{
    "uniprot_canonical_ac": "Q8K2Z8-1",
    "uniprot_ac": "Q8K2Z8",
    "uniprot_id": "UB2Q2_MOUSE",
    "mass": {
        "chemical_mass": 42935.0,
        "monoisotopic_mass": 42935.0
    },
    "refseq": {
        "ac": "NP_001333586",
        "name": "ubiquitin-conjugating enzyme E2 Q2 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586"
    },
    "gene_names": [
        {
            "name": "Ube2q2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8K2Z8",
            "id": "Q8K2Z8"
        },
        {
            "name": "3010021M21Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586",
            "id": "NP_001333586"
        },
        {
            "name": "Ube2q2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586",
            "id": "NP_001333586"
        }
    ],
    "protein_names": [
        {
            "name": "Ubiquitin-conjugating enzyme E2 Q2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8K2Z8"
        },
        {
            "name": "2.3.2.23",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K2Z8"
        },
        {
            "name": "E2 ubiquitin-conjugating enzyme Q2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K2Z8"
        },
        {
            "name": "Ubiquitin carrier protein Q2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K2Z8"
        },
        {
            "name": "Ubiquitin-protein ligase Q2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K2Z8"
        },
        {
            "name": "ubiquitin-conjugating enzyme E2 Q2 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586",
            "id": "NP_001333586"
        },
        {
            "name": "ubiquitin-conjugating enzyme E2 Q2 isoform 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587",
            "id": "NP_001333587"
        },
        {
            "name": "ubiquitin-conjugating enzyme E2 Q2; ubiquitin-protein ligase Q2; ubiquitin carrier protein Q2; E2 ubiquitin-conjugating enzyme Q2; ubiquitin-conjugating enzyme E2Q (putative) 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587",
            "id": "NP_001333587"
        }
    ],
    "function": [
        {
            "annotation": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K2Z8",
                    "url": "https://www.uniprot.org/uniprot/Q8K2Z8#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8WVN8",
                    "url": "https://www.uniprot.org/uniprot/Q8WVN8#function"
                }
            ]
        },
        {
            "annotation": "[Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001333586",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586"
                },
                {
                    "database": "PubMed",
                    "id": "35199132",
                    "url": "https://glygen.org/publication/PubMed/35199132"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001333587",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K2Z8",
                    "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ube2q2",
            "url": "https://www.uniprot.org/uniprot/Q8K2Z8",
            "locus": {
                "chromosome": "9",
                "start_pos": 55114813,
                "end_pos": 55056138,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000032307",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000032307"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000032307",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032307",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00195",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00195",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "109161",
            "url": "https://www.ncbi.nlm.nih.gov/gene/109161",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000608",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016135",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:109161",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:109161",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2388672",
            "url": "http://www.informatics.jax.org/marker/MGI:2388672",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "FKXYVLG",
            "url": "https://omabrowser.org/oma/group/FKXYVLG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "37924at2759",
            "url": "http://www.orthodb.org/?query=37924at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00179",
            "url": "http://pfam.xfam.org/family/PF00179",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8K2Z8",
            "url": "http://purl.obolibrary.org/obo/PR_Q8K2Z8",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-8866652",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8866652",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001333587",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z647",
            "url": "https://www.uniprot.org/uniprot/D3Z647",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z647-1",
            "url": "https://www.uniprot.org/uniprot/D3Z647-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K2Z8",
            "url": "https://www.uniprot.org/uniprot/Q8K2Z8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K2Z8-1",
            "url": "https://www.uniprot.org/uniprot/Q8K2Z8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K2Z8-2",
            "url": "https://www.uniprot.org/uniprot/Q8K2Z8-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPPPPPGSSLSPPPPLTLHCNITESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNSSLRQQLKWLICDLCRLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDVYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG",
        "length": 378,
        "header": "sp|Q8K2Z8-1|UB2Q2_MOUSE Isoform 1 of Ubiquitin-conjugating enzyme E2 Q2  OS=Mus musculus OX=10090 GN=Ube2q2 PE=2 SV=2 CANONICAL=Q8K2Z8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3Z647-1",
            "url": "",
            "sequence": {
                "sequence": "MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPPPPPGSSLSPPPPLTLHCNITESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNSSNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDVYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG",
                "length": 343,
                "header": "tr|D3Z647-1|UB2Q2_MOUSE Computationally mapped isoform of Ubiquitin-conjugating enzyme E2 Q2  OS=Mus musculus OX=10090 GN=Ube2q2 PE=2 SV=1 CANONICAL=Q8K2Z8-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 55113272,
                "end_pos": 55056919,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000121677.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000121677.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000113336.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000113336.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8K2Z8-1",
            "url": "",
            "sequence": {
                "sequence": "MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPPPPPGSSLSPPPPLTLHCNITESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNSSLRQQLKWLICDLCRLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDVYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG",
                "length": 378,
                "header": "sp|Q8K2Z8-1|UB2Q2_MOUSE Isoform 1 of Ubiquitin-conjugating enzyme E2 Q2  OS=Mus musculus OX=10090 GN=Ube2q2 PE=2 SV=2 CANONICAL=Q8K2Z8-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 55113272,
                "end_pos": 55056919,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000059555",
                        "url": "https://www.ensembl.org/id/ENSMUST00000059555"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000059798",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000059798"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8K2Z8-2",
            "url": "",
            "sequence": {
                "sequence": "MLDQPLPTGQNGTTEEVTSEEEEEEEMAEDIEDLDHYEMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDVYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG",
                "length": 255,
                "header": "sp|Q8K2Z8-2|UB2Q2_MOUSE Isoform 2 of Ubiquitin-conjugating enzyme E2 Q2  OS=Mus musculus OX=10090 GN=Ube2q2 PE=2 SV=2 CANONICAL=Q8K2Z8-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 55113272,
                "end_pos": 55075562,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000122441",
                        "url": "https://www.ensembl.org/id/ENSMUST00000122441"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000112745",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000112745"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "[Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].",
            "journal": "Sheng li xue bao : [Acta physiologica Sinica]",
            "date": "2022",
            "authors": "Wang Z, Dong H, Li M, Liang XB",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001333586",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333586"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001333587",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333587"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35199132",
                    "url": "https://glygen.org/publication/PubMed/35199132"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:109161",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:109161",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-8866652",
            "name": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8866652",
            "resource": "Reactome",
            "description": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"
        },
        {
            "id": "R-MMU-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8WVN8-1",
            "protein_name": "Ubiquitin-conjugating enzyme E2 Q2",
            "gene_name": "UBE2Q2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPQQGSPHSLPPPLTLHCNITESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG",
                "length": 375
            },
            "evidence": [
                {
                    "id": "45232337",
                    "url": "http://www.informatics.jax.org/homology/45232337",
                    "database": "MGI"
                },
                {
                    "id": "Q8K2Z8",
                    "url": "https://omabrowser.org/oma/group/Q8K2Z8/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-protein transferase activity",
                        "id": "GO:0004842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin conjugating enzyme activity",
                        "id": "GO:0061631",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "protein K48-linked ubiquitination",
                        "id": "GO:0070936",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8K2Z8",
                                "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 134,
            "end_pos": 136,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 236,
            "end_pos": 238,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 274,
            "end_pos": 276,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 330,
            "end_pos": 332,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 62,
            "end_pos": 64,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 82,
            "end_pos": 84,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 95,
            "end_pos": 97,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 96,
            "end_pos": 98,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Auto-ubiquitinated in vitro.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K2Z8",
                    "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                },
                {
                    "database": "PubMed",
                    "id": "Q8WVN8",
                    "url": "https://glygen.org/publication/PubMed/Q8WVN8"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [
        {
            "id": "R-MMU-8852129",
            "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI2-1",
                "Q921J4-1",
                "P60605-1",
                "P62257-1",
                "Q02053-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q8K2Z8-1",
                "Q9D1C1-1",
                "P52483-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-8852129",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8852129"
                }
            ]
        },
        {
            "id": "R-MMU-983140",
            "name": "Transfer of Ub from E2 to substrate and release of E2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983140",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140"
                }
            ]
        },
        {
            "id": "R-MMU-983152",
            "name": "Transfer of ubiquitin from E1 to E2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q3UE37-1",
                "Q8VDW4-1",
                "P60605-1",
                "P62257-1",
                "Q6ZPJ3-1",
                "Q8C7R4-1",
                "Q02053-1",
                "P61089-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q8C878-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983152",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983152"
                }
            ]
        },
        {
            "id": "R-MMU-983156",
            "name": "Polyubiquitination of substrate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983156",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156"
                }
            ]
        },
        {
            "id": "R-MMU-983157",
            "name": "Interaction of E3 with substrate and E2-Ub complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983157",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A2A5Z6",
            "gene_name": "Smurf2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2A5Z6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A5Z6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2A5Z6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A5Z6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2A7Q9",
            "gene_name": "Rnf19b",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2A7Q9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A7Q9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2A7Q9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A7Q9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2AN08",
            "gene_name": "Ubr4",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2AN08",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2AN08"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2AN08",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2AN08"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D3YYI7",
            "gene_name": "Rnf217",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "D3YYI7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3YYI7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D3YYI7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3YYI7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9Q555",
            "gene_name": "Rnf213",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.4.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9Q735",
            "gene_name": "Ube4a",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "E9Q735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q735"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q735"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "F2Z461",
            "gene_name": "Herc6",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "F2Z461",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F2Z461"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "G5E870",
            "gene_name": "Trip12",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "G5E870",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G5E870"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "G5E870",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G5E870"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O08759",
            "gene_name": "Ube3a",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O08759",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08759"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O08759",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08759"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O55176",
            "gene_name": "Pja1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O55176",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O55176"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O55176",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O55176"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O70263",
            "gene_name": "Lnx1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O70263",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70263"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O70263",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70263"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O70481",
            "gene_name": "Ubr1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O70481",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70481"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O70481",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70481"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P46935",
            "gene_name": "Nedd4",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P46935",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46935"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P46935",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46935"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P50636",
            "gene_name": "Rnf19a",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "P50636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50636"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P50636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50636"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P52482",
            "gene_name": "Ube2e1",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P52483",
            "gene_name": "Ube2e3",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P52483",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52483"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P52483",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52483"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P60605",
            "gene_name": "Ube2g2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P60605",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P60605"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P60605",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P60605"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61079",
            "gene_name": "Ube2d3",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61080",
            "gene_name": "Ube2d1",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61082",
            "gene_name": "Ube2m",
            "activity": [
                {
                    "ec_number": "2.3.2.34",
                    "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61082",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61082"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.34",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61082",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61082"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61087",
            "gene_name": "Ube2k",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61087",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61087"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61087",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61087"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61089",
            "gene_name": "Ube2n",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61089",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61089"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61089",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61089"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61092",
            "gene_name": "Siah1a",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61092",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61092"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61092",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61092"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62254",
            "gene_name": "Ube2g1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62254",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62254"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62254",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62254"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62257",
            "gene_name": "Ube2h",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62838",
            "gene_name": "Ube2d2",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62878",
            "gene_name": "Rbx1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.32",
                    "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.32",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P63147",
            "gene_name": "Ube2b",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P63147",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63147"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P63147",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63147"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P68037",
            "gene_name": "Ube2l3",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P68037",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68037"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P68037",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68037"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P97868",
            "gene_name": "Rbbp6",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P97868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97868"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P97868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97868"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q02053",
            "gene_name": "Uba1",
            "activity": [
                {
                    "ec_number": "6.2.1.45",
                    "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q02053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02053"
                        }
                    ]
                },
                {
                    "ec_number": "6.2.1.45",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q02053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02053"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q05A36",
            "gene_name": "Mex3c",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q05A36",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05A36"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q05A36",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05A36"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q06986",
            "gene_name": "Siah2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q06986",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06986"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q06986",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06986"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q1PSW8",
            "gene_name": "Trim71",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q1PSW8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1PSW8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q1PSW8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1PSW8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q38HM4",
            "gene_name": "Trim63",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q38HM4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q38HM4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q38HM4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q38HM4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3TTA7",
            "gene_name": "Cblb",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3TTA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TTA7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3TTA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TTA7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3U0D9",
            "gene_name": "Hace1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3U0D9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U0D9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3U0D9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U0D9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3U487",
            "gene_name": "Hectd3",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3U487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U487"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3U487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U487"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3UE37",
            "gene_name": "Ube2z",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q3UE37",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UE37"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3UE37",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UE37"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3UIR3",
            "gene_name": "Dtx3l",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3UIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UIR3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3UIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UIR3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q4U2R1",
            "gene_name": "Herc2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q4U2R1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4U2R1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q4U2R1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4U2R1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5FWH2",
            "gene_name": "Unkl",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5FWH2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5FWH2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5NCC3",
            "gene_name": "Trim41",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q5NCC3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5NCC3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5NCC3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5NCC3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5XPI3",
            "gene_name": "Rnf123",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q5XPI3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XPI3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5XPI3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XPI3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62191",
            "gene_name": "Trim21",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q62191",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62191"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62191",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62191"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q69ZI1",
            "gene_name": "Sh3rf1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q69ZI1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZI1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q69ZI1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZI1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q69ZR2",
            "gene_name": "Hectd1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q69ZR2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZR2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q69ZR2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZR2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6A009",
            "gene_name": "Ltn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6A009",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6A009"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6A009",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6A009"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6I6G8",
            "gene_name": "Hecw2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6I6G8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6I6G8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6I6G8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6I6G8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6P073",
            "gene_name": "Ube2j2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q6P073",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6P073"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6P073",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6P073"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PAV2",
            "gene_name": "Herc4",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PAV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PAV2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PAV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PAV2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PCX9",
            "gene_name": "Trim37",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PCX9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCX9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PCX9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCX9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PDX6",
            "gene_name": "Rnf220",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PDX6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PDX6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PDX6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PDX6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6WKZ8",
            "gene_name": "Ubr2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6WKZ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6WKZ8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6WKZ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6WKZ8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZPJ3",
            "gene_name": "Ube2o",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6ZPJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZPJ3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZPJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZPJ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZWZ2",
            "gene_name": "Ube2r2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q6ZWZ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZWZ2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZWZ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZWZ2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q71FD5",
            "gene_name": "Znrf2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q71FD5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q71FD5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q71FD5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q71FD5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TMY8",
            "gene_name": "Huwe1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q7TMY8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TMY8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TMY8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TMY8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TPV2",
            "gene_name": "Dzip3",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q7TPV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TPV2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TPV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TPV2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TSS2",
            "gene_name": "Ube2q1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q7TSS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TSS2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TSS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TSS2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80TR8",
            "gene_name": "Dcaf1",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q80TR8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80TR8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80U04",
            "gene_name": "Pja2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80U04",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U04"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80U04",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U04"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80U95",
            "gene_name": "Ube3c",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80U95",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U95"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80U95",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U95"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80WG7",
            "gene_name": "Trim36",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80WG7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80WG7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80WG7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80WG7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80X56",
            "gene_name": "Trim69",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80X56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80X56"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80X56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80X56"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80ZI6",
            "gene_name": "Lrsam1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80ZI6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80ZI6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80ZI6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80ZI6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q810I2",
            "gene_name": "Trim50",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q810I2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q810I2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q810I2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q810I2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BH75",
            "gene_name": "Rnf41",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BH75",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BH75"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BH75",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BH75"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BKD6",
            "gene_name": "Rnf144b",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BKD6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BKD6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BKD6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BKD6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BM54",
            "gene_name": "Mylip",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BM54",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BM54"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BM54",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BM54"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BX13",
            "gene_name": "Ube3d",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BX13",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BX13"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BX13",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BX13"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BZZ3",
            "gene_name": "Wwp1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BZZ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BZZ3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BZZ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BZZ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C432",
            "gene_name": "Rnf182",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C432",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C432"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C432",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C432"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C7M3",
            "gene_name": "Trim9",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C7M3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C7M3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C7R4",
            "gene_name": "Uba6",
            "activity": [
                {
                    "ec_number": "6.2.1.45",
                    "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8C7R4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7R4"
                        }
                    ]
                },
                {
                    "ec_number": "6.2.1.45",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C7R4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7R4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C863",
            "gene_name": "Itch",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C863",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C863"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C863",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C863"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C878",
            "gene_name": "Uba3",
            "activity": [
                {
                    "ec_number": "6.2.1.64",
                    "activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8C878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C878"
                        }
                    ]
                },
                {
                    "ec_number": "6.2.1.64",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C878"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CCJ3",
            "gene_name": "Ufl1",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CCJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CCJ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CDU6",
            "gene_name": "Hectd2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CDU6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CDU6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CDU6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CDU6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CFI0",
            "gene_name": "Nedd4l",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.36",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.36",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CFI2",
            "gene_name": "Cdc34",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CH72",
            "gene_name": "Trim32",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CH72",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CH72"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CH72",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CH72"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CHG5",
            "gene_name": "Arel1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CHG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CHG5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CHG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CHG5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8K2Z8",
            "gene_name": "Ube2q2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8K2Z8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8K2Z8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8R516",
            "gene_name": "Mib2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8R516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R516"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8R516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R516"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VDW4",
            "gene_name": "Ube2w",
            "activity": [
                {
                    "ec_number": "2.3.2.25",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VEM1",
            "gene_name": "Rnf130",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8VEM1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VEM1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VEM1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VEM1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VIG6",
            "gene_name": "Traip",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8VIG6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VIG6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VIG6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VIG6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91V17",
            "gene_name": "Znrf1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q91V17",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91V17"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91V17",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91V17"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91W82",
            "gene_name": "Ube2e2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q91W82",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91W82"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91W82",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91W82"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91YL2",
