{ "uniprot_canonical_ac": "Q8I7C6-1", "uniprot_ac": "Q8I7C6", "uniprot_id": "Q8I7C6_DICDI", "mass": { "chemical_mass": 78477.0, "monoisotopic_mass": 78477.0 }, "refseq": { "ac": "XP_629373", "name": "NAD+ ADP-ribosyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629373" }, "gene_names": [ { "name": "adprt2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8I7C6", "id": "Q8I7C6" }, { "name": "DDB_G0292820", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8I7C6", "id": "Q8I7C6" }, { "name": "adprt2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629373", "id": "XP_629373" } ], "protein_names": [ { "name": "Poly [ADP-ribose] polymerase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8I7C6" }, { "name": "2.4.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8I7C6" }, { "name": "NAD+ ADP-ribosyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629373", "id": "XP_629373" }, { "name": "PARP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8I7C6" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "adprt2", "url": "https://www.uniprot.org/uniprot/Q8I7C6", "locus": {} } ], "crossref": [ { "id": "cd01437", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01437", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08003", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08003", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0292820", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8628891", "url": "https://www.ncbi.nlm.nih.gov/gene/8628891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0292820", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0292820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGENDRF", "url": "https://omabrowser.org/oma/group/QGENDRF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10459", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10459", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10459:SF104", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10459:SF104", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00533", "url": "http://pfam.xfam.org/family/PF00533", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00644", "url": "http://pfam.xfam.org/family/PF00644", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02877", "url": "http://pfam.xfam.org/family/PF02877", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05406", "url": "http://pfam.xfam.org/family/PF05406", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-110362", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-110362", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-3108214", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696394", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-5696395", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696395", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_629373", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629373", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8I7C6-1", "url": "https://www.uniprot.org/uniprot/Q8I7C6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKKRQLSQSDEDVKTTTTTTTSTSTKPLTEIFDGIVFCFSGTFSVTQTELTKKVEGCGASTSKTCTAKVTHLVSTVDDFKKNGTAVSKALKSGIPIVTEGFITKSIEASKKLEEKDYSLSSSNDDEEEEEEEEEEEEEEEEEEVAKPTRRSSKKAPAKSEEKGEDKNKLTTRPTKKTKTNTSEAETKTAASDLDDSSSESEDEKNQISVKIKGRAANDPHFPDSRFHVYENGKDVYDATLNQTEISQNNNKFYIIQLLEADDGSSYSVWNRWGREGLKGQSSRKDFGKGGLNQAISLFCSKFYEKTKNTFTDRANFKKVAGKYDMIELDYSTDSKPKNGASTTATTTTTKKVVEHKKECSLDERVQELVKLIFDVKMMERTMTEAKYDLKKMPLGKLSKNQITKGYLVLKQIEDVMGGKSGESLSTLSSRFYTIIPHAFGMSVPPVINTNQMLIEKMNMLQNLADIEIATNIIKDSESDESNILELHYAKLKTDIQPLDENSCEYKNILLYVKNTYQGGKKPTIVNIFKIDRDGEADRYKTKKHLGNRKLLWHGSRLTNYASIISQGLRIAPPEAPVSGYRFGKGVYFADCMSLSANYCRTVGSNDFCMLLGDVALGKTADLARDTYMEKPQPNSHSTWALGTVEPDPKVFFQDTEGCITPYGQMIPSQHKGVSCYEHQYVVYDVAQVHLKYLLQLRN", "length": 700, "header": "tr|Q8I7C6-1|Q8I7C6_DICDI Isoform 1 of Poly [ADP-ribose] polymerase OS=Dictyostelium discoideum OX=44689 GN=adprt2 PE=2 SV=1 CANONICAL=Q8I7C6-1" }, "isoforms": [ { "isoform_ac": "Q8I7C6-1", "url": "", "sequence": { "sequence": "MPPKKRQLSQSDEDVKTTTTTTTSTSTKPLTEIFDGIVFCFSGTFSVTQTELTKKVEGCGASTSKTCTAKVTHLVSTVDDFKKNGTAVSKALKSGIPIVTEGFITKSIEASKKLEEKDYSLSSSNDDEEEEEEEEEEEEEEEEEEVAKPTRRSSKKAPAKSEEKGEDKNKLTTRPTKKTKTNTSEAETKTAASDLDDSSSESEDEKNQISVKIKGRAANDPHFPDSRFHVYENGKDVYDATLNQTEISQNNNKFYIIQLLEADDGSSYSVWNRWGREGLKGQSSRKDFGKGGLNQAISLFCSKFYEKTKNTFTDRANFKKVAGKYDMIELDYSTDSKPKNGASTTATTTTTKKVVEHKKECSLDERVQELVKLIFDVKMMERTMTEAKYDLKKMPLGKLSKNQITKGYLVLKQIEDVMGGKSGESLSTLSSRFYTIIPHAFGMSVPPVINTNQMLIEKMNMLQNLADIEIATNIIKDSESDESNILELHYAKLKTDIQPLDENSCEYKNILLYVKNTYQGGKKPTIVNIFKIDRDGEADRYKTKKHLGNRKLLWHGSRLTNYASIISQGLRIAPPEAPVSGYRFGKGVYFADCMSLSANYCRTVGSNDFCMLLGDVALGKTADLARDTYMEKPQPNSHSTWALGTVEPDPKVFFQDTEGCITPYGQMIPSQHKGVSCYEHQYVVYDVAQVHLKYLLQLRN", "length": 700, "header": "tr|Q8I7C6-1|Q8I7C6_DICDI Isoform 1 of Poly [ADP-ribose] polymerase OS=Dictyostelium discoideum OX=44689 GN=adprt2 PE=2 SV=1 