{ "uniprot_canonical_ac": "Q8K2W3-1", "uniprot_ac": "Q8K2W3", "uniprot_id": "TXD11_MOUSE", "mass": { "chemical_mass": 105959.0, "monoisotopic_mass": 105959.0 }, "refseq": { "ac": "NP_083858", "name": "thioredoxin domain-containing protein 11 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858" }, "gene_names": [ { "name": "Txndc11", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8K2W3", "id": "Q8K2W3" }, { "name": "2810408E11Rik; EFP1; Txdc11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "id": "NP_083858" }, { "name": "Txndc11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "id": "NP_083858" } ], "protein_names": [ { "name": "Thioredoxin domain-containing protein 11", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8K2W3" }, { "name": "thioredoxin domain-containing protein 11 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "id": "NP_083858" }, { "name": "thioredoxin domain-containing protein 11; EF-hand binding protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "id": "NP_083858" } ], "function": [ { "annotation": "May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8K2W3", "url": "https://www.uniprot.org/uniprot/Q8K2W3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K2W3", "url": "https://www.uniprot.org/uniprot/Q8K2W3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Txndc11", "url": "https://www.uniprot.org/uniprot/Q8K2W3", "locus": { "chromosome": "16", "start_pos": 10892775, "end_pos": 10952514, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022498", "url": "https://www.ensembl.org/id/ENSMUSG00000022498" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022498", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022498", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02981", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02981", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03006", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03006", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "106200", "url": "https://www.ncbi.nlm.nih.gov/gene/106200", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0004449", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0004449", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0006779", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006779", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:106200", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:106200", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1923620", "url": "http://www.informatics.jax.org/marker/MGI:1923620", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8K2W3", "url": "https://oglcnac.org/atlas/detail/Q8K2W3", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q8K2W3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8K2W3", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ANDLPWE", "url": "https://omabrowser.org/oma/group/ANDLPWE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4541374at2759", "url": "http://www.orthodb.org/?query=4541374at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46497", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46497", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46497:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46497:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "http://pfam.xfam.org/family/PF00085", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8K2W3", "url": "http://purl.obolibrary.org/obo/PR_Q8K2W3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_083858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D3YU69", "url": "https://www.uniprot.org/uniprot/D3YU69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YU69-1", "url": "https://www.uniprot.org/uniprot/D3YU69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RDR0", "url": "https://www.uniprot.org/uniprot/D6RDR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RDR0-1", "url": "https://www.uniprot.org/uniprot/D6RDR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6REU4", "url": "https://www.uniprot.org/uniprot/D6REU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6REU4-1", "url": "https://www.uniprot.org/uniprot/D6REU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RHA0", "url": "https://www.uniprot.org/uniprot/D6RHA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RHA0-1", "url": "https://www.uniprot.org/uniprot/D6RHA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TWZ5", "url": "https://www.uniprot.org/uniprot/Q3TWZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TWZ5-1", "url": "https://www.uniprot.org/uniprot/Q3TWZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K2W3", "url": "https://www.uniprot.org/uniprot/Q8K2W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K2W3-1", "url": "https://www.uniprot.org/uniprot/Q8K2W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K2W3-2", "url": "https://www.uniprot.org/uniprot/Q8K2W3-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITDKHLARLVSLVHSGSVYLHRHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVALEYNNCHGDQVVERLLQHLRRVEAPVLQSLAPELPASLPDTQLMAASPCCNTVVLPQGPALSRTHNVCELCVNQTVGGTRPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVVSGSIECSNFLTSYSPFSYYTACCRTISRGMASFTGSEQNVLTAPAIEFSSLEKSCEATAPSSIPHIEENRYRFPQVGLTSTAFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATIVDVKEESHYILDPKQALMKFTLESFIQNFSVLYSPLKRHLTGSDSAQFPTQHLITEVTTDTFWEVTLRKQDVLLLYYTQWCGFCPSLNHIFIQLARLLPEDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPGDLPITLPNLLRFILHHSDAASAPQDPGISPPTQDCVQSKAVLQREHISHVENAMQKLRSEMSSLRRTQEQVEGRLLSARRDGHRLLRRQRTLEQQHRLLRRHSQKLQALYLKKARELQELARASGTPLPEHTWLKILVATMERELEGQGGAKEPAPLGKARPNHSKSMGTTQLPGDTPPPSTTSSTLASETKHENRTD", "length": 948, "header": "sp|Q8K2W3-1|TXD11_MOUSE Isoform 1 of Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "isoforms": [ { "isoform_ac": "D3YU69-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEVPVFLIACSQGFSLARTGLFVLSEF", "length": 254, "header": "tr|D3YU69-1|TXD11_MOUSE Computationally mapped isoform of Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10934584, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000118679.2", "url": "https://www.ensembl.org/id/ENSMUST00000118679.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000112601.2", "url": "https://www.ensembl.org/id/ENSMUSP00000112601.2" } ] } }, { "isoform_ac": "D6RDR0-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCRCCLWQ", "length": 86, "header": "tr|D6RDR0-1|D6RDR0_MOUSE Computationally mapped isoform of Thioredoxin domain containing 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10940616, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000155221.8", "url": "https://www.ensembl.org/id/ENSMUST00000155221.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114777.2", "url": "https://www.ensembl.org/id/ENSMUSP00000114777.2" } ] } }, { "isoform_ac": "D6REU4-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCRVEQKT", "length": 86, "header": "tr|D6REU4-1|D6REU4_MOUSE Computationally mapped isoform of Thioredoxin domain containing 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10946554, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000147884.2", "url": "https://www.ensembl.org/id/ENSMUST00000147884.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117426.2", "url": "https://www.ensembl.org/id/ENSMUSP00000117426.2" } ] } }, { "isoform_ac": "D6RHA0-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKGLPQGSHELHS", "length": 271, "header": "tr|D6RHA0-1|D6RHA0_MOUSE Computationally mapped isoform of Thioredoxin domain containing 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10909619, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000145225.8", "url": "https://www.ensembl.org/id/ENSMUST00000145225.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116563.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116563.2" } ] } }, { "isoform_ac": "Q3TWZ5-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITDKHLARLVSLVHSGSVYLHRHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVALEYNNCHGDQVVERLLQHLRRVEAPVLQSLAPELPASLPDTQLMAASPCCNTVVLPQGPALSRTHNVCELCVNQTVGGTRPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVVSGSIECSNFLTSYSPFSYYTACCRTISRGMASFTGSEQNVLTAPAIEFSSLEKSCEATAPSSIPHIEENRYRFPQVGLTSTAFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATIVDVKEESHYILDPKQALMKFTLGTVGGLPSSA", "length": 639, "header": "tr|Q3TWZ5-1|TXD11_MOUSE Computationally mapped isoform of Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10905612, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000118362.8", "url": "https://www.ensembl.org/id/ENSMUST00000118362.