The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-RNO-140785" ], "enzyme_list": [ "Q63207-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140736", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140736" } ] }, { "id": "R-RNO-140748", "name": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140748" } ] }, { "id": "R-RNO-140769", "name": "factor VII -> factor VIIa", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63207-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140769", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140769" } ] }, { "id": "R-RNO-140777", "name": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63207-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140777", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140777" } ] }, { "id": "R-RNO-140783", "name": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140783", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140783" } ] }, { "id": "R-RNO-140823", "name": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [ "R-RNO-140886" ], "output_participant_list": [ "R-RNO-140897" ], "enzyme_list": [ "P16296-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140823", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140823" } ] }, { "id": "R-RNO-140825", "name": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63207-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-140825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-140825" } ] }, { "id": "R-RNO-159761", "name": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-RNO-159848" ], "output_participant_list": [ "R-RNO-159722" ], "enzyme_list": [ "Q8K3U6-1", "O88496-1" ], "evidence": [ { "id": "R-RNO-159761", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-159761" } ] }, { "id": "R-RNO-159783", "name": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "COPII-coated ER to Golgi transport vesicle, Golgi lumen, endoplasmic reticulum lumen", "input_participant_list": [], "output_participant_list": [ "R-RNO-159767" ], "enzyme_list": [ "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-159783", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-159783" } ] }, { "id": "R-RNO-159868", "name": "Furin cleaves pro-factor VII to factor VII", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [ "R-RNO-159808", "R-RNO-159847" ], "enzyme_list": [ "P23377-1", "Q8K3U6-1" ], "evidence": [ { "id": "R-RNO-159868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-159868" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-140785", "participant_name": "F10 [extracellular region]", "crossref": [ { "id": "Q63207", "database": "UniProt", "url": "" }, { "id": "Q63207", "database": "ZINC target", "url": "" }, { "id": "Q63207", "database": "PRO", "url": "" }, { "id": "NP_058839.1", "database": "RefSeq", "url": "" }, { "id": "FA10_RAT", "database": "ZINC - Substances", "url": "" }, { "id": "ENSG00000126218", "database": "OpenTargets", "url": "" }, { "id": "61850", "database": "RGD", "url": "" }, { "id": "FA10_RAT", "database": "ZINC - Predictions - Purchasable", "url": "" } ] }, { "participant_id": "R-RNO-140886", "participant_name": "12xCbxE-3D-F9(47-461) [extracellular region]", "crossref": [ { "id": "NP_113728.1", "database": "RefSeq", "url": "" }, { "id": "P16296", "database": "UniProt", "url": "" }, { "id": "2589", "database": "RGD", "url": "" }, { "id": "P16296", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-140897", "participant_name": "factor IX activation peptide [extracellular region]", "crossref": [ { "id": "P16296", "database": "UniProt", "url": "" }, { "id": "2589", "database": "RGD", "url": "" }, { "id": "NP_113728.1", "database": "RefSeq", "url": "" }, { "id": "P16296", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-159722", "participant_name": "10xCbxE-F7(21-466) [endoplasmic reticulum lumen]", "crossref": [ { "id": "Q8K3U6", "database": "UniProt", "url": "" }, { "id": "3.4.21.21", "database": "IntEnz", "url": "" }, { "id": "ENSRNOT00000037806", "database": "Ensembl", "url": "" }, { "id": "628678", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000038466", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000032737", "database": "Ensembl", "url": "" }, { "id": "NP_690059.1", "database": "RefSeq", "url": "" }, { "id": "Q8K3U6", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-159767", "participant_name": "pro-factor VII [Golgi lumen]", "crossref": [ { "id": "Q8K3U6", "database": "UniProt", "url": "" }, { "id": "3.4.21.21", "database": "IntEnz", "url": "" }, { "id": "ENSRNOT00000037806", "database": "Ensembl", "url": "" }, { "id": "628678", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000038466", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000032737", "database": "Ensembl", "url": "" }, { "id": "NP_690059.1", "database": "RefSeq", "url": "" }, { "id": "Q8K3U6", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-159808", "participant_name": "factor VII [Golgi lumen]", "crossref": [ { "id": "Q8K3U6", "database": "UniProt", "url": "" }, { "id": "3.4.21.21", "database": "IntEnz", "url": "" }, { "id": "ENSRNOT00000037806", "database": "Ensembl", "url": "" }, { "id": "628678", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000038466", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000032737", "database": "Ensembl", "url": "" }, { "id": "NP_690059.1", "database": "RefSeq", "url": "" }, { "id": "Q8K3U6", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-159847", "participant_name": "factor VII propeptide [Golgi lumen]", "crossref": [ { "id": "Q8K3U6", "database": "UniProt", "url": "" }, { "id": "3.4.21.21", "database": "IntEnz", "url": "" }, { "id": "ENSRNOT00000037806", "database": "Ensembl", "url": "" }, { "id": "628678", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000038466", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000032737", "database": "Ensembl", "url": "" }, { "id": "NP_690059.1", "database": "RefSeq", "url": "" }, { "id": "Q8K3U6", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-159848", "participant_name": "F7(21-466) [endoplasmic reticulum lumen]", "crossref": [ { "id": "NP_690059.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000037806", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000038466", "database": "Ensembl", "url": "" }, { "id": "Q8K3U6", "database": "UniProt", "url": "" }, { "id": "628678", "database": "RGD", "url": "" }, { "id": "Q8K3U6", "database": "PRO", "url": "" }, { "id": "ENSRNOG00000032737", "database": "Ensembl", "url": "" }, { "id": "3.4.21.21", "database": "IntEnz", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O88496", "gene_name": "Ggcx", "activity": [ { "ec_number": "4.1.1.90", "activity": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol.", "evidence": [ { "id": "O88496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88496" } ] }, { "ec_number": "4.1.1.90", "activity": "", "evidence": [ { "id": "O88496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88496" } ] } ] }, { "uniprot_ac": "P16296", "gene_name": "F9", "activity": [ { "ec_number": "3.4.21.22", "activity": "Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.", "evidence": [ { "id": "P16296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16296" } ] }, { "ec_number": "3.4.21.22", "activity": "", "evidence": [ { "id": "P16296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16296" } ] } ] }, { "uniprot_ac": "P23377", "gene_name": "Furin", "activity": [ { "ec_number": "3.4.21.75", "activity": "Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.", "evidence": [ { "id": "P23377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23377" } ] }, { "ec_number": "3.4.21.75", "activity": "", "evidence": [ { "id": "P23377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23377" } ] } ] }, { "uniprot_ac": "Q63207", "gene_name": "F10", "activity": [ { "ec_number": "3.4.21.6", "activity": "Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.", "evidence": [ { "id": "Q63207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63207" } ] }, { "ec_number": "3.4.21.6", "activity": "", "evidence": [ { "id": "Q63207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63207" } ] } ] }, { "uniprot_ac": "Q8K3U6", "gene_name": "F7", "activity": [ { "ec_number": "3.4.21.21", "activity": "Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.", "evidence": [ { "id": "Q8K3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3U6" } ] }, { "ec_number": "3.4.21.21", "activity": "", "evidence": [ { "id": "Q8K3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3U6" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }