{
    "uniprot_canonical_ac": "Q8K3X0-1",
    "uniprot_ac": "Q8K3X0",
    "uniprot_id": "CASC3_RAT",
    "mass": {
        "chemical_mass": 75904.0,
        "monoisotopic_mass": 75904.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Casc3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8K3X0",
            "id": "Q8K3X0"
        },
        {
            "name": "Mln51",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8K3X0",
            "id": "Q8K3X0"
        }
    ],
    "protein_names": [
        {
            "name": "Protein CASC3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8K3X0"
        },
        {
            "name": "Btz",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K3X0"
        },
        {
            "name": "Cancer susceptibility candidate gene 3 protein homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K3X0"
        },
        {
            "name": "Metastatic lymph node gene 51 protein homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K3X0"
        },
        {
            "name": "Protein barentsz",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K3X0"
        }
    ],
    "function": [
        {
            "annotation": "Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer (By similarity). Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0#function"
                },
                {
                    "database": "PubMed",
                    "id": "12843282",
                    "url": "https://glygen.org/publication/PubMed/12843282"
                },
                {
                    "database": "UniProtKB",
                    "id": "O15234",
                    "url": "https://www.uniprot.org/uniprot/O15234#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Casc3",
            "url": "https://www.uniprot.org/uniprot/Q8K3X0",
            "locus": {
                "chromosome": "10",
                "start_pos": 83788966,
                "end_pos": 83769001,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000009716",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000009716"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000009716",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009716",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "IPR018545",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018545",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028544",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028544",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:259170",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:259170",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "NRNYGRV",
            "url": "https://omabrowser.org/oma/group/NRNYGRV/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5403767at2759",
            "url": "http://www.orthodb.org/?query=5403767at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13434",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13434",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13434:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13434:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09405",
            "url": "http://pfam.xfam.org/family/PF09405",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8K3X0",
            "url": "http://purl.obolibrary.org/obo/PR_Q8K3X0",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-159236",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-159236",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72163",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-72187",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72187",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-73856",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73856",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-975957",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975957",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "628766",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628766",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6AAV4",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AAV4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AAV4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AAV4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G9Z5",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G9Z5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6G9Z5-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6G9Z5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3V793",
            "url": "https://www.uniprot.org/uniprot/G3V793",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3V793-1",
            "url": "https://www.uniprot.org/uniprot/G3V793-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K3X0",
            "url": "https://www.uniprot.org/uniprot/Q8K3X0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K3X0-1",
            "url": "https://www.uniprot.org/uniprot/Q8K3X0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGARSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS",
        "length": 699,
        "header": "sp|Q8K3X0-1|CASC3_RAT Isoform 1 of Protein CASC3  OS=Rattus norvegicus OX=10116 GN=Casc3 PE=1 SV=1 CANONICAL=Q8K3X0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6AAV4-1",
            "url": "",
            "sequence": {
                "sequence": "MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGGRSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS",
                "length": 699,
                "header": "tr|A0A8I6AAV4-1|CASC3_RAT Computationally mapped isoform of Protein CASC3  OS=Rattus norvegicus OX=10116 GN=Casc3 PE=1 SV=1 CANONICAL=Q8K3X0-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 83787996,
                "end_pos": 83769014,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000110187.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000110187.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000089096.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000089096.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6G9Z5-1",
            "url": "",
            "sequence": {
                "sequence": "MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECVSERLPGAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGGRSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSENTDCSSRGPEFNSQQPLGGSQPSVMRSDALFWCV",
                "length": 724,
                "header": "tr|A0A8I6G9Z5-1|CASC3_RAT Computationally mapped isoform of Protein CASC3  OS=Rattus norvegicus OX=10116 GN=Casc3 PE=1 SV=1 CANONICAL=Q8K3X0-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 83788443,
                "end_pos": 83769014,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000103824.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000103824.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000084172.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000084172.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "G3V793-1",
            "url": "",
            "sequence": {
                "sequence": "MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS",
                "length": 637,
                "header": "tr|G3V793-1|G3V793_RAT Computationally mapped isoform of Protein CASC3  OS=Rattus norvegicus OX=10116 GN=Casc3 PE=1 SV=2 CANONICAL=Q8K3X0-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 83787996,
                "end_pos": 83769014,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000013204.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000013204.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000013204.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000013204.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8K3X0-1",
            "url": "",
            "sequence": {
                "sequence": "MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGARSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS",
                "length": 699,
                "header": "sp|Q8K3X0-1|CASC3_RAT Isoform 1 of Protein CASC3  OS=Rattus norvegicus OX=10116 GN=Casc3 PE=1 SV=1 CANONICAL=Q8K3X0-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 115,
            "end_pos": 115,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "site_lbl": "Ser115"
        },
        {
            "start_pos": 145,
            "end_pos": 145,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K3X0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K3X0"
                }
            ],
            "site_lbl": "Ser145"
        },
        {
            "start_pos": 262,
            "end_pos": 262,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K3X0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K3X0"
                }
            ],
            "site_lbl": "Ser262"
        },
        {
            "start_pos": 34,
            "end_pos": 34,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "site_lbl": "Ser34"
        },
        {
            "start_pos": 354,
            "end_pos": 354,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "site_lbl": "Thr354"
        },
        {
            "start_pos": 360,
            "end_pos": 360,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K3X0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K3X0"
                }
            ],
            "site_lbl": "Ser360"
        },
        {
            "start_pos": 370,
            "end_pos": 370,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K3X0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K3X0"
                }
            ],
            "site_lbl": "Ser370"
        },
        {
            "start_pos": 473,
            "end_pos": 473,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "site_lbl": "Ser473"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.",
            "journal": "J. Neurosci.",
            "date": "2003",
            "authors": "Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St Johnston D, Kiebler M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12843282",
                    "url": "https://glygen.org/publication/PubMed/12843282"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "UniProtKB",
                    "id": "G3V793",
                    "url": "https://www.uniprot.org/uniprot/G3V793"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K3X0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K3X0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:259170",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:259170",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-159236",
            "name": "Transport of Mature mRNA derived from an Intron-Containing Transcript",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-159236",
            "resource": "Reactome",
            "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript"
        },
        {
            "id": "R-RNO-72163",
            "name": "mRNA Splicing - Major Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72163",
            "resource": "Reactome",
            "description": "mRNA Splicing - Major Pathway"
        },
        {
            "id": "R-RNO-72187",
            "name": "mRNA 3'-end processing",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-72187",
            "resource": "Reactome",
            "description": "mRNA 3'-end processing"
        },
        {
            "id": "R-RNO-73856",
            "name": "RNA Polymerase II Transcription Termination",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73856",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Termination"
        },
        {
            "id": "R-RNO-975957",
            "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975957",
            "resource": "Reactome",
            "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "mRNA binding",
                        "id": "GO:0003729",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase binding",
                        "id": "GO:0031625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "enzyme binding",
                        "id": "GO:0019899",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "regulation of translation",
                        "id": "GO:0006417",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",
                        "id": "GO:0000184",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA splicing, via spliceosome",
                        "id": "GO:0000398",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular mRNA localization",
                        "id": "GO:0008298",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008298",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA transport",
                        "id": "GO:0051028",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",
                        "id": "GO:2000622",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000622",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA processing",
                        "id": "GO:0006397",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA splicing",
                        "id": "GO:0008380",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 10,
                "go_terms": [
                    {
                        "name": "nuclear speck",
                        "id": "GO:0016607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear membrane",
                        "id": "GO:0031965",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear region of cytoplasm",
                        "id": "GO:0048471",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "U2-type catalytic step 1 spliceosome",
                        "id": "GO:0071006",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071006",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "exon-exon junction complex",
                        "id": "GO:0035145",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic stress granule",
                        "id": "GO:0010494",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ribonucleoprotein complex",
                        "id": "GO:1990904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K3X0",
                                "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 309,
            "end_pos": 311,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 471,
            "end_pos": 473,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Phosphorylated.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K3X0",
                    "url": "https://www.uniprot.org/uniprot/Q8K3X0"
                },
                {
                    "database": "PubMed",
                    "id": "12843282",
                    "url": "https://glygen.org/publication/PubMed/12843282"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 8
                },
                {
                    "field": "total_sites",
                    "count": 8
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl"
            ]
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}