{
    "uniprot_canonical_ac": "Q8QZV0-1",
    "uniprot_ac": "Q8QZV0",
    "uniprot_id": "DEDD2_MOUSE",
    "mass": {
        "chemical_mass": 36786.0,
        "monoisotopic_mass": 36786.0
    },
    "refseq": {
        "ac": "NP_997560",
        "name": "DNA-binding death effector domain-containing protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560"
    },
    "gene_names": [
        {
            "name": "Dedd2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8QZV0",
            "id": "Q8QZV0"
        },
        {
            "name": "2410050E11Rik; FLAME-3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560",
            "id": "NP_997560"
        },
        {
            "name": "Dedd2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560",
            "id": "NP_997560"
        },
        {
            "name": "Flame3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8QZV0",
            "id": "Q8QZV0"
        }
    ],
    "protein_names": [
        {
            "name": "DNA-binding death effector domain-containing protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8QZV0"
        },
        {
            "name": "DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560",
            "id": "NP_997560"
        },
        {
            "name": "DED-containing protein FLAME-3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8QZV0"
        },
        {
            "name": "DNA-binding death effector domain-containing protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560",
            "id": "NP_997560"
        },
        {
            "name": "FADD-like anti-apoptotic molecule 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8QZV0"
        }
    ],
    "function": [
        {
            "annotation": "May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8QZV0",
                    "url": "https://www.uniprot.org/uniprot/Q8QZV0#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8QZV0",
                    "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Dedd2",
            "url": "https://www.uniprot.org/uniprot/Q8QZV0",
            "locus": {
                "chromosome": "7",
                "start_pos": 24899340,
                "end_pos": 24920040,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000054499",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000054499"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000054499",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054499",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "67379",
            "url": "https://www.ncbi.nlm.nih.gov/gene/67379",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001875",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001875",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011029",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038856",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038856",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:67379",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67379",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1914629",
            "url": "http://www.informatics.jax.org/marker/MGI:1914629",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "AFWSDYM",
            "url": "https://omabrowser.org/oma/group/AFWSDYM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3058503at2759",
            "url": "http://www.orthodb.org/?query=3058503at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15205",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15205",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15205:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15205:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01335",
            "url": "http://pfam.xfam.org/family/PF01335",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8QZV0",
            "url": "http://purl.obolibrary.org/obo/PR_Q8QZV0",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_997560",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997560",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8QZV0",
            "url": "https://www.uniprot.org/uniprot/Q8QZV0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8QZV0-1",
            "url": "https://www.uniprot.org/uniprot/Q8QZV0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MALSGSTPAPSWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAPGGLARARSGLELLLELERRGQCDESNLRLLSQLLRVLARHDLLPHLARKRRRPVSPERYSYGNPSSSSKRTEDSCRRRRQASSSSDSPQSQWDTGSPPTKRQRRSRGRPSSGARQRRRAGLAASQQHQQHQELGRPSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRGTEAS",
        "length": 330,
        "header": "sp|Q8QZV0-1|DEDD2_MOUSE Isoform 1 of DNA-binding death effector domain-containing protein 2  OS=Mus musculus OX=10090 GN=Dedd2 PE=2 SV=1 CANONICAL=Q8QZV0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q8QZV0-1",
            "url": "",
            "sequence": {
                "sequence": "MALSGSTPAPSWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAPGGLARARSGLELLLELERRGQCDESNLRLLSQLLRVLARHDLLPHLARKRRRPVSPERYSYGNPSSSSKRTEDSCRRRRQASSSSDSPQSQWDTGSPPTKRQRRSRGRPSSGARQRRRAGLAASQQHQQHQELGRPSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRGTEAS",
                "length": 330,
                "header": "sp|Q8QZV0-1|DEDD2_MOUSE Isoform 1 of DNA-binding death effector domain-containing protein 2  OS=Mus musculus OX=10090 GN=Dedd2 PE=2 SV=1 CANONICAL=Q8QZV0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 24918553,
                "end_pos": 24902968,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000205271",
                        "url": "https://www.ensembl.org/id/ENSMUST00000205271"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000146052",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000146052"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.",
            "journal": "Cell Death Differ.",
            "date": "2002",
            "authors": "Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8QZV0",
                    "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11965497",
                    "url": "https://glygen.org/publication/PubMed/11965497"
                }
            ]
        },
        {
            "title": "DEDD and DEDD2 associate with caspase-8/10 and signal cell death.",
            "journal": "Oncogene",
            "date": "2003",
            "authors": "Alcivar A, Hu S, Tang J, Yang X",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8QZV0",
                    "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12527898",
                    "url": "https://glygen.org/publication/PubMed/12527898"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:67379",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67379",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "M0R7V1-1",
            "protein_name": "Death effector domain containing 2",
            "gene_name": "Dedd2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MALSGSTPAPSWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAPGGLARARSGLELLLELERRGQCDESNLRLLSQLLRVLARHDLLPHLARKRRRPVSPERYSYGNSSSSSKRTEDSGRCRRRASSSSHSPQSQWDTGSPPTKRQRRSQGRPSSGARQRRRAGLAASQQQQQQQQEPGRSSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEEGRRGTEAS",
                "length": 331
            },
            "evidence": [
                {
                    "id": "45224997",
                    "url": "http://www.informatics.jax.org/homology/45224997",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8WXF8-1",
            "protein_name": "DNA-binding death effector domain-containing protein 2",
            "gene_name": "DEDD2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MALSGSTPAPCWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAAGGLARARSGLELLLELERRGQCDESNLRLLGQLLRVLARHDLLPHLARKRRRPVSPERYSYGTSSSSKRTEGSCRRRRQSSSSANSQQGQWETGSPPTKRQRRSRGRPSGGARRRRRGAPAAPQQQSEPARPSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRPTEAS",
                "length": 326
            },
            "evidence": [
                {
                    "id": "45224997",
                    "url": "http://www.informatics.jax.org/homology/45224997",
                    "database": "MGI"
                },
                {
                    "id": "Q8QZV0",
                    "url": "https://omabrowser.org/oma/group/Q8QZV0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleolus",
                        "id": "GO:0005730",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "positive regulation of extrinsic apoptotic signaling pathway",
                        "id": "GO:2001238",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apoptotic nuclear changes",
                        "id": "GO:0030262",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030262",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extrinsic apoptotic signaling pathway via death domain receptors",
                        "id": "GO:0008625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8QZV0",
                                "url": "https://www.uniprot.org/uniprot/Q8QZV0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}