{
    "uniprot_canonical_ac": "Q8C7M3-1",
    "uniprot_ac": "Q8C7M3",
    "uniprot_id": "TRIM9_MOUSE",
    "mass": {
        "chemical_mass": 90870.0,
        "monoisotopic_mass": 90870.0
    },
    "refseq": {
        "ac": "NP_001103673",
        "name": "E3 ubiquitin-protein ligase TRIM9 isoform 3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
    },
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        {
            "name": "Trim9",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3",
            "id": "Q8C7M3"
        },
        {
            "name": "Kiaa0282",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3",
            "id": "Q8C7M3"
        },
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            "name": "Trim9",
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673",
            "id": "NP_001103673"
        }
    ],
    "protein_names": [
        {
            "name": "E3 ubiquitin-protein ligase TRIM9",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8C7M3"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C7M3"
        },
        {
            "name": "E3 ubiquitin-protein ligase TRIM9 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397",
            "id": "NP_444397"
        },
        {
            "name": "E3 ubiquitin-protein ligase TRIM9 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672",
            "id": "NP_001103672"
        },
        {
            "name": "E3 ubiquitin-protein ligase TRIM9 isoform 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673",
            "id": "NP_001103673"
        },
        {
            "name": "RING-type E3 ubiquitin transferase TRIM9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C7M3"
        },
        {
            "name": "Tripartite motif-containing protein 9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C7M3"
        },
        {
            "name": "tripartite motif-containing protein 9; E3 ubiquitin-protein ligase TRIM9; RING-type E3 ubiquitin transferase TRIM9",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672",
            "id": "NP_001103672"
        }
    ],
    "function": [
        {
            "annotation": "E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9C026",
                    "url": "https://www.uniprot.org/uniprot/Q9C026#function"
                }
            ]
        },
        {
            "annotation": "Findings reveal that TRIM9 is essential for resolving NF-kappaB-dependent neuroinflammation to promote recovery and repair after brain injury. Erratum:[Cell Rep. 2023 Aug 29;42(8):113050. PMID: 37597183]",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "PubMed",
                    "id": "30970257",
                    "url": "https://glygen.org/publication/PubMed/30970257"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ]
        },
        {
            "annotation": "MicroRNA-653 Inhibits Thymocyte Proliferation and Induces Thymocyte Apoptosis in Mice with Autoimmune Myasthenia Gravis by Downregulating TRIM9.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "PubMed",
                    "id": "30703767",
                    "url": "https://glygen.org/publication/PubMed/30703767"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ]
        },
        {
            "annotation": "TRIM9 is expressed in the mouse embryonic and adult nervous system",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "PubMed",
                    "id": "11960705",
                    "url": "https://glygen.org/publication/PubMed/11960705"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ]
        },
        {
            "annotation": "The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "PubMed",
                    "id": "33378226",
                    "url": "https://glygen.org/publication/PubMed/33378226"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0080697",
            "recommended_name": {
                "id": "DOID:0080697",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080697",
                "name": "Opitz GBBB syndrome",
                "description": "A syndrome that is a congenital midline malformation syndrome that is characterized by hypertelorism, hypospadias, cleft lip/palate, laryngotracheoesophageal abnormalities, imperforate anus, developmental delay, and cardiac defects and that has_material_basis_in mutation in the MID1 gene on chromosome Xp22."
            },
            "synonyms": [
                {
                    "id": "DOID:0080697",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080697",
                    "name": "Opitz G/BBB Syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0080697",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080697",
                    "name": "Opitz GBBB syndrome type I",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "X-linked Opitz G/BBB syndrome",
                    "description": "X-linked form of Opitz G/BBB syndrome."
