{
    "uniprot_canonical_ac": "Q8CB77-1",
    "uniprot_ac": "Q8CB77",
    "uniprot_id": "ELOA1_MOUSE",
    "mass": {
        "chemical_mass": 87161.0,
        "monoisotopic_mass": 87161.0
    },
    "refseq": {
        "ac": "NP_038764",
        "name": "elongin-A",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
    },
    "gene_names": [
        {
            "name": "Eloa",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8CB77",
            "id": "Q8CB77"
        },
        {
            "name": "110kDa; Tceb3; Tceb3a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764",
            "id": "NP_038764"
        },
        {
            "name": "Eloa",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764",
            "id": "NP_038764"
        },
        {
            "name": "Tceb3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8CB77",
            "id": "Q8CB77"
        }
    ],
    "protein_names": [
        {
            "name": "Elongin-A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "EloA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "Elongin 110 kDa subunit",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "RNA polymerase II transcription factor SIII subunit A1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "SIII p110",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "Transcription elongation factor B polypeptide 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8CB77"
        },
        {
            "name": "elongin-A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764",
            "id": "NP_038764"
        },
        {
            "name": "transcription elongation factor B polypeptide 3; SIII p110; elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764",
            "id": "NP_038764"
        }
    ],
    "function": [
        {
            "annotation": "A linkage between Elongin A function and cell cycle progression",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038764",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
                },
                {
                    "database": "PubMed",
                    "id": "12604609",
                    "url": "https://glygen.org/publication/PubMed/12604609"
                }
            ]
        },
        {
            "annotation": "As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q14241",
                    "url": "https://www.uniprot.org/uniprot/Q14241#function"
                }
            ]
        },
        {
            "annotation": "Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038764",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
                },
                {
                    "database": "PubMed",
                    "id": "33334895",
                    "url": "https://glygen.org/publication/PubMed/33334895"
                }
            ]
        },
        {
            "annotation": "Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038764",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
                },
                {
                    "database": "PubMed",
                    "id": "23828199",
                    "url": "https://glygen.org/publication/PubMed/23828199"
                }
            ]
        },
        {
            "annotation": "Elongin A transcriptional elongation activity, but not its E3 ubiquitin ligase activity, is critical for these functions.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038764",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
                },
                {
                    "database": "PubMed",
                    "id": "23122963",
                    "url": "https://glygen.org/publication/PubMed/23122963"
                }
            ]
        },
        {
            "annotation": "Polycomb repressive complex 2 modulates transcription of a subset of low expression target genes in part via methylation of EloA.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_038764",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764"
                },
                {
                    "database": "PubMed",
                    "id": "29153392",
                    "url": "https://glygen.org/publication/PubMed/29153392"
                }
            ]
        },
        {
            "annotation": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q63187",
                    "url": "https://www.uniprot.org/uniprot/Q63187#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:1508",
            "recommended_name": {
                "id": "DOID:1508",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1508",
                "name": "candidiasis",
                "description": "An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons."
            },
            "synonyms": [
                {
                    "id": "DOID:1508",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1508",
                    "name": "Disseminated candidiasis",
                    "description": ""
                },
                {
                    "id": "DOID:1508",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1508",
                    "name": "systemic candidiasis",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1508",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1508"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Eloa",
            "url": "https://www.uniprot.org/uniprot/Q8CB77",
            "locus": {
                "chromosome": "4",
                "start_pos": 135730679,
                "end_pos": 135749074,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000028668",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028668"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000028668",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028668",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00183",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00183",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "CHEMBL4879488",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4879488",
            "database": "ChEMBL",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "27224",
            "url": "https://www.ncbi.nlm.nih.gov/gene/27224",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8CB77",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8CB77*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001810",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003617",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003617",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010684",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010684",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017923",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017923",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035441",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035441",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:27224",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:27224",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1351315",
            "url": "http://www.informatics.jax.org/marker/MGI:1351315",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "YETYSYS",
            "url": "https://omabrowser.org/oma/group/YETYSYS/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4793at2759",
            "url": "http://www.orthodb.org/?query=4793at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15141",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15141",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15141:SF75",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15141:SF75",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06881",
            "url": "http://pfam.xfam.org/family/PF06881",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08711",
            "url": "http://pfam.xfam.org/family/PF08711",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8CB77",
            "url": "http://purl.obolibrary.org/obo/PR_Q8CB77",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-112382",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112382",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-674695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-674695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-6796648",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6796648",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-75955",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75955",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_038764",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8CB77",
            "url": "https://www.uniprot.org/uniprot/Q8CB77",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8CB77-1",
            "url": "https://www.uniprot.org/uniprot/Q8CB77-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSILPITVDILVETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNSEAEDQDFEKNNSRKRPRDALQREEELEGNYQESWKPSGSRSYSPEHRQKKHKKLSEPERPHKVAHSHEKRDERKRCHKVSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEEDQEPIISHQKPGKVHSNTFQDRLGVSHLGEQGKGAVSHHKQHRSSHKEKHPADAREDEKISAVSREKSHKASSKEESRRLLSGDSAKEKLPSSVVKKDKDREGSSLKKKFSPALDVASDNHFKKPKHKDSEKAKSDKNKQSVDGVDSGRGTGDPLPKAKEKVPNHLKAQEGKVRTNADGKSAGPLHPKAEETDVDDEFERPTMSFESYLSYDQPRKKKKKVVKTSSTALGEKGLKKKDSKSTSKNLNSAQKLPKVNENKSEKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIHANYRPLPSLELIPSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSNFHSSPEELAYDGPSTSSAHLAPVASSSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR",
        "length": 773,
        "header": "sp|Q8CB77-1|ELOA1_MOUSE Isoform 1 of Elongin-A  OS=Mus musculus OX=10090 GN=Eloa PE=1 SV=3 CANONICAL=Q8CB77-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q8CB77-1",
            "url": "",
            "sequence": {
                "sequence": "MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSILPITVDILVETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNSEAEDQDFEKNNSRKRPRDALQREEELEGNYQESWKPSGSRSYSPEHRQKKHKKLSEPERPHKVAHSHEKRDERKRCHKVSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEEDQEPIISHQKPGKVHSNTFQDRLGVSHLGEQGKGAVSHHKQHRSSHKEKHPADAREDEKISAVSREKSHKASSKEESRRLLSGDSAKEKLPSSVVKKDKDREGSSLKKKFSPALDVASDNHFKKPKHKDSEKAKSDKNKQSVDGVDSGRGTGDPLPKAKEKVPNHLKAQEGKVRTNADGKSAGPLHPKAEETDVDDEFERPTMSFESYLSYDQPRKKKKKVVKTSSTALGEKGLKKKDSKSTSKNLNSAQKLPKVNENKSEKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIHANYRPLPSLELIPSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSNFHSSPEELAYDGPSTSSAHLAPVASSSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR",
                "length": 773,
                "header": "sp|Q8CB77-1|ELOA1_MOUSE Isoform 1 of Elongin-A  OS=Mus musculus OX=10090 GN=Eloa PE=1 SV=3 CANONICAL=Q8CB77-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 135748936,
                "end_pos": 135732930,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000030427",
                        "url": "https://www.ensembl.org/id/ENSMUST00000030427"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000030427",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000030427"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 195,
            "end_pos": 195,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q8CB77",
                    "url": "http://phospho.elm.eu.org/byAccession/Q8CB77.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8CB77",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CB77"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                }
            ],
            "site_lbl": "Ser195"
        },
        {
            "start_pos": 309,
            "end_pos": 309,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8CB77",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CB77"
                }
            ],
            "site_lbl": "Ser309"
        },
        {
            "start_pos": 379,
            "end_pos": 379,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                }
            ],
            "site_lbl": "Ser379"
        },
        {
            "start_pos": 390,
            "end_pos": 390,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8CB77",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CB77"
                }
            ],
            "site_lbl": "Thr390"
        },
        {
            "start_pos": 515,
            "end_pos": 515,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                }
            ],
            "site_lbl": "Ser515"
        },
        {
            "start_pos": 82,
            "end_pos": 82,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8CB77",
                    "url": "https://www.uniprot.org/uniprot/Q8CB77"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q8CB77",
                    "url": "http://phospho.elm.eu.org/byAccession/Q8CB77.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8CB77",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8CB77"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                }
            ],
            "site_lbl": "Ser82"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Structural organization and chromosome location of the mouse elongin A gene (Tceb3).",
            "journal": "Cytogenet. Cell Genet.",
            "date": "1999",
            "authors": "Okumura K., Aso T., Hatakeyama M., Amimoto K., Takebayashi S.",
            "evidence": [
                {
                    "database": "UniProtKB",
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            "authors": "Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T",
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            "name": "homologset.mgi",
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