQQIEEIHAGLEASLLVKAPGTGELFVNFDPQILVLFRETQCMSQLGLPVSPFAAALFQKRDMFKKNFSDMKMMLSEYERVKLKMPPAIEQLMFPHLARVDEALQPGLAVLTWTSLNIGGYLENAFAKIKDLELLLDRVNDLIEFRIHAILEEMSSMALCQLPQDDPLTCEEFLQMTKDLCVSGAQLLHFKSSLVEEAVNELINMLLDVDVPPEEAAENVCHENASPSGNTSGRREGHSEALASSFNAGASSLPLTATARKKKETEVLEEARELLSHFNHQNTDALLKVTRNTLEAIRRRIHFSHMINFRDSNDASKAKQNHLPIFRASVTLAIPNIAMTPALEDIQQTLNKAVECIISVPKGVRQWSSELLSKRKMHERKMAAVKNNEDSDSDAEVEENELQETLEIASINLPIPVQTQNYYKNISDNKEIVKLVSVLSTVISSTKKEVITSMDRFKRYNHIWQKEKEDTIMTFIAQNPLLPEFESRILYFQSLEQEINAEPEYIRVGSIALYTADLKLSLTAETKAWMAVIGRHCNRKYRAEMENILTVVEESQKKLSRPIKDLDDIRIAMAALKEIREQQISTDFQVGPIEESYALLNKYGLLVAKEEMDKVDTLRYAWEKLLARASDVQNELGALQPSFRKELISTVEVFLQDCQQFYLDYDLNGPMASGLKPQEASGRLIIFQNQFDNIYRKYITYTGGEELFGLPVTPYPQLLEIKRQLNLLQKIYSLYNNVIETVNSYQDTLWSDVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKTIDDFSECCPLLEYMASNAMVERHWQRITALTGHSLDVGNETFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQKLRQVINEWDNKTLTFSGFKTRGELLLRGDSTSEVIASMEDSLMLLGSLLSNRYNMPFKAQIQKWVQCLSNSTDIIENWMTVQNLWIYLEAVFVGGDIAKQLPKEAKRFSNIDKSWVKIMTRAHEIPNVVQCCVGDETMGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLEILGQASDSHTIQAHLLNVFDNIKTVKFHDKIYDRILSISSREGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQEPGFQLIEFLSSFPAQVGLLGIQMLWTRDSEEALRNAKFDKKIMQKTNQAFLELLNMLIEITTKDLSSMERVKYETLITIHVHQRDIFDDLCHMHVKSPTDFEWLKQCRFYFKEDSDKTMIHITDVAFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCGFIDNVVLARKFFTLYQLCEEQLSKQVHYDFGLRNILSVLRTLGAAKRASPTDTESTIVMRVLRDMNLSKLIDEDEPLFLSLIEDLFPNILLDKAGYPELETAISKQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGSGKTTCIHTLMKAMTDCGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRKTLKAKKGEHIWIVLDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPNCKIVFEPHNIDNASPATVSRNGMVFMSSSVLDWSPILEGFLKRRSPQEAEILRQLYAETFPDLYRFSIQNLEFKMEVLEAFVITQSTHMLQGLIPPKEQAGEVDPEHLGRLFVFAMMWSVGAVLELEGRRRMELWLRSREGPTLHLPQLTDAGDTMFDYYVAPNGTWRHWSLCTPEYVYPPDTTPEYGSILVPNVDNVRTDFLIKTIAKQGKAVLLIGEQGTAKTVIIKGFMSKFDPESHMVKNLNFSSATTPVMFQRTIESYVDKRMGTTYGPPAGKKMAVFIDDLNMPVINEWGDQVTNEIVRQLMEQSGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLKRQFSIFNCTLPSDASMDKIFGVIGAGYYCAQRGFSEEVQDALIKLVPLTRRLWQMTKLKMLPTPAKFHYVFNLRDLSRIWQGMLNITSEVIKDTDELLRLWKHECKRVIADRFSMSSDVTWFDKAVVSLVEEEFGEEKAPVVDCGVDAYFVDFLRDAPEATGETPEEADAEMPKLYEPIASLNHLRERLSVFLQLYNESIRGTGMDMVFFIDAMVHLVKISRVIRTPRGNALLVGVGGSGKQSLTRLASFIAGYTSFQITLTRSYNTSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKEESFLEYMNNVLSSGEVSNLFARDEIDEINSDLTPIMKKEHPRRPPTNDNLYEYFMSRVRGNLHIVLCFSPVGEKFRNRALKFPALISGCTIDWFSRWPKDALVAVSEHFLSSYTIDCTAEIKKELVQCMGSFQDGVAEKCADYFQRFRRSTHVTPKSYLSFIQGYKFIYEEKHMEVQSLANRMNTGLEKLKEASESVAALSKELAGKEKELQVANEKADTVLKEVTMKAQAAEKVKAEVQKVKDKAQAIVDSISKDKAIAEEKLEAAKPALEEAEAALQTIKPSDIATVRTLGRPPHLIMRIMDCVLLLFQRRVNAVKIDVDKGCTMPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLNPYFEMSDYNIETAKRVCGNVAGLCSWTKAMASFFSINKEVLPLKANLIVQENRHILAMQDLQKAQAELDAKQAELDVVQAEYEQAMAEKQTLLEDADRCRHKMQTASTLISGLAGEKERWTEQSKEFAAQTKRLVGDVLLATAFLSYSGPFNQEFRDLLLHDWKKEMKARKIPFGNGLNLNEMLIDAPTISEWNLQGLPNDDLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESQNELQITSLNHKYFRNHLEDSLSLGRPLLIEDVGEELDPALDNVLEKNFIKTGSTFKVKVGDKEVDVMDGFKLYITTKLPNPAYTPEISARTSIIDFTVTVKGLEDQLLGRVILTEKQELEKERTHLLEDVTANKRRMKELEDNLLYRLTSTQGSLVEDESLIIVLSNTKKTAEEVTQKLEISGETEIQINSAREEYRPVATRGSILYFLITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVFKYAARGLYEEHKFLFTLLLTLKIDIQRNLVKHEEFLTLIKGGASLDLKACPPKPSKWILDMTWLNLVELSKLKQFSDILDQISRNEKMWRVWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWCPDRTIAQARKYIMDSMGENYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKIETRYVSMGQGQEVHARKLLHQTMANGGWVLLQNCHLGLDFLDELMDVVTETETVHDTFRLWITTEVHKQFPITLLQMSIKFANEPPQGLRAGLRRTYGGVSQDLLDVSVGAQWKPMLYAVAFLHSTVQERRKFGPLGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTVRYMIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFTFYQGYNIPKCSTVDGYLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDSSGGGDETREAVVARLADDMLEKLPEDYSPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAVDGTIIMSENLRDALDCMFDARIPARWKKASWVSSTLGFWFTELLERNCQFTSWVSNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKFMKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIFAENNTARDPRLYCCPIYKKPVRTDLNYIAAVDLKTAQAPEHWVLRGVALLCDVK", "length": 4621, "header": "sp|Q8VHE6-1|DYH5_MOUSE Isoform 1 of Dynein axonemal heavy chain 5 OS=Mus musculus OX=10090 GN=Dnah5 PE=1 SV=2 CANONICAL=Q8VHE6-1" }, "locus": { "chromosome": "15", "start_pos": 28470651, "end_pos": 28204125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000067048", "url": "https://www.ensembl.org/id/ENSMUST00000067048" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000069751", "url": "https://www.ensembl.org/id/ENSMUSP00000069751" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 3668, "start_aa": "Thr", "end_pos": 3668, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3668", "evidence": [ { "id": "Q8VHE6", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8VHE6" }, { "id": "34418053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34418053" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry.", "journal": "Nat. Genet.", "date": "2002", "authors": "Olbrich H, Haffner K, Kispert A, Volkel A, Volz A, Sasmaz G, Reinhardt R, Hennig S, Lehrach H, Konietzko N, Zariwala M, Noone PG, Knowles M, Mitchison HM, Meeks M, Chung EM, Hildebrandt F, Sudbrak R, Omran H", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "reference": [ { "type": "PubMed", "id": "11788826", "url": "https://glygen.org/publication/PubMed/11788826" } ] }, { "title": "Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.", "journal": "Hum. Mol. Genet.", "date": "2002", "authors": "Ibanez-Tallon I, Gorokhova S, Heintz N", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "reference": [ { "type": "PubMed", "id": "11912187", "url": "https://glygen.org/publication/PubMed/11912187" } ] }, { "title": "Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation.", "journal": "Hum. Mol. Genet.", "date": "2004", "authors": "Ibanez-Tallon