{ "uniprot_canonical_ac": "Q8C0D7-1", "uniprot_ac": "Q8C0D7", "uniprot_id": "ING4_MOUSE", "mass": { "chemical_mass": 28528.0, "monoisotopic_mass": 28528.0 }, "refseq": { "ac": "NP_579923", "name": "inhibitor of growth protein 4 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" }, "gene_names": [ { "name": "Ing4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8C0D7", "id": "Q8C0D7" }, { "name": "D6Wsu147e; D6Xrf92; p29ING4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "id": "NP_579923" }, { "name": "Ing4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "id": "NP_579923" } ], "protein_names": [ { "name": "Inhibitor of growth protein 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8C0D7" }, { "name": "ING1-like protein; inhibitor of growth protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "id": "NP_579923" }, { "name": "inhibitor of growth protein 4 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "id": "NP_579923" }, { "name": "p29ING4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8C0D7" } ], "function": [ { "annotation": "Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890).", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7#function" }, { "database": "PubMed", "id": "11888890", "url": "https://glygen.org/publication/PubMed/11888890" }, { "database": "UniProtKB", "id": "Q9UNL4", "url": "https://www.uniprot.org/uniprot/Q9UNL4#function" } ] }, { "annotation": "IL-6 Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor.", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" }, { "database": "PubMed", "id": "28502470", "url": "https://glygen.org/publication/PubMed/28502470" } ] }, { "annotation": "ING4 alleviated lipopolysaccharide-induced inflammation by regulating the NF-kappaB pathway via a direct interaction with SIRT1.", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" }, { "database": "PubMed", "id": "31811786", "url": "https://glygen.org/publication/PubMed/31811786" } ] }, { "annotation": "ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas-induced apoptosis in a caspase-8-dependent pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" }, { "database": "PubMed", "id": "27070489", "url": "https://glygen.org/publication/PubMed/27070489" } ] }, { "annotation": "Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" }, { "database": "PubMed", "id": "35388759", "url": "https://glygen.org/publication/PubMed/35388759" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ing4", "url": "https://www.uniprot.org/uniprot/Q8C0D7", "locus": { "chromosome": "6", "start_pos": 125026228, "end_pos": 125016723, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000030330", "url": "https://www.ensembl.org/id/ENSMUSG00000030330" } ] } } ], "crossref": [ { "id": "ENSMUSG00000030330", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030330", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15684", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15684", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16862", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16862", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "28019", "url": "https://www.ncbi.nlm.nih.gov/gene/28019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8C0D7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8C0D7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:28019", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:28019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "107307", "url": "http://www.informatics.jax.org/marker/MGI:107307", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "SHGQMIM", "url": "https://omabrowser.org/oma/group/SHGQMIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3140066at2759", "url": "http://www.orthodb.org/?query=3140066at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1WEN", "url": "https://www.rcsb.org/structure/1WEN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1WEU", "url": "https://www.rcsb.org/structure/1WEU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF12998", "url": "http://pfam.xfam.org/family/PF12998", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8C0D7", "url": "http://purl.obolibrary.org/obo/PR_Q8C0D7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C0D7-1", "url": "https://www.uniprot.org/uniprot/Q8C0D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C0D7-2", "url": "https://www.uniprot.org/uniprot/Q8C0D7-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C0D7-3", "url": "https://www.uniprot.org/uniprot/Q8C0D7-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C0D7-4", "url": "https://www.uniprot.org/uniprot/Q8C0D7-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8C0D7-5", "url": "https://www.uniprot.org/uniprot/Q8C0D7-5", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK", "length": 249, "header": "sp|Q8C0D7-1|ING4_MOUSE Isoform 1 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "isoforms": [ { "isoform_ac": "Q8C0D7-1", "url": "", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK", "length": 249, "header": "sp|Q8C0D7-1|ING4_MOUSE Isoform 1 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "locus": { "chromosome": "6", "start_pos": 125025367, "end_pos": 125016824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000140131", "url": "https://www.ensembl.org/id/ENSMUST00000140131" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121519", "url": "https://www.ensembl.org/id/ENSMUSP00000121519" } ] } }, { "isoform_ac": "Q8C0D7-2", "url": "", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKSRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK", "length": 248, "header": "sp|Q8C0D7-2|ING4_MOUSE Isoform 2 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "locus": { "chromosome": "6", "start_pos": 125025367, "end_pos": 125016824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000032480", "url": "https://www.ensembl.org/id/ENSMUST00000032480" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000032480", "url": "https://www.ensembl.org/id/ENSMUSP00000032480" } ] } }, { "isoform_ac": "Q8C0D7-3", "url": "", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKSRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDVRTVSSGLGEEL", "length": 227, "header": "sp|Q8C0D7-3|ING4_MOUSE Isoform 3 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "locus": {} }, { "isoform_ac": "Q8C0D7-4", "url": "", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKSRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRT", "length": 166, "header": "sp|Q8C0D7-4|ING4_MOUSE Isoform 4 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "locus": {} }, { "isoform_ac": "Q8C0D7-5", "url": "", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPMER", "length": 168, "header": "sp|Q8C0D7-5|ING4_MOUSE Isoform 5 of Inhibitor of growth protein 4 OS=Mus musculus OX=10090 GN=Ing4 PE=1 SV=2 CANONICAL=Q8C0D7-1" }, "locus": { "chromosome": "6", "start_pos": 125024880, "end_pos": 125016824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000112417", "url": "https://www.ensembl.org/id/ENSMUST00000112417" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108036", "url": "https://www.ensembl.org/id/ENSMUSP00000108036" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mouse ING1 homologue, a protein interacting with A1, enhances cell death and is inhibited by A1 in mammary epithelial cells.", "journal": "Cancer Res.", "date": "2002", "authors": "Ha S, Lee S, Chung M, Choi Y", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "reference": [ { "type": "PubMed", "id": "11888890", "url": "https://glygen.org/publication/PubMed/11888890" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "ING4 Inhibits Proliferation and Induces Apoptosis in Human Melanoma A375 Cells via the Fas/Caspase-8 Apoptosis Pathway.", "journal": "Dermatology (Basel, Switzerland)", "date": "2016", "authors": "Ma Y, Cheng X, Wang F, Pan J, Liu J, Chen H, Wang Y, Cai L", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" } ], "reference": [ { "type": "PubMed", "id": "27070489", "url": "https://glygen.org/publication/PubMed/27070489" } ] }, { "title": "Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma.", "journal": "Molecular therapy : the journal of the American Society of Gene Therapy", "date": "2017", "authors": "Wang S, Reinhard S, Li C, Qian M, Jiang H, Du Y, Lachelt U, Lu W, Wagner E, Huang R", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" } ], "reference": [ { "type": "PubMed", "id": "28502470", "url": "https://glygen.org/publication/PubMed/28502470" } ] }, { "title": "ING4 alleviated lipopolysaccharide-induced inflammation by regulating the NF-kappaB pathway via a direct interaction with SIRT1.", "journal": "Immunology and cell biology", "date": "2020", "authors": "Yang Y, Liu Y, He X, Yang F, Han S, Qin A, Wu G, Liu M, Li Z, Wang J, Yang X, Hu D", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" } ], "reference": [ { "type": "PubMed", "id": "31811786", "url": "https://glygen.org/publication/PubMed/31811786" } ] }, { "title": "Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).", "journal": "Current cancer drug targets", "date": "2022", "authors": "Cui Z, Sun S, Li J, Li J, Sha T, He J, Zuo L", "evidence": [ { "database": "RefSeq", "id": "NP_579923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579923" } ], "reference": [ { "type": "PubMed", "id": "35388759", "url": "https://glygen.org/publication/PubMed/35388759" } ] } ], "pathway": [ { "id": "mmu:28019", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:28019", "resource": "KEGG Pathway" }, { "id": "R-MMU-3214847", "name": "HATs acetylate histones", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847", "resource": "Reactome", "description": "HATs acetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UNL4-1", "protein_name": "Inhibitor of growth protein 4", "gene_name": "ING4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK", "length": 249 }, "evidence": [ { "id": "45233805", "url": "http://www.informatics.jax.org/homology/45233805", "database": "MGI" }, { "id": "Q8C0D7", "url": "https://omabrowser.org/oma/group/Q8C0D7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "regulation of DNA biosynthetic process", "id": "GO:2000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000278", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "regulation of cell growth", "id": "GO:0001558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "protein acetylation", "id": "GO:0006473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006473", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "regulation of cell cycle G2/M phase transition", "id": "GO:1902749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902749", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone modification", "id": "GO:0016570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016570", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "negative regulation of growth", "id": "GO:0045926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045926", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H4-K5 acetylation", "id": "GO:0043981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043981", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H4-K8 acetylation", "id": "GO:0043982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043982", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H4-K12 acetylation", "id": "GO:0043983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043983", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "id": "GO:1902164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902164", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "DNA replication-dependent chromatin disassembly", "id": "GO:0140889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140889", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "histone H4K12 acetyltransferase activity", "id": "GO:0043997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043997", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H4K5 acetyltransferase activity", "id": "GO:0043995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043995", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H4K8 acetyltransferase activity", "id": "GO:0043996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043996", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "methylated histone binding", "id": "GO:0035064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone H3K14 acetyltransferase activity", "id": "GO:0036408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036408", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton", "id": "GO:0045111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" }, { "name": "histone acetyltransferase complex", "id": "GO:0000123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q8C0D7", "url": "https://www.uniprot.org/uniprot/Q8C0D7" }, { "database": "PubMed", "id": "Q9UNL4", "url": "https://glygen.org/publication/PubMed/Q9UNL4" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }