{ "uniprot_canonical_ac": "Q8K440-1", "uniprot_ac": "Q8K440", "uniprot_id": "ABC8B_MOUSE", "mass": { "chemical_mass": 183039.0, "monoisotopic_mass": 183039.0 }, "refseq": { "ac": "NP_038879", "name": "ABC-type organic anion transporter ABCA8B isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879" }, "gene_names": [ { "name": "Abca8b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8K440", "id": "Q8K440" }, { "name": "Abca8b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "id": "NP_038879" }, { "name": "Abca8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "id": "NP_038879" }, { "name": "Abca8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8K440", "id": "Q8K440" }, { "name": "Kiaa0822", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8K440", "id": "Q8K440" } ], "protein_names": [ { "name": "ABC-type organic anion transporter ABCA8B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8K440" }, { "name": "7.6.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K440" }, { "name": "ABC-type organic anion transporter ABCA8B isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "id": "NP_038879" }, { "name": "ATP-binding cassette sub-family A member 8-B; ABC-type organic anion transporter ABCA8B; ATP-binding cassette, sub-family A (ABC1), member 8b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "id": "NP_038879" }, { "name": "ATP-binding cassette sub-family A member 8B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K440" } ], "function": [ { "annotation": "ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels.", "evidence": [ { "database": "RefSeq", "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879" }, { "database": "PubMed", "id": "28882873", "url": "https://glygen.org/publication/PubMed/28882873" } ] }, { "annotation": "Mediates cholesterol and taurocholate efflux (PubMed:28882873). Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440#function" }, { "database": "UniProtKB", "id": "O94911", "url": "https://www.uniprot.org/uniprot/O94911#function" }, { "database": "PubMed", "id": "28882873", "url": "https://glygen.org/publication/PubMed/28882873" } ] }, { "annotation": "Study results suggest that mABCA8b/ABCA8 functions as a sinusoidal efflux transporter for at least cholesterol and taurocholate in mouse and human liver.", "evidence": [ { "database": "RefSeq", "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879" }, { "database": "PubMed", "id": "29300488", "url": "https://glygen.org/publication/PubMed/29300488" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Abca8b", "url": "https://www.uniprot.org/uniprot/Q8K440", "locus": { "chromosome": "11", "start_pos": 109823016, "end_pos": 109886671, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000020620", "url": "https://www.ensembl.org/id/ENSMUSG00000020620" } ] } } ], "crossref": [ { "id": "ENSMUSG00000020620", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000020620", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "27404", "url": "https://www.ncbi.nlm.nih.gov/gene/27404", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0006787", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006787", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0006788", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006788", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "Q8K440", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8K440*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:27404", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:27404", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1351668", "url": "http://www.informatics.jax.org/marker/MGI:1351668", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GVCYHMP", "url": "https://omabrowser.org/oma/group/GVCYHMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "6951at2759", "url": "http://www.orthodb.org/?query=6951at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229:SF148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF148", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "http://pfam.xfam.org/family/PF00005", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12698", "url": "http://pfam.xfam.org/family/PF12698", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8K440", "url": "http://purl.obolibrary.org/obo/PR_Q8K440", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-382556", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "39051", "url": "https://www.rhea-db.org/rhea/39051", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50052", "url": "https://www.rhea-db.org/rhea/50052", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K440-1", "url": "https://www.uniprot.org/uniprot/Q8K440-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K440-2", "url": "https://www.uniprot.org/uniprot/Q8K440-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA", "length": 1620, "header": "sp|Q8K440-1|ABC8B_MOUSE Isoform 1 of ABC-type organic anion transporter ABCA8B OS=Mus musculus OX=10090 GN=Abca8b PE=1 SV=2 CANONICAL=Q8K440-1" }, "isoforms": [ { "isoform_ac": "Q8K440-1", "url": "", "sequence": { "sequence": "MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA", "length": 1620, "header": "sp|Q8K440-1|ABC8B_MOUSE Isoform 1 of ABC-type organic anion transporter ABCA8B OS=Mus musculus OX=10090 GN=Abca8b PE=1 SV=2 CANONICAL=Q8K440-1" }, "locus": { "chromosome": "11", "start_pos": 109872599, "end_pos": 109825339, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000020948", "url": "https://www.ensembl.org/id/ENSMUST00000020948" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000020948", "url": "https://www.ensembl.org/id/ENSMUSP00000020948" } ] } }, { "isoform_ac": "Q8K440-2", "url": "", "sequence": { "sequence": "MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA", "length": 1558, "header": "sp|Q8K440-2|ABC8B_MOUSE Isoform 2 of ABC-type organic anion transporter ABCA8B OS=Mus musculus OX=10090 GN=Abca8b PE=1 SV=2 CANONICAL=Q8K440-1" }, "locus": { "chromosome": "11", "start_pos": 109872599, "end_pos": 109825339, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106669", "url": "https://www.ensembl.org/id/ENSMUST00000106669" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102280", "url": "https://www.ensembl.org/id/ENSMUSP00000102280" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 723, "start_aa": "Asn", "end_pos": 723, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn723", "evidence": [ { "id": "Q8K440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K440#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.", "journal": "Genomics", "date": "2000", "authors": "Schriml LM, Dean M", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "reference": [ { "type": "PubMed", "id": "10708515", "url": "https://glygen.org/publication/PubMed/10708515" } ] }, { "title": "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.", "journal": "Mamm. Genome", "date": "2003", "authors": "Annilo T, Chen ZQ, Shulenin S, Dean M", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "reference": [ { "type": "PubMed", "id": "12532264", "url": "https://glygen.org/publication/PubMed/12532264" } ] }, { "title": "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.", "journal": "Clin. Exp. Pharmacol. Physiol.", "date": "2005", "authors": "Ando H., Ishibashi K., Kasanuki H., Tsuruoka S., Wakaumi M.", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "reference": [ { "type": "PubMed", "id": "16445568", "url": "https://glygen.org/publication/PubMed/16445568" } ] }, { "title": "ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.", "journal": "Arterioscler. Thromb. Vasc. Biol.", "date": "2017", "authors": "Trigueros-Motos L, van Capelleveen JC, Torta F, Castano D, Zhang LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dube MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" }, { "database": "RefSeq", "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879" } ], "reference": [ { "type": "PubMed", "id": "28882873", "url": "https://glygen.org/publication/PubMed/28882873" } ] }, { "title": "ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.", "journal": "Mol. Pharm.", "date": "2018", "authors": "Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" }, { "database": "RefSeq", "id": "NP_038879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038879" } ], "reference": [ { "type": "PubMed", "id": "29300488", "url": "https://glygen.org/publication/PubMed/29300488" } ] } ], "pathway": [ { "id": "mmu:27404", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:27404", "resource": "KEGG Pathway" }, { "id": "R-MMU-382556", "name": "ABC-family proteins mediated transport", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-382556", "resource": "Reactome", "description": "ABC-family proteins mediated transport" } ], "orthologs": [ { "uniprot_canonical_ac": "O94911-3", "protein_name": "ABC-type organic anion transporter ABCA8", "gene_name": "ABCA8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEP", "length": 1621 }, "evidence": [ { "id": "45233710", "url": "http://www.informatics.jax.org/homology/45233710", "database": "MGI" }, { "id": "Q8K440", "url": "https://omabrowser.org/oma/group/Q8K440/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "sphingomyelin biosynthetic process", "id": "GO:0006686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006686", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "positive regulation of cholesterol efflux", "id": "GO:0010875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010875", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "cholesterol efflux", "id": "GO:0033344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033344", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "cholesterol transport", "id": "GO:0030301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030301", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "regulation of cholesterol efflux", "id": "GO:0010874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010874", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "xenobiotic transport", "id": "GO:0042908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042908", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q8K440", "url": "https://www.uniprot.org/uniprot/Q8K440" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1306, "end_pos": 1308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1371, "end_pos": 1373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 545, "end_pos": 547, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" }, { "start_pos": 879, "end_pos": 881, "annotation": "n_glycosylation_sequon" }, { "start_pos": 917, "end_pos": 919, "annotation": "n_glycosylation_sequon" }, { "start_pos": 965, "end_pos": 967, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39051", "name": "", "equation": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P58428-3", "Q99PE7-1", "D3ZCM3-1", "Q8CF82-1", "A0A0G2K1Q8-1", "O95477-1", "P45844-1", "Q9H221-1", "Q9H222-1", "Q86UQ4-1", "O94911-3", "Q8WWZ7-1", "Q99758-1", "Q9H172-1", "P41233-1", "Q64343-1", "Q9DBM0-1", "Q99PE8-1", "Q8R420-1", "Q8K440-1", "Q8K442-1", "Q8K448-1", "Q5SSE9-1", "Q91WA9-1" ], "evidence": [ { "id": "39051", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39051" } ] }, { "id": "50052", "name": "", "equation": "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70127-1", "O88563-1", "O95342-1", "O15438-1", "O94911-3", "Q96J66-1", "Q9QY30-1", "Q8K440-1", "Q8K442-1", "B2RX12-1" ], "evidence": [ { "id": "50052", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50052" } ] }, { "id": "R-MMU-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K440-1", "P21447-1", "B5X0E4-1" ], "evidence": [ { "id": "R-MMU-1467457", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1467457" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K1Q8", "gene_name": "Abca3", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A0G2K1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1Q8" } ] }, { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1Q8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A0G2K1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1Q8" } ] } ] }, { "uniprot_ac": "B2RX12", "gene_name": "Abcc3", "activity": [ { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "B2RX12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RX12" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "B2RX12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RX12" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate.", "evidence": [ { "id": "B2RX12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RX12" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "B2RX12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RX12" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "B2RX12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RX12" } ] } ] }, { "uniprot_ac": "B5X0E4", "gene_name": "Abcb5", "activity": [ { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "B5X0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5X0E4" } ] } ] }, { "uniprot_ac": "D3ZCM3", "gene_name": "Abcg4", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "D3ZCM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCM3" } ] } ] }, { "uniprot_ac": "O15438", "gene_name": "ABCC3", "activity": [ { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "O15438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15438" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "O15438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15438" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate.", "evidence": [ { "id": "O15438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15438" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "O15438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15438" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "O15438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15438" } ] } ] }, { "uniprot_ac": "O70127", "gene_name": "Abcb11", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "O70127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70127" } ] } ] }, { "uniprot_ac": "O88563", "gene_name": "Abcc3", "activity": [ { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "O88563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88563" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "O88563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88563" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate.", "evidence": [ { "id": "O88563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88563" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "O88563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88563" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "O88563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88563" } ] } ] }, { "uniprot_ac": "O94911", "gene_name": "ABCA8", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "O94911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94911" } ] } ] }, { "uniprot_ac": "O95342", "gene_name": "ABCB11", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "O95342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95342" } ] } ] }, { "uniprot_ac": "O95477", "gene_name": "ABCA1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O95477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95477" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O95477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95477" } ] } ] }, { "uniprot_ac": "P21447", "gene_name": "Abcb1a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P21447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21447" } ] }, { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "P21447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21447" } ] } ] }, { "uniprot_ac": "P41233", "gene_name": "Abca1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P41233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41233" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P41233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41233" } ] } ] }, { "uniprot_ac": "P45844", "gene_name": "ABCG1", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P45844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45844" } ] } ] }, { "uniprot_ac": "P58428", "gene_name": "Abcg8", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P58428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58428" } ] } ] }, { "uniprot_ac": "Q5SSE9", "gene_name": "Abca13", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q5SSE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SSE9" } ] } ] }, { "uniprot_ac": "Q64343", "gene_name": "Abcg1", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q64343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64343" } ] } ] }, { "uniprot_ac": "Q86UQ4", "gene_name": "ABCA13", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q86UQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86UQ4" } ] } ] }, { "uniprot_ac": "Q8CF82", "gene_name": "Abca5", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q8CF82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CF82" } ] } ] }, { "uniprot_ac": "Q8K440", "gene_name": "Abca8b", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q8K440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K440" } ] } ] }, { "uniprot_ac": "Q8K442", "gene_name": "Abca8a", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q8K442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K442" } ] } ] }, { "uniprot_ac": "Q8K448", "gene_name": "Abca5", "activity": [ { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q8K448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K448" } ] } ] }, { "uniprot_ac": "Q8R420", "gene_name": "Abca3", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + 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