{
    "uniprot_canonical_ac": "Q8K394-1",
    "uniprot_ac": "Q8K394",
    "uniprot_id": "PLCL2_MOUSE",
    "mass": {
        "chemical_mass": 125772.0,
        "monoisotopic_mass": 125772.0
    },
    "refseq": {
        "ac": "NP_038908",
        "name": "inactive phospholipase C-like protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908"
    },
    "gene_names": [
        {
            "name": "Plcl2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8K394",
            "id": "Q8K394"
        },
        {
            "name": "Kiaa1092",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8K394",
            "id": "Q8K394"
        },
        {
            "name": "Plce2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8K394",
            "id": "Q8K394"
        },
        {
            "name": "Plcl2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908",
            "id": "NP_038908"
        },
        {
            "name": "mKIAA1092; PLC-L2; Plce2; PRIP-2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908",
            "id": "NP_038908"
        }
    ],
    "protein_names": [
        {
            "name": "Inactive phospholipase C-like protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "PLC-L(2); PLC-epsilon-2; phospholipase C-L2; phospholipase C, epsilon 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908",
            "id": "NP_038908"
        },
        {
            "name": "PLC-L(2)",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "PLC-L2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "PLC-epsilon-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "Phospholipase C-L2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "Phospholipase C-epsilon-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K394"
        },
        {
            "name": "inactive phospholipase C-like protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908",
            "id": "NP_038908"
        }
    ],
    "function": [
        {
            "annotation": "May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394#function"
                },
                {
                    "database": "PubMed",
                    "id": "10581172",
                    "url": "https://glygen.org/publication/PubMed/10581172"
                }
            ]
        },
        {
            "annotation": "PLC-L2 is a novel negative regulator of BCR signaling and immune responses",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038908",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908"
                },
                {
                    "database": "PubMed",
                    "id": "14517301",
                    "url": "https://glygen.org/publication/PubMed/14517301"
                }
            ]
        },
        {
            "annotation": "Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038908",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908"
                },
                {
                    "database": "PubMed",
                    "id": "31589911",
                    "url": "https://glygen.org/publication/PubMed/31589911"
                }
            ]
        },
        {
            "annotation": "These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038908",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908"
                },
                {
                    "database": "PubMed",
                    "id": "28360101",
                    "url": "https://glygen.org/publication/PubMed/28360101"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Plcl2",
            "url": "https://www.uniprot.org/uniprot/Q8K394",
            "locus": {
                "chromosome": "17",
                "start_pos": 50995512,
                "end_pos": 50816431,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000038910",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000038910"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000038910",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038910",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00275",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00275",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd08597",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08597",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd13364",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13364",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd16223",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16223",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "224860",
            "url": "https://www.ncbi.nlm.nih.gov/gene/224860",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "2386",
            "url": "https://glyconnect.expasy.org/browser/proteins/2386",
            "database": "GlyConnect",
            "categories": [
                "Glycan",
                "Glycoproteomics"
            ]
        },
        {
            "id": "IPR000008",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR000909",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001192",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001711",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001849",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011992",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015359",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017946",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028382",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028382",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035892",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:224860",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:224860",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1352756",
            "url": "http://www.informatics.jax.org/marker/MGI:1352756",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "MRTSWIS",
            "url": "https://omabrowser.org/oma/group/MRTSWIS/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2900494at2759",
            "url": "http://www.orthodb.org/?query=2900494at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10336",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10336:SF84",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF84",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00168",
            "url": "http://pfam.xfam.org/family/PF00168",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00387",
            "url": "http://pfam.xfam.org/family/PF00387",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00388",
            "url": "http://pfam.xfam.org/family/PF00388",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09279",
            "url": "http://pfam.xfam.org/family/PF09279",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16457",
            "url": "http://pfam.xfam.org/family/PF16457",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8K394",
            "url": "http://purl.obolibrary.org/obo/PR_Q8K394",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_038908",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K394",
            "url": "https://www.uniprot.org/uniprot/Q8K394",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K394-1",
            "url": "https://www.uniprot.org/uniprot/Q8K394-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAECGRGAAGGALPTSPSPALGAKGALKAGAGEGGGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARTSPGRGPLGVALARTPSPAAGPVPRDSKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENSEAQKPRRSLEAIPEKASDENGD",
        "length": 1128,
        "header": "sp|Q8K394-1|PLCL2_MOUSE Isoform 1 of Inactive phospholipase C-like protein 2  OS=Mus musculus OX=10090 GN=Plcl2 PE=1 SV=2 CANONICAL=Q8K394-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q8K394-1",
            "url": "",
            "sequence": {
                "sequence": "MAECGRGAAGGALPTSPSPALGAKGALKAGAGEGGGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARTSPGRGPLGVALARTPSPAAGPVPRDSKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHITLCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDMMMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENSEAQKPRRSLEAIPEKASDENGD",
                "length": 1128,
                "header": "sp|Q8K394-1|PLCL2_MOUSE Isoform 1 of Inactive phospholipase C-like protein 2  OS=Mus musculus OX=10090 GN=Plcl2 PE=1 SV=2 CANONICAL=Q8K394-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 50994916,
                "end_pos": 50816636,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000043938",
                        "url": "https://www.ensembl.org/id/ENSMUST00000043938"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000046584",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000046584"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G74724QE",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 1064,
            "start_aa": "Asn",
            "end_pos": 1064,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn1064",
            "evidence": [
                {
                    "id": "2386",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2386"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 1114,
            "end_pos": 1114,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q8K394",
                    "url": "http://phospho.elm.eu.org/byAccession/Q8K394.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K394",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K394"
                },
                {
                    "database": "PubMed",
                    "id": "17114649",
                    "url": "https://glygen.org/publication/PubMed/17114649"
                }
            ],
            "site_lbl": "Ser1114"
        },
        {
            "start_pos": 16,
            "end_pos": 16,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394"
                }
            ],
            "site_lbl": "Ser16"
        },
        {
            "start_pos": 18,
            "end_pos": 18,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "phospho.ELM",
                    "id": "Q8K394",
                    "url": "http://phospho.elm.eu.org/byAccession/Q8K394.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K394",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K394"
                },
                {
                    "database": "PubMed",
                    "id": "15345747",
                    "url": "https://glygen.org/publication/PubMed/15345747"
                }
            ],
            "site_lbl": "Ser18"
        },
        {
            "start_pos": 585,
            "end_pos": 585,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K394",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K394"
                }
            ],
            "site_lbl": "Thr585"
        },
        {
            "start_pos": 85,
            "end_pos": 85,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K394",
                    "url": "https://www.uniprot.org/uniprot/Q8K394"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K394",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K394"
                }
            ],
            "site_lbl": "Thr85"
        }
    ],
    "glycation": [],
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        {
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        {
            "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.",
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        {
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            "id": "mmu:224860",
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                    {
                        "name": "gamma-aminobutyric acid signaling pathway",
                        "id": "GO:0007214",
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                        ],
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                    },
                    {
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                        "id": "GO:0002322",
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                        ],
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                    },
                    {
                        "name": "regulation of synaptic transmission, GABAergic",
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                    {
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                    {
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                    {
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