{
"uniprot_canonical_ac": "Q8N3E9-1",
"uniprot_ac": "Q8N3E9",
"uniprot_id": "PLCD3_HUMAN",
"mass": {
"chemical_mass": 89258.0,
"monoisotopic_mass": 89258.0
},
"refseq": {
"ac": "NP_588614",
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
"summary": "This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
"gene_names": [
{
"name": "PLCD3",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/Q8N3E9",
"id": "Q8N3E9"
},
{
"name": "KIAA1964",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/Q8N3E9",
"id": "Q8N3E9"
},
{
"name": "PLC-delta-3",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
"id": "NP_588614"
},
{
"name": "PLCD3",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
"id": "NP_588614"
}
],
"protein_names": [
{
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "Q8N3E9"
},
{
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
"id": "NP_588614"
},
{
"name": "3.1.4.11",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "Q8N3E9"
},
{
"name": "PLC delta3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; phosphoinositide phospholipase C-delta-3",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
"id": "NP_588614"
},
{
"name": "PLC-delta-3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "Q8N3E9"
},
{
"name": "Phosphoinositide phospholipase C-delta-3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "Q8N3E9"
},
{
"name": "Phospholipase C-delta-3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "Q8N3E9"
}
],
"function": [
{
"annotation": "CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
{
"database": "PubMed",
"id": "36071682",
"url": "https://glygen.org/publication/PubMed/36071682"
}
]
},
{
"annotation": "Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
{
"database": "PubMed",
"id": "37166441",
"url": "https://glygen.org/publication/PubMed/37166441"
}
]
},
{
"annotation": "Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9#function"
},
{
"database": "PubMed",
"id": "10336610",
"url": "https://glygen.org/publication/PubMed/10336610"
},
{
"database": "UniProtKB",
"id": "Q8K2J0",
"url": "https://www.uniprot.org/uniprot/Q8K2J0#function"
}
]
},
{
"annotation": "Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
{
"database": "PubMed",
"id": "31808619",
"url": "https://glygen.org/publication/PubMed/31808619"
}
]
},
{
"annotation": "Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
{
"database": "PubMed",
"id": "33674820",
"url": "https://glygen.org/publication/PubMed/33674820"
}
]
},
{
"annotation": "Results identified an interaction between PLCD3 and FLOT2. Inhibition of PLCD3 expression impaired the malignant potential of nasopharyngeal carcinoma (NPC) cells, by restraining its growth, proliferation, mobility and migration. This study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
},
{
"database": "PubMed",
"id": "29115528",
"url": "https://glygen.org/publication/PubMed/29115528"
}
]
},
{
"annotation": "This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
]
}
],
"disease": [],
"snv": [],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "81.32",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "81.75",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "91.8",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "96.42",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "95.62",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "91.79",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "81.96",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "66.63",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "89.23",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "89.07",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "Q8N3E9",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q8N3E9"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
]
}
],
"species": [
{
"name": "Homo sapiens",
"taxid": 9606,
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"common_name": "Human"
}
],
"gene": [
{
"name": "PLCD3",
"url": "https://www.uniprot.org/uniprot/Q8N3E9",
"locus": {
"chromosome": "17",
"start_pos": 45108959,
"end_pos": 45133354,
"strand": "+",
"evidence": [
{
"database": "Ensembl Gene",
"id": "ENSG00000161714",
"url": "https://www.ensembl.org/id/ENSG00000161714"
}
]
}
}
],
"crossref": [
{
"id": "ENSG00000161714",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000161714",
"database": "Bgee",
"categories": [
"Gene Expression"
]
},
{
"id": "cd00275",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00275",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd08630",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08630",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd13363",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13363",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd16218",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16218",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "PLCD3",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PLCD3",
"database": "GeneCards",
"categories": [
"Organism-specific",
"Gene Annotation"
]
},
{
"id": "113026",
"url": "https://www.ncbi.nlm.nih.gov/gene/113026",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "9061",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9061",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "Q8N3E9",
"url": "https://www.ebi.ac.uk/intact/interactors/id:Q8N3E9*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000008",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000008",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR000909",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000909",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001192",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001192",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001711",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001711",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001849",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001849",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR011992",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR011992",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR011993",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR017946",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR017946",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR018247",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR018247",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR035892",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR035892",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR039504",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR039504",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:113026",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:113026",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "608795",
"url": "http://www.omim.org/entry/608795",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_Q8N3E9",
"url": "https://www.nextprot.org/entry/NX_Q8N3E9",
"database": "neXtProt",
"categories": [
"Organism-specific",
"Protein"
]
},
{
"id": "LAVYCHA",
"url": "https://omabrowser.org/oma/group/LAVYCHA/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "2900494at2759",
"url": "http://www.orthodb.org/?query=2900494at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR10336",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR10336:SF33",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF33",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00168",
"url": "http://pfam.xfam.org/family/PF00168",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00387",
"url": "http://pfam.xfam.org/family/PF00387",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00388",
"url": "http://pfam.xfam.org/family/PF00388",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF14788",
"url": "http://pfam.xfam.org/family/PF14788",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "Q8N3E9",
"url": "https://pharos.nih.gov/targets/Q8N3E9",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR_Q8N3E9",
"url": "http://purl.obolibrary.org/obo/PR_Q8N3E9",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "33179",
"url": "https://www.rhea-db.org/rhea/33179",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "F5GXC1",
"url": "https://www.uniprot.org/uniprot/F5GXC1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GXC1-1",
"url": "https://www.uniprot.org/uniprot/F5GXC1-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YGF8",
"url": "https://www.uniprot.org/uniprot/H0YGF8",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YGF8-1",
"url": "https://www.uniprot.org/uniprot/H0YGF8-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "K7EQF2",
"url": "https://www.uniprot.org/uniprot/K7EQF2",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "K7EQF2-1",
"url": "https://www.uniprot.org/uniprot/K7EQF2-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "Q8N3E9-1",
"url": "https://www.uniprot.org/uniprot/Q8N3E9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS",
"length": 789,
"header": "sp|Q8N3E9-1|PLCD3_HUMAN Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=3 CANONICAL=Q8N3E9-1"
},
"isoforms": [
{
"isoform_ac": "F5GXC1-1",
"url": "",
"sequence": {
"sequence": "MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYL",
"length": 127,
"header": "tr|F5GXC1-1|F5GXC1_HUMAN Computationally mapped isoform of Phospholipase C delta 3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=1 CANONICAL=Q8N3E9-1"
},
"locus": {
"chromosome": "17",
"start_pos": 45121343,
"end_pos": 45120436,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000538093.1",
"url": "https://www.ensembl.org/id/ENST00000538093.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000440378.1",
"url": "https://www.ensembl.org/id/ENSP00000440378.1"
}
]
}
},
{
"isoform_ac": "H0YGF8-1",
"url": "",
"sequence": {
"sequence": "XVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGYRHIHLLSKDGASLSPATLFIQIRIQRS",
"length": 111,
"header": "tr|H0YGF8-1|H0YGF8_HUMAN Computationally mapped isoform of Phospholipase C delta 3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=1 CANONICAL=Q8N3E9-1"
},
"locus": {
"chromosome": "17",
"start_pos": 45113548,
"end_pos": 45112618,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000539433.1",
"url": "https://www.ensembl.org/id/ENST00000539433.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000443079.1",
"url": "https://www.ensembl.org/id/ENSP00000443079.1"
}
]
}
},
{
"isoform_ac": "K7EQF2-1",
"url": "",
"sequence": {
"sequence": "MSLPDPGHRPQKRCHLDVPHFAHALWCLHINSLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDM",
"length": 195,
"header": "tr|K7EQF2-1|K7EQF2_HUMAN Computationally mapped isoform of Phospholipase C delta 3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=1 CANONICAL=Q8N3E9-1"
},
"locus": {
"chromosome": "17",
"start_pos": 45133344,
"end_pos": 45120355,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000590644.5",
"url": "https://www.ensembl.org/id/ENST00000590644.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000467800.1",
"url": "https://www.ensembl.org/id/ENSP00000467800.1"
}
]
}
},
{
"isoform_ac": "Q8N3E9-1",
"url": "",
"sequence": {
"sequence": "MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS",
"length": 789,
"header": "sp|Q8N3E9-1|PLCD3_HUMAN Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 OS=Homo sapiens OX=9606 GN=PLCD3 PE=1 SV=3 CANONICAL=Q8N3E9-1"
},
"locus": {
"chromosome": "17",
"start_pos": 45132410,
"end_pos": 45112619,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000619929.5",
"url": "https://www.ensembl.org/id/ENST00000619929.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000479636.1",
"url": "https://www.ensembl.org/id/ENSP00000479636.1"
}
]
}
}
],
"glycosylation": [],
"phosphorylation": [
{
"start_pos": 105,
"end_pos": 105,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "phospho.ELM",
"id": "Q8N3E9",
"url": "http://phospho.elm.eu.org/byAccession/Q8N3E9.html"
}
],
"site_lbl": "Ser105"
},
{
"start_pos": 200,
"end_pos": 200,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
}
],
"site_lbl": "Ser200"
},
{
"start_pos": 496,
"end_pos": 496,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
},
{
"database": "PubMed",
"id": "18452278",
"url": "https://glygen.org/publication/PubMed/18452278"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "phospho.ELM",
"id": "Q8N3E9",
"url": "http://phospho.elm.eu.org/byAccession/Q8N3E9.html"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
}
],
"site_lbl": "Ser496"
},
{
"start_pos": 573,
"end_pos": 573,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"site_lbl": "Ser573"
}
],
"glycation": [],
"keywords": [
"enzyme"
],
"publication": [
{
"title": "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes.",
"journal": "Eur. J. Biochem.",
"date": "1999",
"authors": "Pawelczyk T, Matecki A",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "10336610",
"url": "https://glygen.org/publication/PubMed/10336610"
}
]
},
{
"title": "Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Mochizuki Y, Takenawa T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "10593988",
"url": "https://glygen.org/publication/PubMed/10593988"
}
]
},
{
"title": "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization.",
"journal": "Cytogenet. Cell Genet.",
"date": "1999",
"authors": "Kim H, Suh PG, Ryu SH, Park SH",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "10702670",
"url": "https://glygen.org/publication/PubMed/10702670"
}
]
},
{
"title": "Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.",
"journal": "Cancer research",
"date": "2000",
"authors": "Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "10866302",
"url": "https://glygen.org/publication/PubMed/10866302"
}
]
},
{
"title": "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11022047",
"url": "https://glygen.org/publication/PubMed/11022047"
}
]
},
{
"title": "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11022048",
"url": "https://glygen.org/publication/PubMed/11022048"
}
]
},
{
"title": "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.",
"journal": "The Biochemical journal",
"date": "2000",
"authors": "Yang X, Shears SB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11042108",
"url": "https://glygen.org/publication/PubMed/11042108"
}
]
},
{
"title": "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).",
"journal": "Biochimica et biophysica acta",
"date": "2000",
"authors": "Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11118617",
"url": "https://glygen.org/publication/PubMed/11118617"
}
]
},
{
"title": "Downregulation of phospholipase C delta3 by cAMP and calcium.",
"journal": "Biochem. Biophys. Res. Commun.",
"date": "2001",
"authors": "Lee W.-H., Lee I.-F., Cheng H.-F., Kao H.-J., Lin F.-G., Loh S.-H.",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "11500033",
"url": "https://glygen.org/publication/PubMed/11500033"
}
]
},
{
"title": "Membrane targeting of C2 domains of phospholipase C-delta isoforms.",
"journal": "J. Biol. Chem.",
"date": "2002",
"authors": "Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "11706040",
"url": "https://glygen.org/publication/PubMed/11706040"
}
]
},
{
"title": "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.",
"journal": "Current biology : CB",
"date": "2002",
"authors": "Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11909533",
"url": "https://glygen.org/publication/PubMed/11909533"
}
]
},
{
"title": "The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "12223481",
"url": "https://glygen.org/publication/PubMed/12223481"
}
]
},
{
"title": "The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.",
"journal": "The Biochemical journal",
"date": "2003",
"authors": "Dewaste V, Moreau C, De Smedt F, Bex F, De Smedt H, Wuytack F, Missiaen L, Erneux C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "12747803",
"url": "https://glygen.org/publication/PubMed/12747803"
}
]
},
{
"title": "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.",
"journal": "European journal of biochemistry",
"date": "1992",
"authors": "Carozzi AJ, Kriz RW, Webster C, Parker PJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1333955",
"url": "https://glygen.org/publication/PubMed/1333955"
}
]
},
{
"title": "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Lee SB, Varnai P, Balla A, Jalink K, Rhee SG, Balla T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15037625",
"url": "https://glygen.org/publication/PubMed/15037625"
}
]
},
{
"title": "Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.",
"journal": "Molecular cancer",
"date": "2004",
"authors": "Leung DW, Tompkins C, Brewer J, Ball A, Coon M, Morris V, Waggoner D, Singer JW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15140260",
"url": "https://glygen.org/publication/PubMed/15140260"
}
]
},
{
"title": "Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Chi Y, Zhou B, Wang WQ, Chung SK, Kwon YU, Ahn YH, Chang YT, Tsujishita Y, Hurley JH, Zhang ZY",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15316017",
"url": "https://glygen.org/publication/PubMed/15316017"
}
]
},
{
"title": "Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation.",
"journal": "FEBS letters",
"date": "2004",
"authors": "Schmid AC, Wise HM, Mitchell CA, Nussbaum R, Woscholski R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15474001",
"url": "https://glygen.org/publication/PubMed/15474001"
}
]
},
{
"title": "Expression of phospholipases A2 and C in human corneal epithelial cells.",
"journal": "Invest. Ophthalmol. Vis. Sci.",
"date": "2004",
"authors": "Gelb M.H., Carrier P., Coulombe S., Guerin S.L., Landreville S., Salesse C.",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "15505048",
"url": "https://glygen.org/publication/PubMed/15505048"
}
]
},
{
"title": "Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.",
"journal": "Reproduction (Cambridge, England)",
"date": "2004",
"authors": "Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15579586",
"url": "https://glygen.org/publication/PubMed/15579586"
}
]
},
{
"title": "Molecular cloning and characterization of a novel phospholipase C, PLC-eta.",
"journal": "The Biochemical journal",
"date": "2005",
"authors": "Hwang JI, Oh YS, Shin KJ, Kim H, Ryu SH, Suh PG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15702972",
"url": "https://glygen.org/publication/PubMed/15702972"
}
]
},
{
"title": "The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Kouchi Z, Shikano T, Nakamura Y, Shirakawa H, Fukami K, Miyazaki S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15790568",
"url": "https://glygen.org/publication/PubMed/15790568"
}
]
},
{
"title": "Molecular cloning and characterization of PLC-eta2.",
"journal": "The Biochemical journal",
"date": "2005",
"authors": "Zhou Y, Wing MR, Sondek J, Harden TK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "16107206",
"url": "https://glygen.org/publication/PubMed/16107206"
}
]
},
{
"title": "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.",
"journal": "The Journal of biological chemistry",
"date": "1992",
"authors": "Park D, Jhon DY, Kriz R, Knopf J, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1644792",
"url": "https://glygen.org/publication/PubMed/1644792"
}
]
},
{
"title": "Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis.",
"journal": "J. Biochem.",
"date": "2006",
"authors": "Naito Y., Okada M., Yagisawa H.",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "17041247",
"url": "https://glygen.org/publication/PubMed/17041247"
}
]
},
{
"title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.",
"journal": "Cell",
"date": "2006",
"authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M",
"evidence": [
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
}
]
},
{
"title": "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Ross TS, Jefferson AB, Mitchell CA, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1718960",
"url": "https://glygen.org/publication/PubMed/1718960"
}
]
},
{
"title": "Motif-specific sampling of phosphoproteomes.",
"journal": "Journal of proteome research",
"date": "2008",
"authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd",
"evidence": [
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "18452278",
"url": "https://glygen.org/publication/PubMed/18452278"
}
]
},
{
"title": "A quantitative atlas of mitotic phosphorylation.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2008",
"authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP",
"evidence": [
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
}
]
},
{
"title": "Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.",
"journal": "The Journal of biological chemistry",
"date": "2009",
"authors": "Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "19179337",
"url": "https://glygen.org/publication/PubMed/19179337"
}
]
},
{
"title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.",
"journal": "Science signaling",
"date": "2010",
"authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
]
},
{
"title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.",
"journal": "Electrophoresis",
"date": "2010",
"authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H",
"evidence": [
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
}
]
},
{
"title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.",
"journal": "Journal of proteome research",
"date": "2013",
"authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "iPTMnet",
"id": "Q8N3E9",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
}
]
},
{
"title": "Isolation and characterization of one soluble and two membrane-associated forms of phosphoinositide-specific phospholipase C from human platelets.",
"journal": "Biochemistry",
"date": "1989",
"authors": "Baldassare JJ, Henderson PA, Fisher GJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "2550068",
"url": "https://glygen.org/publication/PubMed/2550068"
}
]
},
{
"title": "Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.",
"journal": "The Journal of biological chemistry",
"date": "1988",
"authors": "Banno Y, Yada Y, Nozawa Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "2841328",
"url": "https://glygen.org/publication/PubMed/2841328"
}
]
},
{
"title": "PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.",
"journal": "Oncology reports",
"date": "2018",
"authors": "Liu W, Liu X, Wang L, Zhu B, Zhang C, Jia W, Zhu H, Liu X, Zhong M, Xie D, Liu Y, Li S, Shi J, Lin J, Xia X, Jiang X, Ren C",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
],
"reference": [
{
"type": "PubMed",
"id": "29115528",
"url": "https://glygen.org/publication/PubMed/29115528"
}
]
},
{
"title": "Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.",
"journal": "Cancer medicine",
"date": "2020",
"authors": "Zhou X, Liao X, Wang X, Huang K, Yang C, Yu T, Han C, Zhu G, Su H, Han Q, Chen Z, Huang J, Gong Y, Ruan G, Ye X, Peng T",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
],
"reference": [
{
"type": "PubMed",
"id": "31808619",
"url": "https://glygen.org/publication/PubMed/31808619"
}
]
},
{
"title": "Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.",
"journal": "Acta biochimica et biophysica Sinica",
"date": "2021",
"authors": "Lin L, Wen J, Lin B, Chen H, Bhandari A, Qi Y, Zheng D, Wang O",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
],
"reference": [
{
"type": "PubMed",
"id": "33674820",
"url": "https://glygen.org/publication/PubMed/33674820"
}
]
},
{
"title": "CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2022-09-07",
"authors": "Ma Yu, Liu Yi, Shu Baotong, Yang Jianguo, Lv Liang, Zhou Lixiao, Wang Lichun, Shi Zongli",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
],
"reference": [
{
"type": "PubMed",
"id": "36071682",
"url": "https://glygen.org/publication/PubMed/36071682"
}
]
},
{
"title": "Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.",
"journal": "Epigenetics",
"date": "2023-12",
"authors": "Dou Xiao-Lin, Xia Fa-Da, Li Xin-Ying",
"evidence": [
{
"database": "RefSeq",
"id": "NP_588614",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_588614"
}
],
"reference": [
{
"type": "PubMed",
"id": "37166441",
"url": "https://glygen.org/publication/PubMed/37166441"
}
]
},
{
"title": "Properties of type II inositol polyphosphate 5-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Jefferson AB, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7721860",
"url": "https://glygen.org/publication/PubMed/7721860"
}
]
},
{
"title": "The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1995",
"authors": "Zhang X, Jefferson AB, Auethavekiat V, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7761412",
"url": "https://glygen.org/publication/PubMed/7761412"
}
]
},
{
"title": "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Cheng HF, Jiang MJ, Chen CL, Liu SM, Wong LP, Lomasney JW, King K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7890667",
"url": "https://glygen.org/publication/PubMed/7890667"
}
]
},
{
"title": "Purification, molecular cloning, and sequencing of phospholipase C-beta 4.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Lee CW, Park DJ, Lee KH, Kim CG, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8407970",
"url": "https://glygen.org/publication/PubMed/8407970"
}
]
},
{
"title": "Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Jhon DY, Lee HH, Park D, Lee CW, Lee KH, Yoo OJ, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8454637",
"url": "https://glygen.org/publication/PubMed/8454637"
}
]
},
{
"title": "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).",
"journal": "Genomics",
"date": "1995",
"authors": "Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8530101",
"url": "https://glygen.org/publication/PubMed/8530101"
}
]
},
{
"title": "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Wilson MP, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8662638",
"url": "https://glygen.org/publication/PubMed/8662638"
}
]
},
{
"title": "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.",
"journal": "Current biology : CB",
"date": "1996",
"authors": "Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8723348",
"url": "https://glygen.org/publication/PubMed/8723348"
}
]
},
{
"title": "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.",
"journal": "Biochemical and biophysical research communications",
"date": "1996",
"authors": "Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8769125",
"url": "https://glygen.org/publication/PubMed/8769125"
}
]
},
{
"title": "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties.",
"journal": "Protein Expr. Purif.",
"date": "1997",
"authors": "Lowenstein J.M., Ghosh S., Pawelczyk T.",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "9056492",
"url": "https://glygen.org/publication/PubMed/9056492"
}
]
},
{
"title": "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3.",
"journal": "Acta Biochim. Pol.",
"date": "1997",
"authors": "Pawelczyk T, Matecki A",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
},
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "9360711",
"url": "https://glygen.org/publication/PubMed/9360711"
}
]
},
{
"title": "Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "9430698",
"url": "https://glygen.org/publication/PubMed/9430698"
}
]
},
{
"title": "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Maehama T, Dixon JE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "9593664",
"url": "https://glygen.org/publication/PubMed/9593664"
}
]
},
{
"title": "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium.",
"journal": "Eur. J. Biochem.",
"date": "1998",
"authors": "Pawelczyk T, Matecki A",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"reference": [
{
"type": "PubMed",
"id": "9799116",
"url": "https://glygen.org/publication/PubMed/9799116"
}
]
}
],
"pathway": [
{
"id": "hsa:113026",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:113026",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-1855204",
"name": "Synthesis of IP3 and IP4 in the cytosol",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204",
"resource": "Reactome",
"description": "Synthesis of IP3 and IP4 in the cytosol"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "D4A978-1",
"protein_name": "Phosphoinositide phospholipase C",
"gene_name": "Plcd3",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MLCGGWRRSRRSPEEPRVSAQVAAPLAFLPSPASSDSSTKRPGLRALKKMGLTEDEDVQAMLRGSKLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLAKLRARLDAMSQRERAHTWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLEDQGEDGATLACAQKLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFTQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVRDHAFTLSPYPVILSLENHCGLEQQIVMARHLRNILGDMLVTQALDSQNPEELPSPEQLKCRVLVKGKKLPAARNEDGRILSDREDEDEDEEEAEEALETAEQRKRAKQISPELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERKARKFTREAGRNQTIPLFNPVDYSTVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLTVQVLTAQQLPKLNVEKPNSIVDPLVRVEIYGVPEDCAHKETDYVLNNGFNPCWEQTLQFQLRAPELVLVRFVVEDYDTTSPNDFVGQFTLPLNSLKQGYRHIHLLSKDGASLSPATLFVHIRIENS",
"length": 762
},
"evidence": [
{
"id": "45229809",
"url": "http://www.informatics.jax.org/homology/45229809",
"database": "MGI"
}
],
"common_name": "Rat"
},
{
"uniprot_canonical_ac": "Q8K2J0-1",
"protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",
"gene_name": "Plcd3",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MLCGGWKRSRRSPEESRVSAQVAAPLAFPPSPASSDSSTKRPGLRALKKMGLTEDEDVQAMLRGSRLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASKHIFFVQHIEAVREGHQSEGLRRFGGAFAPACCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLEDQGEDGATLACAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVRDHAFTSSPYPVILSLENHCGLEQQAVMARHLRSILGDMLVTQALDSQNPEELPSPEQLKGRILVKGKKLPAARSEDGRILSDREEEEEEEEEAEEALEAAEQRSRAKQISPELSALAVYCCATRLRTLDPSPGPPQSCTVGSLSERKARKFTREAGTSFVRHNTQQLTRVYPLGLRMNSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLAIQVLTAQQLPKLNAEKPSSIVDPLVRVEIHGVPEDCAQKETDYVLNNGFNPCWEQTLQFRLRAPELVLVRFVVEDYDTTSPNDFVGQSTLPLSSLKQGYRHIHLLSKDGASLAPATLFVHIRIQNS",
"length": 785
},
"evidence": [
{
"id": "45229809",
"url": "http://www.informatics.jax.org/homology/45229809",
"database": "MGI"
},
{
"id": "Q8N3E9",
"url": "https://omabrowser.org/oma/group/Q8N3E9/",
"database": "OMA"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 6,
"go_terms": [
{
"name": "angiogenesis",
"id": "GO:0001525",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "intracellular signal transduction",
"id": "GO:0035556",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "regulation of cell population proliferation",
"id": "GO:0042127",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "lipid catabolic process",
"id": "GO:0016042",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "labyrinthine layer blood vessel development",
"id": "GO:0060716",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060716",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "lipid metabolic process",
"id": "GO:0006629",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 2,
"go_terms": [
{
"name": "phosphatidylinositol phospholipase C activity",
"id": "GO:0004435",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "metal ion binding",
"id": "GO:0046872",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 4,
"go_terms": [
{
"name": "nucleoplasm",
"id": "GO:0005654",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
},
{
"name": "cleavage furrow",
"id": "GO:0032154",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154",
"evidence": [
{
"database": "UniProtKB",
"id": "Q8N3E9",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 302,
"end_pos": 304,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 596,
"end_pos": 598,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "33179",
"name": "",
"equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q5FX52-1",
"Q62711-1",
"O89040-1",
"P10688-1",
"P10686-1",
"P10687-1",
"P24135-1",
"Q99JE6-1",
"Q99P84-1",
"Q9QW07-1",
"A0A096MJW8-1",
"Q62688-1",
"F1M324-1",
"D4A978-1",
"A0A8I5ZPH5-1",
"Q9UPR0-1",
"Q15111-1",
"Q86YW0-1",
"Q9NQ66-1",
"P16885-1",
"P19174-1",
"O75038-1",
"Q8WTR4-1",
"Q9BRC7-1",
"Q9P212-1",
"Q4KWH8-1",
"Q8N3E9-1",
"Q01970-1",
"Q15147-1",
"Q00722-1",
"P51178-1",
"Q8K4S1-1",
"Q640M6-1",
"Q62077-1",
"Q8K2J0-1",
"Q8K4D7-1",
"Q8K3R3-1",
"Q8R3B1-1",
"A2AP18-1",
"A3KGF7-1",
"P51432-1",
"Q9Z1B3-1",
"Q8CIH5-1",
"Q4KWH5-1",
"Q91UZ1-1",
"P32383-1",
"Q02158-1",
"P25455-3",
"P13217-1",
"Q9VXH3-1"
],
"evidence": [
{
"id": "33179",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/33179"
}
]
},
{
"id": "R-HSA-1855221",
"name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane",
"equation": "",
"summary": "A group of phospholipase C proteins (\u201cPLC(degh)\u201d) bind to the plasma membrane via their PH domains. These phospholipases hydrolyse phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) to inositol 1,4,5 trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). The C2 domains of the enzymes bind to PI(4,5)P2 at the membrane.
The phospholipase C isoforms involved and their corresponding literature references are: phosphoinositide phospholipase C delta-1(PLCD1) (Cheng et al. 1995); epsilon-1 (PLCE1) (Song et al. 2001, Lopez et al. 2001); delta-3 (PLCD3) (Pawelczyk & Matecki 1997); gamma-1 (PLCG1) (Harita et al. 2009, Baldassare et al. 1989); gamma-2 (PLCG2) (Banno et al. 1988); eta-1 (PLCH1) (Hwang et al. 2005); and eta-2 (PLCH2) (Zhou et al 2005).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O75038-1",
"Q4KWH8-1",
"Q9P212-1",
"P19174-1",
"P16885-1",
"Q8N3E9-1",
"P51178-1"
],
"evidence": [
{
"id": "R-HSA-1855221",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855221"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "A0A096MJW8",
"gene_name": "Plch1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "A0A096MJW8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A096MJW8"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "A0A096MJW8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A096MJW8"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZPH5",
"gene_name": "Plch2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "A0A8I5ZPH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZPH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5"
}
]
}
]
},
{
"uniprot_ac": "A2AP18",
"gene_name": "Plch2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "A2AP18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AP18"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "A2AP18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AP18"
}
]
}
]
},
{
"uniprot_ac": "A3KGF7",
"gene_name": "Plcb2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "A3KGF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A3KGF7"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "A3KGF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A3KGF7"
}
]
}
]
},
{
"uniprot_ac": "D4A978",
"gene_name": "Plcd3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "D4A978",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A978"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "D4A978",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A978"
}
]
}
]
},
{
"uniprot_ac": "F1M324",
"gene_name": "Plcl2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "F1M324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M324"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "F1M324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M324"
}
]
}
]
},
{
"uniprot_ac": "O75038",
"gene_name": "PLCH2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "O75038",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75038"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "O75038",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75038"
}
]
}
]
},
{
"uniprot_ac": "O89040",
"gene_name": "Plcb2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "O89040",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O89040"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "O89040",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O89040"
}
]
}
]
},
{
"uniprot_ac": "P10686",
"gene_name": "Plcg1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P10686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10686"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P10686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10686"
}
]
}
]
},
{
"uniprot_ac": "P10687",
"gene_name": "Plcb1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P10687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10687"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P10687",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10687"
}
]
}
]
},
{
"uniprot_ac": "P10688",
"gene_name": "Plcd1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P10688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10688"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P10688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10688"
}
]
}
]
},
{
"uniprot_ac": "P13217",
"gene_name": "norpA",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P13217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13217"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P13217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13217"
}
]
}
]
},
{
"uniprot_ac": "P16885",
"gene_name": "PLCG2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P16885",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16885"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P16885",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16885"
}
]
}
]
},
{
"uniprot_ac": "P19174",
"gene_name": "PLCG1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P19174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19174"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P19174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19174"
}
]
}
]
},
{
"uniprot_ac": "P24135",
"gene_name": "Plcg2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P24135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24135"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P24135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24135"
}
]
}
]
},
{
"uniprot_ac": "P25455",
"gene_name": "Plc21C",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P25455",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25455"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P25455",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25455"
}
]
}
]
},
{
"uniprot_ac": "P32383",
"gene_name": "PLC1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P32383",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32383"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P32383",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32383"
}
]
}
]
},
{
"uniprot_ac": "P51178",
"gene_name": "PLCD1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P51178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51178"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P51178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51178"
}
]
}
]
},
{
"uniprot_ac": "P51432",
"gene_name": "Plcb3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P51432",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51432"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P51432",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51432"
}
]
}
]
},
{
"uniprot_ac": "Q00722",
"gene_name": "PLCB2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q00722",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00722"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q00722",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00722"
}
]
}
]
},
{
"uniprot_ac": "Q01970",
"gene_name": "PLCB3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q01970",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01970"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q01970",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01970"
}
]
}
]
},
{
"uniprot_ac": "Q02158",
"gene_name": "plc",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q02158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02158"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q02158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02158"
}
]
}
]
},
{
"uniprot_ac": "Q15111",
"gene_name": "PLCL1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q15111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15111"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q15111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15111"
}
]
}
]
},
{
"uniprot_ac": "Q15147",
"gene_name": "PLCB4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q15147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15147"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q15147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15147"
}
]
}
]
},
{
"uniprot_ac": "Q4KWH5",
"gene_name": "Plch1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q4KWH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KWH5"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q4KWH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KWH5"
}
]
}
]
},
{
"uniprot_ac": "Q4KWH8",
"gene_name": "PLCH1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q4KWH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KWH8"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q4KWH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KWH8"
}
]
}
]
},
{
"uniprot_ac": "Q5FX52",
"gene_name": "Plcz1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q5FX52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5FX52"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q5FX52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5FX52"
}
]
}
]
},
{
"uniprot_ac": "Q62077",
"gene_name": "Plcg1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q62077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62077"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q62077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62077"
}
]
}
]
},
{
"uniprot_ac": "Q62688",
"gene_name": "Plcl1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q62688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62688"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q62688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62688"
}
]
}
]
},
{
"uniprot_ac": "Q62711",
"gene_name": "Plcd4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q62711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62711"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q62711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62711"
}
]
}
]
},
{
"uniprot_ac": "Q640M6",
"gene_name": "Gdpd5",
"activity": [
{
"ec_number": "3.1.4.2",
"activity": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate.",
"evidence": [
{
"id": "Q640M6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q640M6"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q640M6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q640M6"
}
]
}
]
},
{
"uniprot_ac": "Q86YW0",
"gene_name": "PLCZ1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q86YW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YW0"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q86YW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YW0"
}
]
}
]
},
{
"uniprot_ac": "Q8CIH5",
"gene_name": "Plcg2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8CIH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIH5"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8CIH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIH5"
}
]
}
]
},
{
"uniprot_ac": "Q8K2J0",
"gene_name": "Plcd3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8K2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K2J0"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8K2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K2J0"
}
]
}
]
},
{
"uniprot_ac": "Q8K3R3",
"gene_name": "Plcd4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8K3R3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K3R3"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8K3R3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K3R3"
}
]
}
]
},
{
"uniprot_ac": "Q8K4D7",
"gene_name": "Plcz1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8K4D7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4D7"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8K4D7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4D7"
}
]
}
]
},
{
"uniprot_ac": "Q8K4S1",
"gene_name": "Plce1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8K4S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4S1"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8K4S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4S1"
}
]
}
]
},
{
"uniprot_ac": "Q8N3E9",
"gene_name": "PLCD3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8N3E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8N3E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N3E9"
}
]
}
]
},
{
"uniprot_ac": "Q8R3B1",
"gene_name": "Plcd1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8R3B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3B1"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q8R3B1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3B1"
}
]
}
]
},
{
"uniprot_ac": "Q8WTR4",
"gene_name": "GDPD5",
"activity": [
{
"ec_number": "3.1.4.2",
"activity": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate.",
"evidence": [
{
"id": "Q8WTR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR4"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q8WTR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WTR4"
}
]
}
]
},
{
"uniprot_ac": "Q91UZ1",
"gene_name": "Plcb4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q91UZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91UZ1"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q91UZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91UZ1"
}
]
}
]
},
{
"uniprot_ac": "Q99JE6",
"gene_name": "Plcb3",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q99JE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JE6"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q99JE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JE6"
}
]
}
]
},
{
"uniprot_ac": "Q99P84",
"gene_name": "Plce1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q99P84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99P84"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q99P84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99P84"
}
]
}
]
},
{
"uniprot_ac": "Q9BRC7",
"gene_name": "PLCD4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9BRC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BRC7"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9BRC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BRC7"
}
]
}
]
},
{
"uniprot_ac": "Q9NQ66",
"gene_name": "PLCB1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9NQ66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQ66"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9NQ66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQ66"
}
]
}
]
},
{
"uniprot_ac": "Q9P212",
"gene_name": "PLCE1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9P212",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P212"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9P212",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P212"
}
]
}
]
},
{
"uniprot_ac": "Q9QW07",
"gene_name": "Plcb4",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9QW07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QW07"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9QW07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QW07"
}
]
}
]
},
{
"uniprot_ac": "Q9UPR0",
"gene_name": "PLCL2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9UPR0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPR0"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9UPR0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPR0"
}
]
}
]
},
{
"uniprot_ac": "Q9VXH3",
"gene_name": "sl",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9VXH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXH3"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9VXH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXH3"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1B3",
"gene_name": "Plcb1",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "Q9Z1B3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1B3"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "Q9Z1B3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1B3"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "isoformset.uniprotkb",
"label": "Isoforms"
},
{
"name": "homologset.mgi",
"label": "MGI Homologs"
},
{
"name": "homologset.oma",
"label": "OMA Homologs"
}
],
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 4
},
{
"field": "total_sites",
"count": 4
}
],
"sort_fields": [
"start_pos",
"end_pos",
"kinase_uniprot_canonical_ac",
"kinase_gene_name",
"residue",
"comment",
"site_lbl"
]
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 54
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}