CANONICAL=Q8I7C6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0292820", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0292820", "resource": "KEGG Pathway" }, { "id": "R-DDI-110362", "name": "POLB-Dependent Long Patch Base Excision Repair", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-110362", "resource": "Reactome", "description": "POLB-Dependent Long Patch Base Excision Repair" }, { "id": "R-DDI-3108214", "name": "SUMOylation of DNA damage response and repair proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" }, { "id": "R-DDI-5696394", "name": "DNA Damage Recognition in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" }, { "id": "R-DDI-5696395", "name": "Formation of Incision Complex in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696395", "resource": "Reactome", "description": "Formation of Incision Complex in GG-NER" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "NAD+-protein ADP-ribosyltransferase activity", "id": "GO:1990404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990404", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "NAD+ ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "single strand break repair", "id": "GO:0000012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000012", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial membrane potential", "id": "GO:0010918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010918", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "response to UV-C", "id": "GO:0010225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010225", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "protein poly-ADP-ribosylation", "id": "GO:0070212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070212", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "response to cisplatin", "id": "GO:0072718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072718", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" }, { "name": "hydrogen peroxide-mediated programmed cell death", "id": "GO:0010421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010421", "evidence": [ { "database": "UniProtKB", "id": "Q8I7C6", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q9NGP4-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-4551604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-4551604" } ] }, { "id": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q9NGP4-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-4551768", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-4551768" } ] }, { "id": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-DDI-54745" ], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q54Z28-1", "Q55GU8-1", "P51173-1", "Q1ZXF2-1", "Q54NU0-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5649873", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5649873" } ] }, { "id": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q1ZXF2-1", "Q54NU0-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5649883", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5649883" } ] }, { "id": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q1ZXF2-1", "Q54NU0-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5651723", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5651723" } ] }, { "id": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q1ZXF2-1", "Q54NU0-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5651739", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5651739" } ] }, { "id": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-ALL-5651834" ], "enzyme_list": [ "Q54HY5-1", "Q54Z28-1", "Q55GU8-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5651828", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5651828" } ] }, { "id": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "O00835-1", "Q54X55-1", "Q54XI2-1", "Q55G81-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5690996", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5690996" } ] }, { "id": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "O00835-1", "P54685-1", "Q54X55-1", "Q54XI2-1", "Q55G81-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5691000", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5691000" } ] }, { "id": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-427523" ], "output_participant_list": [ "R-ALL-427497" ], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5696655", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696655" } ] }, { "id": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q54X55-1", "Q54XI2-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-5696664", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696664" } ] }, { "id": "R-DDI-6790454", "name": "SUMOylation of XPC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54HY5-1", "Q55GU8-1", "Q9NGP4-1", "O00835-1", "Q54X55-1", "Q54XI2-1", "Q55G81-1", "Q8I7C6-1" ], "evidence": [ { "id": "R-DDI-6790454", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6790454" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-427497", "participant_name": "NAM [nucleoplasm]", "crossref": [ { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-427523", "participant_name": "NAD+ [nucleoplasm]", "crossref": [ { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" }, { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" }, { "id": "57540", "database": "ChEBI", "url": "" }, { "id": "C00003", "database": "COMPOUND", "url": "" }, { "id": "000008214766", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-5651834", "participant_name": "ADP-D-ribose [nucleoplasm]", "crossref": [ { "id": "16960", "database": "ChEBI", "url": "" }, { "id": "C00301", "database": "COMPOUND", "url": "" }, { "id": "000014880207", "database": "ZINC", "url": "" }, { "id": "HMDB0001178", "database": "HMDB Metabolite", "url": "" }, { "id": "000017654550", "database": "ZINC", "url": "" }, { "id": "16960", "database": "ChEBI", "url": "" }, { "id": "C00301", "database": "COMPOUND", "url": "" }, { "id": "000014880207", "database": "ZINC", "url": "" }, { "id": "HMDB0001178", "database": "HMDB Metabolite", "url": "" }, { "id": "000017654550", "database": "ZINC", "url": "" }, { "id": "16960", "database": "ChEBI", "url": "" }, { "id": "C00301", "database": "COMPOUND", "url": "" }, { "id": "000014880207", "database": "ZINC", "url": "" }, { "id": "HMDB0001178", "database": "HMDB Metabolite", "url": "" }, { "id": "000017654550", "database": "ZINC", "url": "" }, { "id": "C00301", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001178", "database": "HMDB Metabolite", "url": "" }, { "id": "000017654550", "database": "ZINC", "url": "" }, { "id": "000014880207", "database": "ZINC", "url": "" }, { "id": "16960", "database": "ChEBI", "url": "" }, { "id": "16960", "database": "ChEBI", "url": "" }, { "id": "C00301", "database": "COMPOUND", "url": "" }, { "id": "000014880207", "database": "ZINC", "url": "" }, { "id": "HMDB0001178", "database": "HMDB Metabolite", "url": "" }, { "id": "000017654550", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-DDI-54745", "participant_name": "FEN1 [nucleoplasm]", "crossref": [ { "id": "XP_639977.1", "database": "RefSeq", "url": "" }, { "id": "Q54NU0", "database": "UniProt", "url": "" }, { "id": "Q54NU0", "database": "PRO", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O00835", "gene_name": "repB", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] } ] }, { "uniprot_ac": "P51173", "gene_name": "apeA", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P51173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51173" } ] } ] }, { "uniprot_ac": "P54685", "gene_name": "cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] } ] }, { "uniprot_ac": "Q1ZXF2", "gene_name": "polB", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] } ] }, { "uniprot_ac": "Q54HY5", "gene_name": "", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q54HY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY5" } ] } ] }, { "uniprot_ac": "Q54NU0", "gene_name": "repG", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q54NU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NU0" } ] } ] }, { "uniprot_ac": "Q54X55", "gene_name": "adprt1B", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q54X55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54X55" } ] } ] }, { "uniprot_ac": "Q54XI2", "gene_name": "adprt1A", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q54XI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XI2" } ] } ] }, { "uniprot_ac": "Q54Z28", "gene_name": "parG", "activity": [ { "ec_number": "3.2.1.143", "activity": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose.", "evidence": [ { "id": "Q54Z28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Z28" } ] }, { "ec_number": "3.2.1.143", "activity": "", "evidence": [ { "id": "Q54Z28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Z28" } ] } ] }, { "uniprot_ac": "Q55G81", "gene_name": "repD", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q55G81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55G81" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q55G81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55G81" } ] } ] }, { "uniprot_ac": "Q55GU8", "gene_name": "adprt4", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q55GU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GU8" } ] } ] }, { "uniprot_ac": "Q8I7C6", "gene_name": "adprt2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8I7C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8I7C6" } ] } ] }, { "uniprot_ac": "Q9NGP4", 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"glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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