{ "uniprot_canonical_ac": "Q8BJW7-1", "uniprot_ac": "Q8BJW7", "uniprot_id": "EME1_MOUSE", "mass": { "chemical_mass": 63481.0, "monoisotopic_mass": 63481.0 }, "refseq": { "ac": "NP_808420", "name": "crossover junction endonuclease EME1 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, "gene_names": [ { "name": "Eme1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BJW7", "id": "Q8BJW7" }, { "name": "6820428D13", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420", "id": "NP_808420" }, { "name": "Eme1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420", "id": "NP_808420" } ], "protein_names": [ { "name": "Crossover junction endonuclease EME1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BJW7" }, { "name": "3.1.22.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BJW7" }, { "name": "crossover junction endonuclease EME1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420", "id": "NP_808420" }, { "name": "crossover junction endonuclease EME1; essential meiotic endonuclease 1 homolog 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420", "id": "NP_808420" } ], "function": [ { "annotation": "Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males, indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, { "database": "PubMed", "id": "31170160", "url": "https://glygen.org/publication/PubMed/31170160" } ] }, { "annotation": "Indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, { "database": "PubMed", "id": "24076219", "url": "https://glygen.org/publication/PubMed/24076219" } ] }, { "annotation": "Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7#function" }, { "database": "PubMed", "id": "14609959", "url": "https://glygen.org/publication/PubMed/14609959" } ] }, { "annotation": "Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, { "database": "PubMed", "id": "17036055", "url": "https://glygen.org/publication/PubMed/17036055" } ] }, { "annotation": "Study found that a Gen1 mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 and Eme1 are functionally redundant in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, { "database": "PubMed", "id": "27383418", "url": "https://glygen.org/publication/PubMed/27383418" } ] }, { "annotation": "These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 in the cellular response to DNA damage.", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" }, { "database": "PubMed", "id": "18692478", "url": "https://glygen.org/publication/PubMed/18692478" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Eme1", "url": "https://www.uniprot.org/uniprot/Q8BJW7", "locus": { "chromosome": "11", "start_pos": 94535822, "end_pos": 94544790, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000039055", "url": "https://www.ensembl.org/id/ENSMUSG00000039055" } ] } } ], "crossref": [ { "id": "ENSMUSG00000039055", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "268465", "url": "https://www.ncbi.nlm.nih.gov/gene/268465", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047522", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047522", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:268465", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268465", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "3576783", "url": "http://www.informatics.jax.org/marker/MGI:3576783", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "FCVESDW", "url": "https://omabrowser.org/oma/group/FCVESDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3088721at2759", "url": "http://www.orthodb.org/?query=3088721at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21077", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21077", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21077:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21077:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02732", "url": "http://pfam.xfam.org/family/PF02732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BJW7", "url": "http://purl.obolibrary.org/obo/PR_Q8BJW7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5693568", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5693568", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6783310", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BJW7-1", "url": "https://www.uniprot.org/uniprot/Q8BJW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD", "length": 570, "header": "sp|Q8BJW7-1|EME1_MOUSE Isoform 1 of Crossover junction endonuclease EME1 OS=Mus musculus OX=10090 GN=Eme1 PE=1 SV=1 CANONICAL=Q8BJW7-1" }, "isoforms": [ { "isoform_ac": "Q8BJW7-1", "url": "", "sequence": { "sequence": "MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD", "length": 