{ "uniprot_canonical_ac": "Q8CH93-1", "uniprot_ac": "Q8CH93", "uniprot_id": "Q8CH93_RAT", "mass": { "chemical_mass": 65725.0, "monoisotopic_mass": 65725.0 }, "refseq": { "ac": "NP_758826", "name": "hyaluronan synthase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758826" }, "gene_names": [ { "name": "Has1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8CH93", "id": "Q8CH93" }, { "name": "HAS1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8CH93", "id": "Q8CH93" }, { "name": "Has1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758826", "id": "NP_758826" }, { "name": "LOC282821", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8CH93", "id": "Q8CH93" } ], "protein_names": [ { "name": "Hyaluronan synthase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8CH93" }, { "name": "hyaluronan synthase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758826", "id": "NP_758826" } ], "function": [], "disease": [ { "disease_id": "DOID:6432", "recommended_name": { "id": "DOID:6432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries." }, "synonyms": [], "evidence": [ { "id": "6432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "common_name": "Rat" } ], "gene": [ { "name": "Has1", "url": "https://www.uniprot.org/uniprot/Q8CH93", "locus": { "chromosome": "1", "start_pos": 58693411, "end_pos": 58705397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000010994", "url": "https://www.ensembl.org/id/ENSRNOG00000010994" } ] } } ], "crossref": [ { "id": "ENSRNOG00000010994", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.4.1.212", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.212&UniProtAcc=Q8CH93", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GT2", "url": "http://www.cazy.org/GT2.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "282821", "url": "https://www.ncbi.nlm.nih.gov/gene/282821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:282821", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:282821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CILRRDM", "url": "https://omabrowser.org/oma/group/CILRRDM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1361850at2759", "url": "http://www.orthodb.org/?query=1361850at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22913:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22913:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13641", "url": "http://pfam.xfam.org/family/PF13641", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2142850", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2142850", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_758826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758826", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "708528", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=708528", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8CH93-1", "url": "https://www.uniprot.org/uniprot/Q8CH93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQDMPKPSEAARCCSGLARRVLTITFALLILGLMTWAYAAGVPLASDPYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVTVAARRAFAKGPLDAATARSVALTISAYQEDPTYLRQCLTSARALLYPRTRLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAEAAGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPVLPLALWALLLLGGLIRSVAQEVRADWSGPSRAAEAYHLAAGASAYVAYWVIMLTIYWVGVRRLCRRRSGGYRVQV", "length": 583, "header": "tr|Q8CH93-1|Q8CH93_RAT Isoform 1 of Hyaluronan synthase 1 OS=Rattus norvegicus OX=10116 GN=Has1 PE=2 SV=1 CANONICAL=Q8CH93-1" }, "isoforms": [ { "isoform_ac": "Q8CH93-1", "url": "", "sequence": { "sequence": "MRQDMPKPSEAARCCSGLARRVLTITFALLILGLMTWAYAAGVPLASDPYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVTVAARRAFAKGPLDAATARSVALTISAYQEDPTYLRQCLTSARALLYPRTRLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAEAAGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPVLPLALWALLLLGGLIRSVAQEVRADWSGPSRAAEAYHLAAGASAYVAYWVIMLTIYWVGVRRLCRRRSGGYRVQV", "length": 583, "header": "tr|Q8CH93-1|Q8CH93_RAT Isoform 1 of Hyaluronan synthase 1 OS=Rattus norvegicus OX=10116 GN=Has1 PE=2 SV=1 CANONICAL=Q8CH93-1" }, "locus": { "chromosome": "1", "start_pos": 58705355, "end_pos": 58693716, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000014824.5", "url": "https://www.ensembl.org/id/ENSRNOT00000014824.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000014824.4", "url": "https://www.ensembl.org/id/ENSRNOP00000014824.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Itano N, Sawai T, Atsumi F, Miyaishi O, Taniguchi S, Kannagi R, Hamaguchi M, Kimata K", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "reference": [ { "type": "PubMed", "id": "14724275", "url": "https://glygen.org/publication/PubMed/14724275" } ] } ], "pathway": [ { "id": "rno:282821", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:282821", "resource": "KEGG Pathway" }, { "id": "R-RNO-2142850", "name": "Hyaluronan biosynthesis and export", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2142850", "resource": "Reactome", "description": "Hyaluronan biosynthesis and export" } ], "orthologs": [ { "uniprot_canonical_ac": "Q61647-1", "protein_name": "Hyaluronan synthase 1", "gene_name": "Has1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRQDMPKPSEAARCCSGLARRALTIIFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARRSLAKGPLDAATARSVALTISAYQEDPAYLRQCLTSARALLYPHTRLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAEATGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCVRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPVLPLALWALLLLGGLARSVAQEARADWSGPSRAAEAYHLAAGAGAYVAYWVVMLTIYWVGVRRLCRRRSGGYRVQV", "length": 583 }, "evidence": [ { "id": "45225618", "url": "http://www.informatics.jax.org/homology/45225618", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92839-1", "protein_name": "Hyaluronan synthase 1", "gene_name": "HAS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV", "length": 578 }, "evidence": [ { "id": "45225618", "url": "http://www.informatics.jax.org/homology/45225618", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of fibroblast migration", "id": "GO:0010764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010764", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "extracellular matrix assembly", "id": "GO:0085029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085029", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "estrous cycle", "id": "GO:0044849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044849", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "cellular response to platelet-derived growth factor stimulus", "id": "GO:0036120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036120", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "extracellular polysaccharide biosynthetic process", "id": "GO:0045226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045226", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "hyaluronan biosynthetic process", "id": "GO:0030213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030213", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q8CH93", "url": "https://www.uniprot.org/uniprot/Q8CH93" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": 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