{
    "uniprot_canonical_ac": "Q8K0Q5-1",
    "uniprot_ac": "Q8K0Q5",
    "uniprot_id": "RHG18_MOUSE",
    "mass": {
        "chemical_mass": 74930.0,
        "monoisotopic_mass": 74930.0
    },
    "refseq": {
        "ac": "NP_789807",
        "name": "rho GTPase-activating protein 18",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
    },
    "gene_names": [
        {
            "name": "Arhgap18",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8K0Q5",
            "id": "Q8K0Q5"
        },
        {
            "name": "4833419J07Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807",
            "id": "NP_789807"
        },
        {
            "name": "Arhgap18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807",
            "id": "NP_789807"
        }
    ],
    "protein_names": [
        {
            "name": "Rho GTPase-activating protein 18",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8K0Q5"
        },
        {
            "name": "Rho-type GTPase-activating protein 18",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8K0Q5"
        },
        {
            "name": "rho GTPase-activating protein 18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807",
            "id": "NP_789807"
        },
        {
            "name": "rho-type GTPase-activating protein 18",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807",
            "id": "NP_789807"
        }
    ],
    "function": [
        {
            "annotation": "ARHGAP 18 was identified as a novel protective gene against thoracic aortic aneurysm formation.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_789807",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
                },
                {
                    "database": "PubMed",
                    "id": "28701309",
                    "url": "https://glygen.org/publication/PubMed/28701309"
                }
            ]
        },
        {
            "annotation": "In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_789807",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
                },
                {
                    "database": "PubMed",
                    "id": "28251925",
                    "url": "https://glygen.org/publication/PubMed/28251925"
                }
            ]
        },
        {
            "annotation": "Mechanical activation of RhoA in mesenchymal progenitors is dependent on LARG, while ARHGAP18 limits RhoA delineated cytoskeletal structure in static cultures",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_789807",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
                },
                {
                    "database": "PubMed",
                    "id": "29208526",
                    "url": "https://glygen.org/publication/PubMed/29208526"
                }
            ]
        },
        {
            "annotation": "Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_789807",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
                },
                {
                    "database": "PubMed",
                    "id": "25425145",
                    "url": "https://glygen.org/publication/PubMed/25425145"
                }
            ]
        },
        {
            "annotation": "Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8N392",
                    "url": "https://www.uniprot.org/uniprot/Q8N392#function"
                }
            ]
        },
        {
            "annotation": "YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_789807",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807"
                },
                {
                    "database": "PubMed",
                    "id": "32013974",
                    "url": "https://glygen.org/publication/PubMed/32013974"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:5419",
            "recommended_name": {
                "id": "DOID:5419",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:5419",
                "name": "schizophrenia",
                "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness."
            },
            "synonyms": [
                {
                    "id": "DOID:5419",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5419",
                    "name": "schizophrenia-1",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia",
                    "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality."
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia 12",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia (disease)",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia-1",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "SCZD",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizoaffective disorder",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia with or without an affective disorder",
                    "description": ""
                },
                {
                    "id": "MONDO:0005090",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090",
                    "name": "schizophrenia, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MIM:181500",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/181500",
                    "name": "Schizophrenia",
                    "description": "Schizophrenia"
                }
            ],
            "evidence": [
                {
                    "id": "5419",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:5419"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Arhgap18",
            "url": "https://www.uniprot.org/uniprot/Q8K0Q5",
            "locus": {
                "chromosome": "10",
                "start_pos": 26794644,
                "end_pos": 26629417,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000039031",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000039031"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000039031",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039031",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04391",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04391",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "73910",
            "url": "https://www.ncbi.nlm.nih.gov/gene/73910",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8K0Q5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8K0Q5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000198",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008936",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:73910",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:73910",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1921160",
            "url": "http://www.informatics.jax.org/marker/MGI:1921160",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "QHNMESQ",
            "url": "https://omabrowser.org/oma/group/QHNMESQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "11483at2759",
            "url": "http://www.orthodb.org/?query=11483at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14963",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14963",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14963:SF6",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14963:SF6",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00620",
            "url": "http://pfam.xfam.org/family/PF00620",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8K0Q5",
            "url": "http://purl.obolibrary.org/obo/PR_Q8K0Q5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-8980692",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-9013106",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_789807",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789807",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BJL1",
            "url": "https://www.uniprot.org/uniprot/H3BJL1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BJL1-1",
            "url": "https://www.uniprot.org/uniprot/H3BJL1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BLG9",
            "url": "https://www.uniprot.org/uniprot/H3BLG9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "H3BLG9-1",
            "url": "https://www.uniprot.org/uniprot/H3BLG9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K0Q5",
            "url": "https://www.uniprot.org/uniprot/Q8K0Q5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8K0Q5-1",
            "url": "https://www.uniprot.org/uniprot/Q8K0Q5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKSKPV",
        "length": 663,
        "header": "sp|Q8K0Q5-1|RHG18_MOUSE Isoform 1 of Rho GTPase-activating protein 18  OS=Mus musculus OX=10090 GN=Arhgap18 PE=1 SV=1 CANONICAL=Q8K0Q5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "H3BJL1-1",
            "url": "",
            "sequence": {
                "sequence": "MEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLP",
                "length": 190,
                "header": "tr|H3BJL1-1|H3BJL1_MOUSE Computationally mapped isoform of Rho GTPase activating protein 18  OS=Mus musculus OX=10090 GN=Arhgap18 PE=1 SV=1 CANONICAL=Q8K0Q5-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 26736728,
                "end_pos": 26722031,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000176060.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000176060.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000135030.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135030.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "H3BLG9-1",
            "url": "",
            "sequence": {
                "sequence": "MEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAA",
                "length": 73,
                "header": "tr|H3BLG9-1|H3BLG9_MOUSE Computationally mapped isoform of Rho GTPase activating protein 18  OS=Mus musculus OX=10090 GN=Arhgap18 PE=1 SV=8 CANONICAL=Q8K0Q5-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 26725995,
                "end_pos": 26722031,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000135866.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000135866.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000135783.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135783.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8K0Q5-1",
            "url": "",
            "sequence": {
                "sequence": "MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKSKPV",
                "length": 663,
                "header": "sp|Q8K0Q5-1|RHG18_MOUSE Isoform 1 of Rho GTPase-activating protein 18  OS=Mus musculus OX=10090 GN=Arhgap18 PE=1 SV=1 CANONICAL=Q8K0Q5-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 26793089,
                "end_pos": 26648580,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000039557",
                        "url": "https://www.ensembl.org/id/ENSMUST00000039557"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000044834",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000044834"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 156,
            "end_pos": 156,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                }
            ],
            "site_lbl": "Thr156"
        },
        {
            "start_pos": 260,
            "end_pos": 260,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K0Q5",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8K0Q5"
                }
            ],
            "site_lbl": "Ser260"
        },
        {
            "start_pos": 263,
            "end_pos": 263,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                }
            ],
            "site_lbl": "Ser263"
        },
        {
            "start_pos": 610,
            "end_pos": 610,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                }
            ],
            "site_lbl": "Ser610"
        },
        {
            "start_pos": 65,
            "end_pos": 65,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8K0Q5",
                    "url": "https://www.uniprot.org/uniprot/Q8K0Q5"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8K0Q5",
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            ]
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            "title": "ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.",
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            ]
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        {
            "title": "ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.",
            "journal": "Small GTPases",
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            "authors": "Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR",
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                    "database": "RefSeq",
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            ]
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        {
            "title": "The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.",
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        {
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                ]
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            {
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