{
    "uniprot_canonical_ac": "Q8C176-1",
    "uniprot_ac": "Q8C176",
    "uniprot_id": "TAF2_MOUSE",
    "mass": {
        "chemical_mass": 126997.0,
        "monoisotopic_mass": 126997.0
    },
    "refseq": {
        "ac": "NP_001074757",
        "name": "transcription initiation factor TFIID subunit 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757"
    },
    "gene_names": [
        {
            "name": "Taf2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8C176",
            "id": "Q8C176"
        },
        {
            "name": "4732460C16Rik; CIF150; TAF2B; TAFII-150; TAFII150",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757",
            "id": "NP_001074757"
        },
        {
            "name": "Taf2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757",
            "id": "NP_001074757"
        }
    ],
    "protein_names": [
        {
            "name": "Transcription initiation factor TFIID subunit 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "TAF(II)150",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "TAFII-150",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "TAFII150",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "TBP-associated factor 150 kDa; transcription initiation factor TFIID 150 kDa subunit; TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757",
            "id": "NP_001074757"
        },
        {
            "name": "TBP-associated factor 150 kDa",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "Transcription initiation factor TFIID 150 kDa subunit",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8C176"
        },
        {
            "name": "transcription initiation factor TFIID subunit 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757",
            "id": "NP_001074757"
        }
    ],
    "function": [
        {
            "annotation": "TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074757",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757"
                },
                {
                    "database": "PubMed",
                    "id": "34634302",
                    "url": "https://glygen.org/publication/PubMed/34634302"
                }
            ]
        },
        {
            "annotation": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6P1X5",
                    "url": "https://www.uniprot.org/uniprot/Q6P1X5#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0081205",
            "recommended_name": {
                "id": "DOID:0081205",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0081205",
                "name": "autosomal recessive intellectual developmental disorder 40",
                "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the TAF2 gene on chromosome 8q24."
            },
            "synonyms": [
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "microcephaly-thin corpus callosum-intellectual disability syndrome",
                    "description": "Microcephaly-thin corpus callosum-intellectual disability syndrome is a rare, genetic, syndromic intellectual disability disease characterized by progressive postnatal microcephaly and global developmental delay, as well as moderate to profound intellectual disability, difficulty or inability to walk, pyramidal signs (including spasticity, hyperreflexia and extensor plantar response) and thin corpus callosum revealed by brain imaging. Ophthalmologic signs (including nystagmus, strabismus and abnormal retinal pigmentation), foot deformity and genital anomalies may also be associated."
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "intellectual developmental disorder, autosomal recessive 40",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "intellectual disability, autosomal recessive type 40",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "mental retardation, autosomal recessive type 40",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "microcephaly-thin corpus callosum-intellectual disability syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "MRT40",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "intellectual disability, autosomal recessive 40",
                    "description": ""
                },
                {
                    "id": "MONDO:0014273",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014273",
                    "name": "mental retardation, autosomal recessive 40",
                    "description": ""
                },
                {
                    "id": "MIM:615599",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615599",
                    "name": "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity",
                    "description": "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity"
                }
            ],
            "evidence": [
                {
                    "id": "0081205",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081205"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Taf2",
            "url": "https://www.uniprot.org/uniprot/Q8C176",
            "locus": {
                "chromosome": "15",
                "start_pos": 54878527,
                "end_pos": 54935548,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000037343",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037343"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000037343",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037343",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd09839",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09839",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "319944",
            "url": "https://www.ncbi.nlm.nih.gov/gene/319944",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8C176",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8C176*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027268",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027268",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037813",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037813",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042097",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042097",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:319944",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319944",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2443028",
            "url": "http://www.informatics.jax.org/marker/MGI:2443028",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "QYMAAQR",
            "url": "https://omabrowser.org/oma/group/QYMAAQR/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "11119at2759",
            "url": "http://www.orthodb.org/?query=11119at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15137",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15137",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15137:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15137:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8C176",
            "url": "http://purl.obolibrary.org/obo/PR_Q8C176",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-674695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-674695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-6804756",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-73776",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73776",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-73779",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73779",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-75953",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75953",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-76042",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76042",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "B9EJX5",
            "url": "https://www.uniprot.org/uniprot/B9EJX5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B9EJX5-1",
            "url": "https://www.uniprot.org/uniprot/B9EJX5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C176",
            "url": "https://www.uniprot.org/uniprot/Q8C176",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8C176-1",
            "url": "https://www.uniprot.org/uniprot/Q8C176-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYIHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQALAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYHHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYTMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTYGFLKSISNVSGKDIQPLIKQWLDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMEADSPLLWIRIDPDMSVLRKVEFEQADFMWQYELRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKTCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDASLFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQTDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTAHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPEAGVGNQFSSSQDEEEVDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPHHHHHHHEHKKKKKKHKHKHKHKHKHDSKDKDREPFAFSSPASGRSVRSPSLSD",
        "length": 1104,
        "header": "sp|Q8C176-1|TAF2_MOUSE Isoform 1 of Transcription initiation factor TFIID subunit 2  OS=Mus musculus OX=10090 GN=Taf2 PE=2 SV=2 CANONICAL=Q8C176-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B9EJX5-1",
            "url": "",
            "sequence": {
                "sequence": "MPPTGLESSRMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYIHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQALAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYHHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYTMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTYGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYELRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKTCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDASLFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQTDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTAHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPEAGVGNQESASNPGCHAQLAGFQNPFSSSQDEEEVDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPSGSRSSLMPQHSLGCDITPPTKPQWSMELSRKGAGKEQPLEMGVHSMVAAPLSMFAKEALSSRHSEHHHHHHHEHKKKKKKHKHKHKHKHKHDSKDKDREPFAFSSPASGRSVRSPSLSD",
                "length": 1198,
                "header": "tr|B9EJX5-1|B9EJX5_MOUSE Computationally mapped isoform of Transcription initiation factor TFIID subunit 2  OS=Mus musculus OX=10090 GN=Taf2 PE=1 SV=1 CANONICAL=Q8C176-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 54935325,
                "end_pos": 54879741,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000041733.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000041733.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000043733.8",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000043733.8"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C176-1",
            "url": "",
            "sequence": {
                "sequence": "MNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYIHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQALAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYHHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYTMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTYGFLKSISNVSGKDIQPLIKQWLDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMEADSPLLWIRIDPDMSVLRKVEFEQADFMWQYELRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKTCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDASLFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQTDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTAHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPEAGVGNQFSSSQDEEEVDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPHHHHHHHEHKKKKKKHKHKHKHKHKHDSKDKDREPFAFSSPASGRSVRSPSLSD",
                "length": 1104,
                "header": "sp|Q8C176-1|TAF2_MOUSE Isoform 1 of Transcription initiation factor TFIID subunit 2  OS=Mus musculus OX=10090 GN=Taf2 PE=2 SV=2 CANONICAL=Q8C176-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 1090,
            "end_pos": 1090,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "site_lbl": "Ser1090"
        },
        {
            "start_pos": 1093,
            "end_pos": 1093,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "site_lbl": "Ser1093"
        },
        {
            "start_pos": 1099,
            "end_pos": 1099,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "site_lbl": "Ser1099"
        },
        {
            "start_pos": 1101,
            "end_pos": 1101,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "site_lbl": "Ser1101"
        },
        {
            "start_pos": 1103,
            "end_pos": 1103,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8C176",
                    "url": "https://www.uniprot.org/uniprot/Q8C176"
                }
            ],
            "site_lbl": "Ser1103"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.",
            "journal": "The Journal of biological chemistry",
            "date": "2021",
            "authors": "Scheer E, Luo J, Bernardini A, Ruffenach F, Garnier JM, Kolb-Cheynel I, Gupta K, Berger I, Ranish J, Tora L",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074757",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074757"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34634302",
                    "url": "https://glygen.org/publication/PubMed/34634302"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:319944",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319944",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-674695",
            "name": "RNA Polymerase II Pre-transcription Events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-674695",
