{ "uniprot_canonical_ac": "Q8C120-1", "uniprot_ac": "Q8C120", "uniprot_id": "SH3R3_MOUSE", "mass": { "chemical_mass": 93130.0, "monoisotopic_mass": 93130.0 }, "refseq": { "ac": "NP_766376", "name": "E3 ubiquitin-protein ligase SH3RF3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376" }, "gene_names": [ { "name": "Sh3rf3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8C120", "id": "Q8C120" }, { "name": "4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376", "id": "NP_766376" }, { "name": "Posh2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8C120", "id": "Q8C120" }, { "name": "Sh3md4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8C120", "id": "Q8C120" }, { "name": "Sh3rf3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376", "id": "NP_766376" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase SH3RF3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8C120" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C120" }, { "name": "E3 ubiquitin-protein ligase SH3RF3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376", "id": "NP_766376" }, { "name": "Plenty of SH3s 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C120" }, { "name": "SH3 domain-containing RING finger protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C120" }, { "name": "SH3 multiple domains protein 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C120" }, { "name": "insulin-like growth factor binding protein 5 interacting protein; SH3 domain-containing RING finger protein 3; plenty of SH3s 2; SH3 multiple domains protein 4; SH3 multiple domains 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376", "id": "NP_766376" } ], "function": [ { "annotation": "Androgen suppressive therapy increases IGFBP5 in the bone marrow microenvironment and thereby may facilitate the progression of prostate cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_766376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376" }, { "database": "PubMed", "id": "17823924", "url": "https://glygen.org/publication/PubMed/17823924" } ] }, { "annotation": "Has E3 ubiquitin-protein ligase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120#function" }, { "database": "UniProtKB", "id": "Q8TEJ3", "url": "https://www.uniprot.org/uniprot/Q8TEJ3#function" } ] }, { "annotation": "Insulin-like growth factor binding protein 5 interacting protein (IGFBP5-IP) may act as intracellular mediator of growth promoting actions of IGFBP5 and perhaps other osteoregulatory agents in bone cells.", "evidence": [ { "database": "RefSeq", "id": "NP_766376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376" }, { "database": "PubMed", "id": "16269403", "url": "https://glygen.org/publication/PubMed/16269403" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389068473", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389068473" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 625, "end_pos": 625, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TQT->NQT).", "chr_id": "10", "chr_pos": "58940054", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T625", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Sh3rf3", "url": "https://www.uniprot.org/uniprot/Q8C120", "locus": { "chromosome": "10", "start_pos": 58974738, "end_pos": 58649181, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037990", "url": "https://www.ensembl.org/id/ENSMUSG00000037990" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037990", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037990", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11925", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11925", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16750", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16750", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "237353", "url": "https://www.ncbi.nlm.nih.gov/gene/237353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:237353", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2444637", "url": "http://www.informatics.jax.org/marker/MGI:2444637", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8C120", "url": "https://oglcnac.org/atlas/detail/Q8C120", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q8C120", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8C120", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "SEMRGAM", "url": "https://omabrowser.org/oma/group/SEMRGAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5407056at2759", "url": "http://www.orthodb.org/?query=5407056at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "http://pfam.xfam.org/family/PF00097", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14604", "url": "http://pfam.xfam.org/family/PF14604", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8C120", "url": "http://purl.obolibrary.org/obo/PR_Q8C120", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_766376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C120-1", "url": "https://www.uniprot.org/uniprot/Q8C120-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C120-2", "url": "https://www.uniprot.org/uniprot/Q8C120-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C120-3", "url": "https://www.uniprot.org/uniprot/Q8C120-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C120-4", "url": "https://www.uniprot.org/uniprot/Q8C120-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFLSAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 878, "header": "sp|Q8C120-1|SH3R3_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SH3RF3 OS=Mus musculus OX=10090 GN=Sh3rf3 PE=1 SV=2 CANONICAL=Q8C120-1" }, "isoforms": [ { "isoform_ac": "Q8C120-1", "url": "", "sequence": { "sequence": "MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFLSAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 878, "header": "sp|Q8C120-1|SH3R3_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SH3RF3 OS=Mus musculus OX=10090 GN=Sh3rf3 PE=1 SV=2 CANONICAL=Q8C120-1" }, "locus": { "chromosome": "10", "start_pos": 58971807, "end_pos": 58649397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000153031", "url": "https://www.ensembl.org/id/ENSMUST00000153031" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000120938", "url": "https://www.ensembl.org/id/ENSMUSP00000120938" } ] } }, { "isoform_ac": "Q8C120-2", "url": "", "sequence": { "sequence": "MKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 617, "header": "sp|Q8C120-2|SH3R3_MOUSE Isoform 2 of E3 ubiquitin-protein ligase SH3RF3 OS=Mus musculus OX=10090 GN=Sh3rf3 PE=1 SV=2 CANONICAL=Q8C120-1" }, "locus": {} }, { "isoform_ac": "Q8C120-3", "url": "", "sequence": { "sequence": "MDAPEKYTERATPDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRSPHPSHSGEVRVRLAQERVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKVSGPSWANPEPGAGWLLGPSHTLANGAENR", "length": 344, "header": "sp|Q8C120-3|SH3R3_MOUSE Isoform 3 of E3 ubiquitin-protein ligase SH3RF3 OS=Mus musculus OX=10090 GN=Sh3rf3 PE=1 SV=2 CANONICAL=Q8C120-1" }, "locus": {} }, { "isoform_ac": "Q8C120-4", "url": "", "sequence": { "sequence": "MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFLSAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQVIPRAGGLCP", "length": 438, "header": "sp|Q8C120-4|SH3R3_MOUSE Isoform 4 of E3 ubiquitin-protein ligase SH3RF3 OS=Mus musculus OX=10090 GN=Sh3rf3 PE=1 SV=2 CANONICAL=Q8C120-1" }, "locus": { "chromosome": "10", "start_pos": 58885432, "end_pos": 58649397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135526", "url": "https://www.ensembl.org/id/ENSMUST00000135526" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114368", "url": "https://www.ensembl.org/id/ENSMUSP00000114368" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 578, "start_aa": "Thr", "end_pos": 578, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr578", "evidence": [ { "id": "Q8C120", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8C120" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 579, "start_aa": "Ser", "end_pos": 579, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser579", "evidence": [ { "id": "Q8C120", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8C120" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 606, "start_aa": "Thr", "end_pos": 606, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr606", "evidence": [ { "id": "Q8C120", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8C120" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q8C120", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8C120" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" } ] } ], "phosphorylation": [ { "start_pos": 395, "end_pos": 395, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "site_lbl": "Ser395" }, { "start_pos": 792, "end_pos": 792, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "site_lbl": "Ser792" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation.", "journal": "American journal of physiology. Cell physiology", "date": "2006", "authors": "Amaar YG, Tapia B, Chen ST, Baylink DJ, Mohan S", "evidence": [ { "database": "RefSeq", "id": "NP_766376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376" } ], "reference": [ { "type": "PubMed", "id": "16269403", "url": "https://glygen.org/publication/PubMed/16269403" } ] }, { "title": "Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression.", "journal": "The Prostate", "date": "2007", "authors": "Xu C, Graf LF, Fazli L, Coleman IM, Mauldin DE, Li D, Nelson PS, Gleave M, Plymate SR, Cox ME, Torok-Storb BJ, Knudsen BS", "evidence": [ { "database": "RefSeq", "id": "NP_766376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766376" } ], "reference": [ { "type": "PubMed", "id": "17823924", "url": "https://glygen.org/publication/PubMed/17823924" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8C120", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8C120" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "White CW 3rd, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q8C120", "url": "https://oglcnac.org/atlas/detail/Q8C120" } ], "reference": [ { "type": "PubMed", "id": "32848054", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8C120", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8C120" }, { "database": "O-GlcNAc Atlas", "id": "Q8C120", "url": "https://oglcnac.org/atlas/detail/Q8C120" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] } ], "pathway": [ { "id": "mmu:237353", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237353", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "M0R6D9-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Sh3rf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLGASWLCASKAAATAAPGEGDDRQGEQQRGDQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFPALAGGAGGATGSPPRSPVFLSAAAGSSTSSSLCDAATNRSVPVAKNLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGTHGFLPASYIQCMRPLPQTLPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVANVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQASSHRHSMEISAPVLISSSDPRAAARIGELAHLSCAVPTQDSSSAGPVPTAIPRAAAVAGEQGMSPKVQLPLNMYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGISGVFPGNYVTPVSRVPGGAGSPWNNVLGGSPLAKGMATIMHPGGGSLSSPATATRSALPLTTLQDHMQHPATSLPTGSCLRHTAQPAASQAGGTTIPTATHPSAQALDRPTATVSPLRTQTSPSRLPSTSLRPRSVVSPQHSQQPPTQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPTSGLSTPSPINAGYKPDDKKNEKKEKKSGLLKLLAGASTKKKARSPPSVSPTHDPQSAMDSSLQGAVGPEVSPLTIHGRAGSCPVESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSTASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHRKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 878 }, "evidence": [ { "id": "45243636", "url": "http://www.informatics.jax.org/homology/45243636", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TEJ3-1", "protein_name": "E3 ubiquitin-protein ligase SH3RF3", "gene_name": "SH3RF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"database": "MGI" }, { "id": "Q8C120", "url": "https://omabrowser.org/oma/group/Q8C120/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 679, "end_pos": 681, "annotation": "n_glycosylation_sequon" }, { "start_pos": 796, "end_pos": 798, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autoubiquitinated.", "evidence": [ { "database": "UniProtKB", "id": "Q8C120", "url": "https://www.uniprot.org/uniprot/Q8C120" }, { "database": "PubMed", "id": "Q8TEJ3", "url": "https://glygen.org/publication/PubMed/Q8TEJ3" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", 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