{ "uniprot_canonical_ac": "Q8K400-1", "uniprot_ac": "Q8K400", "uniprot_id": "STXB5_MOUSE", "mass": { "chemical_mass": 127651.0, "monoisotopic_mass": 127651.0 }, "refseq": { "ac": "NP_001074813", "name": "syntaxin-binding protein 5 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, "gene_names": [ { "name": "Stxbp5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8K400", "id": "Q8K400" }, { "name": "0710001E20Rik; 4930565N16Rik; LGL3; mKIAA1006", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813", "id": "NP_001074813" }, { "name": "Kiaa4253", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8K400", "id": "Q8K400" }, { "name": "Llgl3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8K400", "id": "Q8K400" }, { "name": "Stxbp5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813", "id": "NP_001074813" } ], "protein_names": [ { "name": "Syntaxin-binding protein 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8K400" }, { "name": "Lethal(2) giant larvae protein homolog 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K400" }, { "name": "Tomosyn-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K400" }, { "name": "syntaxin-binding protein 5 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813", "id": "NP_001074813" }, { "name": "syntaxin-binding protein 5; tomosyn-1; lethal(2) giant larvae protein homolog 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813", "id": "NP_001074813" } ], "function": [ { "annotation": "Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "28746398", "url": "https://glygen.org/publication/PubMed/28746398" } ] }, { "annotation": "Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic beta-cells improving glucose clearance.", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "37432648", "url": "https://glygen.org/publication/PubMed/37432648" } ] }, { "annotation": "In the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "16505218", "url": "https://glygen.org/publication/PubMed/16505218" } ] }, { "annotation": "Interacts with SNAP23 and Syntaxin4 and plays a role in Insulin-stimulated GLUT4 translocacion.", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "12832401", "url": "https://glygen.org/publication/PubMed/12832401" } ] }, { "annotation": "Mouse Embryonic Stem (mES) cells self-differentiated into arginine vasopressin (AVP) neurons (mES-AVP) that expressed tomosyn and two transmembrane SNARE proteins, including SNAP25 and syntaxin1. Tomosyn negatively regulates arginine vasopressin secretion in embryonic stem cell-derived neurons. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "27732637", "url": "https://glygen.org/publication/PubMed/27732637" } ] }, { "annotation": "Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release (By similarity). Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400#function" }, { "database": "PubMed", "id": "12832401", "url": "https://glygen.org/publication/PubMed/12832401" } ] }, { "annotation": "The interaction between syntaxin4 and Munc18c in adipocytes results in enhancement of insulin-stimulated GLUT4 externalization.", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "15690082", "url": "https://glygen.org/publication/PubMed/15690082" } ] }, { "annotation": "Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" }, { "database": "PubMed", "id": "37695731", "url": "https://glygen.org/publication/PubMed/37695731" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Stxbp5", "url": "https://www.uniprot.org/uniprot/Q8K400", "locus": { "chromosome": "10", "start_pos": 9631291, "end_pos": 9776823, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000019790", "url": "https://www.ensembl.org/id/ENSMUSG00000019790" } ] } } ], "crossref": [ { "id": "ENSMUSG00000019790", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000019790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15893", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15893", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "78808", "url": "https://www.ncbi.nlm.nih.gov/gene/78808", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8K400", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8K400*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000664", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000664", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:78808", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78808", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1926058", "url": "http://www.informatics.jax.org/marker/MGI:1926058", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "IVWKFFD", "url": "https://omabrowser.org/oma/group/IVWKFFD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "415950at2759", "url": "http://www.orthodb.org/?query=415950at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10241:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10241:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08366", "url": "http://pfam.xfam.org/family/PF08366", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08596", "url": "http://pfam.xfam.org/family/PF08596", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8K400", "url": "http://purl.obolibrary.org/obo/PR_Q8K400", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_006512989", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006512989", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D3Z079", "url": "https://www.uniprot.org/uniprot/D3Z079", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z079-1", "url": "https://www.uniprot.org/uniprot/D3Z079-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z2Q2", "url": "https://www.uniprot.org/uniprot/D3Z2Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z2Q2-1", "url": "https://www.uniprot.org/uniprot/D3Z2Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6WXQ4", "url": "https://www.uniprot.org/uniprot/F6WXQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6WXQ4-1", "url": "https://www.uniprot.org/uniprot/F6WXQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K400-1", "url": "https://www.uniprot.org/uniprot/Q8K400-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K400-2", "url": "https://www.uniprot.org/uniprot/Q8K400-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKAHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEINDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVANDLAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF", "length": 1152, "header": "sp|Q8K400-1|STXB5_MOUSE Isoform 1 of Syntaxin-binding protein 5 OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=3 CANONICAL=Q8K400-1" }, "isoforms": [ { "isoform_ac": "D3Z079-1", "url": "", "sequence": { "sequence": "MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKAHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEINDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF", "length": 1116, "header": "tr|D3Z079-1|D3Z079_MOUSE Computationally mapped isoform of Syntaxin binding protein 5 (tomosyn) OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=1 CANONICAL=Q8K400-1" }, "locus": { "chromosome": "10", "start_pos": 9776427, "end_pos": 9636660, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141722.8", "url": "https://www.ensembl.org/id/ENSMUST00000141722.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123253.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123253.2" } ] } }, { "isoform_ac": "D3Z2Q2-1", "url": "", "sequence": { "sequence": "MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKAHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEINDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF", "length": 1099, "header": "tr|D3Z2Q2-1|STXB5_MOUSE Computationally mapped isoform of Syntaxin-binding protein 5 OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=1 CANONICAL=Q8K400-1" }, "locus": { "chromosome": "10", "start_pos": 9776427, "end_pos": 9636660, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000125200.8", "url": "https://www.ensembl.org/id/ENSMUST00000125200.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121507.2", "url": "https://www.ensembl.org/id/ENSMUSP00000121507.2" } ] } }, { "isoform_ac": "F6WXQ4-1", "url": "", "sequence": { "sequence": "IELYGSNDPYRREPRSPRKSRQPSGGMLLGTPCMCGLSSLYSESVKKLRSSVITGLCDITEGTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNI", "length": 263, "header": "tr|F6WXQ4-1|STXB5_MOUSE Computationally mapped isoform of Syntaxin-binding protein 5 OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=8 CANONICAL=Q8K400-1" }, "locus": { "chromosome": "10", "start_pos": 9673941, "end_pos": 9645183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000136324.2", "url": "https://www.ensembl.org/id/ENSMUST00000136324.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123355.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123355.2" } ] } }, { "isoform_ac": "Q8K400-1", "url": "", "sequence": { "sequence": "MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKAHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEINDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVANDLAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF", "length": 1152, "header": "sp|Q8K400-1|STXB5_MOUSE Isoform 1 of Syntaxin-binding protein 5 OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=3 CANONICAL=Q8K400-1" }, "locus": { "chromosome": "10", "start_pos": 9776427, "end_pos": 9636660, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000038213", "url": "https://www.ensembl.org/id/ENSMUST00000038213" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000044535", "url": "https://www.ensembl.org/id/ENSMUSP00000044535" } ] } }, { "isoform_ac": "Q8K400-2", "url": "", "sequence": { "sequence": "MSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPPGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVMSLPTQSCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF", "length": 398, "header": "sp|Q8K400-2|STXB5_MOUSE Isoform 2 of Syntaxin-binding protein 5 OS=Mus musculus OX=10090 GN=Stxbp5 PE=1 SV=3 CANONICAL=Q8K400-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1040, "end_pos": 1040, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "site_lbl": "Thr1040" }, { "start_pos": 1059, "end_pos": 1059, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q8K400", "url": "http://phospho.elm.eu.org/byAccession/Q8K400.html" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Ser1059" }, { "start_pos": 1132, "end_pos": 1132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "site_lbl": "Ser1132" }, { "start_pos": 693, "end_pos": 693, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "site_lbl": "Ser693" }, { "start_pos": 724, "end_pos": 724, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser724" }, { "start_pos": 760, "end_pos": 760, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q8K400", "url": "http://phospho.elm.eu.org/byAccession/Q8K400.html" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser760" }, { "start_pos": 763, "end_pos": 763, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "site_lbl": "Thr763" }, { "start_pos": 783, "end_pos": 783, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q8K400", "url": "http://phospho.elm.eu.org/byAccession/Q8K400.html" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser783" }, { "start_pos": 785, "end_pos": 785, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Thr785" }, { "start_pos": 786, "end_pos": 786, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q8K400", "url": "http://phospho.elm.eu.org/byAccession/Q8K400.html" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser786" }, { "start_pos": 901, "end_pos": 901, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser901" }, { "start_pos": 903, "end_pos": 903, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "site_lbl": "Ser903" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Widberg CH, Bryant NJ, Girotti M, Rea S, James DE", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "12832401", "url": "https://glygen.org/publication/PubMed/12832401" } ] }, { "title": "Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.", "journal": "J. Neurochem.", "date": "2005", "authors": "Groffen AJ, Jacobsen L, Schut D, Verhage M", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "reference": [ { "type": "PubMed", "id": "15659226", "url": "https://glygen.org/publication/PubMed/15659226" } ] }, { "title": "Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization.", "journal": "The Journal of clinical investigation", "date": "2005", "authors": "Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, Kasuga M", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "15690082", "url": "https://glygen.org/publication/PubMed/15690082" } ] }, { "title": "Comprehensive identification of phosphorylation sites in postsynaptic density preparations.", "journal": "Mol. Cell. Proteomics", "date": "2006", "authors": "Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "UniProtKB", "id": "F6WXQ4", "url": "https://www.uniprot.org/uniprot/F6WXQ4" }, { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "UniProtKB", "id": "D3Z079", "url": "https://www.uniprot.org/uniprot/D3Z079" } ], "reference": [ { "type": "PubMed", "id": "16452087", "url": "https://glygen.org/publication/PubMed/16452087" } ] }, { "title": "Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.", "journal": "Diabetes", "date": "2006", "authors": "Zhang W, Lilja L, Mandic SA, Gromada J, Smidt K, Janson J, Takai Y, Bark C, Berggren PO, Meister B", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "16505218", "url": "https://glygen.org/publication/PubMed/16505218" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "UniProtKB", "id": "F6WXQ4", "url": "https://www.uniprot.org/uniprot/F6WXQ4" }, { "database": "UniProtKB", "id": "D3Z2Q2", "url": "https://www.uniprot.org/uniprot/D3Z2Q2" }, { "database": "UniProtKB", "id": "D3Z079", "url": "https://www.uniprot.org/uniprot/D3Z079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "UniProtKB", "id": "F6WXQ4", "url": "https://www.uniprot.org/uniprot/F6WXQ4" }, { "database": "UniProtKB", "id": "D3Z2Q2", "url": "https://www.uniprot.org/uniprot/D3Z2Q2" }, { "database": "UniProtKB", "id": "D3Z079", "url": "https://www.uniprot.org/uniprot/D3Z079" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" }, { "database": "iPTMnet", "id": "Q8K400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K400" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.", "journal": "PloS one", "date": "2016", "authors": "Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "27732637", "url": "https://glygen.org/publication/PubMed/27732637" } ] }, { "title": "Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.", "journal": "PloS one", "date": "2017", "authors": "Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "28746398", "url": "https://glygen.org/publication/PubMed/28746398" } ] }, { "title": "Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic \u03b2-cells improving glucose clearance.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2023-08", "authors": "Rahman Md Mostafizur, Pathak Asmita, Schueler Kathryn L, Alsharif Haifa, Michl Ava, Alexander Justin, Kim Jeong-A, Bhatnagar Sushant", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "37432648", "url": "https://glygen.org/publication/PubMed/37432648" } ] }, { "title": "Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.", "journal": "eLife", "date": "2023-09-11", "authors": "Subkhangulova Aygul, Gonzalez-Lozano Miguel A, Groffen Alexander J A, van Weering Jan R T, Smit August B, Toonen Ruud F, Verhage Matthijs", "evidence": [ { "database": "RefSeq", "id": "NP_001074813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074813" } ], "reference": [ { "type": "PubMed", "id": "37695731", "url": "https://glygen.org/publication/PubMed/37695731" } ] } ], "pathway": [ { "id": "mmu:78808", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78808", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5T5C0-1", "protein_name": "Syntaxin-binding protein 5", "gene_name": "STXBP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF", "length": 1151 }, "evidence": [ { "id": "45230049", "url": "http://www.informatics.jax.org/homology/45230049", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WU70-1", "protein_name": "Syntaxin-binding protein 5", "gene_name": "Stxbp5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1152 }, "evidence": [ { "id": "45230049", "url": "http://www.informatics.jax.org/homology/45230049", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "extrinsic component of presynaptic membrane", "id": "GO:0098888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098888", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "acetylcholine-gated channel complex", "id": "GO:0005892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005892", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "extrinsic component of neuronal dense core vesicle membrane", "id": "GO:0098674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098674", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "hippocampal mossy fiber to CA3 synapse", "id": "GO:0098686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098686", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "presynaptic cytosol", "id": "GO:0099523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099523", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "synaptic vesicle cycle", "id": "GO:0099504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099504", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "regulation of protein secretion", "id": "GO:0050708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050708", "evidence": [ { "database": "UniProtKB", "id": "Q8K400", "url": "https://www.uniprot.org/uniprot/Q8K400" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle priming", "id": "GO:0010807", "url": 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