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "Opitz G/BBB syndrome, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "Opitz GBBB syndrome, type I, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "X-linked Opitz BBB/G syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "X-linked Opitz G/BBB syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "X-linked Opitz syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "XLOS",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "GBBB1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010222",
                    "name": "Opitz Bbbg syndrome, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010222",
                    "resource": "MONDO",
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                {
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                {
                    "id": "MONDO:0010222",
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                    "description": ""
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                {
                    "id": "MONDO:0010222",
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            "id": "E9Q524-1",
            "url": "https://www.uniprot.org/uniprot/E9Q524-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9QLH4",
            "url": "https://www.uniprot.org/uniprot/E9QLH4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9QLH4-1",
            "url": "https://www.uniprot.org/uniprot/E9QLH4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-1",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-2",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-3",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-4",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-5",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C7M3-6",
            "url": "https://www.uniprot.org/uniprot/Q8C7M3-6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP",
        "length": 817,
        "header": "sp|Q8C7M3-1|TRIM9_MOUSE Isoform 1 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1Y7VJX8-1",
            "url": "",
            "sequence": {
                "sequence": "XNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP",
                "length": 772,
                "header": "tr|A0A1Y7VJX8-1|A0A1Y7VJX8_MOUSE Computationally mapped isoform of Tripartite motif-containing 9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=1 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393863,
                "end_pos": 70294945,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000221294.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000221294.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152691.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152691.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1Y7VP88-1",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA",
                "length": 710,
                "header": "tr|A0A1Y7VP88-1|A0A1Y7VP88_MOUSE Computationally mapped isoform of RING-type E3 ubiquitin transferase  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=1 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70293166,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000223160.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000223160.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152887.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152887.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A6I8MWZ7-1",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGKALQQYPSERELRGV",
                "length": 550,
                "header": "tr|A0A6I8MWZ7-1|A0A6I8MWZ7_MOUSE Computationally mapped isoform of RING-type E3 ubiquitin transferase  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=1 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70314789,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000222603.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000222603.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000159335.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000159335.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9Q524-1",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKGR",
                "length": 547,
                "header": "tr|E9Q524-1|E9Q524_MOUSE Computationally mapped isoform of RING-type E3 ubiquitin transferase  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=1 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70313262,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000167755.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000167755.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000127081.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000127081.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9QLH4-1",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA",
                "length": 788,
                "header": "tr|E9QLH4-1|E9QLH4_MOUSE Computationally mapped isoform of RING-type E3 ubiquitin transferase  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=1 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70293166,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000110522.10",
                        "url": "https://www.ensembl.org/id/ENSMUST00000110522.10"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000106151.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000106151.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C7M3-1",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP",
                "length": 817,
                "header": "sp|Q8C7M3-1|TRIM9_MOUSE Isoform 1 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70294946,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000222316",
                        "url": "https://www.ensembl.org/id/ENSMUST00000222316"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152147",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152147"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C7M3-2",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP",
                "length": 798,
                "header": "sp|Q8C7M3-2|TRIM9_MOUSE Isoform 2 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q8C7M3-3",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGCNFETQSASYSQLVDIKKLLAVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAITEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA",
                "length": 714,
                "header": "sp|Q8C7M3-3|TRIM9_MOUSE Isoform 3 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70293166,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000110520",
                        "url": "https://www.ensembl.org/id/ENSMUST00000110520"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000106149",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000106149"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C7M3-4",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKGMCGWRQSILRLLGIVLLVD",
                "length": 565,
                "header": "sp|Q8C7M3-4|TRIM9_MOUSE Isoform 4 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70313949,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000221041",
                        "url": "https://www.ensembl.org/id/ENSMUST00000221041"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152496",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152496"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C7M3-5",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP",
                "length": 721,
                "header": "sp|Q8C7M3-5|TRIM9_MOUSE Isoform 5 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q8C7M3-6",
            "url": "",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGR",
                "length": 536,
                "header": "sp|Q8C7M3-6|TRIM9_MOUSE Isoform 6 of E3 ubiquitin-protein ligase TRIM9  OS=Mus musculus OX=10090 GN=Trim9 PE=1 SV=2 CANONICAL=Q8C7M3-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 70393942,
                "end_pos": 70313262,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000221370",
                        "url": "https://www.ensembl.org/id/ENSMUST00000221370"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152692",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152692"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 41,
            "end_pos": 41,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "site_lbl": "Thr41"
        },
        {
            "start_pos": 44,
            "end_pos": 44,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "site_lbl": "Ser44"
        },
        {
            "start_pos": 46,
            "end_pos": 46,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "site_lbl": "Ser46"
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "site_lbl": "Ser49"
        },
        {
            "start_pos": 53,
            "end_pos": 53,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "site_lbl": "Ser53"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "The tripartite motif family identifies cell compartments.",
            "journal": "EMBO J.",
            "date": "2001",
            "authors": "Merla G., Pelicci P.G., Reymond A., Ballabio A., Meroni G., Guffanti A., Messali S., Minucci S., Cairo S., Zanaria E., Cainarca S., Fantozzi A., Luzi L., Riganelli D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11331580",
                    "url": "https://glygen.org/publication/PubMed/11331580"
                }
            ]
        },
        {
            "title": "TRIM9 is specifically expressed in the embryonic and adult nervous system.",
            "journal": "Mech. Dev.",
            "date": "2002",
            "authors": "Berti C, Messali S, Ballabio A, Reymond A, Meroni G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11960705",
                    "url": "https://glygen.org/publication/PubMed/11960705"
                }
            ]
        },
        {
            "title": "TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.",
            "journal": "Neurobiol. Dis.",
            "date": "2010",
            "authors": "Tanji K, Kamitani T, Mori F, Kakita A, Takahashi H, Wakabayashi K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20085810",
                    "url": "https://glygen.org/publication/PubMed/20085810"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8C7M3",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8C7M3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "MicroRNA-653 Inhibits Thymocyte Proliferation and Induces Thymocyte Apoptosis in Mice with Autoimmune Myasthenia Gravis by Downregulating TRIM9.",
            "journal": "Neuroimmunomodulation",
            "date": "2019",
            "authors": "Cao YL, Dong W, Li YZ, Han W",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30703767",
                    "url": "https://glygen.org/publication/PubMed/30703767"
                }
            ]
        },
        {
            "title": "TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.",
            "journal": "Cell reports",
            "date": "2019",
            "authors": "Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30970257",
                    "url": "https://glygen.org/publication/PubMed/30970257"
                }
            ]
        },
        {
            "title": "The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.",
            "journal": "Molecular biology of the cell",
            "date": "2021",
            "authors": "Menon S, Goldfarb D, Ho CT, Cloer EW, Boyer NP, Hardie C, Bock AJ, Johnson EC, Anil J, Major MB, Gupton SL",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001103672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103672"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001103673",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103673"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_444397",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444397"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33378226",
                    "url": "https://glygen.org/publication/PubMed/33378226"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:94090",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:94090",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q91ZY8-1",
            "protein_name": "E3 ubiquitin-protein ligase TRIM9",
            "gene_name": "Trim9",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA",
                "length": 710
            },
            "evidence": [
                {
                    "id": "45231785",
                    "url": "http://www.informatics.jax.org/homology/45231785",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9C026-1",
            "protein_name": "E3 ubiquitin-protein ligase TRIM9",
            "gene_name": "TRIM9",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA",
                "length": 710
            },
            "evidence": [
                {
                    "id": "45231785",
                    "url": "http://www.informatics.jax.org/homology/45231785",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein domain specific binding",
                        "id": "GO:0019904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "SNARE binding",
                        "id": "GO:0000149",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoskeleton",
                        "id": "GO:0005856",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle",
                        "id": "GO:0008021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "presynaptic cytosol",
                        "id": "GO:0099523",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099523",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "proteasome-mediated ubiquitin-dependent protein catabolic process",
                        "id": "GO:0043161",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of calcium ion-dependent exocytosis",
                        "id": "GO:0045955",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045955",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of SNARE complex assembly",
                        "id": "GO:0035544",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035544",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle exocytosis",
                        "id": "GO:0016079",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016079",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C7M3",
                                "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 236,
            "end_pos": 238,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 455,
            "end_pos": 457,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 506,
            "end_pos": 508,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 517,
            "end_pos": 519,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 651,
            "end_pos": 653,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 719,
            "end_pos": 721,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 726,
            "end_pos": 728,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 731,
            "end_pos": 733,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Auto-ubiquitinated.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C7M3",
                    "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                },
                {
                    "database": "PubMed",
                    "id": "Q9C026",
                    "url": "https://glygen.org/publication/PubMed/Q9C026"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [
        {
            "id": "R-MMU-983140",
            "name": "Transfer of Ub from E2 to substrate and release of E2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983140",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140"
                }
            ]
        },
        {
            "id": "R-MMU-983147",
            "name": "Release of E3 from polyubiquitinated substrate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q8CCJ3-3",
                "Q06986-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "Q6WKZ8-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "Q80U95-1",
                "Q9ES34-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983147",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983147"
                }
            ]
        },
        {
            "id": "R-MMU-983156",
            "name": "Polyubiquitination of substrate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
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                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
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                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983156",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156"
                }
            ]
        },
        {
            "id": "R-MMU-983157",
            "name": "Interaction of E3 with substrate and E2-Ub complex",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8CFI0-1",
                "Q6P073-1",
                "Q8CFI2-1",
                "Q91W82-1",
                "Q921J4-1",
                "Q922B6-1",
                "Q99PQ2-1",
                "Q9WUD1-1",
                "Q9WUB0-1",
                "Q8BM54-1",
                "Q8C432-1",
                "Q9DBU5-1",
                "Q9ET26-1",
                "Q9JI90-1",
                "Q7TMY8-1",
                "Q1PSW8-1",
                "Q8R516-1",
                "Q9D074-1",
                "O55176-3",
                "Q8BH75-1",
                "Q99KR6-1",
                "Q9D0C1-1",
                "Q9WTV7-1",
                "G5E870-1",
                "Q80WG7-1",
                "Q80X56-1",
                "Q8CH72-1",
                "Q3UE37-1",
                "Q8CCJ3-3",
                "Q8VDW4-1",
                "Q06986-1",
                "P60605-1",
                "Q3U487-1",
                "P97868-1",
                "Q5XPI3-1",
                "Q6PDX6-1",
                "Q91YL2-1",
                "A2A5Z6-1",
                "Q925F4-1",
                "Q99ML9-1",
                "Q9JIY2-1",
                "Q69ZI1-1",
                "O08759-1",
                "P62257-1",
                "Q6WKZ8-1",
                "Q6ZPJ3-1",
                "A2AN08-1",
                "Q71FD5-1",
                "Q8CHG5-1",
                "P61092-1",
                "Q3UIR3-1",
                "Q6I6G8-1",
                "Q05A36-1",
                "Q9QXP6-1",
                "A2A7Q9-1",
                "E9Q555-1",
                "P50636-1",
                "Q9QZR0-1",
                "Q9QZS2-1",
                "P61089-1",
                "Q38HM4-1",
                "Q9ESN2-1",
                "Q5FWH2-3",
                "Q8BX13-1",
                "O70481-1",
                "P52482-1",
                "P61080-1",
                "P61087-1",
                "P62254-1",
                "P62838-1",
                "P63147-1",
                "P68037-1",
                "Q6ZWZ2-1",
                "Q80U95-1",
                "Q8K2Z8-1",
                "Q9CY34-1",
                "Q9D1C1-1",
                "Q9ES34-1",
                "Q9JJZ4-1",
                "Q9QZU9-1",
                "Q9Z255-1",
                "Q91V17-1",
                "Q9CR50-1",
                "Q3TTA7-1",
                "Q80TR8-1",
                "O70263-1",
                "Q80U04-1",
                "Q80ZI6-1",
                "D3YYI7-1",
                "Q9CQE0-1",
                "Q8C863-1",
                "Q9WVS6-1",
                "Q62191-1",
                "Q7TPV2-1",
                "Q3U0D9-1",
                "Q4U2R1-1",
                "P46935-1",
                "F2Z461-1",
                "P62878-1",
                "Q8BKD6-1",
                "Q9CUN6-1",
                "Q8BZZ3-1",
                "Q69ZR2-1",
                "Q6PAV2-1",
                "Q8CDU6-1",
                "Q8C7M3-1",
                "Q8VIG6-1",
                "E9Q735-1",
                "P52483-1",
                "P61079-1",
                "P61082-1",
                "Q7TSS2-1",
                "Q9Z1K6-1",
                "Q8VEM1-1",
                "Q6A009-1",
                "Q5NCC3-1",
                "Q6PCX9-1",
                "Q810I2-1",
                "Q9DBK7-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-983157",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A2A5Z6",
            "gene_name": "Smurf2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2A5Z6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A5Z6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2A5Z6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A5Z6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2A7Q9",
            "gene_name": "Rnf19b",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2A7Q9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A7Q9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2A7Q9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2A7Q9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2AN08",
            "gene_name": "Ubr4",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A2AN08",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2AN08"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2AN08",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2AN08"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D3YYI7",
            "gene_name": "Rnf217",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "D3YYI7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3YYI7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D3YYI7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D3YYI7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9Q555",
            "gene_name": "Rnf213",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.4.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q555"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "E9Q735",
            "gene_name": "Ube4a",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "E9Q735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q735"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "E9Q735",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/E9Q735"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "F2Z461",
            "gene_name": "Herc6",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "F2Z461",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F2Z461"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "G5E870",
            "gene_name": "Trip12",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "G5E870",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G5E870"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "G5E870",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G5E870"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O08759",
            "gene_name": "Ube3a",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O08759",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08759"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O08759",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O08759"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O55176",
            "gene_name": "Pja1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O55176",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O55176"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O55176",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O55176"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O70263",
            "gene_name": "Lnx1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O70263",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70263"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O70263",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70263"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O70481",
            "gene_name": "Ubr1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "O70481",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70481"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O70481",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O70481"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P46935",
            "gene_name": "Nedd4",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P46935",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46935"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P46935",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46935"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P50636",
            "gene_name": "Rnf19a",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "P50636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50636"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P50636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50636"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P52482",
            "gene_name": "Ube2e1",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P52482",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52482"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P52483",
            "gene_name": "Ube2e3",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P52483",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52483"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P52483",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P52483"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P60605",
            "gene_name": "Ube2g2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P60605",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P60605"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P60605",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P60605"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61079",
            "gene_name": "Ube2d3",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61079"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61080",
            "gene_name": "Ube2d1",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61080",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61080"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61082",
            "gene_name": "Ube2m",
            "activity": [
                {
                    "ec_number": "2.3.2.34",
                    "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61082",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61082"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.34",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61082",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61082"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61087",
            "gene_name": "Ube2k",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61087",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61087"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61087",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61087"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61089",
            "gene_name": "Ube2n",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P61089",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61089"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61089",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61089"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P61092",
            "gene_name": "Siah1a",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P61092",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61092"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P61092",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P61092"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62254",
            "gene_name": "Ube2g1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62254",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62254"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62254",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62254"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62257",
            "gene_name": "Ube2h",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62257",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62257"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62838",
            "gene_name": "Ube2d2",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62838",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62838"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62878",
            "gene_name": "Rbx1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.32",
                    "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.32",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62878",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62878"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P63147",
            "gene_name": "Ube2b",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P63147",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63147"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P63147",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63147"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P68037",
            "gene_name": "Ube2l3",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "P68037",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68037"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P68037",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68037"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P97868",
            "gene_name": "Rbbp6",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "P97868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97868"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P97868",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97868"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q05A36",
            "gene_name": "Mex3c",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q05A36",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05A36"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q05A36",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05A36"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q06986",
            "gene_name": "Siah2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q06986",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06986"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q06986",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06986"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q1PSW8",
            "gene_name": "Trim71",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q1PSW8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1PSW8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q1PSW8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1PSW8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q38HM4",
            "gene_name": "Trim63",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q38HM4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q38HM4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q38HM4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q38HM4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3TTA7",
            "gene_name": "Cblb",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3TTA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TTA7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3TTA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TTA7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3U0D9",
            "gene_name": "Hace1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3U0D9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U0D9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3U0D9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U0D9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3U487",
            "gene_name": "Hectd3",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3U487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U487"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3U487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U487"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3UE37",
            "gene_name": "Ube2z",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q3UE37",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UE37"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3UE37",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UE37"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3UIR3",
            "gene_name": "Dtx3l",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q3UIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UIR3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3UIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UIR3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q4U2R1",
            "gene_name": "Herc2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q4U2R1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4U2R1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q4U2R1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4U2R1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5FWH2",
            "gene_name": "Unkl",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5FWH2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5FWH2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5NCC3",
            "gene_name": "Trim41",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q5NCC3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5NCC3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5NCC3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5NCC3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5XPI3",
            "gene_name": "Rnf123",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q5XPI3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XPI3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5XPI3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XPI3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62191",
            "gene_name": "Trim21",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q62191",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62191"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62191",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62191"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q69ZI1",
            "gene_name": "Sh3rf1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q69ZI1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZI1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q69ZI1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZI1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q69ZR2",
            "gene_name": "Hectd1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q69ZR2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZR2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q69ZR2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZR2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6A009",
            "gene_name": "Ltn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6A009",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6A009"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6A009",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6A009"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6I6G8",
            "gene_name": "Hecw2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6I6G8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6I6G8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6I6G8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6I6G8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6P073",
            "gene_name": "Ube2j2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q6P073",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6P073"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6P073",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6P073"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PAV2",
            "gene_name": "Herc4",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PAV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PAV2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PAV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PAV2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PCX9",
            "gene_name": "Trim37",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PCX9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCX9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PCX9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCX9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PDX6",
            "gene_name": "Rnf220",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6PDX6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PDX6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PDX6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PDX6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6WKZ8",
            "gene_name": "Ubr2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6WKZ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6WKZ8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6WKZ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6WKZ8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZPJ3",
            "gene_name": "Ube2o",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q6ZPJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZPJ3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZPJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZPJ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZWZ2",
            "gene_name": "Ube2r2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q6ZWZ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZWZ2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZWZ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZWZ2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q71FD5",
            "gene_name": "Znrf2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q71FD5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q71FD5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q71FD5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q71FD5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TMY8",
            "gene_name": "Huwe1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q7TMY8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TMY8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TMY8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TMY8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TPV2",
            "gene_name": "Dzip3",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q7TPV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TPV2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TPV2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TPV2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q7TSS2",
            "gene_name": "Ube2q1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q7TSS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TSS2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q7TSS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q7TSS2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80TR8",
            "gene_name": "Dcaf1",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q80TR8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80TR8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80U04",
            "gene_name": "Pja2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80U04",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U04"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80U04",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U04"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80U95",
            "gene_name": "Ube3c",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80U95",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U95"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80U95",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80U95"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80WG7",
            "gene_name": "Trim36",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80WG7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80WG7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80WG7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80WG7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80X56",
