{
    "uniprot_canonical_ac": "Q8BP22-1",
    "uniprot_ac": "Q8BP22",
    "uniprot_id": "CBAR1_MOUSE",
    "mass": {
        "chemical_mass": 33119.0,
        "monoisotopic_mass": 33119.0
    },
    "refseq": {
        "ac": "NP_001297672",
        "name": "CBY1-interacting BAR domain-containing protein 1 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672"
    },
    "gene_names": [
        {
            "name": "Cibar1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8BP22",
            "id": "Q8BP22"
        },
        {
            "name": "6720467C03Rik; Fam92a; Fam92a1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834",
            "id": "NP_080834"
        },
        {
            "name": "Cibar1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834",
            "id": "NP_080834"
        },
        {
            "name": "Fam92a1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BP22",
            "id": "Q8BP22"
        },
        {
            "name": "Fam92a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BP22",
            "id": "Q8BP22"
        }
    ],
    "protein_names": [
        {
            "name": "CBY1-interacting BAR domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8BP22"
        },
        {
            "name": "CBY1-interacting BAR domain-containing protein 1 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834",
            "id": "NP_080834"
        },
        {
            "name": "CBY1-interacting BAR domain-containing protein 1 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672",
            "id": "NP_001297672"
        },
        {
            "name": "protein FAM92A1; family with sequence similarity 92, member A; CBY1-interacting BAR domain-containing protein 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672",
            "id": "NP_001297672"
        }
    ],
    "function": [
        {
            "annotation": "A new nonsyndromic autosomal recessive nonsyndromic postaxial polydactyly type A ciliopathy due to a loss-of-function variant in FAM92A.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001297672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672"
                },
                {
                    "database": "PubMed",
                    "id": "30395363",
                    "url": "https://glygen.org/publication/PubMed/30395363"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834"
                }
            ]
        },
        {
            "annotation": "Acts as a positive regulator of ciliary hedgehog signaling (PubMed:29459677). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (By similarity). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (By similarity). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A1XBS5",
                    "url": "https://www.uniprot.org/uniprot/A1XBS5#function"
                },
                {
                    "database": "PubMed",
                    "id": "29459677",
                    "url": "https://glygen.org/publication/PubMed/29459677"
                },
                {
                    "database": "PubMed",
                    "id": "30395363",
                    "url": "https://glygen.org/publication/PubMed/30395363"
                }
            ]
        },
        {
            "annotation": "Protein expression, expressing profile and subcellular localization of AK078438 gene set the basis for further exploration of its functions.[AK078438]",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001297672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672"
                },
                {
                    "database": "PubMed",
                    "id": "17557235",
                    "url": "https://glygen.org/publication/PubMed/17557235"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:1148",
            "recommended_name": {
                "id": "DOID:1148",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1148",
                "name": "polydactyly",
                "description": "A physical disorder that is characterized by the presence of more than five fingers per hand or five toes per foot."
            },
            "synonyms": [
                {
                    "id": "DOID:1148",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1148",
                    "name": "postaxial polydactyly",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polysyndactyly 4",
                    "description": "Polysyndactyly or PPD4 is a form of preaxial polydactyly of fingers, a limb malformation syndrome, characterized by the presence of a thumb showing the mildest degree of duplication, being broad, bifid or with radially deviated distal phalanx. Syndactyly of various degrees of third-and-fourth fingers is occasionally present."
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "PPD4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polydactyly, preaxial type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polydactyly, preaxial, type IV",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "preaxial polydactyly type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "crossed polydactyly type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "crossed polydactyly, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polydactyly preaxial 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polydactyly, preaxial 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polydactyly, preaxial IV",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polysyndactyly uncomplicated",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "polysyndactyly, uncomplicated",
                    "description": ""
                },
                {
                    "id": "MONDO:0008272",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008272",
                    "name": "preaxial polydactyly 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "polydactyly",
                    "description": "A disease characterized by the presence of polydactyly, including syndromic and non-syndromic forms."
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "hyperdactyly",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "polydactylism",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "polydactyly",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "polydactyly (disease)",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "postaxial polydactyly",
                    "description": ""
                },
                {
                    "id": "MONDO:0021003",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0021003",
                    "name": "supernumerary digit",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "polydactyly, postaxial, type A1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "polydactyly, postaxial, type A1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "polydactyly, postaxial, types A1 and B",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "PAPA1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "polydactyly, postaxial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "postaxial polydactyly, type A",
                    "description": ""
                },
                {
                    "id": "MONDO:0008266",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008266",
                    "name": "postaxial polydactyly, type B",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly of a triphalangeal thumb",
                    "description": "A form of preaxial polydactyly of fingers, a limb malformation syndrome, that is characterized by the presence of a usually opposable triphalangeal thumb with or without additional duplication of one or more skeletal components of the thumb. The thumb appearance can differ widely in shape (wedge to rectangular) or it can be deviated in the radio-ulnar plane (clinodactyly). PPD2 is also associated with systemic syndromes, including Holt-Oram syndrome and Fanconi anemia."
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "PPD2",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly, preaxial type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly, preaxial type II",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "preaxial polydactyly type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "triphalangeal thumb, type i",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "TPT-PS syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly of triphalangeal thumb",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly, preaxial 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "polydactyly, preaxial II",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "triphalangeal thumb",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "triphalangeal thumb with polysyndactyly",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "triphalangeal thumb-polydactyly syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008270",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008270",
                    "name": "triphalangeal thumb-polysyndactyly syndrome",
                    "description": ""
                },
                {
                    "id": "MIM:174700",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/174700",
                    "name": "Polydactyly, preaxial 4",
                    "description": "Polydactyly, preaxial 4"
                },
                {
                    "id": "MIM:174200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/174200",
                    "name": "Polydactyly, postaxial A1",
                    "description": "Polydactyly, postaxial A1"
                },
                {
                    "id": "MIM:174500",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/174500",
                    "name": "Preaxial polydactyly 2",
                    "description": "Preaxial polydactyly 2"
                }
            ],
            "evidence": [
                {
                    "id": "1148",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1148"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Cibar1",
            "url": "https://www.uniprot.org/uniprot/Q8BP22",
            "locus": {
                "chromosome": "4",
                "start_pos": 12153409,
                "end_pos": 12172015,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000028218",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028218"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000028218",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028218",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd07598",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07598",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "68099",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68099",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q8BP22",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8BP22*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR009602",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009602",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027267",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035590",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035590",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:68099",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68099",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1915349",
            "url": "http://www.informatics.jax.org/marker/MGI:1915349",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "WMLMNND",
            "url": "https://omabrowser.org/oma/group/WMLMNND/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2783931at2759",
            "url": "http://www.orthodb.org/?query=2783931at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21223",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21223",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21223:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21223:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06730",
            "url": "http://pfam.xfam.org/family/PF06730",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8BP22",
            "url": "http://purl.obolibrary.org/obo/PR_Q8BP22",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001297672",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8Q0KEJ4",
            "url": "https://www.uniprot.org/uniprot/A0A8Q0KEJ4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8Q0KEJ4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8Q0KEJ4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6VZK2",
            "url": "https://www.uniprot.org/uniprot/F6VZK2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6VZK2-1",
            "url": "https://www.uniprot.org/uniprot/F6VZK2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3UY30",
            "url": "https://www.uniprot.org/uniprot/G3UY30",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3UY30-1",
            "url": "https://www.uniprot.org/uniprot/G3UY30-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3KMP6",
            "url": "https://www.uniprot.org/uniprot/J3KMP6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3KMP6-1",
            "url": "https://www.uniprot.org/uniprot/J3KMP6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BP22",
            "url": "https://www.uniprot.org/uniprot/Q8BP22",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BP22-1",
            "url": "https://www.uniprot.org/uniprot/Q8BP22-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Z4YJZ2",
            "url": "https://www.uniprot.org/uniprot/Z4YJZ2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Z4YJZ2-1",
            "url": "https://www.uniprot.org/uniprot/Z4YJZ2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVISQAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN",
        "length": 286,
        "header": "sp|Q8BP22-1|CBAR1_MOUSE Isoform 1 of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=2 CANONICAL=Q8BP22-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8Q0KEJ4-1",
            "url": "",
            "sequence": {
                "sequence": "MPSGLPCPALDRRGARRVATETPGRRGGAHCALSAPGRSGGVACSRAPWRPGAALVGLPSWVPGGGKGKMLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVISQAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN",
                "length": 355,
                "header": "tr|A0A8Q0KEJ4-1|CBAR1_MOUSE Computationally mapped isoform of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=1 CANONICAL=Q8BP22-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 12171930,
                "end_pos": 12153898,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000108285.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000108285.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000103920.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000103920.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6VZK2-1",
            "url": "",
            "sequence": {
                "sequence": "XFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEMLMNMAKVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVR",
                "length": 216,
                "header": "tr|F6VZK2-1|CBAR1_MOUSE Computationally mapped isoform of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=2 CANONICAL=Q8BP22-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 12171168,
                "end_pos": 12155711,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000154416.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000154416.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000120369.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000120369.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "G3UY30-1",
            "url": "",
            "sequence": {
                "sequence": "XETPGRRGGAHCALSAPGRSGGVACSRAPWRPGAALVGLPSWVPGGGKGKMLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAELYFI",
                "length": 141,
                "header": "tr|G3UY30-1|CBAR1_MOUSE Computationally mapped isoform of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=1 CANONICAL=Q8BP22-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 12171871,
                "end_pos": 12169045,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000126012.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000126012.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000133923.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000133923.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "J3KMP6-1",
            "url": "",
            "sequence": {
                "sequence": "MPSGLPCPALDRRGARRVATETPGRRGGAHCALSAPGRSGGVACSRAPWRPGAALVGLPSWVPGGGKGKMLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVISKAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN",
                "length": 355,
                "header": "tr|J3KMP6-1|J3KMP6_MOUSE Computationally mapped isoform of CBY1 interacting BAR domain containing 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=1 CANONICAL=Q8BP22-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 12171930,
                "end_pos": 12153898,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000177837.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000177837.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000135961.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135961.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8BP22-1",
            "url": "",
            "sequence": {
                "sequence": "MLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVISQAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN",
                "length": 286,
                "header": "sp|Q8BP22-1|CBAR1_MOUSE Isoform 1 of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=2 CANONICAL=Q8BP22-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Z4YJZ2-1",
            "url": "",
            "sequence": {
                "sequence": "MPSGLPCPALDRRGARRVATETPGRRGGAHCALSAPGRSGGVACSRAPWRPGAALVGLPSWVPGGGKGKMLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN",
                "length": 351,
                "header": "tr|Z4YJZ2-1|CBAR1_MOUSE Computationally mapped isoform of CBY1-interacting BAR domain-containing protein 1  OS=Mus musculus OX=10090 GN=Cibar1 PE=1 SV=1 CANONICAL=Q8BP22-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 12171930,
                "end_pos": 12153898,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000087052.11",
                        "url": "https://www.ensembl.org/id/ENSMUST00000087052.11"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000084284.5",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000084284.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "[Cloning, expression, distribution and subcellular localization of AK078438 gene].",
            "journal": "Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics",
            "date": "2007",
            "authors": "Huang L, Song M, Yang HS, Zhang YG, Hu HZ",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001297672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17557235",
                    "url": "https://glygen.org/publication/PubMed/17557235"
                }
            ]
        },
        {
            "title": "BAR domain-containing FAM92 proteins interact with chibby1 to facilitate ciliogenesis.",
            "journal": "Mol. Cell. Biol.",
            "date": "2016",
            "authors": "Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27528616",
                    "url": "https://glygen.org/publication/PubMed/27528616"
                }
            ]
        },
        {
            "title": "A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.",
            "journal": "Nat. Genet.",
            "date": "2018",
            "authors": "Li A., Chen J.K., Nachury M.V., Breslow D.K., Han K., Kennedy M.C., Bassik M.C., Morgens D.W., Hess G.T., Hoogendoorn S., Kopp A.R., Vu B.K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29459677",
                    "url": "https://glygen.org/publication/PubMed/29459677"
                }
            ]
        },
        {
            "title": "FAM92A underlies nonsyndromic postaxial polydactyly in humans and an abnormal limb and digit skeletal phenotype in mice.",
            "journal": "J. Bone Miner. Res.",
            "date": "2019",
            "authors": "Schrauwen I, Giese AP, Aziz A, Lafont DT, Chakchouk I, Santos-Cortez RLP, Lee K, Acharya A, Khan FS, Ullah A, Nickerson DA, Bamshad MJ, Ali G, Riazuddin S, Ansar M, Ahmad W, Ahmed ZM, Leal SM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001297672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297672"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30395363",
                    "url": "https://glygen.org/publication/PubMed/30395363"
                }
            ]
        },
        {
            "title": "FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function.",
            "journal": "J. Cell Biol.",
            "date": "2019",
            "authors": "Wang L, Yan Z, Vihinen H, Eriksson O, Wang W, Soliymani R, Lu Y, Xue Y, Jokitalo E, Li J, Zhao H",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BP22",
                    "url": "https://www.uniprot.org/uniprot/Q8BP22"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30404948",
                    "url": "https://glygen.org/publication/PubMed/30404948"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:68099",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68099",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8I5ZZV0-1",
            "protein_name": "CBY1 interacting BAR domain containing 1",
            "gene_name": "Cibar1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPSGLPCPSLDRRGARRVATETPDRSGGAPGALSAPGGSGGVSCSRAPWRPGAALVGLPSRVPGGAKGKMLRRNLDDRDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEMLMNMAKVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVICSAETELQRATIDATRTTRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVLTAAYQNIQKIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRPLSTKCTSGTGQVATCRTKKDQHVEDEDDEELDVTEDEN",
                "length": 362
            },
            "evidence": [
                {
                    "id": "45228734",
                    "url": "http://www.informatics.jax.org/homology/45228734",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "A1XBS5-1",
            "protein_name": "CBY1-interacting BAR domain-containing protein 1",
            "gene_name": "CIBAR1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MMRRTLENRNAQTKQLQTAVSNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINAYAATETPHLKLGLMNFADEFAKLQDYRQAEVERLEAKVVEPLKTYGTIVKMKRDDLKATLTARNREAKQLTQLERTRQRNPSDRHVISQAETELQRAAMDASRTSRHLEETINNFERQKMKDIKTIFSEFITIEMLFHGKALEVYTAAYQNIQNIDEDEDLEVFRNSLYAPDYSSRLDIVRANSKSPLQRSLSAKCVSGTGQVSTCRLRKDQQAEDDEDDELDVTEEENFLK",
                "length": 289
            },
            "evidence": [
                {
                    "id": "45228734",
                    "url": "http://www.informatics.jax.org/homology/45228734",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "membrane tubulation",
                        "id": "GO:0097749",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097749",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium assembly",
                        "id": "GO:0060271",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "limb morphogenesis",
                        "id": "GO:0035108",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035108",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inner mitochondrial membrane organization",
                        "id": "GO:0007007",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007007",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of smoothened signaling pathway",
                        "id": "GO:0045880",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane organization",
                        "id": "GO:0061024",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "phospholipid binding",
                        "id": "GO:0005543",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centriole",
                        "id": "GO:0005814",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ciliary base",
                        "id": "GO:0097546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial crista",
                        "id": "GO:0030061",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030061",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrion",
                        "id": "GO:0005739",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial inner membrane",
                        "id": "GO:0005743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium",
                        "id": "GO:0005929",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ciliary basal body",
                        "id": "GO:0036064",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
                                "url": "https://www.uniprot.org/uniprot/Q8BP22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extrinsic component of membrane",
                        "id": "GO:0019898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q8BP22",
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