{ "uniprot_canonical_ac": "Q8VCM7-1", "uniprot_ac": "Q8VCM7", "uniprot_id": "FIBG_MOUSE", "mass": { "chemical_mass": 49391.0, "monoisotopic_mass": 49391.0 }, "refseq": { "ac": "NP_598623", "name": "fibrinogen gamma chain isoform 1 precursor", "summary": "This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" }, "gene_names": [ { "name": "Fgg", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8VCM7", "id": "Q8VCM7" }, { "name": "3010002H13Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623", "id": "NP_598623" }, { "name": "Fgg", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623", "id": "NP_598623" } ], "protein_names": [ { "name": "Fibrinogen gamma chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8VCM7" }, { "name": "fibrinogen gamma chain isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623", "id": "NP_598623" }, { "name": "fibrinogen gamma chain isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034", "id": "NP_001304034" }, { "name": "fibrinogen, gamma polypeptide", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034", "id": "NP_001304034" } ], "function": [ { "annotation": "Altered fibrinogen gamma-chain cross-linking in mutant fibrinogen-gamma[Delta5] mice drives acute liver injury.", "evidence": [ { "database": "RefSeq", "id": "NP_001304034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034" }, { "database": "PubMed", "id": "37062522", "url": "https://glygen.org/publication/PubMed/37062522" }, { "database": "RefSeq", "id": "NP_598623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" } ] }, { "annotation": "Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.", "evidence": [ { "database": "RefSeq", "id": "NP_001304034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034" }, { "database": "PubMed", "id": "34183396", "url": "https://glygen.org/publication/PubMed/34183396" }, { "database": "RefSeq", "id": "NP_598623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" } ] }, { "annotation": "This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001304034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034" }, { "database": "RefSeq", "id": "NP_598623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" } ] }, { "annotation": "Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7#function" }, { "database": "PubMed", "id": "19332769", "url": "https://glygen.org/publication/PubMed/19332769" }, { "database": "UniProtKB", "id": "E9PV24", "url": "https://www.uniprot.org/uniprot/E9PV24#function" } ] } ], "disease": [ { "disease_id": "DOID:0112313", "recommended_name": { "id": "DOID:0112313", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112313", "name": "brain small vessel disease", "description": "A brain disease characterized by abnormalities in the small blood vessels in the brain." }, "synonyms": [ { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease 1 with or without ocular anomalies", "description": "Any porencephaly in which the cause of the disease is a mutation in the COL4A1 gene." }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "ADT1P", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "BSVD", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "BSVD1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "COL4A1 porencephaly", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "COL4A1-related brain small vessel disease with haemorrhage", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "COL4A1-related brain small vessel disease with hemorrhage", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "COL4A1-related familial vascular leukoencephalopathy", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "COL4A1-related retinal arteriolar tortuosity-infantile hemiparesis-autosomal dominant leukoencephalopathy syndrome", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "T1P", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "autosomal dominant retinal arteriolar tortuosity, infantile hemiparesis, and leukencephalopathy", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease with Axenfeld-Riegar anomaly", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease with axenfeld-rieger anomaly", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease with haemorrhage", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease with hemorrhage", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "brain small vessel disease with or without ocular anomalies", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "hemiplegia, infantile, with porencephaly", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "infantile hemiparesis", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "leukoencephalopathy with axenfeld-rieger anomaly", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "porencephaly 1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "porencephaly caused by mutation in COL4A1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "porencephaly type 1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "retinal arteriolar tortuosity, infantile hemiparesis, and leukoencephalopathy, autosomal dominant", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "POREN1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "hemiplegia, infantile, with porencephaly porencephaly, type 1", "description": "" }, { "id": "MONDO:0008289", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008289", "name": "porencephaly, type 1, autosomal dominant", "description": "" }, { "id": "MIM:175780", "resource": "MIM", "url": "https://www.omim.org/entry/175780", "name": "Brain small vessel disease 1 with or without ocular anomalies", "description": "Brain small vessel disease 1 with or without ocular anomalies" } ], "evidence": [ { "id": "0112313", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112313" } ] }, { "disease_id": "DOID:2236", "recommended_name": { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "congenital