{
    "uniprot_canonical_ac": "Q8C2S7-1",
    "uniprot_ac": "Q8C2S7",
    "uniprot_id": "AMGO3_MOUSE",
    "mass": {
        "chemical_mass": 55625.0,
        "monoisotopic_mass": 55625.0
    },
    "refseq": {
        "ac": "NP_796249",
        "name": "amphoterin-induced protein 3 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249"
    },
    "gene_names": [
        {
            "name": "Amigo3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7",
            "id": "Q8C2S7"
        },
        {
            "name": "Ali3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7",
            "id": "Q8C2S7"
        },
        {
            "name": "Amigo3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249",
            "id": "NP_796249"
        },
        {
            "name": "Kiaa1851",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7",
            "id": "Q8C2S7"
        },
        {
            "name": "ali3; E430002N15Rik; mKIAA1851",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249",
            "id": "NP_796249"
        }
    ],
    "protein_names": [
        {
            "name": "Amphoterin-induced protein 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8C2S7"
        },
        {
            "name": "AMIGO-3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C2S7"
        },
        {
            "name": "Alivin-3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C2S7"
        },
        {
            "name": "amphoterin induced gene and ORF 3; amphoterin-induced protein 3; alivin 3; AMIGO-3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249",
            "id": "NP_796249"
        },
        {
            "name": "amphoterin-induced protein 3 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249",
            "id": "NP_796249"
        }
    ],
    "function": [
        {
            "annotation": "May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C2S7",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q80ZD5",
                    "url": "https://www.uniprot.org/uniprot/Q80ZD5#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:11446",
            "recommended_name": {
                "id": "DOID:11446",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11446",
                "name": "sciatic neuropathy",
                "description": ""
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "11446",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:11446"
                }
            ]
        }
    ],
    "snv": [
        {
            "evidence": [
                {
                    "id": "rs3389071612",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389071612"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ],
            "start_pos": 471,
            "end_pos": 471,
            "sequence_org": "R",
            "sequence_mut": "S",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGR->NGS).",
            "chr_id": "9",
            "chr_pos": "107931989",
            "ref_nt": "A",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "R471",
            "keywords": [
                "ebi",
                "germline"
            ]
        }
    ],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C2S7",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Amigo3",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7",
            "locus": {
                "chromosome": "9",
                "start_pos": 107932900,
                "end_pos": 107930358,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000032593",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000032593"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000032593",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032593",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00096",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "320844",
            "url": "https://www.ncbi.nlm.nih.gov/gene/320844",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "GPDB0006500",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0006500",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "IPR001611",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003591",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003599",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR007110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013783",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR031283",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031283",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR032675",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036179",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:320844",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320844",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2444854",
            "url": "http://www.informatics.jax.org/marker/MGI:2444854",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "TPCRCPP",
            "url": "https://omabrowser.org/oma/group/TPCRCPP/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3145419at2759",
            "url": "http://www.orthodb.org/?query=3145419at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24368",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24368",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24368:SF62",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24368:SF62",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00560",
            "url": "http://pfam.xfam.org/family/PF00560",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13855",
            "url": "http://pfam.xfam.org/family/PF13855",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8C2S7",
            "url": "http://purl.obolibrary.org/obo/PR_Q8C2S7",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_796249",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796249",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C2S7",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C2S7-1",