570, "header": "sp|Q8BJW7-1|EME1_MOUSE Isoform 1 of Crossover junction endonuclease EME1 OS=Mus musculus OX=10090 GN=Eme1 PE=1 SV=1 CANONICAL=Q8BJW7-1" }, "locus": { "chromosome": "11", "start_pos": 94541820, "end_pos": 94536258, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000039949", "url": "https://www.ensembl.org/id/ENSMUST00000039949" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000036361", "url": "https://www.ensembl.org/id/ENSMUSP00000036361" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser117" }, { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser12" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser15" }, { "start_pos": 84, "end_pos": 84, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser84" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser85" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "site_lbl": "Ser87" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells.", "journal": "EMBO J.", "date": "2003", "authors": "West S.C., Hanada K., Jasin M., Essers J., Arrowsmith C., Kanaar R., Ciccia A., Laister R., Chahwan R., Chahwan C., Abraham J., Hakem R., Shehabeldin A., Hande M.P., Khaw A.K., Lemmers B., McPherson P., Moynahan M.E.", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "reference": [ { "type": "PubMed", "id": "14609959", "url": "https://glygen.org/publication/PubMed/14609959" } ] }, { "title": "The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.", "journal": "The EMBO journal", "date": "2006", "authors": "Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, Kanaar R", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" } ], "reference": [ { "type": "PubMed", "id": "17036055", "url": "https://glygen.org/publication/PubMed/17036055" } ] }, { "title": "Interplay between Np95 and Eme1 in the DNA damage response.", "journal": "Biochemical and biophysical research communications", "date": "2008", "authors": "Mistry H, Gibson L, Yun JW, Sarras H, Tamblyn L, McPherson JP", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" } ], "reference": [ { "type": "PubMed", "id": "18692478", "url": "https://glygen.org/publication/PubMed/18692478" } ] }, { "title": "Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.", "journal": "Molecular cell", "date": "2013", "authors": "Castor D, Nair N, Declais AC, Lachaud C, Toth R, Macartney TJ, Lilley DM, Arthur JS, Rouse J", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" } ], "reference": [ { "type": "PubMed", "id": "24076219", "url": "https://glygen.org/publication/PubMed/24076219" } ] }, { "title": "The GIY-YIG type endonuclease ankyrin repeat and LEM domain-containing protein 1 (ANKLE1) is dispensable for mouse hematopoiesis.", "journal": "PLoS ONE", "date": "2016", "authors": "Braun J, Meixner A, Brachner A, Foisner R", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "reference": [ { "type": "PubMed", "id": "27010503", "url": "https://glygen.org/publication/PubMed/27010503" } ] }, { "title": "Gen1 and Eme1 Play Redundant Roles in DNA Repair and Meiotic Recombination in Mice.", "journal": "DNA and cell biology", "date": "2016", "authors": "Wang X, Wang H, Guo B, Zhang Y, Gong Y, Zhang C, Xu H, Wu X", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" } ], "reference": [ { "type": "PubMed", "id": "27383418", "url": "https://glygen.org/publication/PubMed/27383418" } ] }, { "title": "A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLgamma during crossover formation in meiotic prophase I.", "journal": "PLoS genetics", "date": "2019", "authors": "Toledo M, Sun X, Brieno-Enriquez MA, Raghavan V, Gray S, Pea J, Milano CR, Venkatesh A, Patel L, Borst PL, Alani E, Cohen PE", "evidence": [ { "database": "RefSeq", "id": "NP_808420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808420" } ], "reference": [ { "type": "PubMed", "id": "31170160", "url": "https://glygen.org/publication/PubMed/31170160" } ] } ], "pathway": [ { "id": "mmu:268465", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268465", "resource": "KEGG Pathway" }, { "id": "R-MMU-5693568", "name": "Resolution of D-loop Structures through Holliday Junction Intermediates", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5693568", "resource": "Reactome", "description": "Resolution of D-loop Structures through Holliday Junction Intermediates" }, { "id": "R-MMU-6783310", "name": "Fanconi Anemia Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZCS5-1", "protein_name": "Essential meiotic structure-specific endonuclease 1", "gene_name": "Eme1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRRLSLSLLSTESDSEELPTFAFLKKEPASTDSNPPQREKNIVVVTSDIEASCPPSPGLKDPPCVPSAAEAPTQAGPVRVLSSSSEDEDGLVSLAERITWKLLRNKQLSPERSRSPLKTGSDHQKNASTPCDWKRQPCPKIPDVPLHSALEKSPANDKDSLLDNQCHQLPAYQATGRELAVTKTNPDLPLPKKRTKHIQTAQSRGPQGCWQPRQASRKENTPRQQERKKKAEMVNRLRAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEAQVVPQSITWRRKTELEEDGDDWVEEPTILVLVLKEVFMSMVYNSKQGNPGSTEKGKETLRGFVTDVTARTGKALSLVIVDQEKCLRAQNPPKRRKSGMANKKAKEKHQQRRESSTRLMVSRVDMEEALVDLQLYTEAQARIVQSWRELADFACAFTKAVAEAPFKKLRDQGSFSFFLEKDWAGGVKADHAGRGLALIWRRQIQQLNRVSSEMAGAIVDAYPSPQLLVQAYQQCFSEQERQNLLANIQVRRGEGVTATSRRVGPELSRRIYLQMTTVQPDLILDSVD", "length": 569 }, "evidence": [ { "id": "45235708", "url": "http://www.informatics.jax.org/homology/45235708", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96AY2-1", "protein_name": "Crossover junction endonuclease EME1", "gene_name": "EME1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALSLVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTEAQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTSTSRRIGPELSRRIYLQMTTLQPHLSLDSAD", "length": 570 }, "evidence": [ { "id": "45235708", "url": "http://www.informatics.jax.org/homology/45235708", "database": "MGI" }, { "id": "Q8BJW7", "url": "https://omabrowser.org/oma/group/Q8BJW7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "mitotic intra-S DNA damage checkpoint signaling", "id": "GO:0031573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031573", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "response to intra-S DNA damage checkpoint signaling", "id": "GO:0072429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072429", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nuclear replication fork", "id": "GO:0043596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043596", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "Holliday junction resolvase complex", "id": "GO:0048476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048476", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "endodeoxyribonuclease complex", "id": "GO:1905347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905347", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "Q8BJW7", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-MMU-5686430", "name": "MUS81 binds EME1, EME2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q91ZJ0-1", "Q56A04-1", "Q8BJW7-1" ], "evidence": [ { "id": "R-MMU-5686430", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5686430" } ] }, { "id": "R-MMU-5686440", "name": "MUS81:EME1,EME2 cleaves D-loop", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q91ZJ0-1", "Q56A04-1", "Q8BJW7-1", "Q80YR6-1", "Q62388-1", "P48754-1", "Q8CHK4-1", "P70388-1", "O70157-1", "O88700-1", "O70445-1", "Q5SXJ3-1", "Q9QZ11-1", "Q61216-1" ], "evidence": [ { "id": "R-MMU-5686440", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5686440" } ] }, { "id": "R-MMU-5686475", "name": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q91ZJ0-1", "Q56A04-1", "Q8BJW7-1", "Q8BX32-1" ], "evidence": [ { "id": "R-MMU-5686475", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5686475" } ] }, { "id": "R-MMU-5693584", "name": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q91ZJ0-1", "Q56A04-1", "Q8BJW7-1", "Q80YR6-1", "Q62388-1", "P48754-1", "Q8CHK4-1", "P70388-1", "O70157-1", "O88700-1", "Q8BMI4-1", "O70445-1", "Q5SXJ3-1", "Q9QZ11-1", "Q61216-1", "Q8BX32-1" ], "evidence": [ { "id": "R-MMU-5693584", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5693584" } ] }, { "id": "R-MMU-6785732", "name": "DNA nucleases bind monoubiquitinated ID2 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q69ZT1-1", "Q8BGE5-1", "Q91ZJ0-1", "Q9JIC3-1", "Q56A04-1", "Q8BJW7-1", "Q9QZD4-1", "Q8C7W7-1", "Q8BX32-1", "Q9CR14-1", "Q8BJQ2-1" ], "evidence": [ { "id": "R-MMU-6785732", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6785732" } ] }, { "id": "R-MMU-6785986", "name": "DNA nucleases unhook the interstrand crosslink (ICL)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q69ZT1-1", "Q8BGE5-1", "Q91ZJ0-1", "Q9JIC3-1", "Q56A04-1", "Q8BJW7-1", "Q9QZD4-1", "Q8C7W7-1", "Q8BX32-1", "Q9CR14-1" ], "evidence": [ { "id": "R-MMU-6785986", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6785986" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O70157", "gene_name": "Top3a", "activity": [ { "ec_number": "5.6.2.1", "activity": "ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.", "evidence": [ { "id": "O70157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70157" } ] }, { "ec_number": "5.6.2.1", "activity": "", "evidence": [ { "id": "O70157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70157" } ] } ] }, { "uniprot_ac": "O70445", "gene_name": "Bard1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70445" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70445" } ] } ] }, { "uniprot_ac": "O88700", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] } ] }, { "uniprot_ac": "P48754", "gene_name": "Brca1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P48754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48754" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P48754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48754" } ] } ] }, { "uniprot_ac": "P70388", "gene_name": "Rad50", "activity": [ { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "P70388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70388" } ] } ] }, { "uniprot_ac": "Q56A04", "gene_name": "Eme2", "activity": [ { "ec_number": "3.1.22.-", "activity": "", "evidence": [ { "id": "Q56A04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56A04" } ] } ] }, { "uniprot_ac": "Q5SXJ3", "gene_name": "Brip1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q5SXJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SXJ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5SXJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SXJ3" } ] } ] }, { "uniprot_ac": "Q61216", "gene_name": "Mre11", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q61216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61216" } ] } ] }, { "uniprot_ac": "Q62388", "gene_name": "Atm", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62388" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62388" } ] } ] }, { "uniprot_ac": "Q69ZT1", "gene_name": "Fan1", "activity": [ { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "Q69ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZT1" } ] }, { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "Q69ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZT1" } ] }, { "ec_number": "3.1.4.1", "activity": "", "evidence": [ { "id": "Q69ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZT1" } ] } ] }, { "uniprot_ac": "Q80YR6", "gene_name": "Rbbp8", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q80YR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YR6" } ] } ] }, { "uniprot_ac": "Q8BGE5", "gene_name": "Fancm", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q8BGE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGE5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q8BGE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGE5" } ] } ] }, { "uniprot_ac": "Q8BJQ2", "gene_name": "Usp1", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q8BJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJQ2" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q8BJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJQ2" } ] } ] }, { "uniprot_ac": "Q8BJW7", "gene_name": "Eme1", "activity": [ { "ec_number": "3.1.22.-", "activity": "", "evidence": [ { "id": "Q8BJW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJW7" } ] } ] }, { "uniprot_ac": "Q8BMI4", "gene_name": "Gen1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8BMI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BMI4" } ] } ] }, { "uniprot_ac": "Q8BX32", "gene_name": "Slx1b", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8BX32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX32" } ] } ] }, { "uniprot_ac": "Q8C7W7", "gene_name": "Dclre1b", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8C7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7W7" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q8C7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7W7" } ] } ] }, { "uniprot_ac": "Q8CHK4", "gene_name": "Kat5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8CHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHK4" } ] } ] }, { "uniprot_ac": "Q91ZJ0", "gene_name": "Mus81", "activity": [ { "ec_number": "3.1.22.-", "activity": "", "evidence": [ { "id": "Q91ZJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZJ0" } ] } ] }, { "uniprot_ac": "Q9CR14", "gene_name": "Fancl", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CR14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR14" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CR14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR14" } ] } ] }, { "uniprot_ac": "Q9JIC3", "gene_name": "Dclre1a", "activity": [ { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q9JIC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIC3" } ] } ] }, { "uniprot_ac": "Q9QZ11", "gene_name": "Exo1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q9QZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZ11" } ] } ] }, { "uniprot_ac": "Q9QZD4", "gene_name": "Ercc4", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q9QZD4", 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