{ "uniprot_canonical_ac": "Q8C8H8-1", "uniprot_ac": "Q8C8H8", "uniprot_id": "KY_MOUSE", "mass": { "chemical_mass": 75090.0, "monoisotopic_mass": 75090.0 }, "refseq": { "ac": "NP_077253", "name": "kyphoscoliosis peptidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" }, "gene_names": [ { "name": "Ky", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8C8H8", "id": "Q8C8H8" }, { "name": "CD1; D9Mgc44e", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253", "id": "NP_077253" }, { "name": "Ky", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253", "id": "NP_077253" } ], "protein_names": [ { "name": "Kyphoscoliosis peptidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8C8H8" }, { "name": "3.4.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C8H8" }, { "name": "kyphoscoliosis peptidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253", "id": "NP_077253" } ], "function": [ { "annotation": "Expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" }, { "database": "PubMed", "id": "29914939", "url": "https://glygen.org/publication/PubMed/29914939" } ] }, { "annotation": "KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere.", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" }, { "database": "PubMed", "id": "20206623", "url": "https://glygen.org/publication/PubMed/20206623" } ] }, { "annotation": "Kyphoscoliosis peptidase (Ky), which plays a vital role in muscle growth, was also up-regulated in the transgenic mice. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" }, { "database": "PubMed", "id": "25860951", "url": "https://glygen.org/publication/PubMed/25860951" } ] }, { "annotation": "Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8#function" }, { "database": "PubMed", "id": "11136708", "url": "https://glygen.org/publication/PubMed/11136708" }, { "database": "PubMed", "id": "15385448", "url": "https://glygen.org/publication/PubMed/15385448" } ] }, { "annotation": "The Ky gene was downregulated in CAPN3KO muscles suggesting that Ky protease may play a complementary role in regulating muscle cytoskeleton homeostasis in response to changes in muscle activity.", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" }, { "database": "PubMed", "id": "22820870", "url": "https://glygen.org/publication/PubMed/22820870" } ] } ], "disease": [ { "disease_id": "DOID:0080098", "recommended_name": { "id": "DOID:0080098", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080098", "name": "myofibrillar myopathy 7", "description": "A myofibrillar myopathy that has_material_basis_in homozygous mutation in the KY gene on chromosome 3q22." }, "synonyms": [ { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "myofibrillar myopathy 7", "description": "Any myofibrillar myopathy in which the cause of the disease is a mutation in the KY gene." }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "KY myofibrillar myopathy (disease)", "description": "" }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "alpha-b crystalin-related fatal infantile hypertonic myofibrillar myopathy", "description": "" }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "myofibrillar myopathy (disease) caused by mutation in KY", "description": "" }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "myopathy, myofibrillar, 7", "description": "" }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "myopathy, myofibrillar, type 7", "description": "" }, { "id": "MONDO:0014922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014922", "name": "MFM7", "description": "" }, { "id": "MIM:617114", "resource": "MIM", "url": "https://www.omim.org/entry/617114", "name": "Myopathy, myofibrillar, 7", "description": "Myopathy, myofibrillar, 7" } ], "evidence": [ { "id": "0080098", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080098" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ky", "url": "https://www.uniprot.org/uniprot/Q8C8H8", "locus": { "chromosome": "9", "start_pos": 102423438, "end_pos": 102382949, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000035606", "url": "https://www.ensembl.org/id/ENSMUSG00000035606" } ] } } ], "crossref": [ { "id": "ENSMUSG00000035606", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035606", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "16716", "url": "https://www.ncbi.nlm.nih.gov/gene/16716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16716", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16716", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "96709", "url": "http://www.informatics.jax.org/marker/MGI:96709", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "WFTERQG", "url": "https://omabrowser.org/oma/group/WFTERQG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "316032at2759", "url": "http://www.orthodb.org/?query=316032at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46333:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46333:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01841", "url": "http://pfam.xfam.org/family/PF01841", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8C8H8", "url": "http://purl.obolibrary.org/obo/PR_Q8C8H8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "F8VQF8", "url": "https://www.uniprot.org/uniprot/F8VQF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8VQF8-1", "url": "https://www.uniprot.org/uniprot/F8VQF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C8H8-1", "url": "https://www.uniprot.org/uniprot/Q8C8H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C8H8-2", "url": "https://www.uniprot.org/uniprot/Q8C8H8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNRGGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASASQVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTTTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQPVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQRRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVAFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ", "length": 661, "header": "sp|Q8C8H8-1|KY_MOUSE Isoform 1 of Kyphoscoliosis peptidase OS=Mus musculus OX=10090 GN=Ky PE=1 SV=1 CANONICAL=Q8C8H8-1" }, "isoforms": [ { "isoform_ac": "F8VQF8-1", "url": "", "sequence": { "sequence": "MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNRGGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASASQVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTTTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQPVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQRRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNIAFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ", "length": 661, "header": "tr|F8VQF8-1|F8VQF8_MOUSE Computationally mapped isoform of Kyphoscoliosis peptidase OS=Mus musculus OX=10090 GN=Ky PE=4 SV=1 CANONICAL=Q8C8H8-1" }, "locus": { "chromosome": "9", "start_pos": 102419977, "end_pos": 102383342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000039390.6", "url": "https://www.ensembl.org/id/ENSMUST00000039390.6" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000036032.5", "url": "https://www.ensembl.org/id/ENSMUSP00000036032.5" } ] } }, { "isoform_ac": "Q8C8H8-1", "url": "", "sequence": { "sequence": "MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNRGGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASASQVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTTTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQPVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQRRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVAFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ", "length": 661, "header": "sp|Q8C8H8-1|KY_MOUSE Isoform 1 of Kyphoscoliosis peptidase OS=Mus musculus OX=10090 GN=Ky PE=1 SV=1 CANONICAL=Q8C8H8-1" }, "locus": {} }, { "isoform_ac": "Q8C8H8-2", "url": "", "sequence": { "sequence": "MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNRGGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASASQVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTTTSKFTLDLLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQPVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQRRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVAFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ", "length": 663, "header": "sp|Q8C8H8-2|KY_MOUSE Isoform 2 of Kyphoscoliosis peptidase OS=Mus musculus OX=10090 GN=Ky PE=1 SV=1 CANONICAL=Q8C8H8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein.", "journal": "Hum. Mol. Genet.", "date": "2001", "authors": "Blanco G, Coulton GR, Biggin A, Grainge C, Moss J, Barrett M, Berquin A, Marechal G, Skynner M, van Mier P, Nikitopoulou A, Kraus M, Ponting CP, Mason RM, Brown SD", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "reference": [ { "type": "PubMed", "id": "11136708", "url": "https://glygen.org/publication/PubMed/11136708" } ] }, { "title": "Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres.", "journal": "Hum. Mol. Genet.", "date": "2004", "authors": "Beatham J, Romero R, Townsend SK, Hacker T, van der Ven PF, Blanco G", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "reference": [ { "type": "PubMed", "id": "15385448", "url": "https://glygen.org/publication/PubMed/15385448" } ] }, { "title": "Proteomic changes in hearts of kyphoscoliosis (ky) mutant mice in the absence of structural pathology: implication for the analysis of early human heart disease.", "journal": "Proteomics", "date": "2006", "authors": "Coulton G.R., Hou Y., Le Bihan M.-C., Vega-Avelaira D.", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "reference": [ { "type": "PubMed", "id": "16622832", "url": "https://glygen.org/publication/PubMed/16622832" } ] }, { "title": "Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1.", "journal": "Exp. Cell Res.", "date": "2010", "authors": "Baker J, Riley G, Romero MR, Haynes AR, Hilton H, Simon M, Hancock J, Tateossian H, Ripoll VM, Blanco G", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" }, { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" } ], "reference": [ { "type": "PubMed", "id": "20206623", "url": "https://glygen.org/publication/PubMed/20206623" } ] }, { "title": "C3KO mouse expression analysis: downregulation of the muscular dystrophy Ky protein and alterations in muscle aging.", "journal": "Neurogenetics", "date": "2012", "authors": "Jaka O, Kramerova I, Azpitarte M, Lopez de Munain A, Spencer M, Saenz A", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" } ], "reference": [ { "type": "PubMed", "id": "22820870", "url": "https://glygen.org/publication/PubMed/22820870" } ] }, { "title": "RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptide.", "journal": "International journal of molecular sciences", "date": "2015", "authors": "Miao Y, Yang J, Xu Z, Jing L, Zhao S, Li X", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" } ], "reference": [ { "type": "PubMed", "id": "25860951", "url": "https://glygen.org/publication/PubMed/25860951" } ] }, { "title": "Transcriptional upregulation of Bag3, a chaperone-assisted selective autophagy factor, in animal models of KY-deficient hereditary myopathy.", "journal": "Disease models & mechanisms", "date": "2018", "authors": "Jokl EJ, Hughes GL, Cracknell T, Pownall ME, Blanco G", "evidence": [ { "database": "RefSeq", "id": "NP_077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077253" } ], "reference": [ { "type": "PubMed", "id": "29914939", "url": "https://glygen.org/publication/PubMed/29914939" } ] } ], "pathway": [ { "id": "mmu:16716", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16716", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z953-1", "protein_name": "Kyphoscoliosis peptidase", "gene_name": "Ky", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQADPGALLQNRGGFQGVRNGIRKWQELEENGFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSNLKSMPLDLRHFEKLDASASQVTLKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTNILRTRKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYKTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTATSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENNMYHKSEFYNKGMLSAHPETPMIRTVNGKATVTIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVRLPTELHQPVGPSWFSEQMGIRKPSHPDPIIHTSDGRCSISFVVEEGISILASLHGDDSPITEETKRRYIFQMNREKRTELKVQLPHAGKFALKIFVKKRQEQGNFVFVFNYLLCCANTKVNWPMFPEIYGHWGQDNELLEPLSGVLPANRNIPFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ", "length": 661 }, "evidence": [ { "id": "45235459", "url": "http://www.informatics.jax.org/homology/45235459", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NBH2-4", "protein_name": "Kyphoscoliosis peptidase", "gene_name": "KY", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELKKDINAVSIDMLLIVHSEKRRAAQGTLSDQQANPSSLLQRGGGFQGVGNGVRRWQKLEGNDFHENLVEKQHPQQPQVITSYNSQGTQLTVEVHPRDAMPQLLKKFSLAKRLQGDKNGNTRPRQPGGKDAHAYPWDRSSLKSMSLDLQQFEKLDIYASQVTAKSGLDELVSDLLQEAHTDLERVRAIWIWICHHIEYDIAAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRLAGVQCMTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTITSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENNMYHKSEFYNKGMLSAHPETSMIRTVNGKATVTIESCAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSDIYSSVLEYTLKCNYVDMGVQLPAELHQPVGPSWFSEQMGIMKPSHPDPIIHTSDGRCSISFSVEEGINVLASLHGDDGPITEETQRRYIFQLHREKQTELKVQLPHAGKFALKIFVKKRQEPGNYIFVFNYLVCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVPFKLKLHGIAKVLVKGQDTWPLTLNHEGYWEGSCSTAGCQEVYVMVLENANHNFYSYILKYKVNAQ", "length": 661 }, "evidence": [ { "id": "45235459", "url": "http://www.informatics.jax.org/homology/45235459", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q8C8H8", "url": "https://www.uniprot.org/uniprot/Q8C8H8" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": 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