{
    "uniprot_canonical_ac": "Q8N0T1-1",
    "uniprot_ac": "Q8N0T1",
    "uniprot_id": "RBIS_HUMAN",
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        "monoisotopic_mass": 11456.0
    },
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        "summary": "",
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    },
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            "type": "recommended",
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            "id": "Q8N0T1"
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            "id": "NP_001093140"
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            "id": "Q8N0T1"
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            "type": "recommended",
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            "id": "Q8N0T1"
        },
        {
            "name": "ribosomal biogenesis factor isoform 1",
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            "id": "NP_001093140"
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            "id": "NP_001280249"
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        {
            "name": "uncharacterized protein C8orf59; ribosome biogenesis factor identified in screen",
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280249",
            "id": "NP_001280249"
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    ],
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            "annotation": "Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production.",
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    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
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            "name": "Homo sapiens",
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            ],
            "common_name": "Human"
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                ]
            }
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    ],
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        {
            "id": "ENSG00000176731",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000176731",
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            "categories": [
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        },
        {
            "id": "RBIS",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBIS",
            "database": "GeneCards",
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                "Gene Annotation"
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        },
        {
            "id": "401466",
            "url": "https://www.ncbi.nlm.nih.gov/gene/401466",
            "database": "GeneID",
            "categories": [
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        },
        {
            "id": "32235",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=32235",
            "database": "HGNC",
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        },
        {
            "id": "Q8N0T1",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8N0T1*",
            "database": "IntAct",
            "categories": [
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        },
        {
            "id": "IPR031389",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031389",
            "database": "InterPro",
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            "id": "hsa:401466",
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            "database": "KEGG Pathway",
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        {
            "id": "NX_Q8N0T1",
            "url": "https://www.nextprot.org/entry/NX_Q8N0T1",
            "database": "neXtProt",
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                "Protein"
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        {
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            "id": "AMKNEKV",
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            "database": "OMA",
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        },
        {
            "id": "5083391at2759",
            "url": "http://www.orthodb.org/?query=5083391at2759",
            "database": "OrthoDB",
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        },
        {
            "id": "PTHR35544",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35544",
            "database": "PANTHER",
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        },
        {
            "id": "PTHR35544:SF4",
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        },
        {
            "id": "PF15679",
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        },
        {
            "id": "Q8N0T1",
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        },
        {
            "id": "PR_Q8N0T1",
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        {
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        },
        {
            "id": "A0A087WWE7",
            "url": "https://www.uniprot.org/uniprot/A0A087WWE7",
            "database": "UniProtKB",
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            ]
        },
        {
            "id": "A0A087WWE7-1",
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            "id": "E5RGR5",
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        },
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            "id": "E5RGR5-1",
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            "id": "Q8N0T1",
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        {
            "id": "Q8N0T1-1",
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        },
        {
            "id": "Q8N0T1-2",
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            "database": "UniProtKB",
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            ]
        }
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        "sequence": "MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEEKVNRVNKAFVNVQKELAHFAKSISLEPLQKELIPQQRHESKPVNVDEATRLMALL",
        "length": 100,
        "header": "sp|Q8N0T1-1|RBIS_HUMAN Isoform 1 of Ribosomal biogenesis factor  OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4 CANONICAL=Q8N0T1-1"
    },
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                "header": "tr|A0A087WWE7-1|RBIS_HUMAN Computationally mapped isoform of Ribosomal biogenesis factor  OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=1 CANONICAL=Q8N0T1-1"
            },
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                    },
                    {
                        "database": "Ensembl Peptide",
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                ]
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        },
        {
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                "sequence": "MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEE",
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                "header": "tr|E5RGR5-1|RBIS_HUMAN Computationally mapped isoform of Ribosomal biogenesis factor  OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=1 CANONICAL=Q8N0T1-1"
            },
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                    {
                        "database": "Ensembl Peptide",
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                ]
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        },
        {
            "isoform_ac": "Q8N0T1-1",
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                "header": "sp|Q8N0T1-1|RBIS_HUMAN Isoform 1 of Ribosomal biogenesis factor  OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4 CANONICAL=Q8N0T1-1"
            },
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                        "id": "ENST00000611854.4",
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                ]
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        },
        {
            "isoform_ac": "Q8N0T1-2",
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            "sequence": {
                "sequence": "MAKNKLRGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKVLHFS",
                "length": 43,
                "header": "sp|Q8N0T1-2|RBIS_HUMAN Isoform 2 of Ribosomal biogenesis factor  OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4 CANONICAL=Q8N0T1-1"
            },
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                        "database": "Ensembl Transcript",
                        "id": "ENST00000321777.5",
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                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000319020.5",
                        "url": "https://www.ensembl.org/id/ENSP00000319020.5"
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                ]
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        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
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                    "id": "Q8N0T1",
                    "database": "O-GlcNAc Database",
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                {
                    "id": "37217939",
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                    "url": "https://glygen.org/publication/PubMed/37217939"
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            ]
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            "start_pos": 19,
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            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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                {
                    "database": "PubMed",
                    "id": "23186163",
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                },
                {
                    "database": "iPTMnet",
                    "id": "Q8N0T1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N0T1"
                }
            ],
            "site_lbl": "Ser19"
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        {
            "start_pos": 69,
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            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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                {
                    "database": "PubMed",
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                {
                    "database": "iPTMnet",
                    "id": "Q8N0T1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N0T1"
                }
            ],
            "site_lbl": "Ser69"
        }
    ],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.",
            "journal": "Science",
            "date": "2009",
            "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E5RGR5",
                    "url": "https://www.uniprot.org/uniprot/E5RGR5"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A087WWE7",
                    "url": "https://www.uniprot.org/uniprot/A0A087WWE7"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8N0T1",
                    "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19608861",
                    "url": "https://glygen.org/publication/PubMed/19608861"
                }
            ]
        },
        {
            "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.",
            "journal": "Journal of proteome research",
            "date": "2013",
            "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8N0T1",
                    "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8N0T1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8N0T1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23186163",
                    "url": "https://glygen.org/publication/PubMed/23186163"
                }
            ]
        },
        {
            "title": "Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.",
            "journal": "Cell Rep.",
            "date": "2015",
            "authors": "Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8N0T1",
                    "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "26711351",
                    "url": "https://glygen.org/publication/PubMed/26711351"
                }
            ]
        },
        {
            "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.",
            "journal": "Journal of biomedical science",
            "date": "2023-05-22",
            "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "Q8N0T1",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8N0T1"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "37217939",
                    "url": "https://glygen.org/publication/PubMed/37217939"
                }
            ]
        }
    ],
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        {
            "id": "hsa:401466",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:401466",
            "resource": "KEGG Pathway"
        }
    ],
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        {
            "uniprot_canonical_ac": "Q0VG62-2",
            "protein_name": "Ribosomal biogenesis factor",
            "gene_name": "Rbis",
            "tax_id": 10090,
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            "sequence": {
                "sequence": "MAKNKLKGQKSRNVFHIASHKTFKAKNKAKPVTTNLKKINIMNHEKVNRMNRAFVNIQKELANFSKSLSLKSVQKELKHHENEPANVDEATRLMAQL",
                "length": 97
            },
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                {
                    "id": "45239600",
                    "url": "http://www.informatics.jax.org/homology/45239600",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
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                                "id": "Q8N0T1",
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                        ],
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                    },
                    {
                        "name": "nucleolus",
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                                "database": "UniProtKB",
                                "id": "Q8N0T1",
                                "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "Q8N0T1",
                                "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "ribosome biogenesis",
                        "id": "GO:0042254",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8N0T1",
                                "url": "https://www.uniprot.org/uniprot/Q8N0T1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
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