{ "uniprot_canonical_ac": "Q8NG83-1", "uniprot_ac": "Q8NG83", "uniprot_id": "OR2M3_HUMAN", "mass": { "chemical_mass": 34827.0, "monoisotopic_mass": 34827.0 }, "refseq": { "ac": "NP_001004689", "name": "olfactory receptor 2M3", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689" }, "gene_names": [ { "name": "OR2M3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8NG83", "id": "Q8NG83" }, { "name": "OR1-54; OR2M3P; OR2M6; OST003", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689", "id": "NP_001004689" }, { "name": "OR2M3P", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8NG83", "id": "Q8NG83" }, { "name": "OR2M3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689", "id": "NP_001004689" }, { "name": "OR2M6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8NG83", "id": "Q8NG83" } ], "protein_names": [ { "name": "Olfactory receptor 2M3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8NG83" }, { "name": "Olfactory receptor 2M6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8NG83" }, { "name": "Olfactory receptor OR1-54", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8NG83" }, { "name": "olfactory receptor 2M3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689", "id": "NP_001004689" }, { "name": "olfactory receptor, family 2, subfamily M, member 6; olfactory receptor, family 2, subfamily M, member 3 pseudogene; olfactory receptor OR1-54; novel 7 transmembrane receptor (rhodopsin family) protein; olfactory receptor 2M6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689", "id": "NP_001004689" } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "Q8NG83", "url": "https://www.uniprot.org/uniprot/Q8NG83#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001004689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689" } ] }, { "annotation": "This work shows that the specific thiol function of human OR2M3 is modulated by copper ions. The homology modeling/docking studies together with receptor functional expression studies suggest that this copper sensitivity is mediated by two copper-binding sites within narrowly tuned OR2M3.", "evidence": [ { "database": "RefSeq", "id": "NP_001004689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689" }, { "database": "PubMed", "id": "31435697", "url": "https://glygen.org/publication/PubMed/31435697" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs943719735", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs943719735" }, { "id": "rs943719735", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs943719735" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 186, "end_pos": 186, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ILS->NLS).", "chr_id": "1", "chr_pos": "248203624", "ref_nt": "A", "alt_nt": "null", 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"MARENSTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYLLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYTSLLGSECFLLAVMAYDRYTAICHPLRYTNLMSPKICGLMTAFSWILGSTDGIIDVVATFSFSYCGSREIAHFFCDFPSLLILSCSDTSIFEKILFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLLVVGMYYGAALFMYIRPTSDRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSGE", "length": 312, "header": "sp|Q8NG83-1|OR2M3_HUMAN Isoform 1 of Olfactory receptor 2M3 OS=Homo sapiens OX=9606 GN=OR2M3 PE=2 SV=1 CANONICAL=Q8NG83-1" }, "isoforms": [ { "isoform_ac": "Q8NG83-1", "url": "", "sequence": { "sequence": "MARENSTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYLLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYTSLLGSECFLLAVMAYDRYTAICHPLRYTNLMSPKICGLMTAFSWILGSTDGIIDVVATFSFSYCGSREIAHFFCDFPSLLILSCSDTSIFEKILFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLLVVGMYYGAALFMYIRPTSDRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSGE", "length": 312, "header": "sp|Q8NG83-1|OR2M3_HUMAN Isoform 1 of Olfactory receptor 2M3 OS=Homo sapiens OX=9606 GN=OR2M3 PE=2 SV=1 CANONICAL=Q8NG83-1" }, "locus": { "chromosome": "1", "start_pos": 248204003, "end_pos": 248203068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000456743.3", "url": "https://www.ensembl.org/id/ENST00000456743.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000389625.1", "url": "https://www.ensembl.org/id/ENSP00000389625.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "Q8NG83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG83#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The human olfactory receptor gene family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Malnic B, Godfrey PA, Buck LB", "evidence": [ { "database": "UniProtKB", "id": "Q8NG83", "url": "https://www.uniprot.org/uniprot/Q8NG83" } ], "reference": [ { "type": "PubMed", "id": "14983052", "url": "https://glygen.org/publication/PubMed/14983052" } ] }, { "title": "Profiling of olfactory receptor gene expression in whole human olfactory mucosa.", "journal": "PloS one", "date": "2014", "authors": "Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "24800820", "url": "https://glygen.org/publication/PubMed/24800820" } ] }, { "title": "The human olfactory transcriptome.", "journal": "BMC genomics", "date": "2016", "authors": "Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "27515280", "url": "https://glygen.org/publication/PubMed/27515280" } ] }, { "title": "Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2020", "authors": "Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D", "evidence": [ { "database": "RefSeq", "id": "NP_001004689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004689" } ], "reference": [ { "type": "PubMed", "id": "31435697", "url": "https://glygen.org/publication/PubMed/31435697" } ] }, { "title": "Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "Ikegami K, de March CA, Nagai MH, Ghosh S, Do M, Sharma R, Bruguera ES, Lu YE, Fukutani Y, Vaidehi N, Yohda M, Matsunami H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "31974307", "url": "https://glygen.org/publication/PubMed/31974307" } ] }, { "title": "Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.", "journal": "Nature neuroscience", "date": "2020", "authors": "Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "32066986", "url": "https://glygen.org/publication/PubMed/32066986" } ] } ], "pathway": [ { "id": "hsa:127062", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:127062", "resource": "KEGG Pathway" }, { "id": "R-HSA-9752946", "name": "Expression and translocation of olfactory receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946", "resource": "Reactome", "description": "Expression and translocation of olfactory receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NG81-1", "protein_name": "Olfactory receptor 2M7", "gene_name": "OR2M7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWENQTFNSDFLLLGIFNHSPTHTFLFFLVLAIFSVAFMGNSIMVLLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYISLLGSECFLLAVMSYDRYTAICHPLRYTNLMRPKICGLMTAFSWILGSTDGIIDAVATFSFSYCGSREIAHFCCDFPSLLILSCNDTSIFEEVIFICCIVMLVFPVAIIITSYARVILAVIHMGSGEGRRKAFTTCSSHLMVVGMYYGAGLFMCIQPTSHHSPMQDKMVSVFYTIVTPMLNPLIYSLRNKEVTRALMKILGKGKSGD", "length": 312 }, "evidence": [ { "id": "45242780", "url": "http://www.informatics.jax.org/homology/45242780", "database": "MGI" } ], "common_name": 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