            "resource": "Reactome",
            "description": "RNA Polymerase II Pre-transcription Events"
        },
        {
            "id": "R-MMU-6804756",
            "name": "Regulation of TP53 Activity through Phosphorylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756",
            "resource": "Reactome",
            "description": "Regulation of TP53 Activity through Phosphorylation"
        },
        {
            "id": "R-MMU-73776",
            "name": "RNA Polymerase II Promoter Escape",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73776",
            "resource": "Reactome",
            "description": "RNA Polymerase II Promoter Escape"
        },
        {
            "id": "R-MMU-73779",
            "name": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73779",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
        },
        {
            "id": "R-MMU-75953",
            "name": "RNA Polymerase II Transcription Initiation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75953",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation"
        },
        {
            "id": "R-MMU-76042",
            "name": "RNA Polymerase II Transcription Initiation And Promoter Clearance",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76042",
            "resource": "Reactome",
            "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1LNY6-1",
            "protein_name": "Transcription initiation factor TFIID subunit 2",
            "gene_name": "Taf2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPPTGLESSRMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYVLAIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYHHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYTMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTYGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYELRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKTCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDASLFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQTDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTAHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPEAGVGNQETASNPGCHTQLAGFQNPFSSSQDEEEVDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPSSSRSSLMPQHALGCDITPTTKPQWSMELSRKGAGKEQPLEMGVHPVAAPLSVFAKEALSSARHSEHHHHHHHEHKKKKKKHKHKHKHKHKHDGKDKDKDKEPFTFSSPASGRSVRSPSLSD",
                "length": 1200
            },
            "evidence": [
                {
                    "id": "45238838",
                    "url": "http://www.informatics.jax.org/homology/45238838",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6P1X5-1",
            "protein_name": "Transcription initiation factor TFIID subunit 2",
            "gene_name": "TAF2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQLVGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTASKHSDHHHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD",
                "length": 1199
            },
            "evidence": [
                {
                    "id": "45238838",
                    "url": "http://www.informatics.jax.org/homology/45238838",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 13,
                "go_terms": [
                    {
                        "name": "positive regulation of transcription initiation by RNA polymerase II",
                        "id": "GO:0060261",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein phosphorylation",
                        "id": "GO:0006468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "G2/M transition of mitotic cell cycle",
                        "id": "GO:0000086",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription initiation at RNA polymerase II promoter",
                        "id": "GO:0006367",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mRNA transcription by RNA polymerase II",
                        "id": "GO:0042789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "monoubiquitinated histone H2A deubiquitination",
                        "id": "GO:0035522",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035522",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone H3 acetylation",
                        "id": "GO:0043966",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043966",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA repair",
                        "id": "GO:0006282",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006282",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II preinitiation complex assembly",
                        "id": "GO:0051123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "monoubiquitinated histone deubiquitination",
                        "id": "GO:0035521",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035521",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to organic cyclic compound",
                        "id": "GO:0014070",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "transcription factor TFTC complex",
                        "id": "GO:0033276",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033276",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription factor TFIID complex",
                        "id": "GO:0005669",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "chromatin binding",
                        "id": "GO:0003682",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682",
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                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription cis-regulatory region binding",
                        "id": "GO:0000976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8C176",
                                "url": "https://www.uniprot.org/uniprot/Q8C176"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
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        {
            "start_pos": 139,
            "end_pos": 141,
            "annotation": "n_glycosylation_sequon"
        },
        {
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            "end_pos": 176,
            "annotation": "n_glycosylation_sequon"
        },
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            "end_pos": 238,
            "annotation": "n_glycosylation_sequon"
        },
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            "start_pos": 499,
            "end_pos": 501,
            "annotation": "n_glycosylation_sequon"
        },
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            "start_pos": 566,
            "end_pos": 568,
            "annotation": "n_glycosylation_sequon"
        }
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
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    ],
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}