{
    "uniprot_canonical_ac": "Q8R395-1",
    "uniprot_ac": "Q8R395",
    "uniprot_id": "COMD5_MOUSE",
    "mass": {
        "chemical_mass": 24493.0,
        "monoisotopic_mass": 24493.0
    },
    "refseq": {
        "ac": "NP_079812",
        "name": "COMM domain-containing protein 5",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812"
    },
    "gene_names": [
        {
            "name": "Commd5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8R395",
            "id": "Q8R395"
        },
        {
            "name": "2310065H03Rik; D15Ertd81e; Hcarg",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812",
            "id": "NP_079812"
        },
        {
            "name": "Commd5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812",
            "id": "NP_079812"
        }
    ],
    "protein_names": [
        {
            "name": "COMM domain-containing protein 5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8R395"
        },
        {
            "name": "COMM domain-containing protein 5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812",
            "id": "NP_079812"
        },
        {
            "name": "hypertension-related, calcium regulated",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812",
            "id": "NP_079812"
        }
    ],
    "function": [
        {
            "annotation": "A suggestive localization of mouse Hcarg based on conservation of linkage between human and mouse is on chromosome 15.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079812",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812"
                },
                {
                    "database": "PubMed",
                    "id": "11871861",
                    "url": "https://glygen.org/publication/PubMed/11871861"
                }
            ]
        },
        {
            "annotation": "May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8R395",
                    "url": "https://www.uniprot.org/uniprot/Q8R395#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9ERR2",
                    "url": "https://www.uniprot.org/uniprot/Q9ERR2#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9GZQ3",
                    "url": "https://www.uniprot.org/uniprot/Q9GZQ3#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8R395",
                    "url": "https://www.uniprot.org/uniprot/Q8R395"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Commd5",
            "url": "https://www.uniprot.org/uniprot/Q8R395",
            "locus": {
                "chromosome": "15",
                "start_pos": 76785505,
                "end_pos": 76784110,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000055041",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000055041"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000055041",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000055041",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04753",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04753",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "66398",
            "url": "https://www.ncbi.nlm.nih.gov/gene/66398",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR017920",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037357",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037357",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:66398",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66398",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1913648",
            "url": "http://www.informatics.jax.org/marker/MGI:1913648",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "HIVAGMY",
            "url": "https://omabrowser.org/oma/group/HIVAGMY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "9259at2759",
            "url": "http://www.orthodb.org/?query=9259at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15666",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15666",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15666:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15666:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07258",
            "url": "http://pfam.xfam.org/family/PF07258",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8R395",
            "url": "http://purl.obolibrary.org/obo/PR_Q8R395",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-8951664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_079812",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0R4J0U7",
            "url": "https://www.uniprot.org/uniprot/A0A0R4J0U7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0R4J0U7-1",
            "url": "https://www.uniprot.org/uniprot/A0A0R4J0U7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R395",
            "url": "https://www.uniprot.org/uniprot/Q8R395",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R395-1",
            "url": "https://www.uniprot.org/uniprot/Q8R395-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSALGAPAPYLHHPTDSHSGRVSFLGSQPSAEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQDELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERKLQD",
        "length": 224,
        "header": "sp|Q8R395-1|COMD5_MOUSE Isoform 1 of COMM domain-containing protein 5  OS=Mus musculus OX=10090 GN=Commd5 PE=1 SV=1 CANONICAL=Q8R395-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0R4J0U7-1",
            "url": "",
            "sequence": {
                "sequence": "MSALGAAAPYLHHPTDSHSGRVSFLGSQPSAEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQDELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERKLQD",
                "length": 224,
                "header": "tr|A0A0R4J0U7-1|A0A0R4J0U7_MOUSE Computationally mapped isoform of COMM domain-containing protein 5  OS=Mus musculus OX=10090 GN=Commd5 PE=1 SV=1 CANONICAL=Q8R395-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 76785276,
                "end_pos": 76784605,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000068407.6",
                        "url": "https://www.ensembl.org/id/ENSMUST00000068407.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000069159.6",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000069159.6"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8R395-1",
            "url": "",
            "sequence": {
                "sequence": "MSALGAPAPYLHHPTDSHSGRVSFLGSQPSAEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQDELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERKLQD",
                "length": 224,
                "header": "sp|Q8R395-1|COMD5_MOUSE Isoform 1 of COMM domain-containing protein 5  OS=Mus musculus OX=10090 GN=Commd5 PE=1 SV=1 CANONICAL=Q8R395-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.",
            "journal": "Folia biologica",
            "date": "2002",
            "authors": "Solban N, Dumas P, Gossard F, Sun Y, Pravenec M, Kren V, Lewanczuk R, Hamet P, Tremblay J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079812",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11871861",
                    "url": "https://glygen.org/publication/PubMed/11871861"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:66398",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66398",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-8951664",
            "name": "Neddylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664",
            "resource": "Reactome",
            "description": "Neddylation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9ERR2-1",
            "protein_name": "COMM domain-containing protein 5",
            "gene_name": "Commd5",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSALGAAAPYLHHPADSHSGRVSFLGSQPSPEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVEQLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQEELQELGIPQDLIGDLASLAFGSQRPLLDSVAQQQGSSLPHVSYFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELEKKCERKLQD",
                "length": 224
            },
            "evidence": [
                {
                    "id": "45235229",
                    "url": "http://www.informatics.jax.org/homology/45235229",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9GZQ3-1",
            "protein_name": "COMM domain-containing protein 5",
            "gene_name": "COMMD5",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD",
                "length": 224
            },
            "evidence": [
                {
                    "id": "45235229",
                    "url": "http://www.informatics.jax.org/homology/45235229",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "positive regulation of epithelial cell differentiation",
                        "id": "GO:0030858",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030858",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R395",
                                "url": "https://www.uniprot.org/uniprot/Q8R395"
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                    {
                        "name": "positive regulation of cell growth",
                        "id": "GO:0030307",
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                                "database": "UniProtKB",
                                "id": "Q8R395",
                                "url": "https://www.uniprot.org/uniprot/Q8R395"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "proximal tubule morphogenesis",
                        "id": "GO:0072158",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072158",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "Q8R395",
                                "url": "https://www.uniprot.org/uniprot/Q8R395"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
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                                "id": "Q8R395",
                                "url": "https://www.uniprot.org/uniprot/Q8R395"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
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                            {
                                "database": "UniProtKB",
                                "id": "Q8R395",
                                "url": "https://www.uniprot.org/uniprot/Q8R395"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
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                            {
                                "database": "UniProtKB",
                                "id": "Q8R395",
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        {
            "start_pos": 76,
            "end_pos": 78,
            "annotation": "n_glycosylation_sequon"
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    ],
    "ptm_annotation": [],
    "interactions": [],
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    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
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        {
            "name": "homologset.mgi",
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