            "gene_name": "Trim69",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80X56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80X56"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80X56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80X56"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q80ZI6",
            "gene_name": "Lrsam1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q80ZI6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80ZI6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q80ZI6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q80ZI6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q810I2",
            "gene_name": "Trim50",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q810I2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q810I2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q810I2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q810I2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BH75",
            "gene_name": "Rnf41",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BH75",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BH75"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BH75",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BH75"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BKD6",
            "gene_name": "Rnf144b",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BKD6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BKD6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BKD6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BKD6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BM54",
            "gene_name": "Mylip",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BM54",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BM54"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BM54",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BM54"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BX13",
            "gene_name": "Ube3d",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BX13",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BX13"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BX13",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BX13"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BZZ3",
            "gene_name": "Wwp1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8BZZ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BZZ3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BZZ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BZZ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C432",
            "gene_name": "Rnf182",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C432",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C432"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C432",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C432"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C7M3",
            "gene_name": "Trim9",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C7M3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C7M3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C7M3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8C863",
            "gene_name": "Itch",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8C863",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C863"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8C863",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8C863"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CCJ3",
            "gene_name": "Ufl1",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CCJ3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CCJ3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CDU6",
            "gene_name": "Hectd2",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CDU6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CDU6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CDU6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CDU6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CFI0",
            "gene_name": "Nedd4l",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.36",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.36",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CFI2",
            "gene_name": "Cdc34",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CFI2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CFI2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CH72",
            "gene_name": "Trim32",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CH72",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CH72"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CH72",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CH72"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8CHG5",
            "gene_name": "Arel1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8CHG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CHG5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8CHG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8CHG5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8K2Z8",
            "gene_name": "Ube2q2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8K2Z8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8K2Z8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8K2Z8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8R516",
            "gene_name": "Mib2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8R516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R516"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8R516",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R516"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VDW4",
            "gene_name": "Ube2w",
            "activity": [
                {
                    "ec_number": "2.3.2.25",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VDW4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VDW4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VEM1",
            "gene_name": "Rnf130",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8VEM1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VEM1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VEM1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VEM1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VIG6",
            "gene_name": "Traip",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q8VIG6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VIG6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VIG6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VIG6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91V17",
            "gene_name": "Znrf1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q91V17",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91V17"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91V17",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91V17"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91W82",
            "gene_name": "Ube2e2",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q91W82",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91W82"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91W82",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91W82"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q91YL2",
            "gene_name": "Rnf126",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q91YL2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91YL2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q91YL2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q91YL2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q921J4",
            "gene_name": "Ube2s",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q921J4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q921J4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q921J4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q921J4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q922B6",
            "gene_name": "Traf7",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q922B6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q922B6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q922B6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q922B6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q925F4",
            "gene_name": "Ubox5",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q925F4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q925F4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q925F4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q925F4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99KR6",
            "gene_name": "Rnf34",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99KR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99KR6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99KR6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99KR6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99ML9",
            "gene_name": "Rnf111",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99ML9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99ML9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99ML9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99ML9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q99PQ2",
            "gene_name": "Trim11",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q99PQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99PQ2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q99PQ2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q99PQ2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CQE0",
            "gene_name": "Rnf138",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CQE0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CQE0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CQE0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CQE0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CR50",
