{ "uniprot_canonical_ac": "Q8CGI1-1", "uniprot_ac": "Q8CGI1", "uniprot_id": "F193A_MOUSE", "mass": { "chemical_mass": 136714.0, "monoisotopic_mass": 136714.0 }, "refseq": { "ac": "NP_001230052", "name": "protein FAM193A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052" }, "gene_names": [ { "name": "Fam193a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8CGI1", "id": "Q8CGI1" }, { "name": "Fam193a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052", "id": "NP_001230052" } ], "protein_names": [ { "name": "Protein FAM193A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8CGI1" }, { "name": "family with sequence similarity 193, member A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052", "id": "NP_001230052" }, { "name": "protein FAM193A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052", "id": "NP_001230052" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fam193a", "url": "https://www.uniprot.org/uniprot/Q8CGI1", "locus": { "chromosome": "5", "start_pos": 34643800, "end_pos": 34527277, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037210", "url": "https://www.ensembl.org/id/ENSMUSG00000037210" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037210", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "231128", "url": "https://www.ncbi.nlm.nih.gov/gene/231128", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8CGI1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8CGI1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR029717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:231128", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:231128", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2447768", "url": "http://www.informatics.jax.org/marker/MGI:2447768", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8CGI1", "url": "https://oglcnac.org/atlas/detail/Q8CGI1", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q8CGI1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "AQNTCEC", "url": "https://omabrowser.org/oma/group/AQNTCEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2912697at2759", "url": "http://www.orthodb.org/?query=2912697at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15109", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15109", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15109:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15109:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15914", "url": "http://pfam.xfam.org/family/PF15914", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8CGI1", "url": "http://purl.obolibrary.org/obo/PR_Q8CGI1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001230052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0J9YTW8", "url": "https://www.uniprot.org/uniprot/A0A0J9YTW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YTW8-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YTW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YTZ5", "url": "https://www.uniprot.org/uniprot/A0A0J9YTZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YTZ5-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YTZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QWS6", "url": "https://www.uniprot.org/uniprot/M0QWS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QWS6-1", "url": "https://www.uniprot.org/uniprot/M0QWS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QWZ1", "url": "https://www.uniprot.org/uniprot/M0QWZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QWZ1-1", "url": "https://www.uniprot.org/uniprot/M0QWZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8CGI1-1", "url": "https://www.uniprot.org/uniprot/Q8CGI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASSGSGSSSPITIQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADDEDADGESSGEPPGAPKQEEAIGNGNPKTEESNVNTPPPSYPAQQAEQTPNTCECHVCKQEASGLPASAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKALPPAPVQSHTNKPQAFNASLQDHIYPSCFGNTPDWNSSKFISLWESEMMNDKNWNPGTFLPDTISGNDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKNAAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHGLNKEDHRHSAPAAPRNSPTGLAPLPALSPSALSPASTPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMEQISEREGVVDHRRVEDLLQFINSSEAKPVSSSRAAKRARHKQRKLEEKARLEAEARAREHLHHQEEQKQREEEEDEEEEDEEQHFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATESISNSENIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGPGANGDATDPVDPRDPSKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTSKTSNEPARKPTEPPKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNNKKQLSHIKEEKLSTVTPEPPSPSQLLQNGRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQNRQRLSINWSNFSLKKATFAAH", "length": 1231, "header": "sp|Q8CGI1-1|F193A_MOUSE Isoform 1 of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=2 CANONICAL=Q8CGI1-1" }, "isoforms": [ { "isoform_ac": "A0A0J9YTW8-1", "url": "", "sequence": { "sequence": "XVNTPPPSYPAQQAEQTPNTCECHVCKQEASGLPASAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKEMIYWGQCSQKQDLKPFHLHPAMRLLQFQISK", "length": 129, "header": "tr|A0A0J9YTW8-1|F193A_MOUSE Computationally mapped isoform of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=1 CANONICAL=Q8CGI1-1" }, "locus": { "chromosome": "5", "start_pos": 34616437, "end_pos": 34601066, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000201005.2", "url": "https://www.ensembl.org/id/ENSMUST00000201005.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143885.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143885.2" } ] } }, { "isoform_ac": "A0A0J9YTZ5-1", "url": "", "sequence": { "sequence": "LQSNLPALVSQIRLGTTTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMPDCPNCNYRRSCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADD", "length": 193, "header": "tr|A0A0J9YTZ5-1|F193A_MOUSE Computationally mapped isoform of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=1 CANONICAL=Q8CGI1-1" }, "locus": { "chromosome": "5", "start_pos": 34600970, "end_pos": 34588563, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000202503.2", "url": "https://www.ensembl.org/id/ENSMUST00000202503.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143922.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143922.2" } ] } }, { "isoform_ac": "M0QWS6-1", "url": "", "sequence": { "sequence": "RKPTEPPKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNNKKQLSHIKEEKLSTVTPEPPSPSQLLQNGRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDIDLDSVDMDETEREVEYFKR", "length": 134, "header": "tr|M0QWS6-1|F193A_MOUSE Computationally mapped isoform of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=1 CANONICAL=Q8CGI1-1" }, "locus": { "chromosome": "5", "start_pos": 34633152, "end_pos": 34623473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000181379.2", "url": "https://www.ensembl.org/id/ENSMUST00000181379.