            "url": "https://www.uniprot.org/uniprot/Q8C2S7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAWLVLSGILLCMLGAGLGTSDLEDVLPPAPHNCPDICICAADVLSCAGRGLQDLPVALPTTAAELDLSHNALKRLHPGWLAPLSRLRALHLGYNKLEVLGHGAFTNASGLRTLDLSSNMLRMLHTHDLDGLEELEKLLLFNNSLMHLDLDAFQGLRMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLKHISIPELAALPTYLKNRLYLHNNPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLVFKVSESRVRFFEHSRVFKNCSVAAAPGLELPEEQLHAQVGQSLRLFCNTSVPATRVAWVSPKNELLVAPASQDGSIAVLADGSLAIGRVQEQHAGVFVCLASGPRLHHNQTLEYNVSVQKARPEPETFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCHCCQRACRNRCWPRASSPLQELSAQSSMLSTTPPDAPSRKASVHKHVVFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLVMS",
        "length": 508,
        "header": "sp|Q8C2S7-1|AMGO3_MOUSE Isoform 1 of Amphoterin-induced protein 3  OS=Mus musculus OX=10090 GN=Amigo3 PE=1 SV=1 CANONICAL=Q8C2S7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q8C2S7-1",
            "url": "",
            "sequence": {
                "sequence": "MAWLVLSGILLCMLGAGLGTSDLEDVLPPAPHNCPDICICAADVLSCAGRGLQDLPVALPTTAAELDLSHNALKRLHPGWLAPLSRLRALHLGYNKLEVLGHGAFTNASGLRTLDLSSNMLRMLHTHDLDGLEELEKLLLFNNSLMHLDLDAFQGLRMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLKHISIPELAALPTYLKNRLYLHNNPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLVFKVSESRVRFFEHSRVFKNCSVAAAPGLELPEEQLHAQVGQSLRLFCNTSVPATRVAWVSPKNELLVAPASQDGSIAVLADGSLAIGRVQEQHAGVFVCLASGPRLHHNQTLEYNVSVQKARPEPETFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCHCCQRACRNRCWPRASSPLQELSAQSSMLSTTPPDAPSRKASVHKHVVFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLVMS",
                "length": 508,
                "header": "sp|Q8C2S7-1|AMGO3_MOUSE Isoform 1 of Amphoterin-induced protein 3  OS=Mus musculus OX=10090 GN=Amigo3 PE=1 SV=1 CANONICAL=Q8C2S7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 107932102,
                "end_pos": 107930579,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000085060",
                        "url": "https://www.ensembl.org/id/ENSMUST00000085060"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000082137",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000082137"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 107,
            "start_aa": "Asn",
            "end_pos": 107,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn107",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 142,
            "start_aa": "Asn",
            "end_pos": 142,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn142",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 272,
            "start_aa": "Asn",
            "end_pos": 272,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn272",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 301,
            "start_aa": "Asn",
            "end_pos": 301,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn301",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 362,
            "start_aa": "Asn",
            "end_pos": 362,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn362",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 368,
            "start_aa": "Asn",
            "end_pos": 368,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn368",
            "evidence": [
                {
                    "id": "Q8C2S7",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats.",
            "journal": "J. Cell Biol.",
            "date": "2003",
            "authors": "Kiiltomaeki M., Kuja-Panula J., Rauvala H., Rouhiainen A., Yamashiro T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C2S7",
                    "url": "https://www.uniprot.org/uniprot/Q8C2S7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12629050",
                    "url": "https://glygen.org/publication/PubMed/12629050"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:320844",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320844",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q80ZD5-1",
            "protein_name": "Amphoterin-induced protein 3",
            "gene_name": "Amigo3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAWLVLLGLLLCMLGAGSGTSDLEGVLPPDPHNCPNKCVCAADVLSCAGRGLQDLPAALPATAAELDLSHNALKRLHPGWLAPLSRLRALYLGYNKLDVLGRGVFTNASGLRILDLSSNLLRRLRTYDLDGLEELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLGHVSVPELAALPTFLKNRLYLHNNPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLAFKVAESRVRFFEHSRVFKNCSVAAAPGLELPEEELHTHVGQSLRLFCNTTVPAARVAWVSPKNELLVAPGSQDGSIAVLADGSLAIGRVQEQHAGLFVCLASGPRLHHNQTLEYNVSVHKPRPEPEAFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCRCCRRACRNRCWPRASSPLQELSAQSSVLSTTPPDAPSRKASVHKHVAFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLMMS",
                "length": 508
            },
            "evidence": [
                {
                    "id": "45238265",
                    "url": "http://www.informatics.jax.org/homology/45238265",
                    "database": "MGI"
                },
                {
                    "id": "Q8C2S7",
                    "url": "https://omabrowser.org/oma/group/Q8C2S7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q86WK7-1",
            "protein_name": "Amphoterin-induced protein 3",
            "gene_name": "AMIGO3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWPQTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYNPGGLQLKAGSESASSIGSEGPMTT",
                "length": 504
            },
            "evidence": [
                {
                    "id": "45238265",
                    "url": "http://www.informatics.jax.org/homology/45238265",
                    "database": "MGI"
                },
                {
                    "id": "Q8C2S7",
                    "url": "https://omabrowser.org/oma/group/Q8C2S7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "cell adhesion",
                        "id": "GO:0007155",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C2S7",
                                "url": "https://www.uniprot.org/uniprot/Q8C2S7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nervous system development",
                        "id": "GO:0007399",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C2S7",
                                "url": "https://www.uniprot.org/uniprot/Q8C2S7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of neuron projection development",
                        "id": "GO:0010977",
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