{
    "uniprot_canonical_ac": "Q8VHA6-1",
    "uniprot_ac": "Q8VHA6",
    "uniprot_id": "ASB18_MOUSE",
    "mass": {
        "chemical_mass": 50700.0,
        "monoisotopic_mass": 50700.0
    },
    "refseq": {
        "ac": "NP_631891",
        "name": "ankyrin repeat and SOCS box protein 18 isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891"
    },
    "gene_names": [
        {
            "name": "Asb18",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6",
            "id": "Q8VHA6"
        },
        {
            "name": "Asb-18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891",
            "id": "NP_631891"
        },
        {
            "name": "Asb18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891",
            "id": "NP_631891"
        }
    ],
    "protein_names": [
        {
            "name": "Ankyrin repeat and SOCS box protein 18",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8VHA6"
        },
        {
            "name": "ASB-18",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8VHA6"
        },
        {
            "name": "ankyrin repeat and SOCS box protein 18 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891",
            "id": "NP_631891"
        },
        {
            "name": "ankyrin repeat and SOCS box protein 18; SOCS box protein ASB-18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891",
            "id": "NP_631891"
        }
    ],
    "function": [
        {
            "annotation": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8VHA6",
                    "url": "https://www.uniprot.org/uniprot/Q8VHA6#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8VHA6",
                    "url": "https://www.uniprot.org/uniprot/Q8VHA6"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Asb18",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6",
            "locus": {
                "chromosome": "1",
                "start_pos": 89877942,
                "end_pos": 89942388,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000067081",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000067081"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000067081",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000067081",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03723",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03723",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "208372",
            "url": "https://www.ncbi.nlm.nih.gov/gene/208372",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001496",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036036",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036770",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:208372",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:208372",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2655109",
            "url": "http://www.informatics.jax.org/marker/MGI:2655109",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "DARNGCG",
            "url": "https://omabrowser.org/oma/group/DARNGCG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1787271at2759",
            "url": "http://www.orthodb.org/?query=1787271at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24173",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24173:SF74",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173:SF74",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24189",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24189:SF50",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF50",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07525",
            "url": "http://pfam.xfam.org/family/PF07525",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12796",
            "url": "http://pfam.xfam.org/family/PF12796",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8VHA6",
            "url": "http://purl.obolibrary.org/obo/PR_Q8VHA6",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-8951664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_631891",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631891",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A571BD84",
            "url": "https://www.uniprot.org/uniprot/A0A571BD84",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A571BD84-1",
            "url": "https://www.uniprot.org/uniprot/A0A571BD84-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D6REF8",
            "url": "https://www.uniprot.org/uniprot/D6REF8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D6REF8-1",
            "url": "https://www.uniprot.org/uniprot/D6REF8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H7BX71",
            "url": "https://www.uniprot.org/uniprot/H7BX71",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H7BX71-1",
            "url": "https://www.uniprot.org/uniprot/H7BX71-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VHA6",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VHA6-1",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VHA6-2",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8VHA6-3",
            "url": "https://www.uniprot.org/uniprot/Q8VHA6-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGDLDHIRLLMDQCFWDANAVFEISNGEMEWQVTSLATFGLSGLWTLEYQRELTTPLCIAAAHGHESCVRHLLSRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGPGRDTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETALSAACGAAARSPDEHARCLRLCALLLRGGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATCAPPTAPQRTVQVLLNHGSRSVWPDAFPKVLRTCAQVPEVIEVLFNSYTQLPVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC",
        "length": 467,
        "header": "sp|Q8VHA6-1|ASB18_MOUSE Isoform 1 of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A571BD84-1",
            "url": "",
            "sequence": {
                "sequence": "MERRPEPAGRKLQILQKMSQEPQIRAGTPELAFHAALLAGDLDHIRLLMDQCFWDANAVFEISNGEMEWQVTSLATFGLSGLWTLEYQRELTTPLCIAAAHGHESCVRHLLSRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGPGRDTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETALSAACGAAARSPDEHARCLRLCALLLRGGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATCAPPTAPQRTVQVLLNHGSRSVWPDAFPKVLRTCAQVPEVIEVLFNSYTQLPVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC",
                "length": 438,
                "header": "tr|A0A571BD84-1|A0A571BD84_MOUSE Computationally mapped isoform of Ankyrin repeat and SOCS box-containing 18  OS=Mus musculus OX=10090 GN=Asb18 PE=3 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 89924174,
                "end_pos": 89880403,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000238685.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000238685.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000158643.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000158643.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D6REF8-1",
            "url": "",
            "sequence": {
                "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGLWTLEYQRELTTPLARSRCY",
                "length": 89,
                "header": "tr|D6REF8-1|ASB18_MOUSE Computationally mapped isoform of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 89942299,
                "end_pos": 89895979,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000151330.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000151330.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117836.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117836.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "H7BX71-1",
            "url": "",
            "sequence": {
                "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGLWTLEYQRELTTPLRTVQVLLNHGSRSVWPDAFPKVLRTCAQVPEVIEVLFNSYTQLPVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC",
                "length": 203,
                "header": "tr|H7BX71-1|ASB18_MOUSE Computationally mapped isoform of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 89942299,
                "end_pos": 89880403,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000097656.10",
                        "url": "https://www.ensembl.org/id/ENSMUST00000097656.10"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000095261.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000095261.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8VHA6-1",
            "url": "",
            "sequence": {
                "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGDLDHIRLLMDQCFWDANAVFEISNGEMEWQVTSLATFGLSGLWTLEYQRELTTPLCIAAAHGHESCVRHLLSRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGCARELLEHGATVQLEGGPGRDTPLHVAAQRGLDEHAQLYLGFGARVDARNGRGETALSAACGAAARSPDEHARCLRLCALLLRGGAAADARDEDERSPLHKACGHARPGLCTLLLRHGADAGALDYGGASPLARALQTATCAPPTAPQRTVQVLLNHGSRSVWPDAFPKVLRTCAQVPEVIEVLFNSYTQLPVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC",
                "length": 467,
                "header": "sp|Q8VHA6-1|ASB18_MOUSE Isoform 1 of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 89942299,
                "end_pos": 89880403,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000086882",
                        "url": "https://www.ensembl.org/id/ENSMUST00000086882"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000084095",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000084095"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8VHA6-2",
            "url": "",
            "sequence": {
                "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGLWTLEYQRELTTPLCIAAAHGHESCVRHLLSRKADPNASPGGRGALHEACLGNHTACARLLLQHGADPDLLNSEGLAPLHLCRTPASLGF",
                "length": 159,
                "header": "sp|Q8VHA6-2|ASB18_MOUSE Isoform 2 of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 89942299,
                "end_pos": 89882221,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000154228",
                        "url": "https://www.ensembl.org/id/ENSMUST00000154228"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000117767",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000117767"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8VHA6-3",
            "url": "",
            "sequence": {
                "sequence": "MSSWDSPPDYPLSSDIVRRLKSALATGDEDTVQKLICTEVEPVDAVIELANDDWMKEPSAELPTGVLLGLWTLEYQRELTTPQRTVQVLLNHGSRSVWPDAFPKVLRTCAQVPEVIEVLFNSYTQLPVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEPEGVLC",
                "length": 203,
                "header": "sp|Q8VHA6-3|ASB18_MOUSE Isoform 3 of Ankyrin repeat and SOCS box protein 18  OS=Mus musculus OX=10090 GN=Asb18 PE=2 SV=1 CANONICAL=Q8VHA6-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:208372",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:208372",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-8951664",
            "name": "Neddylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664",
            "resource": "Reactome",
            "description": "Neddylation"
        },
        {
            "id": "R-MMU-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZU92-1",
            "protein_name": "Ankyrin repeat and SOCS box-containing 18",
            "gene_name": "Asb18",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSGWDPPPDYPLSSDLVRRLKSALATGDRDTVQELICTEVEPVDAVLELANDDWMKEPSAKLPTGALLGDLDHIQSLTDQCFWDANVVFEISTEEMEWQVTSLATFGLSGLWTLEYKRELTTPLCIAAAHGHESCVRHLLSRKADPDASPGGRGALHEACLGSHTACARLLLQHGADPDLLSSEGLAPLHLCRTPASLGCAQELLEHGATVQLEGGPNRDTPLHVAAQRGLDKHAQLYLGCGARVDARNGRGETALSAACGAAARSPEEHARCLRLCALLLRGGAATDMRDEDERSPLHKACGHARPGLCTLLLRNGADADALDYGGASPLARALQTATCAPPTAPQRTVQALLNHGSRSVWPDAFPKVLRTCAPVPAVIEVLFNSYTQLRVSESWREAIPEEVYQMHKPFYRSLFALAHTPRCLQHFCRCAIRKLFGKECIHLVPQLPLPETLQNYLLLEPEGVLR",
                "length": 467
            },
            "evidence": [
                {
                    "id": "45240032",
                    "url": "http://www.informatics.jax.org/homology/45240032",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6ZVZ8-1",
            "protein_name": "Ankyrin repeat and SOCS box protein 18",
            "gene_name": "ASB18",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSAQLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH",
                "length": 466
            },
            "evidence": [
                {
                    "id": "Q8VHA6",
                    "url": "https://omabrowser.org/oma/group/Q8VHA6/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "intracellular signal transduction",
                        "id": "GO:0035556",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8VHA6",
                                "url": "https://www.uniprot.org/uniprot/Q8VHA6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
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            "end_pos": 149,
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    "synthesized_glycans": [],
    "cluster_types": [
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            "name": "isoformset.uniprotkb",
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        {
            "name": "homologset.mgi",
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        {
            "name": "homologset.oma",
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