I, Pagenstecher A, Fliegauf M, Olbrich H, Kispert A, Ketelsen UP, North A, Heintz N, Omran H", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "reference": [ { "type": "PubMed", "id": "15269178", "url": "https://glygen.org/publication/PubMed/15269178" } ] }, { "title": "O-GlcNAcylation Is Essential for Rapid Pomc Expression and Cell Proliferation in Corticotropic Tumor Cells.", "journal": "Endocrinology", "date": "2021", "authors": "Massman LJ, Pereckas M, Zwagerman NT, Olivier-Van Stichelen S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8VHE6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8VHE6" } ], "reference": [ { "type": "PubMed", "id": "34418053", "url": "https://glygen.org/publication/PubMed/34418053" } ] } ], "pathway": [ { "id": "mmu:110082", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110082", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8TE73-1", "protein_name": "Dynein axonemal heavy chain 5", "gene_name": "DNAH5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFRIGRRQLWKHSVTRVLTQRLKGEKEAKRALLDARHNYLFAIVASCLDLNKTEVEDAILEGNQIERIDQLFAVGGLRHLMFYYQDVEEAETGQLGSLGGVNLVSGKIKKPKVFVTEGNDVALTGVCVFFIRTDPSKAITPDNIHQEVSFNMLDAADGGLLNSVRRLLSDIFIPALRATSHGWGELEGLQDAANIRQEFLSSLEGFVNVLSGAQESLKEKVNLRKCDILELKTLKEPTDYLTLANNPETLGKIEDCMKVWIKQTEQVLAENNQLLKEADDVGPRAELEHWKKRLSKFNYLLEQLKSPDVKAVLAVLAAAKSKLLKTWREMDIRITDATNEAKDNVKYLYTLEKCCDPLYSSDPLSMMDAIPTLINAIKMIYSISHYYNTSEKITSLFVKVTNQIISACKAYITNNGTASIWNQPQDVVEEKILSAIKLKQEYQLCFHKTKQKLKQNPNAKQFDFSEMYIFGKFETFHRRLAKIIDIFTTLKTYSVLQDSTIEGLEDMATKYQGIVATIKKKEYNFLDQRKMDFDQDYEEFCKQTNDLHNELRKFMDVTFAKIQNTNQALRMLKKFERLNIPNLGIDDKYQLILENYGADIDMISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRIQQPMQLFQQHPAVLSTAEAKPIIRSYNRMAKVLLEFEVLFHRAWLRQIEEIHVGLEASLLVKAPGTGELFVNFDPQILILFRETECMAQMGLEVSPLATSLFQKRDRYKRNFSNMKMMLAEYQRVKSKIPAAIEQLIVPHLAKVDEALQPGLAALTWTSLNIEAYLENTFAKIKDLELLLDRVNDLIEFRIDAILEEMSSTPLCQLPQEEPLTCEEFLQMTKDLCVNGAQILHFKSSLVEEAVNELVNMLLDVEVLSEEESEKISNENSVNYKNESSAKREEGNFDTLTSSINARANALLLTTVTRKKKETEMLGEEARELLSHFNHQNMDALLKVTRNTLEAIRKRIHSSHTINFRDSNSASNMKQNSLPIFRASVTLAIPNIVMAPALEDVQQTLNKAVECIISVPKGVRQWSSELLSKKKIQERKMAALQSNEDSDSDVEMGENELQDTLEIASVNLPIPVQTKNYYKNVSENKEIVKLVSVLSTIINSTKKEVITSMDCFKRYNHIWQKGKEEAIKTFITQSPLLSEFESQILYFQNLEQEINAEPEYVCVGSIALYTADLKFALTAETKAWMVVIGRHCNKKYRSEMENIFMLIEEFNKKLNRPIKDLDDIRIAMAALKEIREEQISIDFQVGPIEESYALLNRYGLLIAREEIDKVDTLHYAWEKLLARAGEVQNKLVSLQPSFKKELISAVEVFLQDCHQFYLDYDLNGPMASGLKPQEASDRLIMFQNQFDNIYRKYITYTGGEELFGLPATQYPQLLEIKKQLNLLQKIYTLYNSVIETVNSYYDILWSEVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKIIDDFSECCPLLEYMASKAMMERHWERITTLTGHSLDVGNESFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQKLKQVINEWDNKTFTFGSFKTRGELLLRGDSTSEIIANMEDSLMLLGSLLSNRYNMPFKAQIQKWVQYLSNSTDIIESWMTVQNLWIYLEAVFVGGDIAKQLPKEAKRFSNIDKSWVKIMTRAHEVPSVVQCCVGDETLGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLEILGQASDSHTIQAHLLNVFDNIKSVKFHEKIYDRILSISSQEGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQETGFQLTEFLSSFPAQVGLLGIQMIWTRDSEEALRNAKFDKKIMQKTNQAFLELLNTLIDVTTRDLSSTERVKYETLITIHVHQRDIFDDLCHMHIKSPMDFEWLKQCRFYFNEDSDKMMIHITDVAFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCGFIDNVVLARKFFTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGAAKRANPMDTESTIVMRVLRDMNLSKLIDEDEPLFLSLIEDLFPNILLDKAGYPELEAAISRQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGAGKTTCIHTLMRAMTDCGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRKTLRAKKGEHIWIILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPNCKIIFEPHNIDNASPATVSRNGMVFMSSSILDWSPILEGFLKKRSPQEAEILRQLYTESFPDLYRFCIQNLEYKMEVLEAFVITQSINMLQGLIPLKEQGGEVSQAHLGRLFVFALLWSAGAALELDGRRRLELWLRSRPTGTLELPPPAGPGDTAFDYYVAPDGTWTHWNTRTQEYLYPSDTTPEYGSILVPNVDNVRTDFLIQTIAKQGKAVLLIGEQGTAKTVIIKGFMSKYDPECHMIKSLNFSSATTPLMFQRTIESYVDKRMGTTYGPPAGKKMTVFIDDVNMPIINEWGDQVTNEIVRQLMEQNGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLKRQFSIFNCTLPSEASVDKIFGVIGVGHYCTQRGFSEEVRDSVTKLVPLTRRLWQMTKIKMLPTPAKFHYVFNLRDLSRVWQGMLNTTSEVIKEPNDLLKLWKHECKRVIADRFTVSSDVTWFDKALVSLVEEEFGEEKKLLVDCGIDTYFVDFLRDAPEAAGETSEEADAETPKIYEPIESFSHLKERLNMFLQLYNESIRGAGMDMVFFADAMVHLVKISRVIRTPQGNALLVGVGGSGKQSLTRLASFIAGYVSFQITLTRSYNTSNLMEDLKVLYRTAGQQGKGITFIFTDNEIKDESFLEYMNNVLSSGEVSNLFARDEIDEINSDLASVMKKEFPRCLPTNENLHDYFMSRVRQNLHIVLCFSPVGEKFRNRALKFPALISGCTIDWFSRWPKDALVAVSEHFLTSYDIDCSLEIKKEVVQCMGSFQDGVAEKCVDYFQRFRRSTHVTPKSYLSFIQGYKFIYGEKHVEVRTLANRMNTGLEKLKEASESVAALSKELEAKEKELQVANDKADMVLKEVTMKAQAAEKVKAEVQKVKDRAQAIVDSISKDKAIAEEKLEAAKPALEEAEAALQTIRPSDIATVRTLGRPPHLIMRIMDCVLLLFQRKVSAVKIDLEKSCTMPSWQESLKLMTAGNFLQNLQQFPKDTINEEVIEFLSPYFEMPDYNIETAKRVCGNVAGLCSWTKAMASFFSINKEVLPLKANLVVQENRHLLAMQDLQKAQAELDDKQAELDVVQAEYEQAMTEKQTLLEDAERCRHKMQTASTLISGLAGEKERWTEQSQEFAAQTKRLVGDVLLATAFLSYSGPFNQEFRDLLLNDWRKEMKARKIPFGKNLNLSEMLIDAPTISEWNLQGLPNDDLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESRNELQITSLNHKYFRNHLEDSLSLGRPLLIEDVGEELDPALDNVLERNFIKTGSTFKVKVGDKEVDVLDGFRLYITTKLPNPAYTPEISARTSIIDFTVTMKGLEDQLLGRVILTEKQELEKERTHLMEDVTANKRRMKELEDNLLYRLTSTQGSLVEDESLIVVLSNTKRTAEEVTQKLEISAETEVQINSAREEYRPVATRGSILYFLITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVYKYAARGLYEEHKFLFTLLLTLKIDIQRNRVKHEEFLTLIKGGASLDLKACPPKPSKWILDITWLNLVELSKLRQFSDVLDQISRNEKMWKIWFDKENPEEEPLPNAYDKSLDCFRRLLLIRSWCPDRTIAQARKYIVDSMGEKYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKIETRYVSMGQGQEVHARKLLQQTMANGGWALLQNCHLGLDFMDELMDIIIETELVHDAFRLWMTTEAHKQFPITLLQMSIKFANDPPQGLRAGLKRTYSGVSQDLLDVSSGSQWKPMLYAVAFLHSTVQERRKFGALGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTIRYMIGEIQYGGRVTDDYDKRLLNTFAKVWFSENMFGPDFSFYQGYNIPKCSTVDNYLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQPKDTSGGGDETREAVVARLADDMLEKLPPDYVPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAIDGTIIMSENLRDALDCMFDARIPAWWKKASWISSTLGFWFTELIERNSQFTSWVFNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKWMKDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIYAENNTLRDPRFYSCPIYKKPVRTDLNYIAAVDLRTAQTPEHWVLRGVALLCDVK", "length": 4624 }, "evidence": [ { "id": "Q8VHE6", "url": "https://omabrowser.org/oma/group/Q8VHE6/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "epithelial cilium movement involved in extracellular fluid movement", "id": "GO:0003351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003351", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "lateral ventricle development", "id": "GO:0021670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021670", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "establishment of localization in cell", "id": "GO:0051649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051649", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "minus-end-directed microtubule motor activity", "id": "GO:0008569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008569", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "axonemal dynein complex", "id": "GO:0005858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005858", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "outer dynein arm", "id": "GO:0036157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036157", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" }, { "name": "9+0 motile cilium", "id": "GO:0097728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097728", "evidence": [ { "database": "UniProtKB", "id": "Q8VHE6", "url": "https://www.uniprot.org/uniprot/Q8VHE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1106, "end_pos": 1108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1508, "end_pos": 1510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1554, "end_pos": 1556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1614, "end_pos": 1616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2002, "end_pos": 2004, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2067, "end_pos": 2069, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2186, "end_pos": 2188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2353, "end_pos": 2355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2381, "end_pos": 2383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2533, "end_pos": 2535, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2615, "end_pos": 2617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2725, "end_pos": 2727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2803, "end_pos": 2805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2915, "end_pos": 2917, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2984, "end_pos": 2986, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4215, "end_pos": 4217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4570, "end_pos": 4572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 748, "end_pos": 750, "annotation": "n_glycosylation_sequon" }, { "start_pos": 905, "end_pos": 907, "annotation": "n_glycosylation_sequon" }, { "start_pos": 911, "end_pos": 913, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }