{ "uniprot_canonical_ac": "Q8BR92-1", "uniprot_ac": "Q8BR92", "uniprot_id": "PALM2_MOUSE", "mass": { "chemical_mass": 42095.0, "monoisotopic_mass": 42095.0 }, "refseq": { "ac": "NP_766456", "name": "paralemmin-2 isoform 5", "summary": "This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" }, "gene_names": [ { "name": "Palm2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BR92", "id": "Q8BR92" }, { "name": "53-H12; AA959716; AI649048; AKAP-2; AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2; Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456", "id": "NP_766456" }, { "name": "Pakap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456", "id": "NP_766456" } ], "protein_names": [ { "name": "Paralemmin-2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BR92" }, { "name": "Palm2-Akap2 readthrough transcript; A-kinase anchor protein 2; AKAP expressed in kidney and lung; Protein kinase A-anchoring protein 2; paralemmin 2; A kinase (PRKA) anchor protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456", "id": "NP_766456" }, { "name": "paralemmin-2 isoform 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456", "id": "NP_766456" } ], "function": [ { "annotation": "A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" }, { "database": "PubMed", "id": "34831084", "url": "https://glygen.org/publication/PubMed/34831084" } ] }, { "annotation": "Knocking down akap2 expression remarkably decreased tumorigenicity and metastatic ability of prostate cancer cells. AKAP2 may serve as a critical component of Calcitonin receptor-mediated oncogenic actions.", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" }, { "database": "PubMed", "id": "26432469", "url": "https://glygen.org/publication/PubMed/26432469" } ] }, { "annotation": "The AKAP2 protein is direct phosphorylation within a regulatory region of aquaporin-0 to modulate water permeability.", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" }, { "database": "PubMed", "id": "22095752", "url": "https://glygen.org/publication/PubMed/22095752" } ] }, { "annotation": "This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Palm2", "url": "https://www.uniprot.org/uniprot/Q8BR92", "locus": {} } ], "crossref": [ { "id": "ENSMUSG00000090053", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000090053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "677884", "url": "https://www.ncbi.nlm.nih.gov/gene/677884", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "1934601", "url": "http://www.informatics.jax.org/marker/MGI:1934601", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8BR92", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BR92", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "HSANPRH", "url": "https://omabrowser.org/oma/group/HSANPRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4318462at2759", "url": "http://www.orthodb.org/?query=4318462at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10498", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10498", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10498:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10498:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03285", "url": "http://pfam.xfam.org/family/PF03285", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BR92", "url": "http://purl.obolibrary.org/obo/PR_Q8BR92", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BR92-1", "url": "https://www.uniprot.org/uniprot/Q8BR92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAELHKERLQAIAEKRKRQTEIEGKRRQLDEQVLLLQHSKSKVLREKWLLQGVPAGTAEEEEARRRQSEEDEFKVKQLEDNIQRLEQEIQALESEESQISAKEQIILEKLKETEKSFKDLQKSFSTADGAIYAMEINVEKDKQTGETKILSASTIGPEGVHQRGVKVYDDGTKVVYEVHSGGTVVENGVHKLSAKDVEELIQKAGQSSFRRHMSERTVVADGSLGHPKEHMLCKEAKLEMVQKSRKDQSSGNPGQQAQPPITEEPGANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPLSDTTEPSSPEGKEESLATDPAPGTQKKKRCQCCVVM", "length": 376, "header": "sp|Q8BR92-1|PALM2_MOUSE Isoform 1 of Paralemmin-2 OS=Mus musculus OX=10090 GN=Palm2 PE=1 SV=1 CANONICAL=Q8BR92-1" }, "isoforms": [ { "isoform_ac": "Q8BR92-1", "url": "", "sequence": { "sequence": "MAEAELHKERLQAIAEKRKRQTEIEGKRRQLDEQVLLLQHSKSKVLREKWLLQGVPAGTAEEEEARRRQSEEDEFKVKQLEDNIQRLEQEIQALESEESQISAKEQIILEKLKETEKSFKDLQKSFSTADGAIYAMEINVEKDKQTGETKILSASTIGPEGVHQRGVKVYDDGTKVVYEVHSGGTVVENGVHKLSAKDVEELIQKAGQSSFRRHMSERTVVADGSLGHPKEHMLCKEAKLEMVQKSRKDQSSGNPGQQAQPPITEEPGANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTDVSTIDGNAAELVSGRPLSDTTEPSSPEGKEESLATDPAPGTQKKKRCQCCVVM", "length": 376, "header": "sp|Q8BR92-1|PALM2_MOUSE Isoform 1 of Paralemmin-2 OS=Mus musculus OX=10090 GN=Palm2 PE=1 SV=1 CANONICAL=Q8BR92-1" }, "locus": { "chromosome": "4", "start_pos": 57710184, "end_pos": 57568371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000102904", "url": "https://www.ensembl.org/id/ENSMUST00000102904" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099968", "url": "https://www.ensembl.org/id/ENSMUSP00000099968" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q8BR92", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BR92" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" } ] } ], "phosphorylation": [ { "start_pos": 315, "end_pos": 315, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "16452087", "url": "https://glygen.org/publication/PubMed/16452087" }, { "database": "phospho.ELM", "id": "Q8BR92", "url": "http://phospho.elm.eu.org/byAccession/Q8BR92.html" }, { "database": "iPTMnet", "id": "Q8BR92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BR92" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Ser315" }, { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" }, { "database": "phospho.ELM", "id": "Q8BR92", "url": "http://phospho.elm.eu.org/byAccession/Q8BR92.html" }, { "database": "iPTMnet", "id": "Q8BR92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BR92" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Ser355" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Comprehensive identification of phosphorylation sites in postsynaptic density preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2006", "authors": "Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" }, { "database": "iPTMnet", "id": "Q8BR92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BR92" } ], "reference": [ { "type": "PubMed", "id": "16452087", "url": "https://glygen.org/publication/PubMed/16452087" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q8BR92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BR92" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" }, { "database": "iPTMnet", "id": "Q8BR92", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BR92" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.", "journal": "EMBO molecular medicine", "date": "2012", "authors": "Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" } ], "reference": [ { "type": "PubMed", "id": "22095752", "url": "https://glygen.org/publication/PubMed/22095752" } ] }, { "title": "A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.", "journal": "Endocrine-related cancer", "date": "2016", "authors": "Thakkar A, Aljameeli A, Thomas S, Shah GV", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" } ], "reference": [ { "type": "PubMed", "id": "26432469", "url": "https://glygen.org/publication/PubMed/26432469" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BR92", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BR92" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction.", "journal": "Cells", "date": "2021", "authors": "Maric D, Paterek A, Delaunay M, Lopez IP, Arambasic M, Diviani D", "evidence": [ { "database": "RefSeq", "id": "NP_766456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766456" } ], "reference": [ { "type": "PubMed", "id": "34831084", "url": "https://glygen.org/publication/PubMed/34831084" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "Q8BR92", "url": "https://www.uniprot.org/uniprot/Q8BR92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }