{
    "uniprot_canonical_ac": "Q8I8V0-1",
    "uniprot_ac": "Q8I8V0",
    "uniprot_id": "TAD2B_DROME",
    "mass": {
        "chemical_mass": 62031.0,
        "monoisotopic_mass": 62031.0
    },
    "refseq": {
        "ac": "NP_001027151",
        "name": "transcriptional adaptor 2b, isoform B",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151"
    },
    "gene_names": [
        {
            "name": "Ada2b",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "ADA2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "Ada2B",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "Ada2S",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "Ada2b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151",
            "id": "NP_001027151"
        },
        {
            "name": "BcDNA:LD24527",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "CG9638",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "Dmel\\CG9638",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "Dmel_CG9638",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "ada2b; Ada2B; ADA2b; Ada2S; BcDNA:LD24527; CG9638; dAda2b; dAda2B; dADA2b; dAda2S; Dmel\\CG9638",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151",
            "id": "NP_001027151"
        },
        {
            "name": "ada2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "dADA2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "dAda2B",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "dAda2S",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        },
        {
            "name": "dAda2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "id": "Q8I8V0"
        }
    ],
    "protein_names": [
        {
            "name": "Transcriptional adapter 2B",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8I8V0"
        },
        {
            "name": "CG9638-PB; Ada2b-PB; transcriptional adapter 2S",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151",
            "id": "NP_001027151"
        },
        {
            "name": "CG9638-PC; Ada2b-PC; transcriptional adapter 2S",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262367",
            "id": "NP_001262367"
        },
        {
            "name": "dADA2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8I8V0"
        },
        {
            "name": "transcriptional adaptor 2b, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151",
            "id": "NP_001027151"
        },
        {
            "name": "transcriptional adaptor 2b, isoform C",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262367",
            "id": "NP_001262367"
        }
    ],
    "function": [
        {
            "annotation": "Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8I8V0",
                    "url": "https://www.uniprot.org/uniprot/Q8I8V0#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "O75478",
                    "url": "https://www.uniprot.org/uniprot/O75478#function"
                },
                {
                    "database": "PubMed",
                    "id": "12482983",
                    "url": "https://glygen.org/publication/PubMed/12482983"
                },
                {
                    "database": "PubMed",
                    "id": "12697829",
                    "url": "https://glygen.org/publication/PubMed/12697829"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8I8V0",
                    "url": "https://www.uniprot.org/uniprot/Q8I8V0"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "Ada2b",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "locus": {
                "chromosome": "3R",
                "start_pos": 8236632,
                "end_pos": 8240515,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0037555",
                        "url": "https://www.ensembl.org/id/FBgn0037555"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0037555",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0037555",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00167",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd02335",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02335",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0037555",
            "url": "https://flybase.org/reports/FBgn0037555",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "40966",
            "url": "https://www.ncbi.nlm.nih.gov/gene/40966",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8I8V0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8I8V0*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000433",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000433",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001005",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016827",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016827",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017884",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017930",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017930",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036388",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041983",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041983",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR043145",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043145",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG9638",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG9638",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HIADPTC",
            "url": "https://omabrowser.org/oma/group/HIADPTC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5491678at2759",
            "url": "http://www.orthodb.org/?query=5491678at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12374",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12374",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12374:SF63",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12374:SF63",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00249",
            "url": "http://pfam.xfam.org/family/PF00249",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00569",
            "url": "http://pfam.xfam.org/family/PF00569",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8I8V0",
            "url": "http://purl.obolibrary.org/obo/PR_Q8I8V0",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-DME-5689880",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5689880",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001027151",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027151",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KFU2",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KFU2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0B4KFU2-1",
            "url": "https://www.uniprot.org/uniprot/A0A0B4KFU2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8I8V0",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8I8V0-1",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8I8V0-2",
            "url": "https://www.uniprot.org/uniprot/Q8I8V0-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQHPQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITPTTYLSVKTVCLSGAPSLGSPMETSLRKFFIKCGWLSH",
        "length": 555,
        "header": "sp|Q8I8V0-1|TAD2B_DROME Isoform 1 of Transcriptional adapter 2B  OS=Drosophila melanogaster OX=7227 GN=Ada2b PE=1 SV=1 CANONICAL=Q8I8V0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0B4KFU2-1",
            "url": "",
            "sequence": {
                "sequence": "MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTLHCIINAPNNERSNGSIRQCLTTGPHAYLQWKSSAAKLFLALPTTESQKGRNVKRRRGKFKFNRTKKHAPHRRPDLLRRIIAQQKLLG",
                "length": 418,
                "header": "tr|A0A0B4KFU2-1|A0A0B4KFU2_DROME Computationally mapped isoform of Transcriptional adapter  OS=Drosophila melanogaster OX=7227 GN=Ada2b PE=4 SV=1 CANONICAL=Q8I8V0-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q8I8V0-1",
            "url": "",
            "sequence": {
                "sequence": "MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQHPQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITPTTYLSVKTVCLSGAPSLGSPMETSLRKFFIKCGWLSH",
                "length": 555,
                "header": "sp|Q8I8V0-1|TAD2B_DROME Isoform 1 of Transcriptional adapter 2B  OS=Drosophila melanogaster OX=7227 GN=Ada2b PE=1 SV=1 CANONICAL=Q8I8V0-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 8240423,
                "end_pos": 8237441,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0100368",
                        "url": "https://www.ensembl.org/id/FBtr0100368"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0099776",
                        "url": "https://www.ensembl.org/id/FBpp0099776"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8I8V0-2",
            "url": "",
            "sequence": {
                "sequence": "MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTLHCIINAPNNERSNGSIRQCLTTGPHAYLQWKSSAAKLFLALPTTESQKGRNVKRRRGKFKFNRTKKHAPHRRPDLLRRIIAQQKLLG",
                "length": 418,
                "header": "sp|Q8I8V0-2|TAD2B_DROME Isoform 2 of Transcriptional adapter 2B  OS=Drosophila melanogaster OX=7227 GN=Ada2b PE=1 SV=1 CANONICAL=Q8I8V0-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 8240423,
                "end_pos": 8237922,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0334315",
                        "url": "https://www.ensembl.org/id/FBtr0334315"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0306430",
                        "url": "https://www.ensembl.org/id/FBpp0306430"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8I8V0",
                    "url": "https://www.uniprot.org/uniprot/Q8I8V0"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0B4KFU2",
                    "url": "https://www.uniprot.org/uniprot/A0A0B4KFU2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10731132",
                    "url": "https://glygen.org/publication/PubMed/10731132"
                }
            ]
        },
        {
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