{
    "uniprot_canonical_ac": "Q8R1K1-1",
    "uniprot_ac": "Q8R1K1",
    "uniprot_id": "UBAC2_MOUSE",
    "mass": {
        "chemical_mass": 39057.0,
        "monoisotopic_mass": 39057.0
    },
    "refseq": {
        "ac": "NP_081137",
        "name": "ubiquitin-associated domain-containing protein 2 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137"
    },
    "gene_names": [
        {
            "name": "Ubac2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8R1K1",
            "id": "Q8R1K1"
        },
        {
            "name": "1190008A14Rik; Phgdhl1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137",
            "id": "NP_081137"
        },
        {
            "name": "Phgdhl1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8R1K1",
            "id": "Q8R1K1"
        },
        {
            "name": "Ubac2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137",
            "id": "NP_081137"
        }
    ],
    "protein_names": [
        {
            "name": "Ubiquitin-associated domain-containing protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8R1K1"
        },
        {
            "name": "Phosphoglycerate dehydrogenase-like protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8R1K1"
        },
        {
            "name": "UBA domain-containing protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8R1K1"
        },
        {
            "name": "phosphoglycerate dehydrogenase like 1; ubiquitin-associated domain-containing protein 2; phosphoglycerate dehydrogenase-like protein 1; UBA domain-containing protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137",
            "id": "NP_081137"
        },
        {
            "name": "ubiquitin-associated domain-containing protein 2 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137",
            "id": "NP_081137"
        }
    ],
    "function": [
        {
            "annotation": "Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8R1K1",
                    "url": "https://www.uniprot.org/uniprot/Q8R1K1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8NBM4",
                    "url": "https://www.uniprot.org/uniprot/Q8NBM4#function"
                },
                {
                    "database": "PubMed",
                    "id": "31073040",
                    "url": "https://glygen.org/publication/PubMed/31073040"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [
        {
            "evidence": [
                {
                    "id": "rs3389345392",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389345392"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ],
            "start_pos": 161,
            "end_pos": 161,
            "sequence_org": "N",
            "sequence_mut": "H",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NKT->HKT).",
            "chr_id": "14",
            "chr_pos": "122211112",
            "ref_nt": "C",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "N161",
            "keywords": [
                "ebi",
                "germline"
            ]
        },
        {
            "evidence": [
                {
                    "id": "rs222481949",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs222481949"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ],
            "start_pos": 289,
            "end_pos": 289,
            "sequence_org": "N",
            "sequence_mut": "S",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIN->NIS).",
            "chr_id": "14",
            "chr_pos": "122246261",
            "ref_nt": "G",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "N289",
            "keywords": [
                "ebi",
                "germline"
            ]
        }
    ],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8R1K1",
                    "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ubac2",
            "url": "https://www.uniprot.org/uniprot/Q8R1K1",
            "locus": {
                "chromosome": "14",
                "start_pos": 122258446,
                "end_pos": 122116032,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000041765",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000041765"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000041765",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041765",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "4.2.3.134",
            "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.3.134&UniProtAcc=Q8R1K1",
            "database": "BRENDA",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "cd14305",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14305",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "68889",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68889",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR009060",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015940",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035952",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041928",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041928",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:68889",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68889",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1916139",
            "url": "http://www.informatics.jax.org/marker/MGI:1916139",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "ISGMCYS",
            "url": "https://omabrowser.org/oma/group/ISGMCYS/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5401095at2759",
            "url": "http://www.orthodb.org/?query=5401095at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR43066",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43066",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR43066:SF21",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43066:SF21",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00627",
            "url": "http://pfam.xfam.org/family/PF00627",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8R1K1",
            "url": "http://purl.obolibrary.org/obo/PR_Q8R1K1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_081137",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081137",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A2I3BQW8",
            "url": "https://www.uniprot.org/uniprot/A0A2I3BQW8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A2I3BQW8-1",
            "url": "https://www.uniprot.org/uniprot/A0A2I3BQW8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R1K1",
            "url": "https://www.uniprot.org/uniprot/Q8R1K1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8R1K1-1",
            "url": "https://www.uniprot.org/uniprot/Q8R1K1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFTSTGSSGLYKAPLSKSLLLVPSALSLLLTLLLPHCQKFFVYDLHAVKHDLQIWRLICGRIICLDLKDAFCSGLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFILVEAVQYSLGVTVASNLPSGFLAPVFALFVPFHCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAMSGLISGMCYDRKVLQVHQVLRIPGRMAEFFSWALEPIFSSSEPTSEARVGMGATVDIQRQQRMEQLDRQLMLSQFAQVRRQRQQQGGMINWNRLFPPLRQRRNINYQDGPRSEQRASPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH",
        "length": 345,
        "header": "sp|Q8R1K1-1|UBAC2_MOUSE Isoform 1 of Ubiquitin-associated domain-containing protein 2  OS=Mus musculus OX=10090 GN=Ubac2 PE=1 SV=1 CANONICAL=Q8R1K1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A2I3BQW8-1",
            "url": "",
            "sequence": {
                "sequence": "MEAGSSHPSCWVPGSCQPCLILSSWKPCSIRLVSQWPATYLLDSWRPCSLSLFHFTAPSQESRWRRSWARCPSQTRH",
                "length": 77,
                "header": "tr|A0A2I3BQW8-1|A0A2I3BQW8_MOUSE Computationally mapped isoform of Ubiquitin associated domain containing 2  OS=Mus musculus OX=10090 GN=Ubac2 PE=4 SV=1 CANONICAL=Q8R1K1-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 122211121,
                "end_pos": 122144803,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000226998.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000226998.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000154341.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000154341.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8R1K1-1",
            "url": "",
            "sequence": {
                "sequence": "MFTSTGSSGLYKAPLSKSLLLVPSALSLLLTLLLPHCQKFFVYDLHAVKHDLQIWRLICGRIICLDLKDAFCSGLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFILVEAVQYSLGVTVASNLPSGFLAPVFALFVPFHCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAMSGLISGMCYDRKVLQVHQVLRIPGRMAEFFSWALEPIFSSSEPTSEARVGMGATVDIQRQQRMEQLDRQLMLSQFAQVRRQRQQQGGMINWNRLFPPLRQRRNINYQDGPRSEQRASPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH",
                "length": 345,
                "header": "sp|Q8R1K1-1|UBAC2_MOUSE Isoform 1 of Ubiquitin-associated domain-containing protein 2  OS=Mus musculus OX=10090 GN=Ubac2 PE=1 SV=1 CANONICAL=Q8R1K1-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 122257466,
                "end_pos": 122116156,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000039803",
                        "url": "https://www.ensembl.org/id/ENSMUST00000039803"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000043245",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000043245"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 161,
            "start_aa": "Asn",
            "end_pos": 161,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn161",
            "evidence": [
                {
                    "id": "Q8R1K1",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8R1K1#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:68889",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68889",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F7FKE7-1",
            "protein_name": "UBA domain containing 2",
            "gene_name": "Ubac2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MYQSLFGDFQSWEPLTCRSLDLDKAPLSKSLLLVPSTLSLLLTLLLPHCQKFFVYDLHAVKNDFQIWRLICGRIICLDLKDAFCSGLLIYNFRIFERRFGSRKFASFLLGSWVLSALFDFILVEAVQYLLGVTVASNLPSGFLAPVFALFVPFHCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAMSGLISGMCYDRRVLQVHQVLCIPSRLAQFFSWALEPIFSSSEPTSEARVGMGATVDIQRQQRMEQLDRQLMLSQFAQVRRQRQQQGGMINWNRLFPPLRQRRNINYQEGPRSEQRAPPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH",
                "length": 357
            },
            "evidence": [
                {
                    "id": "45239707",
                    "url": "http://www.informatics.jax.org/homology/45239707",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8NBM4-1",
            "protein_name": "Ubiquitin-associated domain-containing protein 2",
            "gene_name": "UBAC2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MFTSTGSSGLYKAPLSKSLLLVPSALSLLLALLLPHCQKLFVYDLHAVKNDFQIWRLICGRIICLDLKDTFCSSLLIYNFRIFERRYGSRKFASFLLGSWVLSALFDFLLIEAMQYFFGITAASNLPSGFLAPVFALFVPFYCSIPRVQVAQILGPLSITNKTLIYILGLQLFTSGSYIWIVAISGLMSGLCYDSKMFQVHQVLCIPSWMAKFFSWTLEPIFSSSEPTSEARIGMGATLDIQRQQRMELLDRQLMFSQFAQGRRQRQQQGGMINWNRLFPPLRQRQNVNYQGGRQSEPAAPPLEVSEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH",
                "length": 344
            },
            "evidence": [
                {
                    "id": "45239707",
                    "url": "http://www.informatics.jax.org/homology/45239707",
                    "database": "MGI"
                },
                {
                    "id": "Q8R1K1",
                    "url": "https://omabrowser.org/oma/group/Q8R1K1/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "negative regulation of canonical Wnt signaling pathway",
                        "id": "GO:0090090",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Wnt signaling pathway",
                        "id": "GO:0016055",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein localization to endoplasmic reticulum",
                        "id": "GO:0070972",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070972",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of retrograde protein transport, ER to cytosol",
                        "id": "GO:1904153",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904153",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8R1K1",
                                "url": "https://www.uniprot.org/uniprot/Q8R1K1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 161,
            "end_pos": 163,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 1
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "site_category",
                "site_seq",
                "relation",
                "comment",
                "start_pos",
                "start_aa",
                "end_pos",
                "end_aa",
                "residue",
                "site_lbl"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
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