afibrinogenemia", "description": "A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I)." }, "synonyms": [ { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Factor I deficiency", "description": "" }, { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "congenital afibrinogenemia", "description": "Familial afibrinogenemia is a coagulation disorder characterized by bleeding symptoms due to a complete absence of circulating fibrinogen." }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "factor I deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia, congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "familial afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "hypofibrinogenemia, congenital", "description": "" }, { "id": "MIM:202400", "resource": "MIM", "url": "https://www.omim.org/entry/202400", "name": "Congenital afibrinogenemia", "description": "Congenital afibrinogenemia" } ], "evidence": [ { "id": "2236", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2236" } ] }, { "disease_id": "DOID:4989", "recommended_name": { "id": "DOID:4989", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4989", "name": "pancreatitis", "description": "A pancreas disease that is characterized by inflammation of the pancreas." }, "synonyms": [ { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary chronic pancreatitis", "description": "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas." }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary chronic pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "HPC", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "Hp", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "PCTT", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "autosomal dominant hereditary pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "familial pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, calcific", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, calcific, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, protection against", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, protection against, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, susceptibility to", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, hereditary", "description": "" }, { "id": "MIM:167800", "resource": "MIM", "url": "https://www.omim.org/entry/167800", "name": "Pancreatitis, hereditary", "description": "Pancreatitis, hereditary" } ], "evidence": [ { "id": "4989", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4989" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] }, { "disease_id": "DOID:9477", "recommended_name": { "id": "DOID:9477", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9477", "name": "pulmonary embolism", "description": "An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot." }, "synonyms": [ { "id": "DOID:9477", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9477", "name": "pulmonary artery embolism", "description": "" }, { "id": "DOID:9477", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9477", "name": "pulmonary embolus", "description": "" } ], "evidence": [ { "id": "9477", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9477" } ] }, { "disease_id": "DOID:9538", "recommended_name": { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow." }, "synonyms": [ { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler's disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "medullary plasmacytoma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, resistance to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, susceptibility to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma/plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloid neoplasm of plasma cell", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, multiple", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, plasma cell, malignant", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myelomatosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloid neoplasm", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Al amyloidosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "amyloidosis, systemic", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma - multiple", "description": "" }, { "id": "MIM:254500", "resource": "MIM", "url": "https://www.omim.org/entry/254500", "name": "Multiple myeloma", "description": "Multiple myeloma" } ], "evidence": [ { "id": "9538", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { 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"https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 432, "end_pos": 436, "sequence_org": "QAGDV", "sequence_mut": "", "comment": "Impairs induction of SELP in activated platelets.", "evidence": [ { "database": "UniProtKB", "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7" }, { "database": "PubMed", "id": "19332769", "url": "https://glygen.org/publication/PubMed/19332769" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fgg", "url": "https://www.uniprot.org/uniprot/Q8VCM7", "locus": { "chromosome": "3", "start_pos": 82922356, "end_pos": 82915031, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000033860", "url": "https://www.ensembl.org/id/ENSMUSG00000033860" } ] } } ], "crossref": [ { "id": "ENSMUSG00000033860", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000033860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "99571", "url": "https://www.ncbi.nlm.nih.gov/gene/99571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0004741", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0004741", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0006953", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006953", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "Q8VCM7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8VCM7*", "database": 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"https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "95526", "url": "http://www.informatics.jax.org/marker/MGI:95526", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "TYHNGMR", "url": "https://omabrowser.org/oma/group/TYHNGMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3134470at2759", "url": "http://www.orthodb.org/?query=3134470at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "http://pfam.xfam.org/family/PF00147", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08702", "url": "http://pfam.xfam.org/family/PF08702", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8VCM7", "url": "http://purl.obolibrary.org/obo/PR_Q8VCM7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114608", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-140875", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-354192", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-354194", "url": 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"database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3UER8", "url": "https://www.uniprot.org/uniprot/Q3UER8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UER8-1", "url": "https://www.uniprot.org/uniprot/Q3UER8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8VCM7-1", "url": "https://www.uniprot.org/uniprot/Q8VCM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV", "length": 436, "header": "sp|Q8VCM7-1|FIBG_MOUSE Isoform 1 of Fibrinogen gamma chain OS=Mus musculus OX=10090 GN=Fgg PE=1 SV=1 CANONICAL=Q8VCM7-1" }, "isoforms": [ { "isoform_ac": "Q3UER8-1", "url": "", "sequence": { "sequence": "MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQVSVDHEVEIEY", "length": 443, "header": "tr|Q3UER8-1|Q3UER8_MOUSE Computationally mapped isoform of Fibrinogen gamma chain OS=Mus musculus OX=10090 GN=Fgg PE=1 SV=1 CANONICAL=Q8VCM7-1" }, "locus": { "chromosome": "3", "start_pos": 82921647, "end_pos": 82915215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000194175.2", "url": "https://www.ensembl.org/id/ENSMUST00000194175.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000141648.2", "url": "https://www.ensembl.org/id/ENSMUSP00000141648.2" } ] } }, { "isoform_ac": "Q8VCM7-1", "url": "", "sequence": { "sequence": "MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV", "length": 436, "header": "sp|Q8VCM7-1|FIBG_MOUSE Isoform 1 of Fibrinogen gamma chain OS=Mus musculus OX=10090 GN=Fgg PE=1 SV=1 CANONICAL=Q8VCM7-1" }, "locus": { "chromosome": "3", "start_pos": 82922153, "end_pos": 82915215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000048486", "url": "https://www.ensembl.org/id/ENSMUST00000048486" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000037018", "url": "https://www.ensembl.org/id/ENSMUSP00000037018" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 77, "start_aa": "Asn", "end_pos": 77, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn77", "evidence": [ { "id": "Q8VCM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCM7#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 430, "end_pos": 430, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7" } ], "site_lbl": "Ser430" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.", "journal": "Blood", "date": "2009", "authors": "Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, Brkic J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H", "evidence": [ { "database": "UniProtKB", "id": "Q8VCM7", "url": "https://www.uniprot.org/uniprot/Q8VCM7" } ], "reference": [ { "type": "PubMed", "id": "19332769", "url": "https://glygen.org/publication/PubMed/19332769" } ] }, { "title": "Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Duval C, Baranauskas A, Feller T, Ali M, Cheah LT, Yuldasheva NY, Baker SR, McPherson HR, Raslan Z, Bailey MA, Cubbon RM, Connell SD, Ajjan RA, Philippou H, Naseem KM, Ridger VC, Ariens RAS", "evidence": [ { "database": "RefSeq", "id": "NP_598623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" }, { "database": "RefSeq", "id": "NP_001304034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034" } ], "reference": [ { "type": "PubMed", "id": "34183396", "url": "https://glygen.org/publication/PubMed/34183396" } ] }, { "title": "Altered fibrinogen \u03b3-chain cross-linking in mutant fibrinogen-\u03b3\u03945 mice drives acute liver injury.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2023-08", "authors": "Poole Lauren G, Schmitt Lauren R, Schulte Anthony, Groeneveld Dafna J, Cline Holly M, Sang Yaqiu, Hur Woosuk S, Wolberg Alisa S, Flick Matthew J, Hansen Kirk C, Luyendyk James P", "evidence": [ { "database": "RefSeq", "id": "NP_001304034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304034" }, { "database": "RefSeq", "id": "NP_598623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598623" } ], "reference": [ { "type": "PubMed", "id": "37062522", "url": "https://glygen.org/publication/PubMed/37062522" } ] } ], "pathway": [ { "id": "mmu:99571", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99571", "resource": "KEGG Pathway" }, { "id": "R-MMU-114608", "name": "Platelet degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-MMU-140875", "name": "Common Pathway of Fibrin Clot Formation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-140875", "resource": "Reactome", "description": "Common Pathway of Fibrin Clot Formation" }, { "id": "R-MMU-216083", "name": "Integrin cell surface interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-MMU-354192", "name": "Integrin signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-354192", "resource": "Reactome", "description": "Integrin signaling" }, { "id": "R-MMU-354194", "name": "GRB2:SOS provides linkage to MAPK signaling for Integrins", 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