{
    "uniprot_canonical_ac": "Q8CIV2-1",
    "uniprot_ac": "Q8CIV2",
    "uniprot_id": "MBRL_MOUSE",
    "mass": {
        "chemical_mass": 63561.0,
        "monoisotopic_mass": 63561.0
    },
    "refseq": {
        "ac": "NP_001003949",
        "name": "membralin isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
    },
    "gene_names": [
        {
            "name": "Tmem259",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2",
            "id": "Q8CIV2"
        },
        {
            "name": "AC087114.7gm2; mFLJ00277; ORF61; R32184_3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949",
            "id": "NP_001003949"
        },
        {
            "name": "ORF61",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2",
            "id": "Q8CIV2"
        },
        {
            "name": "Tmem259",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949",
            "id": "NP_001003949"
        }
    ],
    "protein_names": [
        {
            "name": "Membralin",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8CIV2"
        },
        {
            "name": "Transmembrane protein 259",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CIV2"
        },
        {
            "name": "membralin isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949",
            "id": "NP_001003949"
        },
        {
            "name": "membralin",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949",
            "id": "NP_001003949"
        }
    ],
    "function": [
        {
            "annotation": "Genomic organization and expression (membralin)",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                },
                {
                    "database": "PubMed",
                    "id": "12638133",
                    "url": "https://glygen.org/publication/PubMed/12638133"
                }
            ]
        },
        {
            "annotation": "May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CIV2",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2#function"
                },
                {
                    "database": "PubMed",
                    "id": "25977983",
                    "url": "https://glygen.org/publication/PubMed/25977983"
                }
            ]
        },
        {
            "annotation": "Membralin plays a critical role in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                },
                {
                    "database": "PubMed",
                    "id": "25977983",
                    "url": "https://glygen.org/publication/PubMed/25977983"
                }
            ]
        },
        {
            "annotation": "Reduced membralin and EAAT2 levels correlated with disease progression in spinal cord from SOD1-mutant mouse models, and reductions in membralin/EAAT2 were observed in human ALS spinal cord. Importantly, overexpression of membralin in SOD1G93A astrocytes decreased TNFR1 levels and increased EAAT2 expression, and improved motor neuron survival. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                },
                {
                    "database": "PubMed",
                    "id": "31112137",
                    "url": "https://glygen.org/publication/PubMed/31112137"
                }
            ]
        },
        {
            "annotation": "The results identify membralin as an Endoplasmic-reticulum-associated degradation component and demonstrate a critical role for Endoplasmic-reticulum-associated degradation in Alzheimer's disease pathogenesis. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                },
                {
                    "database": "PubMed",
                    "id": "29133892",
                    "url": "https://glygen.org/publication/PubMed/29133892"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CIV2",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tmem259",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2",
            "locus": {
                "chromosome": "10",
                "start_pos": 79810782,
                "end_pos": 79820164,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000013858",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000013858"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000013858",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000013858",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "216157",
            "url": "https://www.ncbi.nlm.nih.gov/gene/216157",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "2506",
            "url": "https://glyconnect.expasy.org/browser/proteins/2506",
            "database": "GlyConnect",
            "categories": [
                "Glycan",
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0002680",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002680",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0006686",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006686",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0006687",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006687",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "Q8CIV2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8CIV2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR019144",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019144",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:216157",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:216157",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2177957",
            "url": "http://www.informatics.jax.org/marker/MGI:2177957",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "TELPHND",
            "url": "https://omabrowser.org/oma/group/TELPHND/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5401221at2759",
            "url": "http://www.orthodb.org/?query=5401221at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21650",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21650",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21650:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21650:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09746",
            "url": "http://pfam.xfam.org/family/PF09746",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8CIV2",
            "url": "http://purl.obolibrary.org/obo/PR_Q8CIV2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001003949",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6RN19",
            "url": "https://www.uniprot.org/uniprot/F6RN19",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6RN19-1",
            "url": "https://www.uniprot.org/uniprot/F6RN19-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8CIV2",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8CIV2-1",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8CIV2-2",
            "url": "https://www.uniprot.org/uniprot/Q8CIV2-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS",
        "length": 574,
        "header": "sp|Q8CIV2-1|MBRL_MOUSE Isoform 1 of Membralin  OS=Mus musculus OX=10090 GN=Tmem259 PE=1 SV=2 CANONICAL=Q8CIV2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F6RN19-1",
            "url": "",
            "sequence": {
                "sequence": "XNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIGESQPAGGGVGSPQALMGGRPVPAVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS",
                "length": 568,
                "header": "tr|F6RN19-1|MBRL_MOUSE Computationally mapped isoform of Membralin  OS=Mus musculus OX=10090 GN=Tmem259 PE=1 SV=1 CANONICAL=Q8CIV2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 79819874,
                "end_pos": 79813255,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000124536.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000124536.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000119572.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119572.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8CIV2-1",
            "url": "",
            "sequence": {
                "sequence": "MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS",
                "length": 574,
                "header": "sp|Q8CIV2-1|MBRL_MOUSE Isoform 1 of Membralin  OS=Mus musculus OX=10090 GN=Tmem259 PE=1 SV=2 CANONICAL=Q8CIV2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 79819965,
                "end_pos": 79813256,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000052885",
                        "url": "https://www.ensembl.org/id/ENSMUST00000052885"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000056792",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000056792"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8CIV2-2",
            "url": "",
            "sequence": {
                "sequence": "MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIGESQPAGGGVGSPQALMGGRPVPAVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS",
                "length": 598,
                "header": "sp|Q8CIV2-2|MBRL_MOUSE Isoform 2 of Membralin  OS=Mus musculus OX=10090 GN=Tmem259 PE=1 SV=2 CANONICAL=Q8CIV2-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G05724UK",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "2506",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "glytoucan_ac": "G06110VR",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "2506",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "glytoucan_ac": "G39188ZX",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "2506",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "glytoucan_ac": "G64527OM",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "2506",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "glytoucan_ac": "G70101JE",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported_with_glycan",
            "site_seq": "N",
            "relation": "attached",
            "comment": "",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "2506",
                    "database": "GlyConnect",
                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                },
                {
                    "id": "30899004",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 180,
            "start_aa": "Asn",
            "end_pos": 180,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn180",
            "evidence": [
                {
                    "id": "Q8CIV2",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2#ptm_processing"
                },
                {
                    "id": "19349973",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/19349973"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system.",
            "journal": "Gene Expr. Patterns",
            "date": "2002",
            "authors": "Andersson O, von Euler G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CIV2",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12638133",
                    "url": "https://glygen.org/publication/PubMed/12638133"
                }
            ]
        },
        {
            "title": "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.",
            "journal": "Nature biotechnology",
            "date": "2009",
            "authors": "Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CIV2",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2#ptm_processing"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8CIV2",
                    "url": "https://www.uniprot.org/uniprot/Q8CIV2"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "19349973",
                    "url": "https://glygen.org/publication/PubMed/19349973"
                }
            ]
        },
        {
            "title": "The critical role of membralin in postnatal motor neuron survival and disease.",
            "journal": "eLife",
            "date": "2015",
            "authors": "Yang B, Qu M, Wang R, Chatterton JE, Liu XB, Zhu B, Narisawa S, Millan JL, Nakanishi N, Swoboda K, Lipton SA, Zhang D",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001003949",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "25977983",
                    "url": "https://glygen.org/publication/PubMed/25977983"
                }
            ]
        },
        {
            "title": "ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating gamma-secretase activity.",
            "journal": "Nature communications",
            "date": "2017",
            "authors": "Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H",
            "evidence": [
                {
                    "database": "RefSeq",
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                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003949"
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                {
                    "type": "PubMed",
                    "id": "29133892",
                    "url": "https://glygen.org/publication/PubMed/29133892"
                }
            ]
        },
        {
            "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.",
            "journal": "Nature communications",
            "date": "2019",
            "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ",
            "evidence": [
                {
                    "database": "GlyConnect",
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                    "url": "https://glyconnect.expasy.org/browser/proteins/2506"
                }
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                {
                    "type": "PubMed",
                    "id": "30899004",
                    "url": "https://glygen.org/publication/PubMed/30899004"
                }
            ]
        },
        {
            "title": "Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.",
            "journal": "The Journal of clinical investigation",
            "date": "2019",
            "authors": "Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H",
            "evidence": [
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                    "type": "PubMed",
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                    "url": "https://glygen.org/publication/PubMed/31112137"
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            ]
        }
    ],
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        {
            "id": "mmu:216157",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:216157",
            "resource": "KEGG Pathway"
        }
    ],
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        {
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            "gene_name": "Tmem259",
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                }
            ],
            "common_name": "Human"
        }
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                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
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                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
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                        ],
                        "pmid": ""
                    },
                    {
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                    {
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                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976",
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                    },
                    {
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                            }
                        ],
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
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            "annotation": "n_glycosylation_sequon"
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    "ptm_annotation": [],
    "interactions": [],
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    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
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    ],
    "section_stats": [
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