{ "uniprot_canonical_ac": "Q8C310-1", "uniprot_ac": "Q8C310", "uniprot_id": "ROBO4_MOUSE", "mass": { "chemical_mass": 108499.0, "monoisotopic_mass": 108499.0 }, "refseq": { "ac": "NP_083059", "name": "roundabout homolog 4 isoform 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, "gene_names": [ { "name": "Robo4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8C310", "id": "Q8C310" }, { "name": "1200012D01Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319", "id": "NP_001296319" }, { "name": "Robo4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319", "id": "NP_001296319" } ], "protein_names": [ { "name": "Roundabout homolog 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8C310" }, { "name": "Magic roundabout; roundabout homolog 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059", "id": "NP_083059" }, { "name": "roundabout homolog 4 isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319", "id": "NP_001296319" }, { "name": "roundabout homolog 4 isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059", "id": "NP_083059" } ], "function": [ { "annotation": "Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8C310", "url": "https://www.uniprot.org/uniprot/Q8C310#function" }, { "database": "UniProtKB", "id": "Q8WZ75", "url": "https://www.uniprot.org/uniprot/Q8WZ75#function" }, { "database": "PubMed", "id": "12941633", "url": "https://glygen.org/publication/PubMed/12941633" } ] }, { "annotation": "Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "PubMed", "id": "36647012", "url": "https://glygen.org/publication/PubMed/36647012" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ] }, { "annotation": "Robo4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development.", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "PubMed", "id": "12941633", "url": "https://glygen.org/publication/PubMed/12941633" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ] }, { "annotation": "Robo4 mRNA level decreases during vascular decline in pulmonary fibrosis.", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "PubMed", "id": "17496152", "url": "https://glygen.org/publication/PubMed/17496152" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ] }, { "annotation": "Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "PubMed", "id": "36634143", "url": "https://glygen.org/publication/PubMed/36634143" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ] }, { "annotation": "[The destructive role of soluble Robo4 secreted by the M1-polarized-microglia during cerebral ischemia-reperfusion in blood-brain barrier integrity].", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "PubMed", "id": "35993202", "url": "https://glygen.org/publication/PubMed/35993202" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ] } ], "disease": [ { "disease_id": "DOID:0080977", "recommended_name": { "id": "DOID:0080977", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080977", "name": "aortic valve disease 3", "description": "A bicuspid aortic valve disease that is characterized by aortic stenosis and/or bicuspid aortic valve, associated in some patients with aneurysm of the aortic root and/or ascending aorta and that has_material_basis_in heterozygous mutation in the ROBO4 gene on chromosome 11q24." }, "synonyms": [ { "id": "MONDO:0032783", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032783", "name": "aortic valve disease 3", "description": "" }, { "id": "MONDO:0032783", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032783", "name": "AORTIC VALVE DISEASE 3", "description": "" }, { "id": "MONDO:0032783", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032783", "name": "AOVD3", "description": "" }, { "id": "MIM:618496", "resource": "MIM", "url": "https://www.omim.org/entry/618496", "name": "Aortic valve disease 3", "description": "Aortic valve disease 3" } ], "evidence": [ { "id": "0080977", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080977" } ] }, { "disease_id": "DOID:10591", "recommended_name": { "id": "DOID:10591", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy." }, "synonyms": [ { "id": "DOID:10591", "resource": "Disease 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Ontology", "url": "http://disease-ontology.org/term/DOID:10591", "name": "pregnancy toxemia", "description": "" }, { "id": "DOID:10591", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10591", "name": "proteinuric hypertension of pregnancy", "description": "" }, { "id": "DOID:10591", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10591", "name": "toxaemia of pregnancy", "description": "" }, { "id": "MONDO:0012266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012266", "name": "preeclampsia/eclampsia 4", "description": "Any preeclampsia in which the cause of the disease is a mutation in the STOX1 gene." }, { "id": "MONDO:0012266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012266", "name": "Preeclampsia/eclampsia type 4", "description": "" }, { "id": "MONDO:0012266", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012266", "name": "STOX1 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}, { "id": "MONDO:0012265", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012265", "name": "PREECLAMPSIA/eclampsia 3", "description": "" }, { "id": "MONDO:0012264", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012264", "name": "preeclampsia/eclampsia 2", "description": "" }, { "id": "MONDO:0012264", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012264", "name": "PEE2", "description": "" }, { "id": "MONDO:0012264", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012264", "name": "PREECLAMPSIA/eclampsia 2", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "preeclampsia/eclampsia 1", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "toxaemia of pregnancy", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "toxemia of pregnancy", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "PEE1", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "PREECLAMPSIA/eclampsia 1", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "PREG1", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "hemolysis, elevated liver enzymes, and low platelet count", "description": "" }, { "id": "MONDO:0100467", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100467", "name": "hypertension, pregnancy-induced", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "bent bone dysplasia syndrome 1", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "FGFR2-related bent bone dysplasia", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "perinatal lethal bent bone dysplasia", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "BBDS", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "bent bone dysplasia (BBD)-FGFR2 type", "description": "" }, { "id": "MONDO:0013815", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013815", "name": "bent bone dysplasia syndrome", "description": "" }, { "id": "MIM:609404", 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"PTHR44170:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44170:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "http://pfam.xfam.org/family/PF00041", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8C310", "url": "http://purl.obolibrary.org/obo/PR_Q8C310", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4J197", "url": "https://www.uniprot.org/uniprot/A0A0R4J197", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4J197-1", "url": "https://www.uniprot.org/uniprot/A0A0R4J197-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SSV2", "url": "https://www.uniprot.org/uniprot/A0A1L1SSV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SSV2-1", "url": "https://www.uniprot.org/uniprot/A0A1L1SSV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SUF8", "url": "https://www.uniprot.org/uniprot/A0A1L1SUF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SUF8-1", "url": "https://www.uniprot.org/uniprot/A0A1L1SUF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z4M4", "url": "https://www.uniprot.org/uniprot/D3Z4M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z4M4-1", "url": "https://www.uniprot.org/uniprot/D3Z4M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6IR38", "url": "https://www.uniprot.org/uniprot/Q6IR38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6IR38-1", "url": "https://www.uniprot.org/uniprot/Q6IR38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C310", "url": "https://www.uniprot.org/uniprot/Q8C310", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C310-1", "url": "https://www.uniprot.org/uniprot/Q8C310-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C310-2", "url": "https://www.uniprot.org/uniprot/Q8C310-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C310-3", "url": "https://www.uniprot.org/uniprot/Q8C310-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1012, "header": "sp|Q8C310-1|ROBO4_MOUSE Isoform 1 of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "isoforms": [ { "isoform_ac": "A0A0R4J197-1", "url": "", "sequence": { "sequence": "MGQGEEPRAAMGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1015, "header": "tr|A0A0R4J197-1|A0A0R4J197_MOUSE Computationally mapped isoform of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=1 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37324680, "end_pos": 37313348, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000239486.2", "url": "https://www.ensembl.org/id/ENSMUST00000239486.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000159318.2", "url": "https://www.ensembl.org/id/ENSMUSP00000159318.2" } ] } }, { "isoform_ac": "A0A1L1SSV2-1", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVRQRSQKTPRAQIRAAMSSLVHYRCSDFFPGERPCCTC", "length": 308, "header": "tr|A0A1L1SSV2-1|A0A1L1SSV2_MOUSE Computationally mapped isoform of Roundabout guidance receptor 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37315611, "end_pos": 37313378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000156972.3", "url": "https://www.ensembl.org/id/ENSMUST00000156972.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000150053.3", "url": "https://www.ensembl.org/id/ENSMUSP00000150053.3" } ] } }, { "isoform_ac": "A0A1L1SUF8-1", "url": "", "sequence": { "sequence": "MGQGEEPRAAMGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1022, "header": "tr|A0A1L1SUF8-1|ROBO4_MOUSE Computationally mapped isoform of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=1 CANONICAL=Q8C310-1" }, "locus": {} }, { "isoform_ac": "D3Z4M4-1", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLGEGKALSISSTPPPCRPSVSQFLSYIFSSSLSCLLVPLTVPLALPLSSTSQTEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1064, "header": "tr|D3Z4M4-1|D3Z4M4_MOUSE Computationally mapped isoform of Roundabout guidance receptor 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37324680, "end_pos": 37313378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000115046.9", "url": "https://www.ensembl.org/id/ENSMUST00000115046.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110698.3", "url": "https://www.ensembl.org/id/ENSMUSP00000110698.3" } ] } }, { "isoform_ac": "Q6IR38-1", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 901, "header": "tr|Q6IR38-1|Q6IR38_MOUSE Computationally mapped isoform of Robo4 protein OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=1 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37324680, "end_pos": 37313378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000115048.10", "url": "https://www.ensembl.org/id/ENSMUST00000115048.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000110700.4", "url": "https://www.ensembl.org/id/ENSMUSP00000110700.4" } ] } }, { "isoform_ac": "Q8C310-1", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGPNSGSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1012, "header": "sp|Q8C310-1|ROBO4_MOUSE Isoform 1 of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37324680, "end_pos": 37313378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000214185", "url": "https://www.ensembl.org/id/ENSMUST00000214185" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000150722", "url": "https://www.ensembl.org/id/ENSMUSP00000150722" } ] } }, { "isoform_ac": "Q8C310-2", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1005, "header": "sp|Q8C310-2|ROBO4_MOUSE Isoform 2 of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "locus": { "chromosome": "9", "start_pos": 37324680, "end_pos": 37313378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000102895", "url": "https://www.ensembl.org/id/ENSMUST00000102895" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099959", "url": "https://www.ensembl.org/id/ENSMUSP00000099959" } ] } }, { "isoform_ac": "Q8C310-3", "url": "", "sequence": { "sequence": "MGSGGTGLLGTEWPLPLLLLFIMGGEALDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLGEGKALSISSTPPPCRPSVSQFLSYIFSSSLSCLLVPLTVPLALPLSSTSQTEQAMEQSARDPRKHVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCIYRRRKAGVHLGPGLYRYTSEDAILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTSTFYGSLIAEQPSSPPVRPSPKTPAARRFPSKLAGTSSPWASSDSLCSRRGLCSPRMSLTPTEAWKAKKKQELHQANSSPLLRGSHPMEIWAWELGSRASKNLSQSPGEAPRAVVSWRAVGPQLHRNSSELASRPLPPTPLSLRGASSHDPQSQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSCPSPSSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYISIPTCSGLADMGRAGGGVGSEVGNLLYPPRPCPTPTPSEGSLANGWGSASEDNVPSARASLVSSSDGSFLADTHFARALAVAVDSFGLSLDPREADCVFTDASSPPSPRGDLSLTRSFSLPLWEWRPDWLEDAEISHTQRLGRGLPPWPPDSRASSQRSWLTGAVPKAGDSS", "length": 1057, "header": "sp|Q8C310-3|ROBO4_MOUSE Isoform 3 of Roundabout homolog 4 OS=Mus musculus OX=10090 GN=Robo4 PE=1 SV=2 CANONICAL=Q8C310-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 201, "start_aa": "Asn", "end_pos": 201, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn201", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 247, "start_aa": "Asn", "end_pos": 247, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn247", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 361, "start_aa": "Asn", "end_pos": 361, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn361", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 390, "start_aa": "Asn", "end_pos": 390, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn390", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 397, "start_aa": "Asn", "end_pos": 397, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn397", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 681, "start_aa": "Asn", "end_pos": 681, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn681", "evidence": [ { "id": "Q8C310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C310#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 713, "start_aa": "Asn", "end_pos": 713, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn713", 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Genet.", "date": "2019", "authors": "Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wunnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Bjork HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Lino Cardenas CL, Butcher JT, Hughes GC, Lindsay ME, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC", "evidence": [ { "database": "UniProtKB", "id": "Q8C310", "url": "https://www.uniprot.org/uniprot/Q8C310" } ], "reference": [ { "type": "PubMed", "id": "30455415", "url": "https://glygen.org/publication/PubMed/30455415" } ] }, { "title": "[The destructive role of soluble Robo4 secreted by the M1-polarized-microglia during cerebral ischemia-reperfusion in blood-brain barrier integrity].", "journal": "Sheng li xue bao : [Acta physiologica Sinica]", "date": "2022", "authors": "Huang JL, Li C, Yang LL, Gao Y, Zhao PY, Yang ZG", "evidence": [ { "database": "RefSeq", "id": "NP_083059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083059" }, { "database": "RefSeq", "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319" } ], "reference": [ { "type": "PubMed", "id": "35993202", "url": "https://glygen.org/publication/PubMed/35993202" } ] }, { "title": "Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2023-01-17", "authors": "Morita Maaya, Yoneda Aki, Tokunoh Nagisa, Masaki Tatsumi, Shirakura Keisuke, Kinoshita Mayumi, Hashimoto Rina, Shigesada Naoya, Takahashi Junya, Tachibana Masashi, Tanaka Shota, Obana Masanori, Hino Nobumasa, Ikawa Masahito, Tsujikawa Kazutake, Ono Chikako, Matsuura Yoshiharu, Kidoya Hiroyasu, Takakura 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