{ "uniprot_canonical_ac": "Q8SX68-1", "uniprot_ac": "Q8SX68", "uniprot_id": "CT2NL_DROME", "mass": { "chemical_mass": 65422.0, "monoisotopic_mass": 65422.0 }, "refseq": { "ac": "NP_001286565", "name": "nausicaa, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565" }, "gene_names": [ { "name": "Naus", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8SX68", "id": "Q8SX68" }, { "name": "CG10915; Dmel\\CG10915; naus", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565", "id": "NP_001286565" }, { "name": "CG10915", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8SX68", "id": "Q8SX68" }, { "name": "Naus", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565", "id": "NP_001286565" } ], "protein_names": [ { "name": "CTTNBP2 N-terminal-like protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8SX68" }, { "name": "CG10915-PB; Naus-PB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565", "id": "NP_001286565" }, { "name": "Protein Nausicaa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8SX68" }, { "name": "nausicaa, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565", "id": "NP_001286565" } ], "function": [ { "annotation": "Regulates lamellipodial actin dynamics in a Cortactin-dependent manner and is therefore likely involved in controlling actin branch density, actin-retrograde flow rates and lamellipodial protrusion. Functions by slowing the dissociation of Cortactin from Arp2/3 nucleated branches thereby increasing branch nucleation and junction stability.", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68#function" }, { "database": "PubMed", "id": "31164339", "url": "https://glygen.org/publication/PubMed/31164339" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 564, "end_pos": 568, "sequence_org": "PPPIP", "sequence_mut": "AAAIA", "comment": "Reduced localization to the lamellipodia, likely resulting from decreased interaction with Cortactin.", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" }, { "database": "PubMed", "id": "31164339", "url": "https://glygen.org/publication/PubMed/31164339" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Naus", "url": "https://www.uniprot.org/uniprot/Q8SX68", "locus": { "chromosome": "2R", "start_pos": 18164746, "end_pos": 18160720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0034308", "url": "https://www.ensembl.org/id/FBgn0034308" } ] } } ], "crossref": [ { "id": "FBgn0034308", "url": "https://bgee.org/?page=gene&gene_id=FBgn0034308", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0034308", "url": "https://flybase.org/reports/FBgn0034308", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "37076", "url": "https://www.ncbi.nlm.nih.gov/gene/37076", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG10915", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG10915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGTAKHN", "url": "https://omabrowser.org/oma/group/AGTAKHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5395797at2759", "url": "http://www.orthodb.org/?query=5395797at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23166:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23166:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09727", "url": "http://pfam.xfam.org/family/PF09727", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8SX68", "url": "http://purl.obolibrary.org/obo/PR_Q8SX68", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-9013405", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9013405", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001286565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286565", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SX68-1", "url": "https://www.uniprot.org/uniprot/Q8SX68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQNSNSSVADTFAEAPATDADYGTENCSGSGMSVGDTVSANHEFQTMKPGPGVVHKVMPVANSASSATATNGRTRSEMPHSELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRESSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERKKILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAKLAKEELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKARQFSDDACATPPMVNIAKIVQPTATVSSMPVSGPQTGIARSIAPGQNIRSAGIATAPTGTATAAIAPLTAVLNHTTTITTTTNNTTTSSNSNSSGSIGVAATAAAVAASVETAATVTVPMVAPPSPSPAKMQPTATIQRAPGGKYAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAPPPIPTKPIVPPKREPSLSRLGSITGSSAIAAATAATTAAGTAKQN", "length": 609, "header": "sp|Q8SX68-1|CT2NL_DROME Isoform 1 of CTTNBP2 N-terminal-like protein OS=Drosophila melanogaster OX=7227 GN=Naus PE=1 SV=1 CANONICAL=Q8SX68-1" }, "isoforms": [ { "isoform_ac": "Q8SX68-1", "url": "", "sequence": { "sequence": "MEQNSNSSVADTFAEAPATDADYGTENCSGSGMSVGDTVSANHEFQTMKPGPGVVHKVMPVANSASSATATNGRTRSEMPHSELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRESSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERKKILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAKLAKEELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKARQFSDDACATPPMVNIAKIVQPTATVSSMPVSGPQTGIARSIAPGQNIRSAGIATAPTGTATAAIAPLTAVLNHTTTITTTTNNTTTSSNSNSSGSIGVAATAAAVAASVETAATVTVPMVAPPSPSPAKMQPTATIQRAPGGKYAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAPPPIPTKPIVPPKREPSLSRLGSITGSSAIAAATAATTAAGTAKQN", "length": 609, "header": "sp|Q8SX68-1|CT2NL_DROME Isoform 1 of CTTNBP2 N-terminal-like protein OS=Drosophila melanogaster OX=7227 GN=Naus PE=1 SV=1 CANONICAL=Q8SX68-1" }, "locus": { "chromosome": "2R", "start_pos": 18163522, "end_pos": 18161029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0345416", "url": "https://www.ensembl.org/id/FBtr0345416" }, { "database": "Ensembl Peptide", "id": "FBpp0311543", "url": "https://www.ensembl.org/id/FBpp0311543" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 586, "end_pos": 586, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" }, { "database": "PubMed", "id": "17372656", "url": "https://glygen.org/publication/PubMed/17372656" }, { "database": "iPTMnet", "id": "Q8SX68", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8SX68" } ], "site_lbl": "Ser586" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells.", "journal": "Molecular bioSystems", "date": "2007", "authors": "Bodenmiller B, Mueller LN, Pedrioli PG, Pflieger D, Junger MA, Eng JK, Aebersold R, Tao WA", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" }, { "database": "iPTMnet", "id": "Q8SX68", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8SX68" } ], "reference": [ { "type": "PubMed", "id": "17372656", "url": "https://glygen.org/publication/PubMed/17372656" } ] } ], "pathway": [ { "id": "dme:Dmel_CG10915", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG10915", "resource": "KEGG Pathway" }, { "id": "R-DME-9013405", "name": "RHOD GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9013405", "resource": "Reactome", "description": "RHOD GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein localization to actin cytoskeleton", "id": "GO:1903119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903119", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "actin filament bundle retrograde transport", "id": "GO:0061573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061573", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "positive regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:2000601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000601", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "positive regulation of lamellipodium morphogenesis", "id": "GO:2000394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000394", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "positive regulation of neuron projection arborization", "id": "GO:0150012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150012", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" }, { "name": "FAR/SIN/STRIPAK complex", "id": "GO:0090443", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090443", "evidence": [ { "database": "UniProtKB", "id": "Q8SX68", "url": "https://www.uniprot.org/uniprot/Q8SX68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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