{ "uniprot_canonical_ac": "Q8INT5-1", "uniprot_ac": "Q8INT5", "uniprot_id": "DAAF1_DROME", "mass": { "chemical_mass": 168194.0, "monoisotopic_mass": 168194.0 }, "refseq": { "ac": "NP_724335", "name": "defective transmitter release", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335" }, "gene_names": [ { "name": "dtr", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8INT5", "id": "Q8INT5" }, { "name": "CG31623; Dmel\\CG31623; Dtr", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335", "id": "NP_724335" }, { "name": "CG31623", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8INT5", "id": "Q8INT5" }, { "name": "dtr", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335", "id": "NP_724335" } ], "protein_names": [ { "name": "Dynein axonemal assembly factor 1 homolog", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8INT5" }, { "name": "CG31623-PA; dtr-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335", "id": "NP_724335" }, { "name": "Defective transmitter-recycling protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8INT5" }, { "name": "Leucine-rich repeat-containing protein 50 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8INT5" }, { "name": "defective transmitter release", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335", "id": "NP_724335" } ], "function": [ { "annotation": "Cilium-specific protein required for cilia structures.", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5#function" } ] } ], "disease": [ { "disease_id": "DOID:0060250", "recommended_name": { "id": "DOID:0060250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060250", "name": "idiopathic scoliosis", "description": "A scoliosis with no known cause." }, "synonyms": [], "evidence": [ { "id": "0060250", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060250" } ] }, { "disease_id": "DOID:0110618", "recommended_name": { "id": "DOID:0110618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110618", "name": "primary ciliary dyskinesia 13", "description": "A primary ciliary dyskinesia that is characterized by inner and outer dynein arm defect, immotile cilia, and variable occurence of laterality defects and has_material_basis_in homozygous or compound heterozygous mutation in the LRRC50 gene on chromosome 16q23-q24." }, "synonyms": [ { "id": "DOID:0110618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110618", "name": "CILD13", "description": "" }, { "id": "DOID:0110618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110618", "name": "primary ciliary dyskinesia 13 with or without situs inversus", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "primary ciliary dyskinesia 13", "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAAF1 gene." }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "CILD13", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "DNAAF1 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "ciliary dyskinesia, primary, type 13", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "primary ciliary dyskinesia 13", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "primary ciliary dyskinesia 13 with or without situs inversus", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "primary ciliary dyskinesia caused by mutation in DNAAF1", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "primary ciliary dyskinesia type 13", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "ciliary dyskinesia, primary, 13", "description": "" }, { "id": "MONDO:0013174", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013174", "name": "ciliary dyskinesia, primary, 13, with or without situs inversus", "description": "" }, { "id": "MIM:613193", "resource": "MIM", "url": "https://www.omim.org/entry/613193", "name": "Ciliary dyskinesia, primary, 13", "description": "Ciliary dyskinesia, primary, 13" } ], "evidence": [ { "id": "0110618", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110618" } ] }, { "disease_id": "DOID:4440", "recommended_name": { "id": "DOID:4440", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4440", "name": "seminoma", "description": "A germinoma that has_material_basis_in cells that make sperm and eggs." }, "synonyms": [ { "id": "DOID:4440", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4440", "name": "Seminoma, Pure", "description": "" } ], "evidence": [ { "id": "4440", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4440" } ] }, { "disease_id": "DOID:5557", "recommended_name": { "id": "DOID:5557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5557", "name": "testicular germ cell cancer", "description": "A testicular cancer that has_material_basis_in germ cells." }, "synonyms": [ { "id": "DOID:5557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5557", "name": "germ cell tumor of testis", "description": "" }, { "id": "MONDO:0010274", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010274", "name": "testicular germ cell tumor 1", "description": "" }, { "id": "MONDO:0010274", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010274", "name": "testicular germ cell tumor", "description": "" }, { "id": "MONDO:0010274", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010274", "name": "testicular germ cell tumour", "description": "" }, { "id": "MONDO:0010274", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010274", "name": "TGCT1", "description": "" }, { "id": "MONDO:0010274", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010274", "name": "testicular germ cell tumor 1", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular germ cell tumor", "description": "A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor." }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "TGCT", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell neoplasm of testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell neoplasm of the testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell tumor of testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell tumor of the testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell tumors, somatic", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell tumour of testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "germ cell tumour of the testis", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "male germ cell tumor, somatic", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "spermatocytic seminoma, somatic", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular germ cell neoplasm", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular germ cell neoplasms", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular germ cell tumor", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular tumor, somatic", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testis germ cell tumor", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testis germ cell