            "gene_name": "Rnf126",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q91YL2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91YL2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91YL2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91YL2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q921J4",
            "gene_name": "Ube2s",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q921J4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q921J4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q921J4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q921J4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q922B6",
            "gene_name": "Traf7",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q922B6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q922B6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q922B6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q922B6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q925F4",
            "gene_name": "Ubox5",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q925F4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q925F4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q925F4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q925F4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99KR6",
            "gene_name": "Rnf34",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99KR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99KR6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99KR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99KR6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99ML9",
            "gene_name": "Rnf111",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99ML9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99ML9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99ML9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99ML9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99PQ2",
            "gene_name": "Trim11",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99PQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99PQ2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99PQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99PQ2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CQE0",
            "gene_name": "Rnf138",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CQE0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CQE0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CQE0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CQE0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CR50",
            "gene_name": "Rchy1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CR50",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CR50"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CR50",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CR50"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CUN6",
            "gene_name": "Smurf1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CUN6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CUN6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CUN6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CUN6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CY34",
            "gene_name": "Ube2f",
            "activity": [
                {
                    "ec_number": "2.3.2.34",
                    "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9CY34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CY34"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.34",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CY34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CY34"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D074",
            "gene_name": "Mgrn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D074",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D074"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D074",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D074"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D0C1",
            "gene_name": "Rnf115",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D0C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D0C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D0C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D0C1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D1C1",
            "gene_name": "Ube2c",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9DBK7",
            "gene_name": "Uba7",
            "activity": [
                {
                    "ec_number": "6.2.1.45",
                    "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9DBK7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBK7"
                        }
                    ]
                },
                {
                    "ec_number": "6.2.1.45",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9DBK7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBK7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9DBU5",
            "gene_name": "Rnf6",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9DBU5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBU5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9DBU5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBU5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ES34",
            "gene_name": "Ube3b",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ES34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ES34"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ES34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ES34"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ESN2",
            "gene_name": "Trim39",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ESN2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ESN2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ESN2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ESN2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ET26",
            "gene_name": "Rnf114",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ET26",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ET26"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ET26",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ET26"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JI90",
            "gene_name": "Rnf14",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9JI90",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JI90"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JI90",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JI90"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JIY2",
            "gene_name": "Cbll1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9JIY2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JIY2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JIY2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JIY2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JJZ4",
            "gene_name": "Ube2j1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9JJZ4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JJZ4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JJZ4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JJZ4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QXP6",
            "gene_name": "Mkrn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QXP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QXP6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QXP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QXP6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZR0",
            "gene_name": "Rnf25",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QZR0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZR0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZS2",
            "gene_name": "Rnf4",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QZS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZS2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZS2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZU9",
            "gene_name": "Ube2l6",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9QZU9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZU9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZU9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZU9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9WTV7",
            "gene_name": "Rlim",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9WTV7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WTV7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9WTV7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WTV7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9WUB0",
            "gene_name": "Rbck1",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9WUB0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUB0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9WUB0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUB0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9WUD1",
            "gene_name": "Stub1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9WUD1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUD1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9WUD1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUD1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9WVS6",
            "gene_name": "Prkn",
            "activity": [
                {
                    "ec_number": "6.3.2.19",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9WVS6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WVS6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9WVS6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WVS6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9WVS6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WVS6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9Z1K6",
            "gene_name": "Arih2",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9Z1K6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z1K6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9Z1K6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z1K6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9Z255",
            "gene_name": "Ube2a",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9Z255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z255"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9Z255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z255"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}