{
    "uniprot_canonical_ac": "Q8K4M9-1",
    "uniprot_ac": "Q8K4M9",
    "uniprot_id": "OSBL1_RAT",
    "mass": {
        "chemical_mass": 107765.0,
        "monoisotopic_mass": 107765.0
    },
    "refseq": {
        "ac": "NP_742020",
        "name": "oxysterol-binding protein-related protein 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742020"
    },
    "gene_names": [
        {
            "name": "Osbpl1a",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8K4M9",
            "id": "Q8K4M9"
        },
        {
            "name": "Orp1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8K4M9",
            "id": "Q8K4M9"
        },
        {
            "name": "Osbpl1a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742020",
            "id": "NP_742020"
        }
    ],
    "protein_names": [
        {
            "name": "Oxysterol-binding protein-related protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8K4M9"
        },
        {
            "name": "ORP-1; OSBP-related protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742020",
            "id": "NP_742020"
        },
        {
            "name": "ORP-1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K4M9"
        },
        {
            "name": "OSBP-related protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K4M9"
        },
        {
            "name": "oxysterol-binding protein-related protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742020",
            "id": "NP_742020"
        }
    ],
    "function": [
        {
            "annotation": "Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K4M9",
                    "url": "https://www.uniprot.org/uniprot/Q8K4M9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9BXW6",
                    "url": "https://www.uniprot.org/uniprot/Q9BXW6#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050545",
            "recommended_name": {
                "id": "DOID:0050545",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050545",
                "name": "visceral heterotaxy",
                "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen."
            },
            "synonyms": [
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "heterotaxia",
                    "description": ""
                },
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "situs ambiguus",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "DTGA2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "transposition of the great arteries, dextro-looped 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "HTX2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "Htx",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "HTX3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia."
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "ZIC3 visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "visceral heterotaxy caused by mutation in ZIC3",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "HTX1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "X-linked visceral heterotaxy 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, multiple types, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "dextrocardia with Other Cardiac malformations",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "laterality, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "HTX6",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": "Any visceral heterotaxy in which the cause of the disease is a mutation in the ACVR2B gene."
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "ACVR2B visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "visceral heterotaxy caused by mutation in ACVR2B",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "HTX4",
                    "description": ""
                },
                {
                    "id": "MIM:605376",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/605376",
                    "name": "Heterotaxy, visceral, 2, autosomal",
                    "description": "Heterotaxy, visceral, 2, autosomal"
                },
                {
                    "id": "MIM:306955",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/306955",
                    "name": "Heterotaxy, visceral, 1, X-linked",
                    "description": "Heterotaxy, visceral, 1, X-linked"
                },
                {
                    "id": "MIM:614779",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614779",
                    "name": "Heterotaxy, visceral, 6, autosomal",
                    "description": "Heterotaxy, visceral, 6, autosomal"
                },
                {
                    "id": "MIM:613751",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613751",
                    "name": "Heterotaxy, visceral, 4, autosomal",
                    "description": "Heterotaxy, visceral, 4, autosomal"
                }
            ],
            "evidence": [
                {
                    "id": "0050545",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050545"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K4M9",
                    "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Osbpl1a",
            "url": "https://www.uniprot.org/uniprot/Q8K4M9",
            "locus": {
                "chromosome": "18",
                "start_pos": 3904006,
                "end_pos": 4094585,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000054058",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000054058"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000054058",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054058",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd13285",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13285",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "259221",
            "url": "https://www.ncbi.nlm.nih.gov/gene/259221",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8K4M9",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8K4M9*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000648",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000648",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001849",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018494",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018494",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036770",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037239",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037239",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:259221",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:259221",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AQTCQQK",
            "url": "https://omabrowser.org/oma/group/AQTCQQK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "960at2759",
            "url": "http://www.orthodb.org/?query=960at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10972",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10972:SF53",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972:SF53",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1Z9O",
            "url": "https://www.rcsb.org/structure/1Z9O",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF01237",
            "url": "http://pfam.xfam.org/family/PF01237",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12796",
            "url": "http://pfam.xfam.org/family/PF12796",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13857",
            "url": "http://pfam.xfam.org/family/PF13857",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8K4M9",
            "url": "http://purl.obolibrary.org/obo/PR_Q8K4M9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-192105",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-192105",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-2132295",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2132295",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_742020",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742020",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "628888",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628888",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K327",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K327",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K327-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K327-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GFS2",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GFS2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GFS2-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GFS2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K4M9",
            "url": "https://www.uniprot.org/uniprot/Q8K4M9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K4M9-1",
            "url": "https://www.uniprot.org/uniprot/Q8K4M9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHGTEMKHILVGNKVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPANSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKTSKQASTSEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY",
        "length": 950,
        "header": "sp|Q8K4M9-1|OSBL1_RAT Isoform 1 of Oxysterol-binding protein-related protein 1  OS=Rattus norvegicus OX=10116 GN=Osbpl1a PE=1 SV=1 CANONICAL=Q8K4M9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K327-1",
            "url": "",
            "sequence": {
                "sequence": "MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDLGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHGTEMKHILVGNKVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDKEIYNFLKMIKECDVAKDMLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPANSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQASASEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRCGFIKALTPTVEHRTGFILAATGTETTSICLIFIKVQRSPGVC",
                "length": 960,
                "header": "tr|A0A0G2K327-1|OSBL1_RAT Computationally mapped isoform of Oxysterol-binding protein-related protein 1  OS=Rattus norvegicus OX=10116 GN=Osbpl1a PE=1 SV=2 CANONICAL=Q8K4M9-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 4085753,
                "end_pos": 3904906,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000091909.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000091909.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000072477.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072477.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6GFS2-1",
            "url": "",
            "sequence": {
                "sequence": "MFSLKVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPANSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQASASEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY",
                "length": 528,
                "header": "tr|A0A8I6GFS2-1|OSBL1_RAT Computationally mapped isoform of Oxysterol-binding protein-related protein 1  OS=Rattus norvegicus OX=10116 GN=Osbpl1a PE=1 SV=1 CANONICAL=Q8K4M9-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 4003290,
                "end_pos": 3904934,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000119742.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000119742.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000087195.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000087195.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8K4M9-1",
            "url": "",
            "sequence": {
                "sequence": "MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHGTEMKHILVGNKVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPANSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKTSKQASTSEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY",
                "length": 950,
                "header": "sp|Q8K4M9-1|OSBL1_RAT Isoform 1 of Oxysterol-binding protein-related protein 1  OS=Rattus norvegicus OX=10116 GN=Osbpl1a PE=1 SV=1 CANONICAL=Q8K4M9-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate.",
            "journal": "Endocrinology",
            "date": "2000",
            "authors": "Nishi N, Shoji H, Miyanaka H, Nakamura T",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K4M9",
                    "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10965890",
                    "url": "https://glygen.org/publication/PubMed/10965890"
                }
            ]
        },
        {
            "title": "Structural basis of FFAT motif-mediated ER targeting.",
            "journal": "Structure",
            "date": "2005",
            "authors": "Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K4M9",
                    "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16004875",
                    "url": "https://glygen.org/publication/PubMed/16004875"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:259221",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:259221",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-192105",
            "name": "Synthesis of bile acids and bile salts",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-192105",
            "resource": "Reactome",
            "description": "Synthesis of bile acids and bile salts"
        },
        {
            "id": "R-RNO-2132295",
            "name": "MHC class II antigen presentation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2132295",
            "resource": "Reactome",
            "description": "MHC class II antigen presentation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q91XL9-1",
            "protein_name": "Oxysterol-binding protein-related protein 1",
            "gene_name": "Osbpl1a",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MNTEAEQQLLHHARNGNAEEVRKLLAAMARMEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVEDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVLLLLEYDADSTVVNGSGQTAKEATHDKEIRNMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAQGAEMKHILVGNKVVHKALKRYEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDSCLFSIRCFDDTVHCFRVPKNSVQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVVSAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADIVSEASRETCVALNDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEEEFYDALSGSESEGSLTCLEAVTAHSFEENEVPGSSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQTSSSEESDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMESVIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY",
                "length": 950
            },
            "evidence": [
                {
                    "id": "45237147",
                    "url": "http://www.informatics.jax.org/homology/45237147",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9BXW6-1",
            "protein_name": "Oxysterol-binding protein-related protein 1",
            "gene_name": "OSBPL1A",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY",
                "length": 950
            },
            "evidence": [
                {
                    "id": "45237147",
                    "url": "http://www.informatics.jax.org/homology/45237147",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "organelle membrane contact site",
                        "id": "GO:0044232",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044232",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome",
                        "id": "GO:0005770",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome",
                        "id": "GO:0005768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular membrane-bounded organelle",
                        "id": "GO:0043231",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear endoplasmic reticulum",
                        "id": "GO:0097038",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097038",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "lipid transport",
                        "id": "GO:0006869",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "lipid binding",
                        "id": "GO:0008289",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cholesterol binding",
                        "id": "GO:0015485",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sterol transporter activity",
                        "id": "GO:0015248",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015248",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K4M9",
                                "url": "https://www.uniprot.org/uniprot/Q8K4M9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 111,
            "end_pos": 113,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 170,
            "end_pos": 172,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 848,
            "end_pos": 850,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 906,
            "end_pos": 908,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
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                    "field": "total",
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                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
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                    "field": "total",
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                {
                    "field": "total_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
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                    "field": "total",
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
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                "date",
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        }
    ]
}