{ "uniprot_canonical_ac": "Q8K0L3-1", "uniprot_ac": "Q8K0L3", "uniprot_id": "ACSM2_MOUSE", "mass": { "chemical_mass": 64269.0, "monoisotopic_mass": 64269.0 }, "refseq": { "ac": "NP_001171448", "name": "acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448" }, "gene_names": [ { "name": "Acsm2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8K0L3", "id": "Q8K0L3" }, { "name": "Acsm2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448", "id": "NP_001171448" } ], "protein_names": [ { "name": "Acyl-coenzyme A synthetase ACSM2, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8K0L3" }, { "name": "6.2.1.25", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "6.2.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "Acyl-CoA synthetase medium-chain family member 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "Benzoate--CoA ligase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "Butyrate--CoA ligase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "Butyryl-coenzyme A synthetase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "Middle-chain acyl-CoA synthetase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8K0L3" }, { "name": "acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448", "id": "NP_001171448" }, { "name": "acyl-coenzyme A synthetase ACSM2, mitochondrial; butyrate--CoA ligase 2; middle-chain acyl-CoA synthetase 2; butyryl-coenzyme A synthetase 2; benzoate--CoA ligase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448", "id": "NP_001171448" } ], "function": [ { "annotation": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3#function" }, { "database": "UniProtKB", "id": "Q68CK6", "url": "https://www.uniprot.org/uniprot/Q68CK6#function" } ] }, { "annotation": "Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001171448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448" }, { "database": "PubMed", "id": "32830538", "url": "https://glygen.org/publication/PubMed/32830538" } ] }, { "annotation": "Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~50%.", "evidence": [ { "database": "RefSeq", "id": "NP_001171448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448" }, { "database": "PubMed", "id": "19372376", "url": "https://glygen.org/publication/PubMed/19372376" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Acsm2", "url": "https://www.uniprot.org/uniprot/Q8K0L3", "locus": { "chromosome": "7", "start_pos": 119199913, "end_pos": 119153563, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000030945", "url": "https://www.ensembl.org/id/ENSMUSG00000030945" } ] } } ], "crossref": [ { "id": "ENSMUSG00000030945", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030945", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "233799", "url": "https://www.ncbi.nlm.nih.gov/gene/233799", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:233799", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:233799", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2385289", "url": "http://www.informatics.jax.org/marker/MGI:2385289", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RVAAYKY", "url": "https://omabrowser.org/oma/group/RVAAYKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5474118at2759", "url": "http://www.orthodb.org/?query=5474118at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "http://pfam.xfam.org/family/PF00501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13193", "url": "http://pfam.xfam.org/family/PF13193", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8K0L3", "url": "http://purl.obolibrary.org/obo/PR_Q8K0L3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-177128", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177128", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-177135", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177135", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-177162", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177162", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9749641", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001171448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10132", "url": "https://www.rhea-db.org/rhea/10132", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33627", "url": "https://www.rhea-db.org/rhea/33627", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33631", "url": "https://www.rhea-db.org/rhea/33631", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43740", "url": "https://www.rhea-db.org/rhea/43740", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46172", "url": "https://www.rhea-db.org/rhea/46172", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48340", "url": "https://www.rhea-db.org/rhea/48340", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140LHG2", "url": "https://www.uniprot.org/uniprot/A0A140LHG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LHG2-1", "url": "https://www.uniprot.org/uniprot/A0A140LHG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LIB0", "url": "https://www.uniprot.org/uniprot/A0A140LIB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LIB0-1", "url": "https://www.uniprot.org/uniprot/A0A140LIB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YXB1", "url": "https://www.uniprot.org/uniprot/D3YXB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YXB1-1", "url": "https://www.uniprot.org/uniprot/D3YXB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6V4U2", "url": "https://www.uniprot.org/uniprot/F6V4U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6V4U2-1", "url": "https://www.uniprot.org/uniprot/F6V4U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6XLJ8", "url": "https://www.uniprot.org/uniprot/F6XLJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6XLJ8-1", "url": "https://www.uniprot.org/uniprot/F6XLJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K0L3-1", "url": "https://www.uniprot.org/uniprot/Q8K0L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K0L3-2", "url": "https://www.uniprot.org/uniprot/Q8K0L3-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8K0L3-3", "url": "https://www.uniprot.org/uniprot/Q8K0L3-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 575, "header": "sp|Q8K0L3-1|ACSM2_MOUSE Isoform 1 of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "isoforms": [ { "isoform_ac": "A0A140LHG2-1", "url": "", "sequence": { "sequence": "XGPSEVENALMEHPAVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 86, "header": "tr|A0A140LHG2-1|ACSM2_MOUSE Computationally mapped isoform of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119195230, "end_pos": 119190494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000207977.2", "url": "https://www.ensembl.org/id/ENSMUST00000207977.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146400.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146400.2" } ] } }, { "isoform_ac": "A0A140LIB0-1", "url": "", "sequence": { "sequence": "YLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRPAH", "length": 83, "header": "tr|A0A140LIB0-1|ACSM2_MOUSE Computationally mapped isoform of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119191507, "end_pos": 119181974, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208019.2", "url": "https://www.ensembl.org/id/ENSMUST00000208019.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146746.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146746.2" } ] } }, { "isoform_ac": "D3YXB1-1", "url": "", "sequence": { "sequence": "MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLSTSDIIWTISDTAWIMNI", "length": 149, "header": "tr|D3YXB1-1|ACSM2_MOUSE Computationally mapped isoform of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119177371, "end_pos": 119162728, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000130583.2", "url": "https://www.ensembl.org/id/ENSMUST00000130583.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115048.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115048.2" } ] } }, { "isoform_ac": "F6V4U2-1", "url": "", "sequence": { "sequence": "XFFSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 216, "header": "tr|F6V4U2-1|ACSM2_MOUSE Computationally mapped isoform of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=2 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119195230, "end_pos": 119179826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000129766.9", "url": "https://www.ensembl.org/id/ENSMUST00000129766.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118174.3", "url": "https://www.ensembl.org/id/ENSMUSP00000118174.3" } ] } }, { "isoform_ac": "F6XLJ8-1", "url": "", "sequence": { "sequence": "PGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVRLSPPMPHVLSEEHLLYFYSLA", "length": 163, "header": "tr|F6XLJ8-1|ACSM2_MOUSE Computationally mapped isoform of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119191634, "end_pos": 119188074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000123638.2", "url": "https://www.ensembl.org/id/ENSMUST00000123638.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118276.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118276.2" } ] } }, { "isoform_ac": "Q8K0L3-1", "url": "", "sequence": { "sequence": "MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 575, "header": "sp|Q8K0L3-1|ACSM2_MOUSE Isoform 1 of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119195229, "end_pos": 119162728, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000167935", "url": "https://www.ensembl.org/id/ENSMUST00000167935" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000126670", "url": "https://www.ensembl.org/id/ENSMUSP00000126670" } ] } }, { "isoform_ac": "Q8K0L3-2", "url": "", "sequence": { "sequence": "MTTGSLDLPFVGSHRWIKWTTASLTMHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 600, "header": "sp|Q8K0L3-2|ACSM2_MOUSE Isoform 2 of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119195229, "end_pos": 119153692, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000098084", "url": "https://www.ensembl.org/id/ENSMUST00000098084" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000095690", "url": "https://www.ensembl.org/id/ENSMUSP00000095690" } ] } }, { "isoform_ac": "Q8K0L3-3", "url": "", "sequence": { "sequence": "MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGAYFCRYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA", "length": 580, "header": "sp|Q8K0L3-3|ACSM2_MOUSE Isoform 3 of Acyl-coenzyme A synthetase ACSM2, mitochondrial OS=Mus musculus OX=10090 GN=Acsm2 PE=1 SV=1 CANONICAL=Q8K0L3-1" }, "locus": { "chromosome": "7", "start_pos": 119195229, "end_pos": 119162728, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000084647", "url": "https://www.ensembl.org/id/ENSMUST00000084647" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000081697", "url": "https://www.ensembl.org/id/ENSMUSP00000081697" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Calvo SE, Pagliarini DJ, Mootha VK", "evidence": [ { "database": "RefSeq", "id": "NP_001171448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448" } ], "reference": [ { "type": "PubMed", "id": "19372376", "url": "https://glygen.org/publication/PubMed/19372376" } ] }, { "title": "Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.", "journal": "American journal of physiology. Renal physiology", "date": "2020", "authors": "Watanabe H, Paxton RL, Tolerico MR, Nagalakshmi VK, Tanaka S, Okusa MD, Goto S, Narita I, Watanabe S, Sequeira-Lomicronpez MLS, Gomez RA", "evidence": [ { "database": "RefSeq", "id": "NP_001171448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171448" } ], "reference": [ { "type": "PubMed", "id": "32830538", "url": "https://glygen.org/publication/PubMed/32830538" } ] } ], "pathway": [ { "id": "mmu:233799", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:233799", "resource": "KEGG Pathway" }, { "id": "R-MMU-177128", "name": "Conjugation of salicylate with glycine", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177128", "resource": "Reactome", "description": "Conjugation of salicylate with glycine" }, { "id": "R-MMU-177135", "name": "Conjugation of benzoate with glycine", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177135", "resource": "Reactome", "description": "Conjugation of benzoate with glycine" }, { "id": "R-MMU-177162", "name": "Conjugation of phenylacetate with glutamine", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177162", "resource": "Reactome", "description": "Conjugation of phenylacetate with glutamine" }, { "id": "R-MMU-9749641", "name": "Aspirin ADME", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9749641", "resource": "Reactome", "description": "Aspirin ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "O70490-1", "protein_name": "Acyl-coenzyme A synthetase ACSM2, mitochondrial", "gene_name": "Acsm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHWLWKIPRLCTFWGTEMFHRTFHMNIKKLMPIQWGHQEVPAKFNFASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISKQTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARAIVAGDEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQCVETVSQESAAIYFTSGTSGPPKMAEHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLEIREIYGQTETGITCRVSRTMKVKPGYLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWLLGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG", "length": 572 }, "evidence": [ { "id": "45240263", "url": "http://www.informatics.jax.org/homology/45240263", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08AH3-1", "protein_name": "Acyl-coenzyme A synthetase ACSM2A, mitochondrial", "gene_name": "ACSM2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWKMSGKARAQ", "length": 577 }, "evidence": [ { "id": "45240263", "url": "http://www.informatics.jax.org/homology/45240263", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q68CK6-1", "protein_name": "Acyl-coenzyme A synthetase ACSM2B, mitochondrial", "gene_name": "ACSM2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ", "length": 577 }, "evidence": [ { "id": "45240263", "url": "http://www.informatics.jax.org/homology/45240263", "database": "MGI" }, { "id": "Q8K0L3", "url": "https://omabrowser.org/oma/group/Q8K0L3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "butyrate-CoA ligase activity", "id": "GO:0047760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047760", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "decanoate-CoA ligase activity", "id": "GO:0102391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102391", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "fatty-acyl-CoA synthase activity", "id": "GO:0004321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004321", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "fatty acid ligase activity", "id": "GO:0015645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015645", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "benzoate-CoA ligase activity", "id": "GO:0018858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018858", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "acyl-CoA metabolic process", "id": "GO:0006637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006637", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "Q8K0L3", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10132", "name": "", "equation": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q08AH1-1", "Q08AH3-1", "Q68CK6-1", "Q91VA0-1", "Q8K0L3-1" ], "evidence": [ { "id": "10132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10132" } ] }, { "id": "33627", "name": "", "equation": "ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q7TN78-1", "P0C7M7-1", "Q08AH1-1", "Q08AH3-1", "Q68CK6-1", "Q91VA0-1", "Q8K0L3-1", "Q80W40-1", "P39518-1" ], "evidence": [ { "id": "33627", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33627" } ] }, { "id": "33631", "name": "", "equation": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q7TN78-1", "Q499N5-1", "Q6SKG1-1", "P0C7M7-1", "Q08AH1-1", "Q08AH3-1", "Q96CM8-1", "Q68CK6-1", "Q53FZ2-1", "Q91VA0-1", "Q8VCW8-1", "Q8K0L3-1", "Q80W40-1", "Q3UNX5-1", "P39518-1" ], "evidence": [ { "id": "33631", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33631" } ] }, { "id": "43740", "name": "", "equation": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q7TN78-1", "P0C7M7-1", "Q08AH1-1", "Q08AH3-1", "Q68CK6-1", "Q91VA0-1", "Q8K0L3-1", "Q80W40-1" ], "evidence": [ { "id": "43740", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43740" } ] }, { "id": "46172", "name": "", "equation": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q6SKG1-1", "A0A0G2K047-1", "Q53FZ2-1", "Q08AH1-1", "Q08AH3-1", "Q68CK6-1", "Q9H6R3-1", "Q91VA0-1", "Q8K0L3-1", "Q14DH7-1", "Q3UNX5-1" ], "evidence": [ { "id": "46172", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46172" } ] }, { "id": "48340", "name": "", "equation": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q7TN78-1", "Q499N5-1", "Q6AYT9-1", "Q6SKG1-1", "Q63151-1", "Q6NUN0-1", "Q53FZ2-1", "Q6P461-1", "P0C7M7-1", "Q08AH1-1", "Q08AH3-1", "Q96CM8-1", "Q68CK6-1", "O95573-1", "Q91VA0-1", "Q8VCW8-1", "Q8BGA8-1", "Q8K0L3-1", "Q80W40-1", "Q3UNX5-1", "Q9CZW4-1" ], "evidence": [ { "id": "48340", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48340" } ] }, { "id": "R-MMU-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-159446" ], "output_participant_list": [ "R-ALL-159447" ], "enzyme_list": [ "Q91VA0-1", "Q8K0L3-1" ], "evidence": [ { "id": "R-MMU-159443", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-159443" } ] }, { "id": "R-MMU-159567", "name": "ACSM2B-like proteins transform ST to ST-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-159559" ], "output_participant_list": [ "R-ALL-159557" ], "enzyme_list": [ "Q8BGA8-1", "Q80W40-1", "Q8K0L3-1" ], "evidence": [ { "id": "R-MMU-159567", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-159567" } ] }, { "id": "R-MMU-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-177153" ], "output_participant_list": [ "R-ALL-177137" ], "enzyme_list": [ "Q91VA0-1", "Q8K0L3-1" ], "evidence": [ { "id": "R-MMU-177157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-177157" } ] }, { "id": "R-MMU-9749971", "name": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-9750012" ], "output_participant_list": [ "R-ALL-9749985" ], "enzyme_list": [ "Q8BGA8-1", "Q80W40-1", "Q8K0L3-1" ], "evidence": [ { "id": "R-MMU-9749971", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9749971" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-159446", "participant_name": "BENZA [mitochondrial matrix]", "crossref": [ { "id": "8145241", "database": "PubChem Substance", "url": "" }, { "id": "000000001011", "database": "ZINC", "url": "" }, { "id": "C00180", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001870", "database": "HMDB Metabolite", "url": "" }, { "id": "30746", "database": "ChEBI", "url": "" }, { "id": "8145241", "database": "PubChem Substance", "url": "" }, { "id": "000000001011", "database": "ZINC", "url": "" }, { "id": "C00180", "database": "COMPOUND", "url": "" }, { "id": "30746", "database": "ChEBI", "url": "" }, { "id": "HMDB0001870", "database": "HMDB Metabolite", "url": "" }, { "id": "30746", "database": "ChEBI", "url": "" }, { "id": "HMDB0001870", "database": "HMDB Metabolite", "url": "" }, { "id": "C00180", "database": "COMPOUND", "url": "" }, { "id": "000000001011", "database": "ZINC", "url": "" }, { "id": "8145241", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-159447", "participant_name": "BEZ-CoA [mitochondrial matrix]", "crossref": [ { "id": "C00512", "database": "COMPOUND", "url": "" }, { "id": "000008551184", "database": "ZINC", "url": "" }, { "id": "57369", "database": "ChEBI", "url": "" }, { "id": "C00512", "database": "COMPOUND", "url": "" }, { "id": "57369", "database": "ChEBI", "url": "" }, { "id": "000008551184", "database": "ZINC", "url": "" }, { "id": "C00512", "database": "COMPOUND", "url": "" }, { "id": "57369", "database": "ChEBI", "url": "" }, { "id": "000008551184", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-159557", "participant_name": "ST-CoA [mitochondrial matrix]", "crossref": [ { "id": "32587", "database": "ChEBI", "url": "" }, { "id": "HMDB0011636", "database": "HMDB Metabolite", "url": "" }, { "id": "000096068394", "database": "ZINC", "url": "" }, { "id": "8147635", "database": "PubChem Substance", "url": "" }, { "id": "32587", "database": "ChEBI", "url": "" }, { "id": "8147635", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0011636", "database": "HMDB Metabolite", "url": "" }, { "id": "000096068394", "database": "ZINC", "url": "" }, { "id": "32587", "database": "ChEBI", "url": "" }, { "id": "8147635", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0011636", "database": "HMDB Metabolite", "url": "" }, { "id": "000096068394", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-159559", "participant_name": "ST [mitochondrial matrix]", "crossref": [ { "id": "HMDB0302214", "database": "HMDB Metabolite", 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