tumour", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "Male germ cell tumor", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "Male germ cell tumour", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "embryonal cell carcinoma", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "endodermal sinus tumor", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "endodermal sinus tumour", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "nonseminomatous germ cell tumors", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "nonseminomatous germ cell tumours", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "seminoma", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "spermatocytic seminoma", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "teratoma, testicular", "description": "" }, { "id": "MONDO:0010108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010108", "name": "testicular germ cell cancer", "description": "" }, { "id": "MIM:273300", "resource": "MIM", "url": "https://www.omim.org/entry/273300", "name": "Testicular germ cell tumor", "description": "Testicular germ cell tumor" } ], "evidence": [ { "id": "5557", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5557" } ] }, { "disease_id": "DOID:898", "recommended_name": { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "autosomal dominant polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion." }, "synonyms": [ { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "Congenital biliary ectasias", "description": "" }, { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1", "description": "" } ], "evidence": [ { "id": "898", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:898" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "dtr", "url": "https://www.uniprot.org/uniprot/Q8INT5", "locus": { "chromosome": "2L", "start_pos": 21367288, "end_pos": 21361216, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0023090", "url": "https://www.ensembl.org/id/FBgn0023090" } ] } } ], "crossref": [ { "id": "FBgn0023090", "url": "https://bgee.org/?page=gene&gene_id=FBgn0023090", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0023090", "url": "https://flybase.org/reports/FBgn0023090", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "318856", "url": "https://www.ncbi.nlm.nih.gov/gene/318856", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8INT5", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8INT5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG31623", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG31623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKREGYE", "url": "https://omabrowser.org/oma/group/WKREGYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "129594at2759", "url": "http://www.orthodb.org/?query=129594at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "http://pfam.xfam.org/family/PF14580", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8INT5", "url": "http://purl.obolibrary.org/obo/PR_Q8INT5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_724335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724335", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8INT5-1", "url": "https://www.uniprot.org/uniprot/Q8INT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNSNRKEITGLNRMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDDKQDQLFAKILDDATENIPKRIFGTGCDALSSVWPQEECLLQLTLPENKESPAQEDTFKKSITNSTSFEKANEICVRMDQKMAEEEEALGKLLHDLEGEINNVYDINTKVKYEENTSTNESDAVSICTSLLDDIIVGLTFDEVLCHEKPKSFEFGLIESDEEFSYSFEPKLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKIRAAQELLKTKNLSDLYKDTAESLNSQVAKEIEKRKRRVAASATRCFNQRDKYDDTLELVENRLMIVKKDSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDSKEHLMSNLLNQNQDDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLDLQKVNASEDSEPAINCMRSYNELQAYMKSGSLNTQLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEEDDLLKKMVLRMKEYEEREHQLQLISHETSSELGPIKLSIGGSKLFEQNTKIPESVLVHSENEPTRNNKPINTKNTNDKESSDIMEKNGDPSVTTSFKTSHKSIDDDIQSDVSTDYESGEEVVVVEPPTLSEAVLKSFYSDEFEADSKMVHELEEATRRNLRRYNPNIMHISTSNHPFSTNNILPTKTSTSELSEGAKAKWAKIAERLHEFLDPETIANLNKEQFGESDECEDSQDDNITDITVEETNLKKDTKLVVLEEYNNTHTCDGNSCPSKLDDSDQFASLKGFEKIKETPTHNMGLSSVMSASQNKTSETLPNEIGNKITDFSSFKTSSTDLINSEGVKTEQIQCNLQILSDEGDVVVEELSVNAQVSSFK", "length": 1483, "header": "sp|Q8INT5-1|DAAF1_DROME Isoform 1 of Dynein axonemal assembly factor 1 homolog OS=Drosophila melanogaster OX=7227 GN=dtr PE=2 SV=2 CANONICAL=Q8INT5-1" }, "isoforms": [ { "isoform_ac": "Q8INT5-1", "url": "", "sequence": { "sequence": "MSNSNRKEITGLNRMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDDKQDQLFAKILDDATENIPKRIFGTGCDALSSVWPQEECLLQLTLPENKESPAQEDTFKKSITNSTSFEKANEICVRMDQKMAEEEEALGKLLHDLEGEINNVYDINTKVKYEENTSTNESDAVSICTSLLDDIIVGLTFDEVLCHEKPKSFEFGLIESDEEFSYSFEPKLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKIRAAQELLKTKNLSDLYKDTAESLNSQVAKEIEKRKRRVAASATRCFNQRDKYDDTLELVENRLMIVKKDSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDSKEHLMSNLLNQNQDDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLDLQKVNASEDSEPAINCMRSYNELQAYMKSGSLNTQLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEEDDLLKKMVLRMKEYEEREHQLQLISHETSSELGPIKLSIGGSKLFEQNTKIPESVLVHSENEPTRNNKPINTKNTNDKESSDIMEKNGDPSVTTSFKTSHKSIDDDIQSDVSTDYESGEEVVVVEPPTLSEAVLKSFYSDEFEADSKMVHELEEATRRNLRRYNPNIMHISTSNHPFSTNNILPTKTSTSELSEGAKAKWAKIAERLHEFLDPETIANLNKEQFGESDECEDSQDDNITDITVEETNLKKDTKLVVLEEYNNTHTCDGNSCPSKLDDSDQFASLKGFEKIKETPTHNMGLSSVMSASQNKTSETLPNEIGNKITDFSSFKTSSTDLINSEGVKTEQIQCNLQILSDEGDVVVEELSVNAQVSSFK", "length": 1483, "header": "sp|Q8INT5-1|DAAF1_DROME Isoform 1 of Dynein axonemal assembly factor 1 homolog OS=Drosophila melanogaster OX=7227 GN=dtr PE=2 SV=2 CANONICAL=Q8INT5-1" }, "locus": { "chromosome": "2L", "start_pos": 21367196, "end_pos": 21361379, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0081516", "url": "https://www.ensembl.org/id/FBtr0081516" }, { "database": "Ensembl Peptide", "id": "FBpp0081044", "url": "https://www.ensembl.org/id/FBpp0081044" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] } ], "pathway": [ { "id": "dme:Dmel_CG31623", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG31623", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "Q8INT5", "url": "https://www.uniprot.org/uniprot/Q8INT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1012, "end_pos": 1014, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1345, "end_pos": 1347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1369, "end_pos": 1371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1417, "end_pos": 1419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 769, "end_pos": 771, "annotation": "n_glycosylation_sequon" }, { "start_pos": 773, "end_pos": 775, "annotation": "n_glycosylation_sequon" }, { "start_pos": 887, "end_pos": 889, "annotation": "n_glycosylation_sequon" }, { "start_pos": 973, "end_pos": 975, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }