{ "uniprot_canonical_ac": "Q8VDP3-1", "uniprot_ac": "Q8VDP3", "uniprot_id": "MICA1_MOUSE", "mass": { "chemical_mass": 116785.0, "monoisotopic_mass": 116785.0 }, "refseq": { "ac": "XP_011241439", "name": "F-actin-monooxygenase MICAL1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011241439" }, "gene_names": [ { "name": "Mical1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "id": "Q8VDP3" }, { "name": "MICAL; MICAL-1; Nical", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011241439", "id": "XP_011241439" }, { "name": "Mical1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011241439", "id": "XP_011241439" }, { "name": "Mical", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "id": "Q8VDP3" }, { "name": "Nical", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "id": "Q8VDP3" } ], "protein_names": [ { "name": "[F-actin]-monooxygenase MICAL1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8VDP3" }, { "name": "1.14.13.225", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" }, { "name": "1.6.3.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" }, { "name": "F-actin-monooxygenase MICAL1 isoform X2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011241439", "id": "XP_011241439" }, { "name": "MICAL-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" }, { "name": "Molecule interacting with CasL protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" }, { "name": "NEDD9-interacting protein with calponin homology and LIM domains", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" }, { "name": "mMical1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8VDP3" } ], "function": [ { "annotation": "Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3#function" }, { "database": "PubMed", "id": "23911929", "url": "https://glygen.org/publication/PubMed/23911929" }, { "database": "PubMed", "id": "25007825", "url": "https://glygen.org/publication/PubMed/25007825" }, { "database": "UniProtKB", "id": "Q8TDZ2", "url": "https://www.uniprot.org/uniprot/Q8TDZ2#function" }, { "database": "PubMed", "id": "26935886", "url": "https://glygen.org/publication/PubMed/26935886" }, { "database": "PubMed", "id": "21730291", "url": "https://glygen.org/publication/PubMed/21730291" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mical1", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "locus": { "chromosome": "10", "start_pos": 41363028, "end_pos": 41352310, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000019823", "url": "https://www.ensembl.org/id/ENSMUSG00000019823" } ] } } ], "crossref": [ { "id": "ENSMUSG00000019823", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000019823", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.14.13.225", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.13.225&UniProtAcc=Q8VDP3", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd09358", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09358", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21196", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21196", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "171580", "url": "https://www.ncbi.nlm.nih.gov/gene/171580", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8VDP3", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8VDP3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:171580", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:171580", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2385847", "url": "http://www.informatics.jax.org/marker/MGI:2385847", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DTIEQWI", "url": "https://omabrowser.org/oma/group/DTIEQWI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5399346at2759", "url": "http://www.orthodb.org/?query=5399346at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2BRA", "url": "https://www.rcsb.org/structure/2BRA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2BRY", "url": "https://www.rcsb.org/structure/2BRY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2C4C", "url": "https://www.rcsb.org/structure/2C4C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TXI", "url": "https://www.rcsb.org/structure/4TXI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TXK", "url": "https://www.rcsb.org/structure/4TXK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00307", "url": "http://pfam.xfam.org/family/PF00307", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01494", "url": "http://pfam.xfam.org/family/PF01494", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12130", "url": "http://pfam.xfam.org/family/PF12130", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8VDP3", "url": "http://purl.obolibrary.org/obo/PR_Q8VDP3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_011241439", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011241439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11260", "url": "https://www.rhea-db.org/rhea/11260", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "51308", "url": "https://www.rhea-db.org/rhea/51308", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "D3Z5P6", "url": "https://www.uniprot.org/uniprot/D3Z5P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z5P6-1", "url": "https://www.uniprot.org/uniprot/D3Z5P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PUI4", "url": "https://www.uniprot.org/uniprot/E9PUI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PUI4-1", "url": "https://www.uniprot.org/uniprot/E9PUI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VDP3-1", "url": "https://www.uniprot.org/uniprot/Q8VDP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VDP3-2", "url": "https://www.uniprot.org/uniprot/Q8VDP3-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VDP3-3", "url": "https://www.uniprot.org/uniprot/Q8VDP3-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA", "length": 1048, "header": "sp|Q8VDP3-1|MICA1_MOUSE Isoform 1 of [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "isoforms": [ { "isoform_ac": "D3Z5P6-1", "url": "", "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGG", "length": 43, "header": "tr|D3Z5P6-1|D3Z5P6_MOUSE Computationally mapped isoform of Microtubule associated monooxygenase, calponin and LIM domain containing 1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "locus": { "chromosome": "10", "start_pos": 41354181, "end_pos": 41354053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000151486.2", "url": "https://www.ensembl.org/id/ENSMUST00000151486.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116386.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116386.2" } ] } }, { "isoform_ac": "E9PUI4-1", "url": "", "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGDGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQALQNSRRNSGWISCYGSFRRRTA", "length": 939, "header": "tr|E9PUI4-1|E9PUI4_MOUSE Computationally mapped isoform of F-actin monooxygenase OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "locus": { "chromosome": "10", "start_pos": 41362436, "end_pos": 41354053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000126436.2", "url": "https://www.ensembl.org/id/ENSMUST00000126436.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114969.2", "url": "https://www.ensembl.org/id/ENSMUSP00000114969.2" } ] } }, { "isoform_ac": "Q8VDP3-1", "url": "", "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA", "length": 1048, "header": "sp|Q8VDP3-1|MICA1_MOUSE Isoform 1 of [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "locus": { "chromosome": "10", "start_pos": 41362881, "end_pos": 41354053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000019967", "url": "https://www.ensembl.org/id/ENSMUST00000019967" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000019967", "url": "https://www.ensembl.org/id/ENSMUSP00000019967" } ] } }, { "isoform_ac": "Q8VDP3-2", "url": "", "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA", "length": 975, "header": "sp|Q8VDP3-2|MICA1_MOUSE Isoform 2 of [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "locus": { "chromosome": "10", "start_pos": 41362881, "end_pos": 41354053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000099934", "url": "https://www.ensembl.org/id/ENSMUST00000099934" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000097519", "url": "https://www.ensembl.org/id/ENSMUSP00000097519" } ] } }, { "isoform_ac": "Q8VDP3-3", "url": "", "sequence": { "sequence": "MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGDGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA", "length": 1048, "header": "sp|Q8VDP3-3|MICA1_MOUSE Isoform 3 of [F-actin]-monooxygenase MICAL1 OS=Mus musculus OX=10090 GN=Mical1 PE=1 SV=1 CANONICAL=Q8VDP3-1" }, "locus": { "chromosome": "10", "start_pos": 41362881, "end_pos": 41354053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000119962", "url": "https://www.ensembl.org/id/ENSMUST00000119962" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000113783", "url": "https://www.ensembl.org/id/ENSMUSP00000113783" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 475, "end_pos": 475, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "site_lbl": "Thr475" }, { "start_pos": 616, "end_pos": 616, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "site_lbl": "Ser616" }, { "start_pos": 777, "end_pos": 777, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8VDP3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8VDP3" } ], "site_lbl": "Ser777" }, { "start_pos": 781, "end_pos": 781, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8VDP3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8VDP3" } ], "site_lbl": "Ser781" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2005", "authors": "Siebold C, Berrow N, Walter TS, Harlos K, Owens RJ, Stuart DI, Terman JR, Kolodkin AL, Pasterkamp RJ, Jones EY", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "16275925", "url": "https://glygen.org/publication/PubMed/16275925" } ] }, { "title": "The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.", "journal": "Mol. Biol. Cell", "date": "2008", "authors": "Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "18094055", "url": "https://glygen.org/publication/PubMed/18094055" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" }, { "database": "iPTMnet", "id": "Q8VDP3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.", "journal": "Mol. Cell. Biol.", "date": "2011", "authors": "Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "21730291", "url": "https://glygen.org/publication/PubMed/21730291" } ] }, { "title": "MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.", "journal": "Mol. Cell", "date": "2013", "authors": "Lee BC, Peterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "23911929", "url": "https://glygen.org/publication/PubMed/23911929" } ] }, { "title": "The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections.", "journal": "Nat. Commun.", "date": "2014", "authors": "Van Battum EY, Gunput RA, Lemstra S, Groen EJ, Yu KL, Adolfs Y, Zhou Y, Hoogenraad CC, Yoshida Y, Schachner M, Akhmanova A, Pasterkamp RJ", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "25007825", "url": "https://glygen.org/publication/PubMed/25007825" } ] }, { "title": "Modulation of MICAL monooxygenase activity by its calponin homology domain: structural and mechanistic insights.", "journal": "Sci. Rep.", "date": "2016", "authors": "Alqassim SS, Urquiza M, Borgnia E, Nagib M, Amzel LM, Bianchet MA", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "reference": [ { "type": "PubMed", "id": "26935886", "url": "https://glygen.org/publication/PubMed/26935886" } ] } ], "pathway": [ { "id": "mmu:171580", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:171580", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZBP4-1", "protein_name": "[F-actin]-monooxygenase MICAL1", "gene_name": "Mical1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPTSTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLPQYHKIKAQLNYWSAKSLWAKLDKRASQPAYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGFTFTGLQPPPKKGSGWRARIQPSPPAQLASYEFDVLISAGGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDLPETDQLLGKANVVPEALQQFARAAADFATQGKLGKLEFAQDARGRPDVAAFDFTSMMRSESSARIQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGTGPLELLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDIMDKEHARKKSDETDARKTTTGSAGTEELLHWCQEQTAGFPGVSVTDFSSSWADGRALCALVHRLQPGLLEPSELQGMSALEATAWALRVAEYELGIIPVLSAQAVVAGSDPLGLIAYLSHFHSAFKNTPHSSGLVSQPHGTPSAILFLGKLQRSLQRTRTKVEEETPCTEEPPVSEPSVPPALPSEHEEAGAEDVCELCGKRLYILERFCVDGHFFHRGCFCCRTCEATLRPGGYGQYPGDGYFYCLQHLPQEDQKEADNNGSPENQELPTPGDSTTQSGPSSPVPPVTEASPVPSPSQPARRLIRLSSVERLRLSSLNIIPDSGVEPPPKPPRSCLDLAQESLKSSFMGWGVLRAPQVPEAIEKGEEEEEEEEEEEEEEEELPPPLALEVEQSLLTLAKNSGDMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEAAMRELETEGMKLEVALRKESSSPEKQKKLWLEQLLQLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHEFRGINREETLKTQADRLSEDRVLRKLLDVVNQRDALIQFQEERRLREMPV", "length": 1047 }, "evidence": [ { "id": "Q8VDP3", "url": "https://omabrowser.org/oma/group/Q8VDP3/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TDZ2-1", "protein_name": "[F-actin]-monooxygenase MICAL1", "gene_name": "MICAL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSAKSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPDPEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTSGTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAEDQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG", "length": 1067 }, "evidence": [ { "id": "Q8VDP3", "url": "https://omabrowser.org/oma/group/Q8VDP3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "id": "GO:0016709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016709", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "NAD(P)H oxidase H2O2-forming activity", "id": "GO:0016174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "NADPH oxidase H202-forming activity", "id": "GO:0106294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106294", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "hippocampal mossy fiber expansion", "id": "GO:1990026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990026", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "negative regulation of protein phosphorylation", "id": "GO:0001933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "regulation of regulated secretory pathway", "id": "GO:1903305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903305", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "sulfur oxidation", "id": "GO:0019417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019417", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" }, { "name": "actin filament depolymerization", "id": "GO:0030042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030042", "evidence": [ { "database": "UniProtKB", "id": "Q8VDP3", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 748, "end_pos": 750, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11260", "name": "", "equation": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CIY2-1", "Q9ES45-1", "Q8K4C0-1", "D3ZD07-1", "D3ZBP4-1", "Q9NRD8-1", "Q9NRD9-1", "P49326-1", "Q8TDZ2-1", "P97872-1", "A2AQ92-1", "A0A494BAW1-1", "Q8C116-1", "B2RWH8-1", "Q8VDP3-1", "Q9VQH2-1" ], "evidence": [ { "id": "11260", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11260" } ] }, { "id": "51308", "name": "", "equation": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZBP4-1", "D4A1F2-3", "D3ZGN7-1", "Q7RTP6-1", "O94851-7", "Q8TDZ2-1", "Q8BML1-4", "Q8CJ19-1", "Q8VDP3-1", "Q86BA1-1" ], "evidence": [ { "id": "51308", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51308" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A494BAW1", "gene_name": "Duox2", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A0A494BAW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A494BAW1" } ] } ] }, { "uniprot_ac": "A2AQ92", "gene_name": "Duox1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "A2AQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQ92" } ] } ] }, { "uniprot_ac": "B2RWH8", "gene_name": "Gm4846", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "B2RWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWH8" } ] } ] }, { "uniprot_ac": "D3ZBP4", "gene_name": "Mical1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "D3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBP4" } ] } ] }, { "uniprot_ac": "D3ZD07", "gene_name": "Fmo9", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "D3ZD07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD07" } ] } ] }, { "uniprot_ac": "D3ZGN7", "gene_name": "Mical3", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "D3ZGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGN7" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "D3ZGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGN7" } ] } ] }, { "uniprot_ac": "D4A1F2", "gene_name": "Mical2", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "D4A1F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1F2" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "D4A1F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1F2" } ] } ] }, { "uniprot_ac": "O94851", "gene_name": "MICAL2", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "O94851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94851" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "O94851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94851" } ] } ] }, { "uniprot_ac": "P49326", "gene_name": "FMO5", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] }, { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "P49326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49326" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline 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[ { "id": "Q7RTP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7RTP6" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q7RTP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7RTP6" } ] } ] }, { "uniprot_ac": "Q86BA1", "gene_name": "Mical", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q86BA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BA1" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q86BA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BA1" } ] } ] }, { "uniprot_ac": "Q8BML1", "gene_name": "Mical2", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8BML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BML1" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8BML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BML1" } ] } ] }, { "uniprot_ac": "Q8C116", "gene_name": "Fmo9", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q8C116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C116" } ] } ] }, { "uniprot_ac": "Q8CIY2", "gene_name": "Duox1", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] }, { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8CIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIY2" } ] } ] }, { "uniprot_ac": "Q8CJ19", "gene_name": "Mical3", "activity": [ { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8CJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CJ19" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8CJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CJ19" } ] } ] }, { "uniprot_ac": "Q8K4C0", "gene_name": "Fmo5", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.14.13.8", "activity": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+).", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] }, { "ec_number": "1.14.13.8", "activity": "", "evidence": [ { "id": "Q8K4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4C0" } ] } ] }, { "uniprot_ac": "Q8TDZ2", "gene_name": "MICAL1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8TDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDZ2" } ] } ] }, { "uniprot_ac": "Q8VDP3", "gene_name": "Mical1", "activity": [ { "ec_number": "1.6.3.1", "activity": "H(+) + NADH + O2 = H2O2 + NAD(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+).", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.14.13.225", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] }, { "ec_number": "1.6.3.1", "activity": "", "evidence": [ { "id": "Q8VDP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDP3" } ] } ] }, { "uniprot_ac": "Q9ES45", "gene_name": "Duox2", "activity": [ { 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