{
    "uniprot_canonical_ac": "Q8BXK4-1",
    "uniprot_ac": "Q8BXK4",
    "uniprot_id": "SAMTR_MOUSE",
    "mass": {
        "chemical_mass": 45952.0,
        "monoisotopic_mass": 45952.0
    },
    "refseq": {
        "ac": "NP_780521",
        "name": "S-adenosylmethionine sensor upstream of mTORC1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521"
    },
    "gene_names": [
        {
            "name": "Bmt2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4",
            "id": "Q8BXK4"
        },
        {
            "name": "B630005N14Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521",
            "id": "NP_780521"
        },
        {
            "name": "B630005N14Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4",
            "id": "Q8BXK4"
        },
        {
            "name": "Bmt2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521",
            "id": "NP_780521"
        },
        {
            "name": "Samtor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4",
            "id": "Q8BXK4"
        }
    ],
    "protein_names": [
        {
            "name": "S-adenosylmethionine sensor upstream of mTORC1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8BXK4"
        },
        {
            "name": "2.1.1.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8BXK4"
        },
        {
            "name": "Probable methyltransferase BMT2 homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q8BXK4"
        },
        {
            "name": "S-adenosylmethionine sensor upstream of mTORC1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521",
            "id": "NP_780521"
        },
        {
            "name": "UPF0532 protein C7orf60 homolog; probable methyltransferase BTM2 homolog; probable methyltransferase BMT2 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521",
            "id": "NP_780521"
        }
    ],
    "function": [
        {
            "annotation": "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BXK4",
                    "url": "https://www.uniprot.org/uniprot/Q8BXK4#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "MF_03044",
                    "url": "https://www.uniprot.org/uniprot/MF_03044#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BXK4",
                    "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Bmt2",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4",
            "locus": {
                "chromosome": "6",
                "start_pos": 13625672,
                "end_pos": 13677965,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000042742",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000042742"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000042742",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000042742",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "101148",
            "url": "https://www.ncbi.nlm.nih.gov/gene/101148",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR021867",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR021867",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029063",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:101148",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:101148",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2141466",
            "url": "http://www.informatics.jax.org/marker/MGI:2141466",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "ASIMKNW",
            "url": "https://omabrowser.org/oma/group/ASIMKNW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3669878at2759",
            "url": "http://www.orthodb.org/?query=3669878at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21008",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21008",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21008:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21008:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF11968",
            "url": "http://pfam.xfam.org/family/PF11968",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8BXK4",
            "url": "http://purl.obolibrary.org/obo/PR_Q8BXK4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-9639288",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9639288",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_780521",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780521",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0N4SUJ1",
            "url": "https://www.uniprot.org/uniprot/A0A0N4SUJ1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0N4SUJ1-1",
            "url": "https://www.uniprot.org/uniprot/A0A0N4SUJ1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BXK4",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BXK4-1",
            "url": "https://www.uniprot.org/uniprot/Q8BXK4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEEEEYSNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPFYELEDPILLLS",
        "length": 403,
        "header": "sp|Q8BXK4-1|SAMTR_MOUSE Isoform 1 of S-adenosylmethionine sensor upstream of mTORC1  OS=Mus musculus OX=10090 GN=Bmt2 PE=2 SV=2 CANONICAL=Q8BXK4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0N4SUJ1-1",
            "url": "",
            "sequence": {
                "sequence": "MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVEVCGFIYRLCF",
                "length": 204,
                "header": "tr|A0A0N4SUJ1-1|SAMTR_MOUSE Computationally mapped isoform of S-adenosylmethionine sensor upstream of mTORC1  OS=Mus musculus OX=10090 GN=Bmt2 PE=2 SV=1 CANONICAL=Q8BXK4-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 13677832,
                "end_pos": 13630559,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000203078.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000203078.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000144704.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000144704.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8BXK4-1",
            "url": "",
            "sequence": {
                "sequence": "MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEEEEYSNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPFYELEDPILLLS",
                "length": 403,
                "header": "sp|Q8BXK4-1|SAMTR_MOUSE Isoform 1 of S-adenosylmethionine sensor upstream of mTORC1  OS=Mus musculus OX=10090 GN=Bmt2 PE=2 SV=2 CANONICAL=Q8BXK4-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 13677832,
                "end_pos": 13628473,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000045235",
                        "url": "https://www.ensembl.org/id/ENSMUST00000045235"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000040578",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000040578"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:101148",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:101148",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-9639288",
            "name": "Amino acids regulate mTORC1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9639288",
            "resource": "Reactome",
            "description": "Amino acids regulate mTORC1"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZV22-1",
            "protein_name": "S-adenosylmethionine sensor upstream of mTORC1",
            "gene_name": "Bmt2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS",
                "length": 403
            },
            "evidence": [
                {
                    "id": "45240125",
                    "url": "http://www.informatics.jax.org/homology/45240125",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q1RMZ1-1",
            "protein_name": "S-adenosylmethionine sensor upstream of mTORC1",
            "gene_name": "BMT2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS",
                "length": 405
            },
            "evidence": [
                {
                    "id": "45240125",
                    "url": "http://www.informatics.jax.org/homology/45240125",
                    "database": "MGI"
                },
                {
                    "id": "Q8BXK4",
                    "url": "https://omabrowser.org/oma/group/Q8BXK4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9W138-1",
            "protein_name": "S-adenosylmethionine sensor upstream of mTORC1",
            "gene_name": "Samtor",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MATEEHQRLASIVKSCHESLRQLTKEYGATAAWQEHTSPRNAKQLAEYAKAMKQLAAIWETNDGKVELQARSRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDSQHVGKNAHLMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIHREEGMCEEIRIPQDDS",
                "length": 302
            },
            "evidence": [
                {
                    "id": "Q8BXK4",
                    "url": "https://omabrowser.org/oma/group/Q8BXK4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "KICSTOR complex",
                        "id": "GO:0140007",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140007",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GATOR1 complex",
                        "id": "GO:1990130",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990130",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "methyltransferase activity",
                        "id": "GO:0008168",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "S-adenosyl-L-methionine binding",
                        "id": "GO:1904047",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transferase activity",
                        "id": "GO:0016740",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "methylation",
                        "id": "GO:0032259",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to amino acid starvation",
                        "id": "GO:0034198",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of TORC1 signaling",
                        "id": "GO:1904262",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BXK4",
                                "url": "https://www.uniprot.org/uniprot/Q8BXK4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 145,
            "end_pos": 147,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 352,
            "end_pos": 354,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-MMU-9640195",
            "name": "RRAGA,B hydrolyzes GTP",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9JLN9-1",
                "P58043-1",
                "Q99K70-1",
                "Q8BXK4-1",
                "Q7TT45-1",
                "P50516-1",
                "Q6NTA4-1",
                "Q80X95-1",
                "P58006-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-9640195",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9640195"
                }
            ]
        },
        {
            "id": "R-MMU-9640254",
            "name": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "lysosomal membrane",
            "input_participant_list": [],
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