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000113432.2", "url": "https://www.ensembl.org/id/ENSMUSP00000113432.2" } ] } }, { "isoform_ac": "Q8K2W3-1", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITDKHLARLVSLVHSGSVYLHRHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVALEYNNCHGDQVVERLLQHLRRVEAPVLQSLAPELPASLPDTQLMAASPCCNTVVLPQGPALSRTHNVCELCVNQTVGGTRPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVVSGSIECSNFLTSYSPFSYYTACCRTISRGMASFTGSEQNVLTAPAIEFSSLEKSCEATAPSSIPHIEENRYRFPQVGLTSTAFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATIVDVKEESHYILDPKQALMKFTLESFIQNFSVLYSPLKRHLTGSDSAQFPTQHLITEVTTDTFWEVTLRKQDVLLLYYTQWCGFCPSLNHIFIQLARLLPEDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPGDLPITLPNLLRFILHHSDAASAPQDPGISPPTQDCVQSKAVLQREHISHVENAMQKLRSEMSSLRRTQEQVEGRLLSARRDGHRLLRRQRTLEQQHRLLRRHSQKLQALYLKKARELQELARASGTPLPEHTWLKILVATMERELEGQGGAKEPAPLGKARPNHSKSMGTTQLPGDTPPPSTTSSTLASETKHENRTD", "length": 948, "header": "sp|Q8K2W3-1|TXD11_MOUSE Isoform 1 of Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": { "chromosome": "16", "start_pos": 10952373, "end_pos": 10892885, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000038424", "url": "https://www.ensembl.org/id/ENSMUST00000038424" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000041113", "url": "https://www.ensembl.org/id/ENSMUSP00000041113" } ] } }, { "isoform_ac": "Q8K2W3-2", "url": "", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSSYEKQQATQY", "length": 236, "header": "sp|Q8K2W3-2|TXD11_MOUSE Isoform 2 of Thioredoxin domain-containing protein 11 OS=Mus musculus OX=10090 GN=Txndc11 PE=1 SV=1 CANONICAL=Q8K2W3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 52, "start_aa": "Ser", "end_pos": 52, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser52", "evidence": [ { "id": "Q8K2W3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8K2W3" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "Q8K2W3", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8K2W3" } ] } ], "phosphorylation": [ { "start_pos": 798, "end_pos": 798, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8K2W3", "url": "https://www.uniprot.org/uniprot/Q8K2W3" } ], "site_lbl": "Ser798" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8K2W3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8K2W3" }, { "database": "O-GlcNAc Atlas", "id": "Q8K2W3", "url": "https://oglcnac.org/atlas/detail/Q8K2W3" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] } ], "pathway": [ { "id": "mmu:106200", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:106200", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RYB1-1", "protein_name": "Thioredoxin domain containing 11", "gene_name": "Txndc11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASSEGRIRRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAVNCWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVALEYSNCRGDQVVERLLQHLRRAEAPVFQSLAPELQAPLPDAQLMAASPCCNTVVLPQGPALSRTHNVCELCVNQSVGTRPSSVSVPQCSFFEMAAALDSFYLKEQTFYRVVSGSIECSNFLTSYSPFSFYTACCRTISRGTASFSGSAQDVFTAPAIEFSALEKSCEATAPSSIPHIEENRYRFPEVGLSSTAFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATIVDVKEESHYILDPKQALVKLTLESFIQNFSVLYSPLKRHLTGSDSAQFPTQHLITEVTTDTFWEVTLRKQDVLLLYYTQWCGFCPSLNHIFIQLARLLPEDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPGDLPITLPNLLRFILHHSDPASAPQGLTTSPPTQECAQSAAVLQREHISHVENAMQELRSEMSSLRRTQEQVEGRLFSARRDGHRLLRRQRTLEQQHRLLRRHSQKLQALYLKKARELQELASASETPLPEHTWLKVLVATMERELERQGDAKEPTPLGKAHPNHSKPMGATQLPGDTPPPSSASSTLASERKHENRTD", "length": 947 }, "evidence": [ { "id": "45238958", "url": "http://www.informatics.jax.org/homology/45238958", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PKC3-1", "protein_name": "Thioredoxin domain-containing protein 11", "gene_name": "TXNDC11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKALESTSSPRALVSFTGEWHLETKIYVLDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRPHGGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGMKPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTACCRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTSTNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDPKQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRGHISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHSEQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESLAAQREVHPKQPEPSATPQLPGSSPPPANVSATLVSERNKENRTD", "length": 985 }, "evidence": [ { "id": "45238958", "url": "http://www.informatics.jax.org/homology/45238958", "database": "MGI" }, { "id": "Q8K2W3", "url": "https://omabrowser.org/oma/group/Q8K2W3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q8K2W3", "url": "https://www.uniprot.org/uniprot/Q8K2W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 913, "end_pos": 915, "annotation": "n_glycosylation_sequon" }, { "start_pos": 945, "end_pos": 947, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }