{ "uniprot_canonical_ac": "Q8VGP0-1", "uniprot_ac": "Q8VGP0", "uniprot_id": "Q8VGP0_MOUSE", "mass": { "chemical_mass": 34590.0, "monoisotopic_mass": 34590.0 }, "refseq": { "ac": "NP_667193", "name": "olfactory receptor family 4 subfamily C member 10B", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193" }, "gene_names": [ { "name": "Or4c10b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8VGP0", "id": "Q8VGP0" }, { "name": "MOR232-1; Olfr1257", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193", "id": "NP_667193" }, { "name": "Olfr1257", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8VGP0", "id": "Q8VGP0" }, { "name": "Or4c10b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193", "id": "NP_667193" } ], "protein_names": [ { "name": "Olfactory receptor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8VGP0" }, { "name": "olfactory receptor MOR232-1; GA_x6K02T2Q125-51319458-51320387; olfactory receptor 1257", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193", "id": "NP_667193" }, { "name": "olfactory receptor family 4 subfamily C member 10B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193", "id": "NP_667193" } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_667193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Or4c10b", "url": "https://www.uniprot.org/uniprot/Q8VGP0", "locus": { "chromosome": "2", "start_pos": 89713370, "end_pos": 89708781, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000049057", "url": "https://www.ensembl.org/id/ENSMUSG00000049057" } ] } } ], "crossref": [ { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "258984", "url": "https://www.ncbi.nlm.nih.gov/gene/258984", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:258984", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:258984", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "3031091", "url": "http://www.informatics.jax.org/marker/MGI:3031091", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DAIMLCI", "url": "https://omabrowser.org/oma/group/DAIMLCI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4052270at2759", "url": "http://www.orthodb.org/?query=4052270at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "http://pfam.xfam.org/family/PF13853", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_667193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667193", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VGP0-1", "url": "https://www.uniprot.org/uniprot/Q8VGP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENQNNVTEFILLGLTENPKMQKIVFIMFFLIYIISITGNVLIVVTITSTSLLESPMYFFLAYLSFIDACYSSVSTPKLIADSLCEKKTIPFNGCMTQIFGEHLFGGAEIILLTVMAYDRYVAICKPLHYATIMSRRLCSLLVGVSWLGGFLHATIQILFIFQLPFCGPNIIDHFMCDLNPLLNLVCTDTHTLGIFVAANSGFICLLNFLLLLVSYVAILRSLKNHSAEGRRKALSTCISHITVVVLFFVPCIFVYMRPVATLPIDKAVAMFYTMITPMLNPLIYTLRNAQMKDAIKKLGSTKILSSNK", "length": 309, "header": "tr|Q8VGP0-1|Q8VGP0_MOUSE Isoform 1 of Olfactory receptor OS=Mus musculus OX=10090 GN=Or4c10b PE=2 SV=1 CANONICAL=Q8VGP0-1" }, "isoforms": [ { "isoform_ac": "Q8VGP0-1", "url": "", "sequence": { "sequence": "MENQNNVTEFILLGLTENPKMQKIVFIMFFLIYIISITGNVLIVVTITSTSLLESPMYFFLAYLSFIDACYSSVSTPKLIADSLCEKKTIPFNGCMTQIFGEHLFGGAEIILLTVMAYDRYVAICKPLHYATIMSRRLCSLLVGVSWLGGFLHATIQILFIFQLPFCGPNIIDHFMCDLNPLLNLVCTDTHTLGIFVAANSGFICLLNFLLLLVSYVAILRSLKNHSAEGRRKALSTCISHITVVVLFFVPCIFVYMRPVATLPIDKAVAMFYTMITPMLNPLIYTLRNAQMKDAIKKLGSTKILSSNK", "length": 309, "header": "tr|Q8VGP0-1|Q8VGP0_MOUSE Isoform 1 of Olfactory receptor OS=Mus musculus OX=10090 GN=Or4c10b PE=2 SV=1 CANONICAL=Q8VGP0-1" }, "locus": { "chromosome": "2", "start_pos": 89712098, "end_pos": 89711172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000111519.3", "url": "https://www.ensembl.org/id/ENSMUST00000111519.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000107144.2", "url": "https://www.ensembl.org/id/ENSMUSP00000107144.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:258984", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:258984", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NHA9-1", "protein_name": "Olfactory receptor 4C46", "gene_name": "OR4C46", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENRNNMTEFVLLGLTENPKMQKIIFVVFFVIYIITVVGYVLIVVTITASPSLGSPMYLSLAYLSFIDACYSSVNTPNLITHSLYGKKAILFNGCMTQVFGEHFFGGAEGILLTVMAYDHYVAICKPLHYMTIMNQCVCALLMGVVWMGGFLHATIQILFIFQLPFCGPNVIDHFMCDLNPLLNLACTDTHMLELFIAANSGFICLLNFALLLVSYVVILCSLRTHSLEARHKALSTCVSHITVVILFFVPCIFVYMRPAATLPIDKAVAIFYTMITPMLNPLIYTLKNAQMKNAIRKLCSRKDISGDK", "length": 309 }, "evidence": [ { "id": "45242843", "url": "http://www.informatics.jax.org/homology/45242843", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8NGP0-1", "protein_name": "Olfactory receptor 4C13", "gene_name": "OR4C13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANRNNVTEFILLGLTENPKMQKIIFVVFSVIYINAMIGNVLIVVTITASPSLRSPMYFFLAYLSFIDACYSSVNTPKLITDSLYENKTILFNGCMTQVFGEHFFRGVEVILLTVMAYDHYVAICKPLHYTTVMKQHVCSLLVGVSWVGGFLHATIQILFICQLPFCGPNVIDHFMCDLYTLINLACTNTHTLGLFIAANSGFICLLNCLLLLVSCVVILYSLKTHSLEARHEALSTCVSHITVVILSFIPCIFVYMRPPATLPIDKAVAVFYTMITSMLNPLIYTLRNAQMKNAIRKLCSRKAISSVK", "length": 309 }, "evidence": [ { "id": "45242843", "url": "http://www.informatics.jax.org/homology/45242843", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "Q8VGP0", "url": "https://www.uniprot.org/uniprot/Q8VGP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], 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