            "gene_name": "Rchy1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CR50",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CR50"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CR50",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CR50"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CUN6",
            "gene_name": "Smurf1",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9CUN6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CUN6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CUN6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CUN6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9CY34",
            "gene_name": "Ube2f",
            "activity": [
                {
                    "ec_number": "2.3.2.34",
                    "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9CY34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CY34"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.34",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9CY34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9CY34"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D074",
            "gene_name": "Mgrn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D074",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D074"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D074",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D074"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D0C1",
            "gene_name": "Rnf115",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D0C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D0C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D0C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D0C1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9D1C1",
            "gene_name": "Ube2c",
            "activity": [
                {
                    "ec_number": "2.3.2.24",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9D1C1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9D1C1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9DBK7",
            "gene_name": "Uba7",
            "activity": [
                {
                    "ec_number": "6.2.1.45",
                    "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9DBK7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBK7"
                        }
                    ]
                },
                {
                    "ec_number": "6.2.1.45",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9DBK7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBK7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9DBU5",
            "gene_name": "Rnf6",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9DBU5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBU5"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9DBU5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9DBU5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ES34",
            "gene_name": "Ube3b",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ES34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ES34"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ES34",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ES34"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ESN2",
            "gene_name": "Trim39",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ESN2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ESN2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ESN2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ESN2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9ET26",
            "gene_name": "Rnf114",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9ET26",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ET26"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9ET26",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9ET26"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JI90",
            "gene_name": "Rnf14",
            "activity": [
                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9JI90",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JI90"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JI90",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JI90"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JIY2",
            "gene_name": "Cbll1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9JIY2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JIY2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JIY2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JIY2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JJZ4",
            "gene_name": "Ube2j1",
            "activity": [
                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9JJZ4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JJZ4"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9JJZ4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JJZ4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QXP6",
            "gene_name": "Mkrn1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QXP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QXP6"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QXP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QXP6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZR0",
            "gene_name": "Rnf25",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QZR0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZR0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZR0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZS2",
            "gene_name": "Rnf4",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "Q9QZS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZS2"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZS2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZS2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9QZU9",
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                {
                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
                    "evidence": [
                        {
                            "id": "Q9QZU9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZU9"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9QZU9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9QZU9"
                        }
                    ]
                }
            ]
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        {
            "uniprot_ac": "Q9WTV7",
            "gene_name": "Rlim",
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                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
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                            "id": "Q9WTV7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WTV7"
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                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
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                            "id": "Q9WTV7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WTV7"
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                }
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        {
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                {
                    "ec_number": "2.3.2.31",
                    "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.",
                    "evidence": [
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                            "id": "Q9WUB0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUB0"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.31",
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                            "id": "Q9WUB0",
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                }
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                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
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                            "id": "Q9WUD1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9WUD1"
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                    ]
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                {
                    "ec_number": "2.3.2.27",
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                            "id": "Q9WUD1",
                            "database": "UniProtKB",
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                {
                    "ec_number": "6.3.2.19",
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                            "id": "Q9WVS6",
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                            "id": "Q9WVS6",
                            "database": "UniProtKB",
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                    "ec_number": "2.3.2.31",
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                            "id": "Q9Z1K6",
                            "database": "UniProtKB",
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                {
                    "ec_number": "2.3.2.31",
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                            "id": "Q9Z1K6",
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                    "ec_number": "2.3.2.23",
                    "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.",
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                            "id": "Q9Z255",
                            "database": "UniProtKB",
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                {
                    "ec_number": "2.3.2.23",
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                            "id": "Q9Z255",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z255"
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    "biomarkers": [],
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        {
            "name": "isoformset.uniprotkb",
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            "name": "homologset.mgi",
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