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000137979.2", "url": "https://www.ensembl.org/id/ENSMUSP00000137979.2" } ] } }, { "isoform_ac": "M0QWZ1-1", "url": "", "sequence": { "sequence": "MSPADAKRGAKRRKNKRGGGGGSGGGGSGGKAGSAAALRGPQAPGPGAAGLLGGAAAHGPLGAGAGGAAGGYFETPFSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGVKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHSGLDQPGQDFLLHSSLGGSQPETSGAGRLALGTQTMTSSGLGTTPSDACSCEACSERRDISAETEREPQQLQNYWSEVRYMVRCIYRQAGTPLAEDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASSGSGSSSPITIQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADDEDADGESSGEPPGAPKQEEAIGNGNPKTEESNVNTPPPSYPAQQAEQTPNTCECHVCKQEASGLPASAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKALPPAPVQSHTNKPQAFNASLQDHIYPSCFGNTPDWNSSKFISLWESEMMNDKNWNPGTFLPDTISGNDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKNAAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHGLNKEDHRHSAPAAPRNSPTGLAPLPALSPSALSPASTPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMEQISEREGVVDHRRVEDLLQFINSSEAKPVSSSRAAKRARHKQRKLEEKARLEAEARAREHLHHQEEQKQREEEEDEEEEDEEQHFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATESISNSENIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGPGANGDATDPVDPRDPSKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTSKTSNEPARKPTEPPKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNNKKQLSHIKEEKLSTVTPEPPSPSQLLQNGRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQNRQRLSINWSNFSLKKATFAAH", "length": 1517, "header": "tr|M0QWZ1-1|F193A_MOUSE Computationally mapped isoform of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=1 CANONICAL=Q8CGI1-1" }, "locus": { "chromosome": "5", "start_pos": 34643088, "end_pos": 34527550, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000180376.8", "url": "https://www.ensembl.org/id/ENSMUST00000180376.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000138082.2", "url": "https://www.ensembl.org/id/ENSMUSP00000138082.2" } ] } }, { "isoform_ac": "Q8CGI1-1", "url": "", "sequence": { "sequence": "MKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASSGSGSSSPITIQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADDEDADGESSGEPPGAPKQEEAIGNGNPKTEESNVNTPPPSYPAQQAEQTPNTCECHVCKQEASGLPASAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKALPPAPVQSHTNKPQAFNASLQDHIYPSCFGNTPDWNSSKFISLWESEMMNDKNWNPGTFLPDTISGNDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKNAAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHGLNKEDHRHSAPAAPRNSPTGLAPLPALSPSALSPASTPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMEQISEREGVVDHRRVEDLLQFINSSEAKPVSSSRAAKRARHKQRKLEEKARLEAEARAREHLHHQEEQKQREEEEDEEEEDEEQHFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATESISNSENIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGPGANGDATDPVDPRDPSKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTSKTSNEPARKPTEPPKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNNKKQLSHIKEEKLSTVTPEPPSPSQLLQNGRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQNRQRLSINWSNFSLKKATFAAH", "length": 1231, "header": "sp|Q8CGI1-1|F193A_MOUSE Isoform 1 of Protein FAM193A OS=Mus musculus OX=10090 GN=Fam193a PE=1 SV=2 CANONICAL=Q8CGI1-1" }, "locus": { "chromosome": "5", "start_pos": 34643088, "end_pos": 34583681, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000094867", "url": "https://www.ensembl.org/id/ENSMUST00000094867" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000092463", "url": "https://www.ensembl.org/id/ENSMUSP00000092463" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "Q8CGI1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q8CGI1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 708, "start_aa": "Thr", "end_pos": 708, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr708", "evidence": [ { "id": "Q8CGI1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q8CGI1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 709, "start_aa": "Thr", "end_pos": 709, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr709", "evidence": [ { "id": "Q8CGI1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q8CGI1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] } ], "phosphorylation": [ { "start_pos": 1136, "end_pos": 1136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" } ], "site_lbl": "Ser1136" }, { "start_pos": 1151, "end_pos": 1151, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" } ], "site_lbl": "Ser1151" }, { "start_pos": 293, "end_pos": 293, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8CGI1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CGI1" } ], "site_lbl": "Ser293" }, { "start_pos": 648, "end_pos": 648, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" } ], "site_lbl": "Ser648" }, { "start_pos": 683, "end_pos": 683, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q8CGI1", "url": "http://phospho.elm.eu.org/byAccession/Q8CGI1.html" }, { "database": "iPTMnet", "id": "Q8CGI1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CGI1" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" } ], "site_lbl": "Ser683" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Phosphoproteomic analysis of the developing mouse brain.", "journal": "Molecular & cellular proteomics : MCP", "date": "2004", "authors": "Ballif BA, Villen J, Beausoleil SA, Schwartz D, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q8CGI1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8CGI1", "url": "https://www.uniprot.org/uniprot/Q8CGI1" }, { "database": "iPTMnet", "id": "Q8CGI1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8CGI1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" }, { "database": "O-GlcNAc Atlas", "id": "Q8CGI1", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8CGI1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" }, { "database": "O-GlcNAc Atlas", "id": "Q8CGI1", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Cytosolic N-GlcNAc proteins are formed by the action of endo-beta-N-acetylglucosaminidase.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q8CGI1", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "32782141", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "title": "Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "White CW 3rd, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q8CGI1", "url": "https://oglcnac.org/atlas/detail/Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "32848054", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8CGI1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8CGI1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8CGI1" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] } ], "pathway": [ { "id": "mmu:231128", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:231128", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GBK1-1", "protein_name": "Family with sequence similarity 193, member A", "gene_name": "Fam193a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1516 }, "evidence": [ { "id": "45239107", "url": "http://www.informatics.jax.org/homology/45239107", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P78312-1", "protein_name": "Protein FAM193A", "gene_name": "FAM193A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1265 }, "evidence": [ { "id": "45239107", "url": "http://www.informatics.jax.org/homology/45239107", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1217, "end_pos": 1219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1220, "end_pos": 1222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 860, "end_pos": 862, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" }, { "start_pos": 997, "end_pos": 999, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }